C15 A Longevity Game Changer? | The Studies Reviewed

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C15 or Pentadecanoic acid, also known as Fatty 15 may be an essential fatty acid and we may not be getting enough of it. Here we go through the science of C15, its benefits and natural sources.
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Serum pentadecanoic acid (15:0), a short-term marker of dairy food intake, is inversely associated with incident type 2 diabetes and its underlying disorders
www.ncbi.nlm.nih.gov/pmc/arti...
Pentadecanoic Acid (C15:0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds
www.ncbi.nlm.nih.gov/pmc/arti...
Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?
www.ncbi.nlm.nih.gov/pmc/arti...
The lipidomic correlates of epigenetic aging across the adult lifespan: A population-based study
onlinelibrary.wiley.com/doi/1...
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#C15 #fatty15 #fattyacids

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9 апр 2024

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Комментарии : 93

@ModernHealthspan 3 месяца назад

Renue By Science 10% discount code MHS: tinyurl.com/35jyuk33 Liposomal NMN tinyurl.com/ys4hxwyf CardioMax tinyurl.com/569mahmb TMG Methylation tinyurl.com/445whc2u DoNotAge 10% discount code MHS tinyurl.com/6dbvhv87 CoQ10 tinyurl.com/4tpjxw7r Omega-3 tinyurl.com/2h79stt2 Glycine & NAC tinyurl.com/4tr7ppsp SIRT6 Activator tinyurl.com/2syw2yp3 Oxford Healthspan Primeadine Spermidine supplements: 15% discount Code MHS tinyurl.com/28admfxr Nuchido Time+ 20% discount of first purchase with code MODERN20 nuchido.com/MODERN Bulletproof 15% off with coupon code: HEALTHSPAN15: tinyurl.com/4npjk5vp OmegaQuant 5% Omega3 test discount Code MODERN omegaquant.com/shop/ NMN Bio 10% off all products tinyurl.com/2af2v2fw Code ModernHealthSpan10 in link Neurohacker Qualia Senolytic tinyurl.com/22t9thrn Pendulum Akkermansia pendulumtherapeutics.sjv.io/baoQVg Metabolic Daily pendulumtherapeutics.sjv.io/NkqE0q BiOptimizers 10% Discount Code MODERN bioptimizers.com/modern Wellness Extract 5% discount Code MODERN10 GG Essential collabs.shop/ivoshz ☕If you would like to support our channel, we’d love a coffee…thank you! www.buymeacoffee.com/mhealthspan

@leonaroberts7989 2 месяца назад

To further improve health and mitigate damage to mitochondria, the RDA is insufficient. Increasing dairy consumption would also increase the even-chained, inflammation causing acids/fats and caloric intake. C-15 supplementation would offer swifter resolution for health issues. I suppose if you aren’t worried about aging or health issues, the RDA would be fine..

@veeveemille8830 3 месяца назад

Thank you for the recommendation of 100 grams of C15 per day, the approximate amount in one tablespoon (12 grams) of butter. Easy enough to add to my day. Thank you so much, Richard!

@ModernHealthspan 3 месяца назад

Hi V, thanks for your comment. Cool! Sounds good.

@joshlocher71 3 месяца назад

@@ModernHealthspan hi I recently just emailed you about the chemical cocktail from harvard that I heard about I got a response in the email saying please type your reply above this line what line are you talking about

@badabing308 2 месяца назад

@@eman1989z I believe it was a mistyping error. I think it was meant that there is about 100mg C15 in 12 grams of butter. That jives with a couple sources I've found that put the C15 content of butter fat at ~1%. Use real cream in your coffee and real butter on your veggies and you're getting more than the postulated 100mg/day.

@rajeevarora190 Месяц назад

A healthy source for C15 is Ghee. It is a high smoke point fat extracted from cows milk which is used in Indian cooking and for many other purposes.

@jaym9846 15 дней назад

To make ghee, butter is heated to high temperatures (+325 F) for some time. Is ghee still healthy?

@rajeevarora190 15 дней назад

@@jaym9846 Ghee's smoke point is 485 F which should be high enough to maintain its healthy attributes. Ghee is used in a lot of high heat Indian cooking but I have never heard of any deterioration concerns.

