274 - Performance-enhancing drugs and hormones-risks, rewards, & broader implications for the public

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Watch the full episode & view show notes here: bit.ly/3RH63et
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Derek is a fitness educator & the entrepreneur behind More Plates More Dates & an expert in molecules commonly used & misused by bodybuilders & athletes. This conversation explores various compounds like growth hormone, testosterone, androgens, SARMs, estrogen, finasteride, peptides, & much more. Derek walks through how these molecules are used by athletes to gain an edge while also exploring their impact on disease risk, hair loss, fertility, & more. This conversation aims to provide insights into whether these compounds are uniformly harmful or if there are broader implications that could benefit the general population.
We discuss:
0:00:00-Intro
0:00:47-Derek’s experimentation with anabolic steroids at a young age
0:10:28-Acquiring steroids from underground labs & the potential long-term fertility concerns early in his bodybuilding career
0:15:56-Backstory on More Plates, More Dates & Derek’s unique ability to blend scientific knowledge with personal observation
0:21:23-Growth hormone-from extreme use-cases to the more typical-& the misconception that it’s the “elixir of life”
0:29:34-Growth hormone 101: definition, where it comes from, & the challenges of measuring it
0:41:43-Does exogenous growth hormone compromise one’s ability to make endogenous growth hormone?
0:43:51-Use of growth hormone in restoration of tissue during periods of healing
0:51:45-Growth hormone-releasing peptides to increase endogenous GH: various peptides, risks, benefits & comparison to exogenous growth hormone
1:07:12-Role of growth hormone in building muscle & burning fat, as well as its effects on sleep & daytime lethargy
1:15:00-Evolution of drug use in the sport of bodybuilding
1:27:01-What explains the protruding abdomens on some bodybuilders & athletes?
1:33:20-Death of bodybuilders
1:42:15-Complex interplay of hormones, & the conversion of testosterone into metabolites like DHT & estrogen
1:52:23-Post-finasteride syndrome & how Derek successfully treated his hair loss
2:07:55-Testosterone replacement therapy: compelling use-cases, side effects, & optimal dosing schedules
2:28:56-Aromatase inhibitors to suppress estrogen, & the misconceptions around estrogen in men
2:34:38-Other hormones beyond testosterone for male sex hormone replacement
2:38:45-History of anabolic compounds, & the differing effects of various anabolic testosterone derivatives & related drugs
2:44:24-Use of SARMs by bodybuilders
2:51:53-Anabolic steroid & testosterone regimens of professional bodybuilders & the downstream consequences
3:01:20-Challenge of accurate hormone testing in the presence of anabolic steroids & supplements
3:04:10-Use of Clomid, hCG, & enclomiphene
3:18:37-Concerns about fertility: comparing the use of testosterone & hCG
3:31:33-Use of BPC-157 peptide for healing injuries
--------
About:
The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, & all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, & much more.
Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan & simultaneously improving their healthspan.
Learn more: peterattiamd.com
Connect with Peter on:
Facebook: bit.ly/PeterAttiaMDFB
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Instagram: bit.ly/PeterAttiaMDIG
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Disclaimer: This podcast is for general informational purposes only & does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information & the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, & they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures & the companies I invest in or advise, please visit my website where I keep an up-to-date & active list of such companies. For a full list of our registered & unregistered trademarks, trade names, & service marks, please review our Terms of Use: peterattiamd.com/terms-of-use/

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23 июл 2024

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@PeterAttiaMD 9 месяцев назад

