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Nucleophiles and Electrophiles: Crash Course Organic Chemistry #12 

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Organic reactions are kind of like carefully choreographed fight scenes, and nucleophilic attack is a key move. This episode of Crash Course Organic Chemistry is all about nucleophiles and electrophiles, or what happens at those molecular hot spots we’ve been talking about. We’ll also learn about what IR spectra can tell us about reactions, and how cyanide is more than just a poison from mystery stories. Let’s get to it organophiles!
Series Sources:
Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.
Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.
Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.
Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014.
Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.
Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.
McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.
Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.
Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.
***
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5 июл 2024

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Комментарии : 118   
@yourstruly4817
@yourstruly4817 3 года назад
A neutron walks into a bar and asks "how much for a beer?" The bartender says "for you, no charge."
@mykro1
@mykro1 3 года назад
lol
@rohanjuggler1861
@rohanjuggler1861 3 года назад
That's from The Big Bang Theory
@liampb3555
@liampb3555 3 года назад
thats bad but i did laugh
@Karajorma
@Karajorma 3 года назад
The bartender says "So shall I pour you a beer then?" The neutron says "I'm not positive"
@ShauryaSingh-ts2oc
@ShauryaSingh-ts2oc 3 года назад
Original jokes are hard to find nowadays :(
@pvtpain66k
@pvtpain66k 3 года назад
"Girl, I've got a hot spot for your positive regions"
@prioritalpanic629
@prioritalpanic629 6 месяцев назад
This probably won't ever be seen, but I wanted to say thank you so much for all your help. I'm currently doing some last-minute studying for my chem final and I'm finally understanding these concepts after going over them in lecture for weeks. Not only do I better understand them, but you made chemistry fun again! I honestly can't stand lectures that "suck the life" out of incredibly interesting subjects like chemistry and it kills my motivation to learn about them. But this was very enlightening. Thank you! ^_^
@crashcourse
@crashcourse 6 месяцев назад
Best of luck on your finals!
@zayrael
@zayrael 3 года назад
Catch me owning my entire grade for organic to crash course. Thank you crash course, for such good and free teaching!
@honey3194
@honey3194 3 года назад
i love you as the teacher to this series! for me, it's usually really hard to watch crash course videos because they go so fast and everything goes over my head (no shade to the other series'), but you help make everything seem so clear :)
@colmryan9289
@colmryan9289 3 года назад
Why did I read the title as “Necrophiles and Electrophiles”?
@hugogamboas.5550
@hugogamboas.5550 3 года назад
Hmmm... kinky.
@scptime1188
@scptime1188 3 года назад
SAME
@greenfilly
@greenfilly 3 года назад
Same
@thevioletskull8158
@thevioletskull8158 3 года назад
Oh
@Tentacular
@Tentacular 3 года назад
Just be glad you didn't read it as "Necrophiles and Ephebophiles."
@nieks9212
@nieks9212 3 года назад
As a chemist, this show has been so entertaining to watch! It is really interesting to see how you explain all the complicated nomenclature, principles and theories and try and combine them to create an allround understanding of the subject. Can't wait to see you explain some of the more complicated topics later on in the series (Are the Diels-Alder or click reaction making an appearance by any chance?).
@MolecularMemory
@MolecularMemory 3 года назад
Yep! We'll be doing an episode on pericyclic reactions later in the series!
@henryelicker2403
@henryelicker2403 3 года назад
Bromoethane talking to it's Br group when it sees a nucleophile. - "I don't wanna play with you anymore".
@taeganmcfarlane
@taeganmcfarlane 3 года назад
This CC series is so good! Can't wait for the next episode!
@newplanet9540
@newplanet9540 3 года назад
This episode took so long. Am happy it's finally here 💞
@joelw5996
@joelw5996 3 года назад
This is so well explained!
@watuphoney1
@watuphoney1 3 года назад
This is an amazing course.