@lovethisworld 2 месяца назад

Is fatty15 the only company that produces this? $40-$45 per month depending if you elect for the subscription. $30-$35 maybe, But $40-$45 a month equals nearly $500 a year. From my understanding they take c14 from plants (abundant source) and add one carbon? (Whatever it is I don’t know!) the point is, it seems a little overpriced for what it is. I want to take it, but sheesh, that’s quite a financial investment on the consumer’s part…

@boonkailee8237 Месяц назад

❤❤❤

@alaneverett9767 3 месяца назад

If one tablespoon of butter makes the recommendation then there are millions of people around the world that are getting this amount of c15. Dr Venn-Watson in one of her presentations on the internet mentioned that she had started menopause (with all problems) and doubled her dose with good results. This leads me to wonder if this is one of those molecules that gets less and less as we age. Anyway an incredible analysis and review Richard...

@Baabaabelle 2 месяца назад

Ha, all the foods we eat since we embarked on the proper human diet, labeled the Carnivore diet but really it's a way of eating rather than a 'diet'. Loads of info on YT, but Dr Ken Berry is a good starting point.

@rogerreich2721 3 месяца назад

Nice to see you adding biochemical commentary from your expanding knowledge,,, love the evolution of the channel as such....

@larsandreasaronsson 3 месяца назад

A great and timely video. Thank you for this Richard.

@ModernHealthspan 3 месяца назад

Hi Lars, thanks!

@xenasloan6859 2 месяца назад

Really enjoyable; appreciate the work

@scottmiller2591 3 месяца назад

Very nice deep dive. Stearic acid (C18:0) is kind of magical, also, and has dropped dramatically in Western diets due to the general fear of fats. Since it didn't fall in consumption simultaneously in the same way across all cultures (France, for instance, continued having stearic acid as part of their diets well after the United States had all but eliminated it), however, there's interesting evidence out there that suggests that the correlation of the fall in stearic acid consumption with the increase in cardiovascular and other problems is not merely coincidental.

@ModernHealthspan 3 месяца назад

Hi Scott, thanks for sharing. Interesting, based on the reading I did I would have thought that an even chained fat would have a negative impact on health - though there did not seem to be a mechanistic explanation for this. I do think eliminating nearly all fats is not a good idea. I did see that Dr Venn-Watson also highlighted the correlation of lower dairy fat and increased CVD as being possibly related to lower C15. There have been many changes in the diet over the last 40 years so difficult to pull it apart after the fact!

@marnold2791 2 месяца назад

Odd number fats like c15 are better than even number fats like c18.

@benv.5170 3 месяца назад

You look young Richard, thank you for this presentation.

@ModernHealthspan 3 месяца назад

Hi Ben, thanks! I hope that you found the video helpful.

@jackbuaer3828 3 месяца назад

Unless you're a vegan or otherwise don't eat dairy, it would seem relatively easy to get more than the recommended amount through food with small amount Dairy fat.

@eman1989z 2 месяца назад

How much is that?

@jackbuaer3828 2 месяца назад

@@eman1989z 100mg of c15. Supposedly 1 ounce of cheese contains that amount.

@CL-im9lk 2 месяца назад

⁠⁠⁠@@eman1989z apparently you need 100 mg. 100 grams butter= 830 mg of C15 100 grams of full fat cream= 450 mg 100 grams cheddar cheese = 390 mg

@obessedwithhealth 22 дня назад

You get all the bad "even chained" saturated fats in dairy.. They cause heart disease..

@jaym9846 15 дней назад

~18 mg Pentadecanoic acid (C15:0) in 1 kg of Chinese Yam.

@liverMD 2 месяца назад

Thank you for this insightful

@obessedwithhealth 22 дня назад

I developed athersclerosis eating butter, cheese and milk. Eating dairy comes with a lot if bad fats! I'll stick with fatty15. I take 2 per day and feel fantastic and now sleep great. I'm in my 70s.

@jaym9846 15 дней назад

I'm not sure if taking isolated nutrients is superior to consuming whole foods (ie milk).

@ronm6585 3 месяца назад

Thank you Richard.

@ModernHealthspan 3 месяца назад

Hi Ron, thank you!

@jaimeballester840 2 месяца назад

Thanks for this video. I just ordered C15 from the company in San Diego.

@investigativereports1622 Месяц назад

Amazing Supplement!!!

@gaston. Месяц назад

great everyone is now recommending butter.. their cells will look younger when the kick the cardiac bucket at least

@CyrilAndPriscilla 3 месяца назад

I tried taking C15 (aka commercially as "Fatty 15") for a couple of weeks. I had negative neurological symptoms that started, including tingling and numbness in extremities and a psychological sense of unreality and a generalized feeling of being way off. It was frightening. I'm not going to try taking it again,

@ModernHealthspan 3 месяца назад

Hi Thanks for sharing. Can I ask did you reach out to the vendor? Also, do you eat dairy products? If you do, you would probably have similar levels of C15 in the blood.