In this episode, we discuss: 0:00:47-Derek’s experimentation with anabolic steroids at a young age 0:10:28-Acquiring steroids from underground labs & the potential long-term fertility concerns early in his bodybuilding career 0:15:56-Backstory on More Plates, More Dates & Derek’s unique ability to blend scientific knowledge with personal observation 0:21:23-Growth hormone-from extreme use-cases to the more typical-& the misconception that it’s the “elixir of life” 0:29:34-Growth hormone 101: definition, where it comes from, & the challenges of measuring it 0:41:43-Does exogenous growth hormone compromise one’s ability to make endogenous growth hormone? 0:43:51-Use of growth hormone in restoration of tissue during periods of healing 0:51:45-Growth hormone-releasing peptides to increase endogenous GH: various peptides, risks, benefits & comparison to exogenous growth hormone 1:07:12-Role of growth hormone in building muscle & burning fat, as well as its effects on sleep & daytime lethargy 1:15:00-Evolution of drug use in the sport of bodybuilding 1:27:01-What explains the protruding abdomens on some bodybuilders & athletes? 1:33:20-Death of bodybuilders 1:42:15-Complex interplay of hormones, & the conversion of testosterone into metabolites like DHT & estrogen 1:52:23-Post-finasteride syndrome & how Derek successfully treated his hair loss 2:07:55-Testosterone replacement therapy: compelling use-cases, side effects, & optimal dosing schedules 2:28:56-Aromatase inhibitors to suppress estrogen, & the misconceptions around estrogen in men 2:34:38-Other hormones beyond testosterone for male sex hormone replacement 2:38:45-History of anabolic compounds, & the differing effects of various anabolic testosterone derivatives & related drugs 2:44:24-Use of SARMs by bodybuilders 2:51:53-Anabolic steroid & testosterone regimens of professional bodybuilders & the downstream consequences 3:01:20-Challenge of accurate hormone testing in the presence of anabolic steroids & supplements 3:04:10-Use of Clomid, hCG, & enclomiphene 3:18:37-Concerns about fertility: comparing the use of testosterone & hCG 3:31:33-Use of BPC-157 peptide for healing injuries

@jbartmontage6737 9 месяцев назад

Thank you both 🏆

@Munga1976 9 месяцев назад

Peter, I’ve just been on Enclomiphene 25mg ED for the past 12 months. I’m more than happy To have a chat with you about my experiences with it if you’d like . Kind Regards Craig

@JOHNWAYNE1920 9 месяцев назад

UGL is not some guy. The steroids you buy online are from India and china. They're manufactured just like normal prescriptions. Its just not regulated over there like it is here.

@aaronortega1083 9 месяцев назад

EXCELLENT PODCAST !!!!!! 11/10. Would it be possible to edit in charts, graphs, images of some of the things talked about for future episodes ? Such as chemical pathways, MOA images etc. Thank you for the knowledge, god bless !

@BritishMoralHQ 9 месяцев назад

I follow below 1) enclomiphene 2) Luteolin 3) PORTULACA OLERACEA -seeds which has shown to successfully restore hpta .... 4) AC262 for crouch muscle growth 5) MK4,MK7 6) will chew black seed 7) schissandra , i3c, cordyceps, foti, maca,cocoa 8) sumac for antioxidant bomb ...with brocolli salmon soup 9) bromocriptine, bromontane

@MorePlatesMoreDates 9 месяцев назад

3.5 hours felt like it flew by! Had a blast, and what an honor to be featured on The Drive. I've been a member for years myself, and can't say enough positive things about Peter and his work. I really hope you guys enjoy the episode. I hosted Peter on my podcast as well and will be posting that next Monday.

@jamesoneill4571 9 месяцев назад

@MorePlatesMoreDates There is a real interest from the general audience for more specific discussions with experts like this, I hope you keep this up!

@michealmclaughlin429 9 месяцев назад

Two goats

@ayo9057 9 месяцев назад

Did Pete apologize for calling you a huckster?

@wellplayed3995 9 месяцев назад

Man Derek its crazy to see how far you've come over the years! Congrats man you've always stayed true to yourself!

@paddy3622 9 месяцев назад

that was awesome. every young person or even older weight lifters should watch this. appreciate your honesty.

@MrRawnerves 9 месяцев назад

How a guy with no medical degree can carry a conversation like this with a fully certified Doctor. Way to go Derek!!!

@mugshotmarley 9 месяцев назад

He's over doing it a little, like he's trying to impress. Wish he took it down a notch tbh

@Biz97 9 месяцев назад

@@mugshotmarley Thats just how he explains it everywhere I've seen him. You need to have a baseline level of knowledge about hormone signaling to really appreciate his responses.

@Hugh.G.Rection. 9 месяцев назад

@@mugshotmarleythat’s pretty much how he is all the time, it’s not him overdoing it, just his personality of enjoying explaining and expanding on points.

@karlmeaden6868 9 месяцев назад

@mugshotmarley what a strange comment, if he was over playing it the certified doctor he's speaking to would surely pull him up. This is literally how he talks about these topics all the time. Justbsay you can't comprehend it, it's ok non of us do at this level.

