5 most promising anti-aging compounds (for 2021)

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There are more than 200 different geroprotective compounds. Some of these are already available as supplements, some are in clinical trials and some have FDA approval. Which are my top 5 that I think i most promising in terms of their anti-aging effects (so focusing more on healthspan than lifespan). And note the use of "promising" - there is still much work to be done to better investigate the long-term safety, dose and timings of different supplements which you should always bear in mind.
Anyway, I made this video more for a bit of fun and to make a longer summary video to pull ideas together from multiple previous videos with some new info too! So hope you like it!
Do my top 5 match yours?
#aging #anti-aging #supplements #nmn #akg
TIMESTAMPS:
Intro & useful resources - 00:00
Pick #1 - 03:10
Pick #2 - 06:14
Pick #3 - 08:52
Pick #4 - 11:24
Pick #5 - 12:54
Round-up - 15:28
Bonus #1 - 16:10
Bonus #2 - 16:25
References;
Check out ‪@LifespanIO‬ rejuvenation road map;
www.lifespan.io/road-maps/the...
Nature comment - www.nature.com/articles/d4158....
AKG news - www.buckinstitute.org/news/a-...
TAME trial - www.afar.org/tame-trial
Table I showed - Partridge, L., Fuentealba, M. & Kennedy, B.K. The quest to slow ageing through drug discovery. Nat Rev Drug Discov 19, 513-532 (2020). doi.org/10.1038/s41573-020-00...
eLife rapamycin - doi.org/10.7554/eLife.16351.001
Suggested Brian Kennedy interview (rapamycin)- www.lifespan.io/news/brian-ke...
Rapamycin Opinion article - Aging (Albany NY). 2019 Oct 15; 11(19): 8048-8067.
Published online 2019 Oct 4. doi: 10.18632/aging.102355
Previous videos of use;
NAD - • NMN experiment
Icons in intro; "www.freepik.com/free-photos-v..."Background vector created by freepik - www.freepik.com

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11 июл 2024

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@TheSheekeyScienceShow 3 года назад

I made this video more for a bit of fun, these are just my opinions, *not recommendations* and to make a longer summary video to pull ideas together from multiple previous videos with some new info too! So hope you like it! Do my top 5 match yours?

@adviceguyy 3 года назад

Matches most of mine. I’ve been following spemidine and it’s found in concentration wheat germs. However would it be safe to take a small mg dose 2-3mg from this? Spermidine Free Base, 25 Grams smile.amazon.com/dp/B0771PZQ62/ref=cm_sw_r_cp_api_glt_fabc_NHJ2FbKHX9G2D

@PaulBeauchemin 3 года назад

1-rapamycin dosed weekly 2- metformin 3- CaAKG 4- spermidine 5-GDF-11 Tried nr and nmn, neither showed effect on my bio markers

@ZeyphodZeyphod 3 года назад

What are your views on Berberine as a substitute for prescription Metformin?

@FieldFarmForest 3 года назад

What do you think of red algae?

@randenrichards5461 3 года назад

Could be because they only are 25% bioavailable. I take 600 mg of NR and 1g of nmn because of this. I know it’s expensive but it works.

@GMKA01 3 года назад

These are the supplements I take; -NAD - Resveratrol - Glutathione - alpha lipoic acid - D3-K2 - Turmeric-Ginger compound - Multi-vitamin - Vitamin C 1000 mg - CoenzymeQ10 200 mg I'm 68 years old and bench press 36kg+36kg dumbbells 3 sets 12 reps. This formula is working quite well for me.

@bluellamaslearnbeyondthele2456 3 года назад

Turmeric is pretty much a liver poison, isn't it?

@GMKA01 3 года назад

@@bluellamaslearnbeyondthele2456 I think the dosage is the key factor. Too much of every supplement is harmful for the body. I have my liver functions checked now and then. I personally didn't come across any problem.

@karga9014 3 года назад

Turmeric ginger compound nedir curcumin mi?

@GMKA01 3 года назад

@@karga9014 ZADE VİTAL Curcumin Forte

@azerko 3 года назад

Nmn?

@margyrowland 3 года назад

I’m 64.....My top 5....bio-identical HRT, marine collagen, biotin, NAD, vitamin D. What I don’t consume......sugar, omega 6 oils, artificial sweeteners flavours and colours, refined carbohydrates. Love from Australia 🇦🇺

@margyrowland 3 года назад

@pr k You need to be consistent. It takes a month to feel better and a year to look younger

@margyrowland 3 года назад

@pr k Some for years, marine collagen and NAD for 6 months so far. They need time so make them part of what you do EVERY day 😊

@MrTrda Год назад

You are a GILF.

