A Novel NAD+ Precursor Trigonelline More Stable Than NR & NMN | Dr Vincenzo Sorrentino Ep 1

Подписаться 84 тыс.

Просмотров 5 тыс.

50% 1

BiOptimizers Stress Guardian 10% with code Modern10 stressguardian.com/modern. This video brought to you by BiOptimizers.
Here Dr Sorrentino introduces trigonelline a methylated form of nicotinic acid which can boost NAD levels. He also talks about his work at Singapore and the translation of longevity science into the clinic.
Some links are affiliate links so we will earn a commission when they are used to purchase products.
ProHealth 15% discount Code MODERN : prohealth.pxf.io/zNOPoW
NMN prohealth.pxf.io/DKeEmd
Renue By Science 10% : Code MHS tinyurl.com/35jyuk33,
NMN tinyurl.com/ys4hxwyf
DoNotAge 10% discount code MHS tinyurl.com/6dbvhv87
Pure NMN tinyurl.com/wyzj2f3d
Momentous Supplements 15% discount Code MHS momentous.go2cloud.org/SH2s
Creatine Monohydrate momentous.go2cloud.org/SH3E
Oxford Healthspan Primeadine Spermidine supplements: 15% discount Code MHS tinyurl.com/28admfxr
Nuchido Time+ 20% discount of first purchase with code MODERN20 nuchido.com/MODERN
NMN Bio 10% off all products tinyurl.com/2af2v2fw Code ModernHealthSpan10 in link
☕If you would like to support our channel, we’d love a coffee…thank you! www.buymeacoffee.com/mhealthspan
NOVOS Core & Boost novos.sjv.io/QyWP7o code 5OFFMHS
Insidetracker 20% discount Code MODERN20 insidetracker.sjv.io/NkbP7V
Bulletproof 15% off with coupon code: HEALTHSPAN15: tinyurl.com/4npjk5vp
SiPhox Health 20 % Code MODERN blood test (only in US & Canada) siphoxhealth.com/discount/modern
OmegaQuant 5% discount Code MODERN omegaquant.com/shop/
⏲️Chapters
00:00 Introduction to Dr Sorrentino
01:50 Translation from lab to clinic
05:50 How to tailor interventions
08:00 Singapore longevity framework
11:30 Trigonelline
14:50 Trigonelline metabolism
18:30 cf. Nicotinic acid
19:30 Raising NAM
🌐Links in this video
Dr Sorrentino's page at NUS
medicine.nus.edu.sg/bch/facul...
Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular degeneration. He obtained his PhD Cum Laude at the University of Amsterdam on LDL-cholesterol regulation by the ubiquitin-proteasome system. Subsequently, he moved to Lausanne, Switzerland, for his postdoctoral research in Prof. Johan Auwerx’s lab at the EPFL. His work there focused on the understanding of mitochondria and NAD+ metabolism in neurodegeneration and muscle aging. He then obtained a position as Group Leader at the Nestlé Institute of Health Sciences in Lausanne, to lead research focused on integrating basic discoveries on nutraceuticals and their effects on mitochondria and protein homeostasis with their translation into novel clinical applications. Since December 2022, he is an Assistant Professor at the NUS with the Dept. of Biochemistry and the Healthy Longevity TRP, Yong Loo Lin School of Medicine, to continue to develop his research on how metabolism, nutrition and proteostasis are linked and impact on health and aging.
***************************************
Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation.
Audio Copyright Disclaimer
Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here www.wevideo.com/terms-of-use and any following inquiries should be addressed to legal@wevideo.com.
**************************************************
📖Books
Dr Peter Attia
Outlive: The Science and Art of Longevity - amzn.to/472lu68
Dr David Sinclair
Lifespan Book - amzn.to/2MESFVb
Dr Sandra Kaufmann
The Kaufmann Protocol: Aging Solutions amzn.to/3Typ41x
The Kaufmann Protocol: Why we Age and How to Stop it amzn.to/3yWnEEo
Dr Steven Gundry -
Unlocking the Keto Code - amzn.to/3ID7pi4
The Longevity Paradox - amzn.to/3q7t2nC
The Plant Paradox - amzn.to/3Q9E32j
Dr Mary Newport
Clearly Keto: For Healthy Brain Aging and Alzheimer’s Prevention amzn.to/3XRhKih
The Complete Book of Ketones: A Practical Guide to Ketogenic Diets and Ketone Supplements amzn.to/4008cmX
#NAD #trigonelline #nr