@gympho1 9 месяцев назад

Hope you know “Derek” got ALL his information from Victor Black…WHICH HE NEVER TELL ANYONE OR HE WOULD BE BROKE STILL!!! Victor Black is the REAL PED EDUCATOR

@nothere941 9 месяцев назад

Supraphysiological levels of knowledge efficaciously blasted into my existence bro. 2 of my favorite health specialists finally getting together, I love it. Looking forward to part 2

@Bokuverruckt 9 месяцев назад

Hahahah love it

@oracle6621 9 месяцев назад

😂😂😂

@meghan42 8 месяцев назад

How many hours per week do you spend looking after your body? And how much money?

@6StormShadow 6 месяцев назад

Nice bro

@Mike-xq7ib 6 месяцев назад

@meghan42 He's not a specialist dude. You can't fake a medical degree or just wing it... doesn't matter how smart you sound or how many scientific papers you read.

@WhiteNorthStar1 9 месяцев назад

I really admire how Peter didn't pretend to know everything in this area. Instead, he sincerely, courageously, and politely expanded his own and his audiences knowledge with Derek's expertise. This is a tremendous podcast session 🙏

@ClintByrne 9 месяцев назад

It's also really great to see a Dr like Peter willing to set aside title and rank and listen to someone who is obviously dedicated and well read but hasn't studied as a Dr. Also really shows how smart Derek is

@WhiteNorthStar1 9 месяцев назад

Exactly@@ClintByrne

@rxyz123 7 месяцев назад

Yes... Plus I also think Peter is very smart..... Knows what he thinks the answers to be.... But regards Derek as a deep expert on this subject so Peter is silently measuring his answers while taking Derek s as data that either confirms Peter's belief or signals Peter needs to rethink.

@Brando-_-440 7 месяцев назад

Absolutely, Peter expertly sets the stage and carefully probes the knowledge from the lens of the likes that rarely step to the spotlight and talk open and honest, and as technical as Derek. I respect Derek in his knowledge and his willingness to be honest with his experience in these areas that are not certifiable in society.

@misteratoz 9 месяцев назад

I'm a board certified internist (IM physician) . I'm 100% sure that Derek knows more about hormones than I do 😅

@Joseph1NJ 9 месяцев назад

We're assuming you're not an endocrinologist right?

@Drjohncurry 9 месяцев назад

@@misteratoz100% on point. I’ve defended Derek and his doc (Hotchkis sp?) at Marek multiple times for this.. we don’t learn (nor would we need to learn for our populations) this kind of esoteric information in our training. This is the kind of knowledge only passion and experience get you. Even endo doesn’t deal with optimizing a healthy population. They’re well trained in treating pathology like DM and the like, however I’ve seen TRT done terribly by classically trained endos.. even Peter, trained in surgery, likely understands the nuances of TRT much better than the bulk of endos. Again, at no fault to them.. it just isn’t in our training.

@terminator2348 9 месяцев назад

That's because he's never been asked about basic physiology. He just regurgitates shit. He doesn't understand most of what he says 😂

@MeesterJ 9 месяцев назад

@@DrjohncurryI thought his doc was Kyle Gillett?

@kungfoochicken08 9 месяцев назад

@@Joseph1NJAll three of the people I know who are on TRT are having their treatments mismanaged by their endocrinologists or urologists. All of these “experts” seem to think it’s appropriate to give 75mg-125mg of test-c every two weeks. A lot of doctors are just trying to check the boxes so they can get through their patients for the day.

@EmperorSeneca 9 месяцев назад

Derek teaching Peter new things about biology is WILD. Love this interview.

@DeusExMachina50 9 месяцев назад

Derek knows more than 99% of MDs.

@ManjiMachine 9 месяцев назад

Considering Derek is essentially an enthusiast in the field lol

@TheOneMastodon 9 месяцев назад

That's literally how good Derek is, the OGs know

@AQGOAT24 9 месяцев назад

@@DeusExMachina50 Medical education does not cover hormones and the such in the depth that you know about PEDS. So docs not in endocrinology likely know less than Derrick about this stuff unless they teach themselves which is essentially what Derrick has done

@oliround 9 месяцев назад

Self education always outweighs classical education

@SpencerHHO 9 месяцев назад

Derek is one of the most responsible commentators on these topics. He doesn't glorify or scaremonger, he gives facts where they exist and speculates in an intelligent and responsible manner.