@jacklan4103 Год назад

Ur hot for a 64 year old.

@hellothere152 3 года назад

1. AKG 2. Metformin 3. Nad+ (nmn) 4. Resveratrol 5. Rapamycin

@madsencc 2 года назад

My Top Five Anti-Ageing Supplements 1. Sirolimus (Rapamycin) 2. NR + Niacinamide (Not MNM) 3. Lithium Orotate 4. Melatonin 5. Resveratol (Regular exercise is by far the most proven healthspan extender. Number 2 is time-restricted eating.) The reason Metformin does not make the list is that while an excellent supplement for younger people it is very problematic for older people. I am 80 yrs. old and do not take it. I think melatonin is an extremely underrated and underappreciated healthspan and life extension supplement. I have been using it for 40 yrs and long before I started taking the other supplements. I am in excellent health and epigenetic age tests claim my epigenetic age is 64. I go to the gym 3 to 6 times a week. My BMI is 22.

@gabrielepirovano3529 2 года назад

Congrats dude :) I’m 24 and looking to stay healthy for the rest of my life I feel lucky to be on the bio-hacking train already :)

@sgill4833 Год назад

Reservatol doesn't do anything.

@BryanHocking 2 года назад

#1 Epitalon #2 Thymalin #3 Emoxypine #4 SS-31 #5 Maritime Bark Extract

@Holypikemanz 2 года назад

newer and probably better choices than hers

@BryanHocking 2 года назад

@@Holypikemanz I thought it was a good list. Just passing on info I've learned. Thanks for the reply

@Holypikemanz 2 года назад

@@BryanHocking reliable source for epitalon? benefits of Emoxypine?

@antoinejutras-carignan8710 3 года назад

1. lack of compound, see calorie restriction/fasting 2. berberine 3. garlic, 4.sulforaphane 5.ubiquinol

@GuidetteExpert 2 года назад

Fasting for sure and eating right all year around (recommend getting a dietitian), lyft weights, sunscreen and max 10 minutes a day out in the sun.

@nooch190 2 года назад

Good to see that you added sulforaphane.

@simjumsores 2 года назад

@@GuidetteExpert "Sunscreen and max 10 minutes a day out in the sun." Er, no. You are confusing sunshine and sunburn. Sunshine has cardiovascular benefits - and these quite apart from vitamin D3, and cardiovascular benefits that are not trivial. Remember the principle advised by natural medicine cardiologist Dr Jack Wolfson of "Sunshine good, sunburn bad" and you can't go far wrong. Also, sunscreens have chemicals that are not part of humans' natural environment, for which there is no physiological requirement or known deficiency disease, and which could be toxic; a few of these are. The foregoing stated without frivolity or vexatiousness.

@BryanHocking 2 года назад

Epitalon and Thymalin

@corpsertag5967 2 года назад

@@JahreadyKnow Sad truth is that humanity evolved within the shelters they built. Their DNA got corrupted by false environment. If humans never stayed inside homes and always outside and let the environment decide their evolution, then they'd be genetically superior species today. Skin would've evolved protective layers to screen from harmful radiations as well.

@Faz-Ahmed 3 года назад

So much quality, I'm in love. All the books I've read summised in one vid

@michaelmcgee335 3 года назад

I'd say she's already taken.

@BryanHocking 2 года назад

Epitalon and Thymalin

@JM-us3fr 3 года назад

Wow, this was a great video. Thanks Sheeky!

@tomastrajan3377 3 года назад

Thank you, epic content ! Keep it coming! "On" brocolli / avos / fish / berries for years now, never felt better, occasional NR / resveratrol... Let's see where this is going :D

@BryanHocking 2 года назад

Epitalon and Thymalin

@FinTra_ 3 года назад

my top 5. 1. Nac. 2. niacin. 3. resveretrol 4. apigenin 5. D3 & C

@jimtempleton4312 3 года назад

Great needed that 💖💖💖💖💖💖

@jimtempleton4312 3 года назад

2. NmN ? A particular type of niacin kept in fridge cold. Should be white powder as if brown oxidated to nicamidide and isnt NMN??💖