@EdgarVegaCarrasco
@EdgarVegaCarrasco 3 года назад
I really love this series
@leen8175
@leen8175 Год назад
Great efforts and amazing way of teaching , you saved my grade!
@alexbrockwell8158
@alexbrockwell8158 3 года назад
I don't know if I'm into BH3. It's kinda borane (ba-dum-tss)
@nicolepere2056
@nicolepere2056 3 года назад
PLEASE HURRY AND MAKE THE OTHER VIDEOS! My o chem class has already covered everything you’ve made a video for plus some other stuff and your videos are the only thing getting me through this class right now 💀💀💀
@bangladeshivloggeradventures
This is incredible. Thank you.
@ishikasingh9254
@ishikasingh9254 3 года назад
People plz make more video!!! This is my last life line to get me through my chem classes and my final exams. This is highly requested!!
@Noellexafael
@Noellexafael 3 года назад
Finally getting to the good stuff, check ur sit belts because u are about to get into a really wild ride haha.
@SciFactsYT118
@SciFactsYT118 3 года назад
Completely random fact: Like fingerprints, everyone's tongue print is different.
@Soveliss1986
@Soveliss1986 3 года назад
Or ears
@randomness2622
@randomness2622 3 года назад
Or probably any print of a similar size skin from any region..
@ShirinRose
@ShirinRose 3 года назад
Also, koala fingerprints are almost indistinguishable from human fingerprints 🐨
@kashmerykame
@kashmerykame 3 года назад
H1 NMR got fingerprint regions that are unique to each compound
@HoshikawaHikari
@HoshikawaHikari 3 года назад
I should ask my chemistry teacher to show the class this video before she goes into organic chemistry, and probably the whole playlist once it's done~ XD
@kaneezezainab3224
@kaneezezainab3224 3 года назад
Its way easier than i thought. . 😀😀😀 thanks !
@gentrymower3963
@gentrymower3963 3 года назад
Excellent video, this helped me so much! Thank you!
@illinijamie
@illinijamie 3 года назад
Hi crash course- i love you & your vids. Can you make one on antitrust law & the sherman act?
@saracahn
@saracahn 3 года назад
At 9:54 is that taunting guy Gary from Pokémon?
@SuperAndrewlove
@SuperAndrewlove 3 года назад
It is!
@mystrawxd9940
@mystrawxd9940 3 года назад
Wow I am finally early
@vaughnjohnson8767
@vaughnjohnson8767 3 года назад
0:45 Me: innocently watching* The video: And Neutrophiles, lovers of their positive regions. Also me:🤨......😳
@vaughnjohnson8767
@vaughnjohnson8767 3 года назад
@Eutanazol 95% yeah, I know that. I’m just playing off of the chemistry aspect of it
@jessicadecuir5622
@jessicadecuir5622 3 года назад
Cyanide also keeps you alive. It forms part of the structure of vitamin B12.
@brianodiero7637
@brianodiero7637 Год назад
Deboki you a life saver
@tany3306
@tany3306 3 года назад
Yes.thank you for this video..helped me cover up the lecture I had missed at school..whoops
@nihaal7750
@nihaal7750 3 года назад
4:30 GARRY OAK!!! ayy
@BeccaMoses
@BeccaMoses 3 года назад
my chem foundations class is structured really strangely and this is the first year they’re doing this format so there’s just random orgo showing up places - thank u so much for this oml
@growthmedia97
@growthmedia97 3 года назад
We want new series as a review for the MCAT please
@danielm.1441
@danielm.1441 3 года назад
Not going to lie... 'Borane' nearly made me giggle.
@silverfairy125
@silverfairy125 Год назад
this was such a good refresher for org chem reactions and nucleophilic substitutions
@jamesprince571
@jamesprince571 3 года назад
Organophiles 😍😍😍
@pauljackson3491
@pauljackson3491 3 года назад
When the OH- was substituting into the C4H9Cl why does the Cl- just not go back into the Butyl Alcohol and switch again; probably related to electronegativity? Since it is a simple linear molecule could C4H10O just be called Butyl Alcohol instead of Butyl-1-alcohol or even Butyl-1-hydroxide?