@Cloudnine2024 9 месяцев назад

Probably my favorite Derek podcast! Peter is always a beast on the mic, but in this one, Derek also really seemed to enjoy it.

@scottgilmour749 9 месяцев назад

He has a knack of getting the best from his host. His interview of Lance Armstrong was the best I've watched

@connormatthews522 9 месяцев назад

It's nice to see Derek talking to someone who can actually keep up haha

@briancohen-doherty4392 4 месяца назад

No shit huh!?

@emilybarry9410 9 месяцев назад

This conversation is yet another reminder to me of how grateful I am that HIGHLY educated and prolific people come together to share their knowledge, passion, views on confusing topics with clarity and grace. Thank you Peter and Derek!!🙏💜 🤗

@jimmy4993 9 месяцев назад

Incorrect, educated people to be exact.

@coryg121 9 месяцев назад

info I would consider superior to any kind of formal education all jam-packed into 3.5hrs and all for free. Pretty remarkable!

@VigorousSteve 9 месяцев назад

In before Supraphysiological amounts of views!

@mortenpaskins6073 9 месяцев назад

Vigorous Views

@CalebTheHumbled 9 месяцев назад

Not gonna lie, Steve for some reason I thought you were dead fr.

@masonflanrey9095 9 месяцев назад

The front double bicep legend himself!

@wesj1064 9 месяцев назад

You're quite capable of doing a round table with these two gentlemen and perhaps Huberman as well. Bump this for Steve to get on one of these podcasts sometime!

@tydupont8084 9 месяцев назад

The amount of knowledge Derek has from experience and his own research is crazy. Always learn something new from him

@enid681 9 месяцев назад

Dr. Attia, Please! do a part two of your interview. I follow both you and Derek and this interview was out of this world. Nice to see how people have things in common and can provide the public information that enhances and educates their lives.

@joerobberechts4547 9 месяцев назад

Probably one of the best 2 content creators in this space, amazing to see you two together. The bro science- evidence based combo makes for some funny moments lol

@LasheXX 9 месяцев назад

Wow, not expected Derek and Peter 🙂

@kateaye3506 9 месяцев назад

Right?! First time in ages I am actually going to listen to the entire episode. More of these sorts of collabs.

@aquilesmasdmd 9 месяцев назад

I’m so impressed with the depth of knowledge Derek has. He spews the stuff out like gospel. He should be a resource for Peter they would make a great team.

@Real28 9 месяцев назад

That's what you get when a smart person becomes obsessed with a topic and spends their life just learning everything they can about it, all the time.

@jacksonr260 9 месяцев назад

I love that Peter judges Derek as a legitimate source on this stuff because of the content of what he says, not based simply on whether or not he is a doctor or has a degree in it. Those indicators of knowledge are often important, but not the be all-end all of people who can contribute meaninfully to this discussion.

@joserobertoguerreroroldan8406 9 месяцев назад

Certanly this is one of the best interviews with Derek. Mr Peter Attia is so respectful of what Derek is going to say, having the humbleness to lissen and learn something else outside of the medical field is very pleasing to watch. Unfortunally, almost every doctor is so narrow minded and most of them get offended if You give your opinion on some topic related to medicine. First thing they say ¿Are You a doctor? That bothers me a lot.

@Reformsqua 9 месяцев назад

As incredibly impressive that Derek's expertise is, he would admittedly defer to his friend Laith Rex (RIP) on many topics. This podcast and the comment section really makes me understand how incredible Laith was

@scarylarry4625 8 месяцев назад

His real name was actually Laith Algaz. "Rex" was just part of his stage name "Leo Rex". I couldn't agree more though. His knowledge and dedication were truly one of a kind

@simplyhuman2213 8 месяцев назад

Laith loved Peter’s podcast too. He would be proud

@aberwood 8 месяцев назад

This is a great advert for self education. Derek holding an in depth discussion with a guy whos at the top of the medical field despite zero formal education. Great talk!

@thefunctionaloncologist7811 9 месяцев назад

I am very glad that this discussion happened. I think it probably raised Dr. Attia’s awareness about the alternative health care options that are broadly used in the community as he has a very niche patient population. I am glad that he is interested in learning about strategies used for aesthetics, body building, and by many active gym goers/ fitness influencers. Derek is well aware of this world of peptides and other compounds used to improve aesthetics often under the guise of or supporting health. I respect both of their perspectives as they definitely serve different demographics with quite a bit of cross over in some areas. Thanks, guys! I am an avid fan of both of you!

