Trigonelline is a methylation product of niacin (vitamin B3), and thus is also known as “methylated niacin.” At higher temperatures, trigonelline breaks down to niacin I really wish you would tell people what the sources of these rare molecules that you cover on your channel. Truly is because you cover them from highly expensive sources when there are cheaper alternatives and or ways to get at the same molecule
@@Anonymousextb fennel Greek or methylated niacin. There's something to be said to letting the body do stuff. Think of it as a workout for the molecular system of the body. I think sometimes when you take two pure of a substance you compromise your own body system because it stops doing something and then to relearn it takes time. Diversity is probably the key to a long life Diversity in the correct fashion. I'm not endorsing going out and using cocaine for a couple of weeks, but certain things for shorter periods and others for longer based on historical context of success
Hi thanks for your comment. I would disagree with this as I normally talk about natural sources as well as commercially available ones. In terms of trigonelline, I am not aware of a pure trigonelline supplement with fenugreek being the closest, though looking at the data it seems that drinking coffee would give you more trigonelline. In terms of breaking down into NA during my research I am sure I saw that roasting did affect the levels of trigonelline in coffee, but not by much.
Hello, I have a question for you. In a 2021 interview that you did to DR Sandra, she mentioned about NAC Drops N-Acetyl-Carnosine Antioxidant, How did you went with the eye drops ? I want to prevent presbyopia.
Well I looked up fenugreek in grip strength and studies there's a study about fenugreek that fenugreek majorly improves grip strength and it's a double-blind study
Your videos are super informative and clear! I was wondering if you could make a video ranking life extending strategies or supplements in order of effectiveness. For example isn't that true that that a Caloric Restriction Diet with Optimal Nutrition is the only proven (on various animals) strategy that is most likely to seriously extend human life? And that no supplement come even close? thanks a lot. Hope this is of general interest for your viewers.
Hi Carlo, thanks for the suggestion. Let me think about that. It would be good to do, but the question is not simple. It is not possible to show life extension in humans so data would need to be based on animal models and the quality of the data is different for the various interventions. Let me see if I can do a summary.
My trig level is ~ 1.6 microM (per the rather expensive Iollo test) which seems to be a good level but I haven't seen an age vs trig chart (i'm 69). I drink about 3 cups of mostly decaf coffee a day. Very interesting that it is positively associated with DNA repair which could also have major significance for aging.
Hi Peter, thanks for sharing. I was not aware that there were commercial trigonelline tests. I have not seen any data on what would be an expected level and there is no reference in the paper to where they say that trigonelline levels are lower with sarcopenia.
@@ModernHealthspan Trig is only a small part of the test. Michael Lustgarten pushes the Iollo test on his channel but I still have questions about how the whole blood sample they take is translated to plasma result. Seems to provide a huge amount of data but still questions. Really need a scientist rep from Iollo to be interviewed about the test and how to relate it's result to published literature which often gives concentrations in serum or plasma. Spermidine is also measured....
Hi Thanks for the question. I use this guide "A simple practice guide for dose conversion between animals and human" (www.ncbi.nlm.nih.gov/pmc/articles/PMC4804402/). For the conversion rate it says mice to human requires to divide by 12.3. This is because mice have faster metabolism. It should be noted that this is not agreed science and is just a best estimate.