@jimtempleton4312 3 года назад

Also need amounts in Grams pls 💖

@FinTra_ 3 года назад

@@jimtempleton4312 This is just my stack and not what you should be taking for example Nicain B3 with flush, I increased slowly. 1. Nac. --> 3000mg per day in 2 doses 2. niacin. --> 500mg per day and every few days 750mg in 500mg + 250mg 3. resveretrol --> 500mg trans resveratrol in yogurt with olive oil 4. apigenin --> from dried parley added to Yogurt. 2 table spoons in a cup of yogurt 5. D3 & C --> D3 is combined with K2-MK7 --> that I use once a week 5000UI of D3 and 200 mcg this is every few days loosely every 3'd day or so. C I take 2 times a day 500mg each.

@racemom777 3 года назад

Great list. Im learning alot about Nac and niacin.

@screwmatrix 3 года назад

Thanks for making this video. Appreciated!

@suzannecase6170 3 года назад

Enjoyed you video and took notes. Thank you for doing the research for me.

@h0ll0wm9n 2 года назад

Thanks! Dosing, synergistic response (with other compounds, supplements, medication, diet, etc), medical pre-conditions, , age at which administered, etc, are among key issues if one chooses to go the compound route, 1: AKG 2. Metformin 3. NAD+ precursors 4. Resveratrol 5. Rapamycin

@BrentNally 3 года назад

Awesome video as always!

@jodyguilbeaux8225 3 года назад

yes, but she sounds 12 or 13 years old. she should not see any real aging till she is 45 years old. just saying

@adamzeuspowell6424 3 года назад

Great Video. I'd definitely think about adding Urolithin A to the list due to it's ability to induce mitophagy. Plus maybe Nobiletin as it's a potential clock enhancing molecule and circadian dampening is highly associated with ageing and disease progression.

@BryanHocking 2 года назад

Epitalon and Thymalin

@lifesrealityis 3 года назад

Hey Sheekey! wOw I love your content. I have been looking for this sort of thing for a while and thought it just might not exist. As someone who is trying to get into cellular therapies and the field of aging I really appreciate you following the science and not jumping to conclusion or making exaggerated claims!!! Please keep up the good work.

@wmp3346 3 года назад

Lifespan is the key to a good retirement, never heard of akg interested

@kelvinyu339 3 года назад

Great content thanks for the concise information.

@jayaybe1 3 года назад

Great upload! Tip for the future though, always do Top 5s or 10s starting at the bottom and working your way up to the Number 1 ( best thing ) last. It keeps people hooked and builds excitement ; - )

@rtnjo6936 3 года назад

amazing content as allways) ty!!

@swizzler5554 3 года назад

Cheers for the video it really helps with research towards improving my health, you deserve a shit tonne more subs!

@JBulsa 3 года назад

And I’ll get them for her. Super star 🌟

@lawnmower11 3 года назад

I take nmn sublingual 750mg, trans resveratrol, TMG, parsley flakes, olive oil for anti-aging. And intermittent fasting as well

@murrayflewelling1258 3 года назад

I follow all the main people involved in anti aging and after seeing Dr Nichola Conlon speak at the main anti aging conference (RAAD I think) two years ago , I was looking forward to the NAD+ product Time , which I now use. The data is on the website, but they appear to have boosted NAD levels 4x over the other NMN and NAD products. There are many great NAD , NMN products so I am not trying to sell lol, it just should be looked at by anyone looking for the best boost without IV infusions !

@lawnmower11 3 года назад

@pr k in short yes for sure; energy and focus heightened and skin nails are outward youthful improvements

@BennyAshurov 3 года назад

is it working

@swclar99 2 года назад

where do you get the sublingual trans resveratrol? I have allergies to the pill form.

@mvrao29 Год назад

Excellent video packed with highly valuable and well supported statements

@AndrewHooper_MD 3 года назад

Really excellent video. Possibly the best I've seen on this subject so far (and I've watched loads!!). Thank you, you have a new subscriber!

@TheSheekeyScienceShow 3 года назад

Thank you!! 😊

@Health.First. 3 года назад

Love it!

@sveingustavhovland1913 3 года назад

I'm glad you mentioned ND38, this might become more and more important as a precursessor

@tinox12 3 года назад

you are awesome, please keep on doing this :)

@RawLu. 3 года назад

Please make this video a habit? Maybe once or twice a year? or whenever you feel their are changes worth updating? TY for all your excellent videos :-)

@marilyng8127 2 года назад

I absolutely love this channel

@beautyofthailand7393 3 года назад

So much great info!