@mortenpaskins6073 9 месяцев назад

This was so good, please have Derek back on soon. Looking forward to part two

@paddy3622 9 месяцев назад

derek's honesty is so refreshing. younger kids should watch this and learn.

@Terrorist_Hunter 9 месяцев назад

As one of Australia's original sports supplement and body building nutritionist (Former Australian INBA President and EAS Body 4 Life nutritionist)I love EVERYTHING that both Peter and Derek do individually so having them discuss the advancements of supplements & anabolics is AWESOME!

@fitafanatomy3359 9 месяцев назад

I never competed before and I’m bigger than both of you

@2K9s 3 месяца назад

Bill Phillips, EAS… Legend.

@LT3D 9 месяцев назад

I'm glad Derek set the record straight about 70s bodybuilders. The drug abuse was rampant, but no growth or insulin. They also came off completely from time to time.

@justvibing2497 9 месяцев назад

Yeah 70's juiced hard

@peternagy-im4be 8 месяцев назад

@justvibing2497 who doesn't?

@creez1 9 месяцев назад

Great pod! You guys rocked it! I probably only understood half of it. Derek, you're a beast when it comes to homrone function, production and impact. Awesome!!!

@rufisdodd4318 9 месяцев назад

Strange to me that he comes all the way to Austin and when they film they don't have any wide shots with both of them. It's nice sometime to see reactions.

@Bnbleverage 9 месяцев назад

The craziest thing about this video is that its a doctor asking questions to a RU-vidr. Shows how much Derek really knows his stuff.

@BigDees19 9 месяцев назад

Peter knew everything already just didnt want to make derek sound dumb

@peternagy-im4be 8 месяцев назад

@yourDoom8 very funny

@googoo7750 3 месяца назад

@@BigDees19on paper but he lacks the knowledge of the underworld, and even if it's not some double blind placebo controlled trial it's very valuable as actually this is the only real, long term high dose usage of these substances.

@user-eg8so2dg7t 9 месяцев назад

So interesting. I also follow Derek who gave the initial education to absorb this detailed conversation. Part 2 sounds even better because it's the actionable info I can use to get leaner - not for bodybuilding - but for general fitness. Thanks guys...

@SamGeorgeRowe 9 месяцев назад

Loved listening to this conversation. It’s refreshing to hear an MD with a fascination in bodybuilding and it’s relevance to pharma and healthcare. Will tune in for Part 2

@RamRod333 8 месяцев назад

Derek is one of my favorite people on RU-vid. He is unbelievably knowledgeable. Just him talking motivates me to go the gym😂 Been watching his channel for years.

@peterneil4786 9 месяцев назад

This is great! Thanks Peter and Derek for putting this together.

@courtneycartwright4975 9 месяцев назад

This is the collaboration I need!!!! I am reading outlive and I’ve been a long time mpmd subscriber!!!

@jundurahman1 9 месяцев назад

Wow! This is packed to the brim with knowledge. Two of my favorite online health professionals.

@aquilesmasdmd 9 месяцев назад

I feel I’ve been to a three hour top tier pharmacology, biology, and endocrinology lecture with two absolute experts. Totally mind blowing on many levels. First that some people do so many and so much drugs. And the ability to control so many hormones at different parts of the development pathways or exogenously is just fascinating.

@treblecharged 9 месяцев назад

Always blown away by how much Derek knows

@dylandimo 9 месяцев назад

2 gems here. The best of both worlds. Great interview

@BillHesse 7 месяцев назад

I really enjoyed this. I’m a physical therapist and on TRT. Some of the topics covered here have been thought provoking about the role an excellent PT could contribute to someone who has an injury or orthopedic pain and will jump to a drug they maybe could go without in this very specific population. Really good talk and it’s been a joy to listen to this all.

@dradeel 9 месяцев назад

This was a really good episode. Comprehensive, yet detailed, and wonderfully concise, yet broad spectrum. Loved it. Would even love a follow up with even more detailed on treatments, protocols, side effects, and discussions on the experimental stuff and the potential future treatments on the horizon.