@nieks9212
@nieks9212 3 года назад
Yes, it is related to relative electronegativity; Cl- is much more stable then OH-, and the C-O bond is less polarized then the C-Cl bond.
3 года назад
please more chemical vids!!
@shyamnavarun
@shyamnavarun 3 года назад
which animation software/app do you use?
@SuperAndrewlove
@SuperAndrewlove 3 года назад
We use a combination of Illustrator for the artwork and After Effects to animate :)
@diegonayalazo
@diegonayalazo 3 года назад
Gracias
@feitocomfruta
@feitocomfruta 3 года назад
Organic chemistry adjacent question (for biology or medicine experts): With the cyanide example, is the neucleophilic attack part of the reason why cyanide is so deadly as a poison? Is it that strong of a neucleophile?
@ysbi_
@ysbi_ 3 года назад
Not quite, but kind of! Its actually more of an inorganic chemistry question! Cyanide binds to iron in a protein called cytochrome c oxidase, and prevents electron transfer needed to synthesise ATP.
@feitocomfruta
@feitocomfruta 3 года назад
Arlexa thanks! I guess I ask because it seems like logically, on an atomic level, these kinds of reactions are why poisons and venoms act the way they do.
@LangThoughts
@LangThoughts 3 года назад
@@ysbi_ Would cyanide antidotes then be strong, non-toxic electrophiles that would produce a non-toxic compound if attacked by cyanide?
@ysbi_
@ysbi_ 3 года назад
@@LangThoughts Not really my area of knowledge sorry, but some quick research seems like cyanide antidotes are typically oxidising agents to oxidise iron in blood. This strongly binds the cyanide at hemoglobin (now methemoglobin) instead of at the cytochrome c complex. Too much of this can prevent oxygen transport in the blood though!
@Shazistic
@Shazistic 3 года назад
Dreaming is wonderful, goal setting is crucial, but action is supreme. To make something great happen you must get busy and make it happen. -The Shades 🖤🖤
@sajayp
@sajayp 3 года назад
I have heard enough phile for the year lol
@taelororbe3375
@taelororbe3375 3 года назад
Please do a podcast
@Chemistry-Rocks
@Chemistry-Rocks 3 года назад
crashcourseophile
@hishamkazia4719
@hishamkazia4719 3 года назад
Please do accounting crash course
@videoglitter1483
@videoglitter1483 3 года назад
Please make video about pharmacology lesson
@nahfid2003
@nahfid2003 3 года назад
I love the host
@kocengineering769
@kocengineering769 3 года назад
I can't stop loving you mam u explain very nicely Thanks a lot
@josenellandrewtumulak2400
@josenellandrewtumulak2400 3 года назад
Dope
@sumanmehta7206
@sumanmehta7206 3 года назад
Can u please increase the frequency of these videos, As I need them very much this year😟🙁😔😌
@crashcourse
@crashcourse 3 года назад
we would love to, but unfortunately, due to the schedules of our content team, this series will continue rolling out on a biweekly basis until the end of the academic year (May 2021) -NS
@sumanmehta7206
@sumanmehta7206 3 года назад
@@crashcourse Ok then, Waiting for the next video 🥰😊🥰
@jaidamuhammad
@jaidamuhammad 3 года назад
How did y’all know this is what I was just going over in Ochem???
@gennik7966
@gennik7966 3 года назад
I read the thumbnail as "Necrophile" and was confused as to why crash course would be making a video on the subject.
@mvp_health-n-beauty
@mvp_health-n-beauty 3 года назад
lol, i would be too ☺️
@vahzu
@vahzu 3 года назад
Cd
@AZ-wg3eg
@AZ-wg3eg 3 года назад
oh baby...when you understand what you don't understand you truly realize your limitations of comprehension lol.
@gg3675
@gg3675 3 года назад
Nucleophilic attack, not to be confused with nuclear attacks.
