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Basicity vs Nucleophilicity - Steric Hindrance 

The Organic Chemistry Tutor
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This organic chemistry video tutorial highlights the difference between basicity and nucleophilicity. It provides the periodic trend of base strength vs nucleophile strength and discusses the two in terms of the solvent used such as a polar protic solvent or an aprotic solvent. In addition, it highlights the relationship between steric hindrance and the strength of the base and the nucleophile. This video contains a few examples and practice problems that discusses the reaction mechanism favored by bases and nucleophiles. Bases favor elimination reactions E1 or E2 and nucleophiles favor nucleophilic substitution reactions SN1 and SN2.

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26 дек 2016

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Комментарии : 77   
@TheOrganicChemistryTutor
@TheOrganicChemistryTutor 6 месяцев назад
Final Exams and Video Playlists: www.video-tutor.net/ Full-Length Math & Science Videos: www.patreon.com/mathsciencetutor/collections
@carcharodon9827
@carcharodon9827 2 года назад
I have an exam today and this video saved my sanity. Thank you so much 🙏🏻
@theimprovist4158
@theimprovist4158 2 года назад
Great explanation I already have my BS in Chemistry but your videos are still extremely valuable
@hayatm7933
@hayatm7933 7 лет назад
thank u so much! love this channel you've helped a lot u have no idea 😅 and your timing is on point man...love from belgium ✌️
@harshavenkatesh898
@harshavenkatesh898 6 лет назад
This was the most helpful video out there.. Thank you!
@AkashYadav-po5kb
@AkashYadav-po5kb 5 лет назад
Best of the best channel. You make the things very simple
@meryemcemileerol
@meryemcemileerol Год назад
In 15 minutes, I understand the whole lecture. Thank you so much SIRRR! 💕🥰
@Jeeprep-dm3pq
@Jeeprep-dm3pq Год назад
The fact that I understood everything brings me such joy. You just made a desperate student's day ❤
@user-yx9cy9zg9s
@user-yx9cy9zg9s 4 года назад
I can't thank you enough, I finally understood everything now
@hemanth7753
@hemanth7753 4 года назад
This lecture is like a gift bcoz it cleared all my misconceptions
@saikirans5497
@saikirans5497 9 месяцев назад
Now i feel like i can be the god of organic chem
@peterpace3379
@peterpace3379 5 лет назад
Much needed videos before an exam, you come as a blessing to us students. Thank you!
@rickyfernando8864
@rickyfernando8864 2 года назад
I guess Im randomly asking but does anybody know of a tool to log back into an Instagram account..? I somehow forgot my password. I love any help you can give me.
@yashwantmoharil5892
@yashwantmoharil5892 6 лет назад
The best way to understand is that neuckeophilicity is inversely related to electronegativity for polar protic and directly for polar a protic
@aang7505
@aang7505 4 года назад
Yash Moharil easy way to remember thanks!
@hariviratian697
@hariviratian697 4 года назад
Yash Moharil for non polar ?
@ahmednayf8985
@ahmednayf8985 4 года назад
Thanks man !!
@kiankelly6442
@kiankelly6442 4 года назад
what the fuck does that mean
@pranjalverma3501
@pranjalverma3501 3 года назад
@@kiankelly6442 solvent types , polar protic solvent and polar aprotic solvent , google it to know better.
@alexfrostbound4401
@alexfrostbound4401 2 года назад
Literally a hero, thank you!
@drhussienhayichowarra7167
@drhussienhayichowarra7167 5 лет назад
your explanation is very good and i interested with this channel
@md.akibhasan5633
@md.akibhasan5633 7 лет назад
You are simply awesome. ❤
@nagamhadie6939
@nagamhadie6939 7 лет назад
Best of the Bests ! :) thanx
@anubhavkumarjha8158
@anubhavkumarjha8158 3 года назад
Probably the best lecture on nucleophilicity and bases❤
@captainlux409
@captainlux409 3 года назад
I agree.
@jyotirai9931
@jyotirai9931 5 лет назад
thank you brother great stuffs
@stevethebeve
@stevethebeve 5 лет назад
He protecc. He attacc. He get the right producc.
@SIZLIANO
@SIZLIANO 4 года назад
bruH+
@parahumour4619
@parahumour4619 3 года назад
the way this is structured pains me
@Andrew-kh7rz
@Andrew-kh7rz 4 года назад
Way better than Khan Academy ...they don't do a great job at all at being able to setting apart one thing from the other relating to lots of stuff
@aang7505
@aang7505 4 года назад
Way better than Leah’s explanation thank you thank you
@casualcasual1234
@casualcasual1234 4 года назад
Could someone please explain the 4 trends at 5:54 on basicity and nucleophilicity? Thank you very much
@zainmsd6303
@zainmsd6303 Год назад
Superb lecture 👌
@amirmurtaza1721
@amirmurtaza1721 Год назад
Crystal clear concept
@jesusmrosario-claudio4104
@jesusmrosario-claudio4104 3 года назад
Thank you once again.
@pritamkarmakar7212
@pritamkarmakar7212 5 лет назад
Nice lecture👍
@ravercidknee5
@ravercidknee5 5 лет назад
you are just the best
@Potatocat5
@Potatocat5 4 года назад
What is the relationship between nucleophile and base ? And is there any kind of relationship between the size of an atom and nucleophilisty ?
@kellypaulson7272
@kellypaulson7272 2 года назад