@NEWMAN1HAAS 3 года назад

Thank you very much for the very interesting video.

@richjnev70 3 года назад

Wow, you really do your homework, really in-depth stuff.

@BryanHocking 2 года назад

Epitalon and Thymalin

@octopiinthesky44 3 года назад

Great information 👍

@vladsikorsky7931 2 года назад

Thanks for the video!

@cliffmode2000 3 года назад

Thanks so much!

@mattepton5731 2 года назад

Great video thank you! 😎

@llicit1833 3 года назад

Metformin is difficult to obtain without a prescription, even on the Internet. An alternative is berberine ("poor mans" metformin) which can be purchased.

@alkeegan9915 3 года назад

I think that the TAME study will change all that. Nils Barzilai predicts that in a few years once you turn 60/65 metformin will automatically be given out by gps.

@DanDascalescu-dandv 3 года назад

I bought a lot of metformin OTC in Colombia and Mexico

@jamesrice8736 3 года назад

Lots of Indian pharmacies on the internet that will send you metformin. Had good luck with alldaychemists. The online order from will ask for a prescription, but as long as you make a valid payment, they will send your order anyway.

@APBCTechnique 3 года назад

I’m in Thailand now stocking up on metformin 18 months supply

@DanDascalescu-dandv 3 года назад

@@APBCTechnique Careful about recalls - www.fda.gov/drugs/drug-safety-and-availability/fda-updates-and-press-announcements-ndma-metformin

@RaffiTheQuokka 2 года назад

just stumbled on your channel and instant subbed, keep it up :)

@peterz53 3 года назад

Thanks. I take some of these like fisetin episodically. Likewise, with apigenin as a senolytic and CD38 modulator. Very true, dose matter, as well as duration.

@BK-dy8jk 3 года назад

What is a CD 38?

@Hansulf Год назад

@@BK-dy8jk a NAD+ depletor that is overexpresed on a proaging enviroment

@CryptoLuver 3 года назад

Great job!

@allanwoodward6136 3 года назад

Sheekey keep up yr informed analysis. With regard to healthspan do u have any views on proteolytic enzymes and/or proresolving mediators to reduce inflamtion and repair. Also AKG supplements are mostly not calcium but arginine based. Does this make a difference. (I'm an ageing engineer not biochemist).

@basic48 3 года назад

Very complete...good job

@michaelpawluk5475 3 года назад

Great list and info as always, Eleanor! Glucosinolates also come to mind. Are you familiar with DR Jed Fahey's work? I know Rhonda Patrick is a huge fan!

@nooch190 3 года назад

definitely nrf2 activators such as sulforaphane as well as other isothiocyanates should be mentioned. I love Rhonda.

@tacpreppers4906 3 года назад

Brilliant, thanks for the info. My Top 5: NR, Fisetin, Quercetin, Tumeric, Gamma E and as a bonus: C, D3-K2 ;) p.s. Intermittent fasting and I HIGHLY recommend reading The Phoenix Protocol Dry Fasting for Rapid Healing and Radical Life Extension: Functional Immortality it's an eye opener. Would love to get your take on it.

@BryanHocking 2 года назад

Epitalon and Thymalin

@MakingTomorrowBetter 3 года назад

I agree, the list can change so quickly now, the exponential growth in computing power is coupled with an ever increasing number of people researching year after year and it now seems like there's always something new being announced. A very exciting time to be alive...

@luckyhanger1326 3 года назад

Another cool science show! :)

@MrLIVE150 3 года назад

EXCELLENT !

@livics610 3 года назад

Yes, I would like to ask you what are your thoughts on Epitalon?

@q44444q 2 года назад

What do you make of the GSK research from roughly 2012 and the most recent 2020 paper using CRISPR which both seem to show that resveratrol does not activate Sirtuin pathways?

@batsmasherbatsmasher3177 3 года назад

Great . please keep the good work .

@Boulevardfree 2 года назад

Any insights on berberine vs metformin? The former seems to have the edge in the supplemental space, no? Kind regards

@ahmedalhajri6175 3 года назад

great work, in an interesting field. for human trials i think the socioeconomic confounding should be but into consideration for longevity studies

@learnhope7895 3 года назад

I subscribed just because you are so close to 100,000

@Jade-sm3pk 2 года назад

Great videos! Where can you purchase these? Such as reversatrol that will not be fake and have actual potency ? Is Berberine ok to take if you can’t get a prescription for metformin? Thank you :)

@nicolaspadron3167 3 года назад

Great info. Anything on car t and cancer? Cure?