Наука

Опубликовано:

4 авг 2024

Ссылка:

Скачать:

Готовим ссылку...

Добавить в:

Мой плейлист

Посмотреть позже

Комментарии : 32

@ModernHealthspan 7 месяцев назад

BiOptimizers Stress Guardian 10% with code Modern10 stressguardian.com/modern. This video brought to you by BiOptimizers. ProHealth 15% discount Code MODERN : prohealth.pxf.io/zNOPoW NMN prohealth.pxf.io/DKeEmd Renue By Science 10% : Code MHS tinyurl.com/35jyuk33 NMN tinyurl.com/ys4hxwyf DoNotAge 10% discount code MHS tinyurl.com/6dbvhv87 Pure NMN tinyurl.com/wyzj2f3d Momentous Supplements 15% discount Code MHS momentous.go2cloud.org/SH2s Oxford Healthspan Primeadine Spermidine supplements: 15% discount Code MHS tinyurl.com/28admfxr Nuchido Time+ 20% discount of first purchase with code MODERN20 nuchido.com/MODERN NMN Bio 10% off all products tinyurl.com/2af2v2fw Code ModernHealthSpan10 in link ☕If you would like to support our channel, we’d love a coffee…thank you! www.buymeacoffee.com/mhealthspan

@Anonymousextb 6 месяцев назад

in my country Trigonella foenum was used by old grampa's so we can say old ppl know or they were thinking that this is a good think hehehe

@paulwolf3302 7 месяцев назад

15:13 interesting that this works through the Preiss Handler pathway. NMN & NR use the salvage pathway. It's still an open question, though, whether raising NAD levels provides any health benefit. It seems like it would, but the clinical trials haven't shown much. Maybe they don't know what to look for. Great new format with the live interviews, by the way. Since your guests are from all over the world, it might be hard to maintain.

@Vgallo 7 месяцев назад

I think you’ll find lots of recent studies have shown benefit.

@ModernHealthspan 7 месяцев назад

Hi Paul, thanks for your comment. Why some of the results from mice have not translated into humans is a good point. We discussed it with Dr Joseph Baur, but until we get solid results in clinical trials it is still an open question. Though if the NAD precursor is helping to remove protein aggregates (which we talk about later) it may help sarcopenia and AD but would not be visible in the short time frame of a clinical trial. I would love to do more in person interviews! We were lucky that Dr Sorrentino was visiting Hong Kong so we could meet in person. Hopefully I can get out more this year and have a few of these but most will be remote for the moment.

@msplateaugal 7 месяцев назад

@@ModernHealthspan I also enjoyed the in person format, realizing it won't be the norm.

@lgroves336 7 месяцев назад

I gave my 83 yr old mother NMN and watched the symptoms of dementia disappear within a month. I'm NOT the only one that have seen and experienced the benefits.

@tc7500 7 месяцев назад

Great information!

@ModernHealthspan 7 месяцев назад

Hi Thank you!

@abdelilahbenahmed4350 7 месяцев назад

Thx Richard for these valuable infos.Would be intresting to have more on this topic.

@ModernHealthspan 7 месяцев назад

Hi Abdelilah, thanks for comment. Dr Sorrentino spoke at ARDD about trigonelline and also has a paper based on the research currently in the review process. I will talk about the paper when it comes out.

@konagraziosi5574 7 месяцев назад

Great interview, I became a fans of Dr Sorrentino! will follow his works from now on, thank you Richard!