@petermartff 9 месяцев назад

I love the fact that Dr attia, with his traditional medical background, will delve into these topics that most doctors are clueless about.This is fantastic. The fact that derrick is even in the same room with Peter, goes to show that derrick is the real deal. Highest level of Respect to both of them !

@AAAAAA-fj3dh 9 месяцев назад

One of the best episodes. Looking forward to part 2, 3, 4.....

@stuartbowenjr8393 8 месяцев назад

Super high-level! Utterly fascinating! Thank you for never dumbing down your content. Keep up the excellent work!

@neikoortiz136 8 месяцев назад

Thank you for this amazing podcast has truly changed my life. I’ve been going through some crazy stuff this past year. This podcast truly just solidifies everything. Thank you.

@marknolan2799 9 месяцев назад

I'm approaching my senior years so I have little interest in PED's but it was still a very interesting conversation. This is without a doubt my favorite podcast. Dr. Attia's skills as a communicator and interviewer are among the very best. Not to mention his knowledge base and intellect. When you consider the other demands on his time, I don't know how he does it.

@danielwhyte9172 9 месяцев назад

I personally think the senior years are when intelligent use of PED's might be most useful and needed.

@marknolan2799 9 месяцев назад

@@danielwhyte9172 I don't know enough to say either way. I feel pretty good so if it's not broken.... That said I'm sure it would put some pep in my step. But alas, these are first world concerns.

@StaRStuNinHD 9 месяцев назад

Some of the smartest guys in the fitness industry. Very interesting podcast to watch!

@theandrewaragon 6 месяцев назад

Derek is mentally and physically a beast. To have nuanced convo with a cerebral beast like Peter is awesome. Thank u both.

@doop445 9 месяцев назад

I loved this, two men differently informed on a shared interest and calmly respecting the flow of the conversation

@giosasso 9 месяцев назад

Fascinating discussion. I think I almost understood 7 minutes of it but intetesting on every level. I have to admit, I 'm surprised with all the talk about treatments for balding that neither of you mentioned Low Level Laser treatment. It's FDA approved and no side effects and as effective as the drugs. I bought an LLLT device in 2003, before FDA approval and it was one of the best purchases i ever made. It definitely works. I still use it and I still have hair. All the men on my dads side are bald. I am not. Anybody looking for a safe treatment for alopecia, i highly recommend it. And the earlier you start, the more hair you'll regain and keep. Great show!

@miaash3870 9 месяцев назад

Would you please share the name of your LLLT device?

@giosasso 9 месяцев назад

@@miaash3870I have a Hairmax device. They have more advanced models now compared to 20 years ago when I bought one. I need to upgrade😅

@farsa022 9 месяцев назад

Wow this is the craziest crossover 🤯 like iron man and captain America teaming up. Excited for this one!

@jpezman1 8 месяцев назад

As a Medic I have witnessed on two occasions pt's with pain in their necks and TBI like symptoms. These pt's both were in their 40's and later diagnosed to have carotid dissection. Both passed away in the operating room unfortunately and I have been told the mortality rate is very high.

@maritimetees2315 9 месяцев назад

Every single fitness person should watch this. It's youtube University at its best. Thank you for this. 😊

@bradleyhiphop 9 месяцев назад

Some of the best content on the internet. Love the advanced/next level content between you two cognitive heavyweights!!

@ianstaniskov7198 9 месяцев назад

This is the best podcast episode ever 👌 two greatest minds in optimisation

@los31388 9 месяцев назад

This is a great crossover for science and sports medicine and a magnificent tactic to expand your audience Dr. Attia

@jerrymorrison7501 9 месяцев назад

Another excellent show. The number of "Low T and male clinics" that prescribe various HRT protocols but really don't know what they are doing has driven me insane for years. Great interview!

@lgingermcdonaldfrederiksen7437 9 месяцев назад

What a thoughtful and detailed discussion of hormonal axis in men and women..way to go

@Vscustomprinting 8 месяцев назад

Trying to keep control whole talking about biology is so weird..

@kagefisk 9 месяцев назад

This man made me go into medschool and I thank him

@stephm4047 8 месяцев назад

Well that was impressive ! 3 1/2 hours with dense knowledge from both sides and a conversation which is always enjoyable to listen to.