@TheMedicalMythbuster 3 года назад

For skin anti aging, I would say sunscreen and vitamin A. And for hair, I would say 5-alpha-reductases and minoxidil. Pterostilbene may be another honorable mention.

@mostafa202023 3 года назад

Minoxidil is life commitment

@austaneousc5802 2 года назад

@@mostafa202023 so is everything else...

@pramuanchutham7355 3 года назад

My top 5: Benfotiamine(fat-soluble B1), Niacin, PQQ, Astaxanthin, Phospholipids(Antarctic Krill)...

@juliontrump7539 3 года назад

2nd category list

@pramuanchutham7355 3 года назад

@@juliontrump7539 what's your first category list? Please kindly elaborate.

@Schu2505 2 года назад

What do you think of Pterostilbene vs Resveratrol? Elysium uses Pterostilbene in their NR supplement (Basis) instead of Resveratrol. They do a pretty good job of explaining why on their site.

@mimilili99 2 года назад

Thank you for your work. Please is there any research regarding the foxOgene or telomere regulating gene? I believe the answer to health and longevity is there, but who am I to say this hehe

@cathompson58 3 года назад

Wow .. I had to listen more than once just for the accent !

@joselitonavarro1776 2 года назад

Can you substitute rapamycin (sirolimus) with tacrolimus? If so, any suggestions on the optimal dose

@Chris-kr7gg 2 года назад

Sheekey, what is your take on the best diet for a human ? I understand there are many variables, just out of interest what would be your idea for the best diet ?

@johnm6866 Год назад

Do you think that using streptomyces hygroscopicus the bacteria that produces rapamycin as a yogurt probiotic would have similar or better results?

@jasonstrong4610 3 года назад

Very interesting. You may find yoga study touches on aging too. Hatha yoga, very ancient teaching, serious studies are mostly avoided in the west at least.. Inverted postures slow the aging process. As do slow breathing. Great benefits for hormonal system. How about fo-ti? Gives greater energy in 2 weeks. And shilajit from high altitude mountains. (15,000' ft+)

@Cyclone546 7 месяцев назад

Mine: 1. Ca-akg 2. Glycine 3. NAC

@jamesthomas1628 3 года назад

Excellent.

@prole1917 3 года назад

What is the best NAD+ precursor - NR or NMN?

@jan-peterschuring88 3 года назад

1. “Mediterranean Keto” Diet. 4 liters EVOO, fiber, green veggies, fatty fish, eight cloves garlic, polyphenols, Italian spices, Natto, 2. Six hour time restricted eating window and quarterly 48 hr fasts 3. Berberine taken with milk thistle. 4. Theracummin or Longvida Curcumin 5. HITT and resistance training

@supercal333 2 года назад

If you aren't pre-diabetic or diabetic drop berberine/metformin. Recent studies have shown no benefit over excercise alone and in fact they reduce exercise performance.

@nooch190 3 года назад

how about telomerase activators such as cycloastragenol come to mind Love your channel. You do fantastic work. Thank you.

@TheSheekeyScienceShow 3 года назад

i made a recent video on telomeres, thanks

@zzzxxzzz3248 2 года назад

I think TMG should be used to counter the negative effect of sulforaphane+niacinamide reaction . What do you think ?

@adkenporter2829 3 года назад

would you be likely to do a video on Creatine because i have suspicion it also has an anti aging affect side note i have not looked too deep into Creatine I've just looked into its affects on muscles and i seems to have and effect on the brain but i don't know

@geraldfriend256 2 года назад

Yes.Ive heard ot helps slow brain aging

@izzerstennisscorekeeper3971 3 года назад

For me, AKG is a no-brainer. I have been taking it before my NAD+ booster in the am for 2 months now. The reason it is a no-brainer is that it is so easily tolerated. No side effects; just less inflammation. AKG has not once caused me stomach upset or sleep problem.

@PandaA-cv3mm 3 года назад

That’s great! May I ask what form and brand you take? ( Ca-AKG or Arginine AKG). Appreciate you sharing your positive results.