Saved me thank you
@abdullahnadeem108
@abdullahnadeem108 4 года назад
Wow so nice
@aayushjha5137
@aayushjha5137 3 года назад
THANK YOU
@sakthipriyar2483
@sakthipriyar2483 3 года назад
Finally I found some peace ❤💯
@irynalebedyeva7900
@irynalebedyeva7900 3 года назад
Are you taking o chem during summer? Brave
@sakthipriyar2483
@sakthipriyar2483 3 года назад
@@irynalebedyeva7900 Nope, I don't even know what that means😂 I'm giving my pre meds.
@ayushgupta4725
@ayushgupta4725 4 года назад
Most of the people watching him must be preparing for iit...
@sambhavmishra5423
@sambhavmishra5423 3 года назад
Yo bro !
@ayushgupta4725
@ayushgupta4725 3 года назад
@@sambhavmishra5423 yoo!
@yashnarang3014
@yashnarang3014 3 года назад
yes XD
@siddharth7511
@siddharth7511 3 года назад
NEET aspirants too.
@RAJEEVKUMAR-pe2if
@RAJEEVKUMAR-pe2if 3 года назад
Neet👍
@012arnavtripathi7
@012arnavtripathi7 5 лет назад
Best.
@Motivation_diary_ms
@Motivation_diary_ms 2 года назад
Thanks
@srijankumarpaul6828
@srijankumarpaul6828 6 лет назад
I can’t hear properly . NH2- Stornger base and bad Nucleophile or better Nucleophile ?
@chukwuonyinye2627
@chukwuonyinye2627 6 лет назад
NH2 stronger Nucleophile
@user-gj1mn6hk2j
@user-gj1mn6hk2j Год назад
Help, what is the correct order of nucleophilicity for ch3o-, ho- and ch3coo-??
@naturallysimi
@naturallysimi 6 лет назад
Confused... Polar aprotic solvent F- is free to react but polar protic it isn't? I thought the steric hindrance presented in aprotic acetone prevents F- to react.
@tunneltrance
@tunneltrance 6 лет назад
Flourine is the smallest of the halides, so it will kinetically be the best nucleophile.. it will be small and able to get in to tight spots (also it's the most electronegative of the halides - so that helps out reactivity wise). The problem is when you have protic solvents, you have the possibility (and likelihood) of the fluorine ion becoming protonated to form HF (which a weak acid - this is a situation where the electronegativity of fluorine sort of undermines itself). With protic solvents, Iodide is the best nucleophile because its the weakest base. It's not going to donate a pair of electrons (lewis definition of a base) to the partially positive protic hydrogen on the solvent. -OR- it's not going to receive a proton from the solvent (brownstead lowry definition of a base... same difference) This would result in HI forming. Hydroiodic acid is a very strong acid, so in terms of acid-base reactions this is not favorable, mostly likely HI would be a WAY stronger acid then the solvent. So in the circumstance of polar protic solvents, the big bulky iodide ion (which normally is not a good nucleophile kinetic-wise) becomes a better nucleophile then fluoride, because at least iodide will BE ABLE to act as a nucleophile, it will still exist as an ion... fluoride won't be an ion anymore, it will be tied up as HF (a weak acid)
@adityasrivatsa4115
@adityasrivatsa4115 6 лет назад
And HF is also stabilised by H-Bonds I presume?
@irynalebedyeva7900
@irynalebedyeva7900 3 года назад
Secondary c+ aren’t stable unless stabilized via resonance or can rearrange.
@widksshdklsc
@widksshdklsc 2 года назад
c+ are overall not stable what re you trying to say?
@ketiperanidze8603
@ketiperanidze8603 3 года назад
please, someone, answer me, if bromine ion is a good nucleophile and can attack carbocation and form bond, then why can't it attack hydrogen ion and form HBr?
@pravargupta6285
@pravargupta6285 3 года назад
Its because HBr is a stronger acid than a carbon conpound with bromine. When there is a loss of proton from carbon adjacent to Bromine, Bromine does backbonding and makes it a bit more stable but Br- is much more stable in solution. Well the reaction is feasible only if a weaker acid/base is formed in product. And carbon with Bromine is less acidic than HBr.
@somnisnemoris4957
@somnisnemoris4957 4 года назад
How substituted does the molecule have to be considered "bulky" should it be completely filled?
@fancykook4388
@fancykook4388 7 месяцев назад
4:42 solvent
@amacgregor92
@amacgregor92 3 года назад
My ACS for orgo 1 is in a half hour
@mobarkalwahishi3323
@mobarkalwahishi3323 4 года назад
How the leaving group leaves??? I really want to know
@9gao
@9gao 4 года назад
Mobark Alwahishi LG have high electronegativity or positive charge. LG is happy with electron.
@dhawalarora7544
@dhawalarora7544 4 года назад
Through the door.
@tiredcat6653
@tiredcat6653 4 года назад
@@dhawalarora7544 😂😂😂 why would you do that
@na-chan163
@na-chan163 4 года назад
Carbon is tetravalent. It can't have 5 bonds so when the nucleophile attaches, the tendency is for the carbon to kick out the atom that is relatively stable on its own -- a good leaving group (usually halide).
@utkarshmunshi1658
@utkarshmunshi1658 2 года назад
The stronger the acid, weaker it's conjugate base , More weaker the conjugate base , Better the leaving group is and vice versa
@UtkPpp-gc5uh
@UtkPpp-gc5uh Месяц назад
4:12 😢
@yousefmohamed5353
@yousefmohamed5353 2 года назад
you are a fucking god
@Obenai-j4t
@Obenai-j4t 22 дня назад
I will surpass Elon Musk
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