@addyb5645
@addyb5645 3 года назад
CAN YALL HELP ME???? WHY DID THE ANCESTORS OF NATIVE AMERICANS MIGRATE TO AMERICA??? PLS IM DOING A TEST RIGHT NOW
@beastamaki7940
@beastamaki7940 3 года назад
Hai
@lauranight4572
@lauranight4572 3 года назад
If she was a molecule then I'd be a nucleophile, because I love her positive regions :')
@Karasus_drug_dealer
@Karasus_drug_dealer 3 года назад
Please don't be creepy, thanks
@zuccthecucc9260
@zuccthecucc9260 3 года назад
Yeaaaaah i dont think adding philes at the end of something is a good idea
@cara.bella15
@cara.bella15 Год назад
I’m so screwed
@lovemoreponi3682
@lovemoreponi3682 3 года назад
👏
@brahimbelmouhand9888
@brahimbelmouhand9888 3 года назад
Fitst
@brahimbelmouhand9888
@brahimbelmouhand9888 3 года назад
First*
@cerealkeepsyougoingeveryda555
@cerealkeepsyougoingeveryda555 3 года назад
Well done
@brahimbelmouhand9888
@brahimbelmouhand9888 3 года назад
@@cerealkeepsyougoingeveryda555 thanx
@mvp_health-n-beauty
@mvp_health-n-beauty 3 года назад
Wow. I didn’t know comments started like this! Pretty cool! I totally like it 😄
@ThatOneOddGuy
@ThatOneOddGuy 3 года назад
What would a person who loves explosions be called
@comradeofthebalance3147
@comradeofthebalance3147 3 года назад
Unknown ekrixiphile
@ThatOneOddGuy
@ThatOneOddGuy 3 года назад
@@comradeofthebalance3147 what typo?
@comradeofthebalance3147
@comradeofthebalance3147 3 года назад
Unknown what
@ThatOneOddGuy
@ThatOneOddGuy 3 года назад
@@comradeofthebalance3147 exactly
@comradeofthebalance3147
@comradeofthebalance3147 3 года назад
Unknown bruh.
@trishhart8766
@trishhart8766 3 года назад
🙋🏼‍♀️
@Patrick-ob7ll
@Patrick-ob7ll 3 года назад
Copaze
@abrakadabra1682
@abrakadabra1682 3 года назад
Slow down pls
@aadityakarnataki9427
@aadityakarnataki9427 3 года назад
second
@milindkundal1518
@milindkundal1518 3 года назад
Really you look kinda camilla.
@abhiprakash74999
@abhiprakash74999 3 года назад
Yes. Couldn't they finish cc organic chemistry first. Then start with linguistics. Jeez why stagger it like this ? Pls CC , put out one organic chem video each week
@Mr1995Musicman
@Mr1995Musicman 3 года назад
I'm a computer scientist, what am I doing here?
@karolinamikesova
@karolinamikesova 3 года назад
Learning something new, heh.
@ManEprz
@ManEprz 3 года назад
Hey you guys are wrong in your video Newton’s Laws:Crash course physics #5. The women presenting was wrong on her force of gravity. It’s actually -9.8 not 9.81. It’s negative because it’s going the opposite direction (down) and acting upon the object. Ask your physics teacher if you don’t believe me. I’m trying to help everyone find their actual answer. Unless you live in the South Pole, either your being brain washed or I don’t know. The force of gravity will always be the same where ever you go.
@nieks9212
@nieks9212 3 года назад
You might be confusing some things; That is the value for the gravitational acceleration (en.wikipedia.org/wiki/Gravitational_acceleration), which differs slightly depending on your location, and is positive by definition.
@utkarshmishra7416
@utkarshmishra7416 3 года назад
That -ve is just a sign convention, Assuming UP to be positive , also gravity isnt same everywhere it changes depending on latitude and even the local rock densities by small amounts.
@matthewwilliams602
@matthewwilliams602 3 года назад
She is pretty...
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