A New Novel Weight Loss Mechanism? Response to

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A new novel weight loss mechanism?
I have been meaning to post about this for ages.
But, being straight with you, it’s a bit of a niche topic. After James Smith tagged me in his video, I thought I would seize the chance to break it down.
The best way to simplify it is something like this:
If you diet and lose weight, your body often fights back and makes it more difficult. There are hormonal changes that can make you hungrier, for example. This is one reason why many people struggle to adhere to a reduced-calorie diet in the long term.
So, we know hormones are important.
BUT, is there another mechanism, that senses you are losing weight and therefore fights back by making weight loss more difficult?
If so, is it possible to overcome this by using external loading, like a weight vest? Some people have tested this anecdotally, but there isn’t yet a lot of super convincing research supporting its use. Think of it as ‘weird things you might want to try if you fancy it’.
So, let’s talk about weight vests, implanted rodents with weight capsules and something terms the ‘gravitostat’.
Any questions?
P.S. my best-selling book, ‘Everything Fat Loss’ is currently on sale at Barnes and Noble, Apple, Kobo, Google, and at Amazon with an extra 10% off in the USA and an extra 29% off in Canada. Feel free to grab it before the price goes up.
geni.us/Everyth...
References:
- Leptin: a pivotal regulator of human energy homeostasis
- Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism
- 20 years of leptin: role of leptin in energy homeostasis in humans
- Regulation of Food Intake, Energy Balance, and Body Fat Mass: Implications for the Pathogenesis and Treatment of Obesity
- Metabolic adaptation to weight loss: implications for the athlete
- Body weight homeostat that regulates fat mass independently of leptin in rats and mice
- The Gravitostat Regulates Fat Mass in Obese Male Mice While Leptin Regulates Fat Mass in Lean Male Mice
- Interactions Between the Gravitostat and the Fibroblast Growth Factor System for the Regulation of Body Weight
- Reduction of body weight by increased loading is associated with activation of norepinephrine neurones in the medial nucleus of the solitary tract
- Increased weight loading reduces body weight and body fat in obese subjects - A proof of concept randomized clinical trial
- Feasibility of Weighted Vest Use during a Dietary Weight Loss Intervention and Effects on Body Composition and Physical Function in Older Adults
- The gravitostat protects diet-induced obese rats against fat accumulation and weight gain

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21 сен 2024

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Комментарии : 22

@UnCoolDad 10 месяцев назад

Kind of makes sense to my layman brain. If you weigh more, you are expending more energy to actually move around, and you have more cells in your body which need energy. For at least half of that equation the weight vest makes theoretical sense.

@pavelvenediktov4049 10 месяцев назад

Akira Toriyama was right.

@grunt9950 10 месяцев назад

To me that seems similar to walking around while being obese vs not being obese. One will spend way more calories per day than the other, just existing and doing normal activities day to day. I'm not sure why we would even need studies to prove that. It's just common sense

@jdsalinger2 7 месяцев назад

i believe the difference here is that muscle mass was not reduced which is what typically happens when one simply does caloric restriction. could be misinterpreting it though.

@migas360 Месяц назад

The second study loses a lot of validity by pursuing such an aggressive calorie deficit. 1100-1300/ cals/day a day is insane, at such a high calorie deficit I'm not sure if even steroids could prevent muscle loss.

@kamo7293 21 день назад

okay a few people here are thinking that if they increase the weight on their legs they'll break... no you won't

@_nebulousthoughts 10 месяцев назад

Can confirm. I start everyday with a 6km weighted hike.

@chloecrawford5426 10 месяцев назад

I've started introducing rucking/pack training into my routine because I like hiking and I want to be able to carry all my gear easily over beautiful country.

@rachellesawyer6523 9 месяцев назад

I've just started rucking so too early to see results but feel better for it 1st time put 2 10kg wt plates in backpack and went hard on treadmill for 30 mins at gym then 2nd time about 11.75kg of water bottles pkts of rice in backpack and 30 mins walk on beach am going to keep trying as have lost weight and put weight back on An extra 10 - 20 kgs would unlikely be enough to harm as you would likely only wear it for relatively short durations over the cousre of a whole week - need to be sensible in how you wear the extra weight eg properly fit the backpack

@chloecrawford5426 9 месяцев назад

@@rachellesawyer6523 I did 18kgs over 2 days, but that was my gear for the hike and the pack got lighter over the days as we drank the water and ate the food. I think day 2 was more like 16kgs. It felt good in a properly adjusted pack. I use about 10kgs for my training weight at the moment.

@serban2139 2 месяца назад

I mean obviously you'll lose weight wearing that, it's difficult to move IN THAT!

@jasentracy8711 10 месяцев назад

Could it just be that wearing a weight vest increases your NEAT?

@tomjones8235 10 месяцев назад

I am puzzled by how wearing a vest that weighs 11% of one's weight for eight hours should be classified. Is it non-exercise (the NE part of NEAT), or it is low-level, long-lasting exercise?

@jasentracy8711 10 месяцев назад

Categories can be tough. I have the same question for my semi-active job. @@tomjones8235

@frankquinn6872 10 месяцев назад

@@tomjones8235Could be a good excuse for packing on a lot of weight: “why are you eating all those burgers and fries?” “I’m trying to up my NEAT” 😂

@tomjones8235 10 месяцев назад

At about 1:42 the list of adverse reactions to wearing a weight vest does not include knee pain, unless that is included in arthragia and/or myalgia. I am somewhat surprised by that. I thought that one of the benefits of losing weight is less stress on one's knees. Wearing a weight vest would add that stress back.

@sdegueldre 10 месяцев назад

Arthralgia is "joint pain", so it does indeed include knee pain. Keep in mind that in the table we can see that basically all differences in adverse effects except "musculoskeletal disorders" are "NS", i.e. not statistically significant. Doesn't mean there is no difference but the size of the study is too small to assess the direction or magnitude of differences, if there are any.