@CyrilAndPriscilla 3 месяца назад

@@ModernHealthspan I did not contact the company yet. It's the company founded by Venn-Watson, the scientist who did the dolphin studies. I did some subsequent research on C15:0. It is actually one of the fatty acids that is HIGHER in people with MS, a neurological condition. There is actually good research on this. So, the idea that C15:0 is some sort of panacea is not completely accurate--- there are diseases associated with higher levels of C15:0. Omega-3 fatty acids have been shown to help people with MS, which is also interesting. Omega-3 fatty acids make cell walls more flexible, C15:0 makes them more stiff. (BTW, I DO eat butter, a lot of it.)

@mystrength5640 2 месяца назад

@@ModernHealthspanThere must be other Areas in ones Body Blocking absorption of this newly discovered c. 15.. or everyone who eats sufficient dairy and Red meat, Would have a Normal Insulin level! ESPECIALLY IF one has Methylation issues. Which apparently 40% of people do have. OR more! No wonder. So many people have high Insulin! Thank you soo interesting! 🎉👏🏻🎉

@LloydsofRochester 2 месяца назад

Eat real butter. Problem solved.

@investigativereports1622 Месяц назад

@@LloydsofRochester C15:0 from food is tied up in complex lipids called triacylglycerides, which our bodies cannot absorb.

@mikeghafoori8227 3 месяца назад

Thanks

@ModernHealthspan 3 месяца назад

Hi Mike, thanks!

@marnold2791 2 месяца назад

I put ghee in my coffee. I hope it has the recommended amount of c15!

@Danny-mg1hu 2 месяца назад

nope~! there is one hour special done by Thomas DeLauer. not enough. whatever is left is destroyed by the liver if i remember right.

@bluereef9530 2 месяца назад

I thought dairy products causes inflammation. So adding cheese butter dairy are good fats. Why take a $50 supplement if you get it from your diet?.

@starraider25 2 месяца назад

Because there's lot more C16 in dairy than C15, and that's inflamatory

@investigativereports1622 Месяц назад

C15:0 from food is tied up in complex lipids called triacylglycerides, which our bodies cannot absorb.

@slowmopoke День назад

No double bonds, I'm looking at a double bond

@merdankoc_ 2 месяца назад

you should watch the visser podcast

@Ardentic-aa 3 месяца назад

Looking at the fatty acids in Sphingolipids, it looks like they might be about 15 carbons long. I also don't understand how we're not making any, if it's in beef and butter. Perhaps it's a fermentation byproduct?

@ModernHealthspan 3 месяца назад

Hi Thanks for comment. The papers did address that humans do not make it but did not talk about where it was originally produced and I cannot find an answer.

@ws7001 Месяц назад

High amounts in high oleic sunflower oils

@Ardentic-aa Месяц назад

I have several reasons to stick with butter and away from seed oils. But thanks for the feedback !

@2coryman 2 месяца назад

What about ghee ?

@goatmonkey2112 3 месяца назад

Is there a reason to take it as a supplement? I've seen other places say that you can get plenty by eating a little butter or cheese.

@ModernHealthspan 3 месяца назад

Hi thanks for the question. As the slide with the availability in foods shows, it is certainly possible to get the required amount from food sources. You could consider pure C15 as being more healthy as it does not contain the even chained fatty acids that come with butter and cheese.

@investigativereports1622 Месяц назад

C15:0 from food is tied up in complex lipids called triacylglycerides, which our bodies cannot absorb.

@Battery-kf4vu 3 месяца назад

Is C-15 increased or modified by fermenting milk?

@Ardentic-aa 3 месяца назад

If true that we're not making any but ruminants do... that's a legit question.

@ModernHealthspan 3 месяца назад

Hi thanks for your question. I don't have an answer for that, but looking at this table (wholefoodcatalog.info/nutrient/pentadecanoic_acid/foods/high/) it seems that fermenting does not seem to reduce the level by much. It is an interesting question as to how it gets into the milk. Whether the cows make it or get it from their diet.

@Battery-kf4vu 3 месяца назад

@@ModernHealthspan Thanks Richard.

@marnold2791 2 месяца назад

If you can get c15 from cheese, then fermenting should be fine. In the Netherlands, a woman was trying to sell us tourists some cheese and attributed her young looks to eating cheese. I took it with a grain of salt but she may be right!