@ModernHealthspan 7 месяцев назад

Hey, thanks for you comment. We will be posting more from Dr Sorrentino soon.

@Jessica-kk1cz 7 месяцев назад

Great interview and it’s great to hear he is working with Brian Kennedy

@ronm6585 7 месяцев назад

Thanks Richard.

@sparklingsake4908 7 месяцев назад

Richard, another great guest. Singapore now seems another blue zone and maybe why so many brilliant scientists related to aging are moving there.

@ModernHealthspan 7 месяцев назад

Hi Sparkling, thanks for your comment. Yes, Singapore certainly seems to be thinking about aging in a much more progressive way than many other countries.

@rainerlanglotz3134 7 месяцев назад

Another great reason to consume Coffee. Trigonelline should be even contained in decaffeinated coffee. (As a zwitterion it should be barely soluble in organic solvents)

@fredrik7922 7 месяцев назад

Would it also be retained in the CO2 (solvent free) way of decaffeinating coffee?

@ModernHealthspan 7 месяцев назад

Hi Rainer, thanks for sharing. Not that I need another reason to drink coffee!

@rainerlanglotz3134 7 месяцев назад

Liquid CO2 behaves as a solvent much like Aceton. As a chemist I would guess that it should leave the Trigonellin untouched while the much less polar Caffeine dissolves.

@HvdHaghen 7 месяцев назад

In the IKON TRIAL COPD is targeted with NR (Nicotinamide Riboside). Is there a good chance that Trigonelline can be used for COPD patients?

@peterz53 7 месяцев назад

One more way to keep NAD+ up and skip all the NMN and NR hype and expense. I recently learned that coffee ( I drink 3 cups of decaf/d) was high in trigonelline (prior presentation by Vincenzo). Also eat other plant foods high in trig. Turns out in testing my blood my trigonelline level (fasting) my level is about 3 times normal (1.5 micromolar per two tests vs about 0.5 micromolar normal plasma level). Haven't correlated to NAD+ level yet however I exercise and do TRE daily which also helps keep NAD+ up among other benefits. Diet and exercise.

@in2caffeine 6 месяцев назад

More reasons to drink more lighter roasted coffee?

@popeyeseamaster87 4 месяца назад

Take TMG with Niacin

@MikeG-js1jt 7 месяцев назад

25% Vulcan 75% Italian.......

@timskolnik3819 7 месяцев назад

I'd much rather just here the science, rather than a large explanation of the scientists background

@msplateaugal 7 месяцев назад

It is important to establish credentials. There are many without them and making false statements.

@konagraziosi5574 7 месяцев назад

I found interesting to know more about the scientist though...

@Vgallo 7 месяцев назад

Unfortunately many people think truth can only be accessed through prestige, when in reality prestige will more often than not increase the chances that the claims were made with more rigour, because the prestige usually means the person has more knowledge and insight on said topic, meaning the claims have met a higher standard of rigour, than a claim made by someone without that prestige. But what elitists overlook is sometimes prestige can reinforce biases that make truth harder to access. So in short prestige is a very important & vital marker - but only if you understand that it can simultaneously be problematic too.

@msplateaugal 7 месяцев назад

@@Vgallo I could not agree more. I am a research scientist/mathematician at a prestigious university. My most important works arose when I questioned the status quo and quietly developed my ideas until I knew I had something. However, most research papers in math and science are incremental. Peer reviewing does not catch all mistakes. It is only when others want to cite us that they will go through every detail because their reputations will be at stake. We have a lot to lose if we claim or cite something controversial and it turns out to be wrong. FQXi funds maverick ideas in physics because it can be hard to get funding off the beaten track.

@ModernHealthspan 7 месяцев назад

Hi Tim, thanks for your comment and for the people who have replied. I would add that the key topic Dr Sorrentino talked about and the direction of his study, the translation of aging therapies to the clinic, is one of the major obstacles in longevity at the moment. There are also chapters so you can skip to the section you want to listen to.