@izzerstennisscorekeeper3971 3 года назад

@@PandaA-cv3mm Hi Panda, I still take 300mg dissolved in water first thing in the am. Kirkman. Ingredients say Alpha Ketoglutaric acid 300 mg. 20 mg of that is calcium AKG and 10 mg of that is magnesium AKG. My PA also has me on a gram a day of apigenin before the NAD+ booster. That is newish. To me, does the same sorta thing: anti-inflammatory.

@PandaA-cv3mm 3 года назад

@@izzerstennisscorekeeper3971 That’s good to know. Thanks so much for sharing ;)

@izzerstennisscorekeeper3971 3 года назад

@@PandaA-cv3mm Let me know if you like the effects.

@PandaA-cv3mm 3 года назад

@@izzerstennisscorekeeper3971 I surely will. I live in the U.K. now but will try to get that brand as there aren’t many available that are well respected from what I can see. How quickly would you say you noticed a difference in inflammation? Best wishes 😊

@equsnarnd 3 года назад

Consider Pterostilbene as an analog of Resveratrol that is more bio available and less expensive.

@GenghisKhanSays 3 года назад

What about pure NAD+ by injection, Patch or Nasal Spray? Curious why precursors would rank, but the real-deal wouldn't?

@sveingustavhovland1913 3 года назад

I've divided my anti-aging/bio-hacking into three levels. Level 1. Lifestyle such as IF, CR, sleep, HIT/HIIT ie. Level 2. Hormon level. Level 3. Pathways and cells. My number one go to is dr. Khavidson protocol on Epitalon. Then d3/K2, B12, C, Magnesium, GlyNAC, DHEA/7-keto DHEA, Omega-3, fermented broccoli sprouts - some...

@kavemanbites 3 года назад

good stuff. you could have tossed in a few CD 38 inhibitors :)

@wmp3346 3 года назад

Thanks 🙏

@TheDavidlloydjones 2 года назад

1.) 3:10 Alpha-Ketoglutarate. (AKG) Particularly good if you are a black mouse. 2.) 6:16 Metformin. 3.) 8:54 NAD+ precursors (NMN, NR, Niacin) 4.) 11:30 Resveratrol. Not just for mice. Also good if you are a fruitfly. 5.) 12:50 Rapamycin Excellent sensible commentary and details along the way.

@BryanHocking 2 года назад

Epitalon and Thymalin

@strigoi5890 3 года назад

Are C-AKG and A-AKG basically the same compound attached to a different salt? Any indication they’ll work the same?

@geraldfriend256 2 года назад

I've heard cakg for anti aging only

@raychance9696 3 года назад

What about sulforaphane for anti-aging? isn't Nrf2 activation better than taking anti-oxidants directly?

@BryanHocking 2 года назад

Epitalon and Thymalin. Peptides baby

@firewillian5905 3 года назад

NAD+ precusor NMN/NR/NA is very hot compound right now, however, there will be many side effect too, Metformin also show around 1/3 effectless for human, I suggest trial period shall be less than 3 month for taking these compound, otherwise side affect will be more than benifit.

@adamscottv 2 года назад

I take these at the moment: Hydrolyzed collagen peptides, Hyaluronic acid, NR, AKG, Apigenin, Quercetin, DHEA, Ubiquinol

@eovarendre7877 3 года назад

So how do you prevent all the benefits for healthy cells working for cancer cells as well?

@johnprice8655 2 года назад

I have followed much of these anti aging trials and like the research in metformin and the anti aging benefits. My first try with this was under and It bother my stomach. Dosage is important

@top5videos727 3 года назад

What is your opinion of Aubrey de Grey predictions? (Robust mouse rejuvenation could be by 2022)

@TheSheekeyScienceShow 3 года назад

i get asked this a lot, will make a video later this year! :)

@philipharned944 Год назад

I have robust mouses but don't brag about it. 😆

@johngriffin6006 День назад

I would ask if the Niacin for NAD+ precursors, was Niacin flush or non flush. I do do Niacin flushes. The supplements I take are AKG, Resveratrol, and NR. I gotta switch to CaAKG because I accidentally just bought 60 days of regular AKG.

@Paladyr7 3 года назад

Is it worth supplementing AKG if a person already consumes a high protein diet?