@juanvaldes1837 9 месяцев назад

Very good. Been listening to both for a long time. Great to see them together

@bogrunberger 9 месяцев назад

Taking DHEA changed my life. I'm 46 and for years I've been feeling exhausted all the time, moody, anxious and irritable. Since I began taking DHEA (50 mg) daily - except weekends - it's like I got the old me back. My mood is fine, I'm calm and my energy levels are high. I don't think it's changed anything regarding my physiology, but quality of life has skyrocketed.

@leelunk8235 8 месяцев назад

I TAKE 100 MGS OF DHEA BEFORE BEDTIME BEEN DOING IT FOR MANY YEARS..IM STEROID FREE ALL MY LIFE..CANT DAY DHEA IS DOING ANYTHING

@bigzachful 8 месяцев назад

Have you noticed any negatives at all?

@leelunk8235 8 месяцев назад

@@bigzachful NOTHING NEGETIVE, I WOULD LIKE TO DO BLOOD WORK TO SEE IF MY DHEA IS HIGHER OR WHAT NOT

@user-wx1hp5zd8p 9 месяцев назад

3 1/2 hours of a doctor asking how the body works is the most surreal thing I've ever seen

@Matt-mb3tk 9 месяцев назад

I’ve been waiting around 2 years for this collaboration, fantastic!

@mikyoela 9 месяцев назад

What a brilliant combo! so much interesting info. Thanks guys.

@Jharry510 9 месяцев назад

More Plate More Dates! Go Derek man big now.

@HeliosEffect 9 месяцев назад

Wow, cool to see Derek here!

@shawnbouvier1 7 месяцев назад

Love how the Doc is asking Derik all the med questions...it shows the medical community doesn't know much about this topic when it comes to real life use. Intresting video lots of knowledge from both parties.

@electricviking 9 месяцев назад

Dave Palumbo, who was known for his distended stomach, gives a far better explanation of why this occurs and what causes it: 1:27:01-What explains the protruding abdomens on some bodybuilders & athletes?

@DoomDarkness 9 месяцев назад

Downloaded, can’t wait to listen. Next vigorous Steve please 🙏

@maxrises 9 месяцев назад

2:07:59 "when are you starting" killed me^^

@liamcregan5187 6 месяцев назад

I was one of Derek first subs on youtube when he created his channel when he was a GLL member. He really is a great guy.

@musclemedicine_M.D 9 месяцев назад

Aortic dissections more common in CT disorders like EDS’s, Marfans syndrome, or 2ndary to HTN; remember GH/IGF1 improves collagen synthesis (%of each type I’d have to double check but certain AAS like Nandrolones specifically really improves prepro-coll.3 levels by ~277%) & should reduce dissections. But keep in mind, Acromegalics may have other endocrine abnormalities (Test/E2/E1,T4/T3, increased binding proteins etc) which could offset the findings.

@monztermovies 9 месяцев назад

Awesome! Way to go Derek!

@jeremytrapp4394 9 месяцев назад

Derek's most refined, top of his game in this one. Wonder what nootropic stack he was on too.

@Peter-wo7tv 9 месяцев назад

As someone hanging around this subject and dabbling for a number of years it was so refreshing to get a long form, intelligent discussion rather than bro science or even what comes for some doctors. I wish they would have touched on testosterone undecanoate as a choice for TRT. But just a fascinating discussion. Loved it.

@Vscustomprinting 8 месяцев назад

Ego is so irrational, huh

@ham_Yai 7 месяцев назад

I've listened to this twice now, exactly the topic and info of interest to me. Can't wait for a part 2.

@rockroll7649 9 месяцев назад

Derek's IQ must be off the charts. He could be a guest lecturer at any medical school.

@BigDees19 9 месяцев назад

😂😂 to talk about steroids and tren ?

@rockroll7649 7 месяцев назад

@@BigDees19I'm sure that you are capable of, with no formal education, discussing androgenic alopecia, C reactive proteins, the side effects of androgens and estrogenic metabolites, aromatase inhibitors, the details of the relevant genetic factors, and the details of CBC testing with one of the world's most recognizable doctors in a public forum while still retaining your credibility.

@BigDees19 7 месяцев назад

@@rockroll7649 😆so you learned all that from him ? 😂 When there's actual medical professional channels out there and plenty of books, that talk and are the real deal like Peter is. Or ya know maybe school too? But I also learned everything myself as well. I know the basic information he does. That's all basic biology bro 😂. But hey if knowing simple cbc complete blood is so omg to you then cool rockroll. This is literally a steroid gym douche. That' tries way to hard to sound smart and got lucky thats all since there wasn't many channels like him for gym douches so his blew up that's it it could of been anyone else.