@Battery-kf4vu 2 месяца назад

@@marnold2791 The ratio of C:15 to other saturated fats is 1 to 100 in dairy products, so it is not obvious that eating them is worth it. She said in another video that grain fed cows have lower C:15 so it might be better to chose organic dairies. I'd be curious to know how animals like cows make C:15 and if we could emulate that one way or another in a way that doesn't create other saturated fats at the same time.

@itscwoffeetimeandcookiesto5351 2 месяца назад

The trouble with getting C15:0 from food is that it is tied up in complex lipids called triacylglycerides, which our bodies cannot absorb. For this reason C15:0 absorption from only food has not been studied in depth on humans. What we do know is this- natural C15:0 levels started decreasing when the "Low Fat" movement happened in the 80's and 90's. That said, C15:0 is found in some foods. This means that we all have some baseline level of C15:0. What fatty15 is expected to do is to raise this level to achieve the desired circulating C15:0 concentrations of 10 to 20 uM needed to attain key benefits.

@jmdennis1967 2 месяца назад

I know when I took this product it did nothing for me so I stopped taking it but glad maybe it was just the amount that I did not get enough of.

@teeduck Месяц назад

I tried this product for 3 months. Did nothing. In fact. My HS- CRP increased from 1.5 to 2.4 mg/ L. Scam

@Kalamak-x3e Месяц назад

This is not good point

@teeduck Месяц назад

@@Kalamak-x3e why not. Their literally say it will lower inflammation and to check your HS CRP after 3 months So I did.

@birage9885 7 дней назад

C15 much safer and produces the same benefits as n-3 oils, which are PUFAs that are pro-aging.

@mrpig6742 2 месяца назад

I poop out c15 it is

@jackbuaer3828 3 месяца назад

Just 1 ounce of cheese per day gives you the recommended amount. Unless you're a vegan or otherwise avoid dairy, why consider a supplement?

@cactuscanine3531 3 месяца назад

Where are you getting “recommended amount” from?

@jackbuaer3828 3 месяца назад

@@cactuscanine3531 The video references 100mg as being recommended by the Researcher cited in the video.

@MarmaladeINFP 3 месяца назад

This is one of the many problems of a plant-based diet, particulary a plant-exclusive diet. When such diets are studied, they are almost always compared against a standard American diet (SAD). Ironically, SAD is described as animal-based, even though it's 70% plant foods. What never gets included in such studies is a diet that is 70-100% animal foods, especially not one that is whole foods, nose-to-tail, organic, and pasture-raised. Or rather such research is typically only found in Asia where higher meat intake is correlated to better health and longer longevity.

@jackbuaer3828 3 месяца назад

@@MarmaladeINFP Well, there are several people that live past 100 on exclusive plant based diets, so at least certain people can thrive on them Now are these people genetic longevity freaks that would live long on any diet, maybe, maybe not.

@ModernHealthspan 3 месяца назад

Hi Jack, thanks for your comment. I would think that that is correct. The downside is that you get the other saturated fats too, but if you are eating full fat dairy then you have already decided that you are OK with this. As well as vegans, you could see if people are lactose intolerant it would be helpful.

@The-Contractor 2 месяца назад

Way over priced and riding the "latest great thing" wave. Just take a daily dose of Mega-3 three times a day.

@investigativereports1622 Месяц назад

You are confused. This literally blows away your Mega-3

@simonkeeling6280 2 месяца назад

All the more reason to be on carnivore diet

@sleepinglaffey3886 3 месяца назад

Why not stearic acid?

@ModernHealthspan 3 месяца назад

Hi thanks for your question, however, I am not clear as to your meaning. The video is not about a supplement but about C15, the fatty acid and the benefits that it has. Stearic acid does not seem to have the negative effects of the other even chained saturated fats and it is available in common food sources. I am not sure if it would be a substitute or not.

@sleepinglaffey3886 3 месяца назад

@@ModernHealthspan It is cheap even if you ate it as a cosmetic grade powder supplement melted into food, it has mitochondrial fusion effects and it is the slowest to reach fat cells and it directly fights visceral fat and ectopic organ fat (palmitic acid has some of these benefits but not all of them). the main benefit of MCT fats would be driving BCAA catabolism.

@T-aka-T 2 месяца назад

Anyone who cites Dr Steven Gundry approvingly should immediately be assumed to be profit-driven bunk prone. PS Does the guy happen to be selling this nonsense? PS Oh, right. Yup. The guy is flogging stuff. Not a researcher. Not a clinician. Just a marketer.