@andrewboss2018 3 года назад

Thanks for the vid. I know this is dated but j also know you update your info on these vids. Resveratrol dietary supplements IMO are a waste of money. The compound has 3 hydroxyl groups and is metabolized very quickly as a result, resulting in poor absorption. I believe most of the RCTs for resveratrol are either done in vitro, ex vivo, or done IV. Correct me if I'm wrong on that last part. Its methylated analog, pterostilbene, is FAR SUPERIOR, and I find it works best when paired with an NM supplement, even if research on dietary NM is also conflicting.

@whatthefunction9140 2 года назад

Your channle is completely underrated. My issue is trusting the supplement makers. So hard to know what you are really getting.

@ditchweed2275 3 года назад

Full flush/regular Niacin is a LOT cheaper as a precursor to NAD than NMN supplements. Is it as effective as NMN? Can you take both?

@ew2886 3 года назад

Unfortunately NMN is blocked by CD38. Niacin isnt.

@ditchweed2275 3 года назад

@@ew2886 is that a good thing?

@geraldfriend256 3 года назад

Man, check out Ford Brewer md he takes megadoses of regular naicin..just build up to it..To me nmn and nad are proven on a cellular level but not long term ingestion by humans..too expensive for me until it is proven.Niacin may even be more effectatious..

@ditchweed2275 3 года назад

@@geraldfriend256 thnx. ✌i watcjed that dude. Never knew his name. He turned me on cinnamon. Also, Rhonda Patrick. All this stuff works together. I can vouch for it. Im 49 and i have abs and i dont work out at the moment. I see overweight men/coworkers my age with land nad cars and property but in such poor health, overweight with one foot in the grave. But people are so clueless and uniformed and dont want to listen because its just too much info and they are too far gone.

@ew2886 3 года назад

Sorry for my slow reply. I can't say it is a good thing. You can watch Brad Stanfield, Rhonda Patrick etc.

@rhyothemisprinceps1617 3 года назад

AKG might be good for macular degeneration; would like to see a trial.

@thedreamsoldierful 3 года назад

I couldn’t find akg in your store. Do you have a brand that you recommend?

@TheSheekeyScienceShow 3 года назад

Can't recommend as not something i currently take, sorry - you may find some answers in the comments section of a previous akg video i made!! ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-3I7TxBT8FmI.html

@yuvalkapellner2551 3 года назад

Why didnt you include senolytic combination as anti aging approach together with what you already mentioned. such as fiestin or quercetin combination with dasatinib. Also quercetin with theaflavins.

@TheSheekeyScienceShow 3 года назад

No particular reason, there are many things i didnt include!! 😊

@hkarten 2 года назад

what if you combined NMN and Icariin ? Could well condens the list of 5 to 2 ?

@blackmartini7684 3 года назад

I think retinol should be included, increases skin cell turnover rate and prevents skin cancer

@rhyothemisprinceps1617 3 года назад

hmmm... a trial of topical all-trans retinoic acid (tretinoin) had to be halted because the intervention arm experienced higher mortality. The authors stated that they did not think there was a causal relationship, but it is a bit troubling. jamanetwork.com/journals/jamadermatology/fullarticle/711869 The study population was comprised of military veterans, mostly male. Veterans often have higher rates of toxic exposure related to their military service - lead exposure from ammunition, in particular. There may be some interaction there - it is difficult to search on the topic since 'lead' is a homograph. I did manage to find one article that looks interesting but of course it is paywalled: pubmed.ncbi.nlm.nih.gov/24291063/ More on this topic here: rhyobrain.blogspot.com/2020/12/topical-all-trans-retinoic-acid-and.html

@auriellenazro2516 Год назад

Since I cannot get metformin without a prescription, I searched for an alternative supplement… My research showed that Berberine has been found to assist in lowering glucose levels and to help regulate as well as assist in preventing Type 2 Diabetes. Is this a good substitute? Does this supplement have the potential to have the same effect upon our bodies as Metformin and its role in anti-aging??

@iewauhedoc9970 Год назад

Yeah, I think it interrupts MPC1 pathway in mitochondria also and activates AMPK so it is a calorie restriction mimetic

@pankajchand6761 3 года назад

Must we have AKG on empty stomach or with food?

@Hansulf Год назад

Metformin and rapamicin should be avoided if you want a peak phisique... They both inhibir regeneration and growth, which of course is good for longevity. NAD+ and alfa cetoglutarate, which improves mitocondrial health are the way. I'm not sure about revestarol... BAM15 should be in you list pretty soon! A safe decoupler that seems to remove unhealthy mitocondria and increase energy expenditure. Anyways, good video.