@andrewgallegos7448 9 месяцев назад

Such a good podcast PACKED with information

@user-lh2xn5iy2p 6 месяцев назад

This is like a compilation of all the good videos of mpmd before reactions videos. Love it and will keep watching it back to back

@ryanshigley7595 9 месяцев назад

Great pod gentlemen. Can’t wait for round 2!

@ankurd2889 9 месяцев назад

Derek just blew me away... this guy goes deep...\m/

@akaKillZoNe 9 месяцев назад

Fascinating stuff. I had no idea compounding pharmacies were basically glorified supplement manufacturing for pharamcy grade drugs. A couple random things derek brought up that were very insightful to somethings i have been wondering about. I guess I'm a nerd, i watched and listened adamantly to the entire video almost in 2 sittings and I don't even lift bro.

@JamesSmith-cm7sg 5 месяцев назад

It's always impressive when someone really knows their stuff. Great work Derek.

@freddysalgado641 9 месяцев назад

Thank you gentlemen!!! Cant wait for part 2! Enclomiphene is of particular interest, any way you can expand on this compound in regards to ideal candidates who may benefit the most if it gets fda approval in US. Thank you for the education!

@jeffreyramirez8183 9 месяцев назад

2 of my favorites in 1 podcast. Can’t wait for part 2

@RobertNaik 9 месяцев назад

Same

@johnmacdonald713 9 месяцев назад

Dude is holding his own with one of the smartest dudes around. Derrick is legit

@bagifaction 7 месяцев назад

What a fabulous conversation! Thank you to both such enlightened individuals. 🙏😊💓

@modanafil 9 месяцев назад

This collab deployed a suprapysiological amount of knowledge into my brain that I hope to leverage efficaciously in my future interventions with the purpose of getting diced to the socks

@iblisthemage 9 месяцев назад

My two favourite sources of health and biohacking knowledge. I am going to watch and rewatch, so happy that this collab happened. Also, this is intense! Peter is really diving in with the questions, obvious that Derek is not used to that level of scientific curiosity, I think both are in heaven. These minds meet and exchange ideas, coming from such different worlds. Bravo to both for the bravery.

@jeffreysummers6843 9 месяцев назад

They didn’t touch on using cooling of the testicles and working out to increase Luteinizing hormone naturally. I have 1060 total T from cold showers and exercise. Better to bump up your hormones with environmental stimulus. Probably why the Scottish wore kilts.

@iblisthemage 9 месяцев назад

@@jeffreysummers6843 You have 1060 from your genes. Excercise and other similar interventions have minor impact, much greater is (bad) food, and (bad) sleep. 1060 means nothing. My natty T was 1150 before going on TRT (M54), and I felt like shit. Bumping it to 1400 was the "ahhhh" sensation of feeling great again. I do excercise, cold, diet, sleep, yada yada. You (and I) just have high natural levels of T. At a certain point in time, that level will drop below your feel-good threshhold, at that point in time you will probably need a higher dose of Test than normal people. When that day comes, hopefully when you are very old: Please please start with 250 IU of HCG (daily pinning), and then add T Enanthate, daily pinning, on top of that. If your doc says T only, or T Cypionate, find a new doc. You will probably need 175mg/week +/- something, which is highish, but that is because your natty baseline is borderline supraphysical. Copy/paste this into your phone, and review it when the day comes. I would have sworn it would never be me. But age is a thing, and you loose 1-2% pr year, it accellerates after 50.

@proddreamatnight 9 месяцев назад

Damn dude Derek is super knowledgable

@cliftonnobles5600 9 месяцев назад

2:21:30 This is one of those "duhs" that makes so much sense when you hear it, but Derek articulated it so perfectly that it was a real "aha!" moment for me when I heard it.

@WyattWesterftw 8 месяцев назад

MAN I WAS IN A MOTORCYCLE ACCIDENT AND BROKE MY ELBOW REQUIRING SURGERY ! 4 months after surgery I was still suffering severely from these symptoms! Finally my surgeon gave me a cortisone shot and I found this after… they all thought tennis elbow but after trying just 1 set of all your excersizes I dent all the affected areas feel looser and less pain!! I think it really is the radial nerve!