Critical Findings From 12 Key NMN Human Studies 

Really unexpected finding in that last study 💊 MicroVitamin (multivitamin & mineral that I take): drstanfield.com/products/microvitamin 💪 Join Patreon for early access to my videos & Discord chat: www.patreon.com/bradstanfieldmd 💊 My full supplement stack: drstanfield.com/my-supplements

Weird. I am 40, worked out all my life. 1. Took NMN for 8 months and was a beast at the gym. 2. Stoped taking it for 2 months and i felt tired..gym activity went down...i felt old. 3. Took it again....after a while...the beast came back. I love it. I Will keep taking it.

I have been on MNM 1000mg, resveratrol 1000mg and Berberine since 7/19 Since then my blood tests are perfect, my blood pressure is 110/70 I’m 70 my grey hair and grey beard has turned to salt and pepper, my A1C is 5.1% down from 6.4% pre-diabetic. I have a feeling of wellness since I started. My weight is 160lbs down from 210lbs. That’s all I can contribute to this video.

Here's a study for you. I've been taking NMN for 11 months. 1g daily along with 1g TMG twice per day. I just turned 65. My results are profound. Eyesight, taste, hearing, sense of touch, sense of smell. All improved. Memory, cognition, ability to multi-task. All improved. I have never in my life been able to focus like I can now. Learning is easy. reading comprehension, very good. For the past few years, when I felt the urge to urinate. I had to drop everything and go NOW. Around 4 months into taking NMN I noticed that was much reduced. In fact I don't have that strong urge any longer. My ability to do tasks that I had been doing for years such as typing, running the machinery in my shop.. all things that were classified as "muscle memory". They had all become more difficult. I had to think about doing them or I would not do them correctly. Too many times I pressed the wrong button on a machine, simply due to my "muscle memory" being screwed up. No longer. I can type without looking and rapidly. I don't have to think about which buttons to press on my machines.. just like I used to do. One small thing that may not seem important but.. I can now put my pants on without holding on to something, just like I used to do but had not been able to over the past 2 to 3 years. Can I attribute all those "improvements" to NMN? Nothing else in my life changed. Same diet, same routine, same bed, same job so.. yes I can. What else? My skin is softer, the age spots on my hands are gone, my energy level is flat out amazing. I lost about 20 pounds without even trying. I feel like my testosterone level is going up. How do I know that? I wake up with a woody every morning. Been a few years (longer actually) since I had that problem. Anyway. there it is. My study.

I appreciate the video but it doesn't seem to address the 'anti-aging' question as mentioned in the title. I don't take NMN as a sports supplement, I am only interested in it's potential effect of helping to repair DNA. Are there any studies which answer this question? Thanks!

My dad is 90 years old and is in stage 7 of Alzheimer's disease. At the beginning of this year he was basically an unresponsive zombie. On April 1st I started him on NMN, NR, Resveratrol, Quercetin, Fisetin, and a few other vitamins. Today he is just like he was 4 years ago. The improvement is astonishing. I have to pinch myself every day to make sure it's not a dream. Sorry but trying to outsmart the science doesn't look good on you. And it's not very helpful to the public interest.

This is weird because I have been taking NMN for 1 year, and my gray hair has diminished. My recovery at the gym is way better. My testeroon went up 200 points, and I feel sharper. How is this a placebo effect? Why are they trying to make NMN a prescription drug if it didn't work?????????.

NMN has been a game changer for me. Y’all can take what you want, I don’t really care. But If you are over 55 you may want to consider it. Don’t take my word for it, get your NAD levels tested before and after.

As a 53 year old cancer survivor (prostate surgery, and follow up radiation therapy) I found NMN to be helpful. I've been on it (500mg a day from Renue by Science) since Dec 2022. My opinion is that it is essentially just a vitamin, and acts very much in the background. In fact, it is a type of niacin (vitamin B3). You can also take nicotinamide, for perhaps a better effect. The immediate effects I felt was a decrease in muscle and joint stiffness and soreness. A decrease in inflammation. Though, perhaps it was working in tandem with other supplements I take. Hard to say. I would say that it helped my energy levels enough, that I started running again three months ago.

You will see the difference when you are doing heavy exercises intermittently, say once a week or intervals more than that. Muscle recovery is far more improved when taking NMN based on my experience. Before taking NMN, it takes me 2 to 3 days before my muscle sores go away. But after taking it, my muscles are no longer sore after a heavy workout even after being sedentary for a while.

Hi, Brad thanks for the review. I've looked up all of the 12 studies and 11 of them mention oral supplementation. Not liposomal capsules or sublingual powder. I think it is important to point it out, as we know that NMN is a fragile molecule that breaks down in our digestive system, so these findings are of very limited use.

Dr. Stanfield - Here's an account of my personal experience when starting NMN supplementation. I learned of NMN in 2019. I was interested in its supposed DNA benefits. At the time, I was in my late 40s and actively training in Brazilian Jiu Jitsu. In Jiu Jitsu class, we always spent the last 30-45 minutes sparing, or "rolling" as we called it. This was very intense physical activity, especially so given my age. Each round was 5 minutes, with a 1 minute rest between rounds. At my peek physically condition in those days, I was able to do two 5 minute rounds in a row (or on rare occasions three), and then I typically had to rest a full round before I'd have one more round in me. After that I'd be done for the day. When I started taking NMN, I found I was immediately able to do 5-6 rounds in a row. At the time, I was unaware of the supposed cardiovascular benefits of NMN supplementation, so I'm disinclined to think it was simply placebo effect. Adding on to that is the unlikelihood of placebo effect resulting in a sudden doubling exercise ability. Is that an incorrect assumption? That said, if it wasn't the NMN, what could it have been besides placebo effect? I wondered if maybe the NMN brand I was using contained an additive like caffeine, but I can't say for sure. I don't think so because I know I'm very sensitive to stimulants as they greatly disrupt my sleep. I've never had any sleep disruptions from taking NMN (or products labeled NMN).

I have been taking NMN for years. Not counting. I will be 57 this year and I can do more pushups than when I arrived at bootcamp when I was 18 years old and in the greatest shape of my life. I don't know man, something is working.

I use NMN for recovery in endurance sports. I’m an iron man triathlete and train 13-19 hours a week and sublingual NMN makes a MASSIVE difference in performance and recovery feels like a 100% boost. Would not want to train without it. Anti aging is irrelevant to me and these studies looked at vo2 max and max strength. Again, irrelevant, the only drugs to boost these are anabolic steroids. NMN boosts RECOVERY AND RECOVERY IS MASSIVE IN SPORTS TRAINING…. Also muscle NAD is boosted with sublingual rout and IV not oral. Something the study didn’t look at… increased insulin sensitivity at the muscle may play a very important role in both recovery and endurance.

I've been taking NMN for several years and have made no lifestyle changes but my results are amazing. Maybe these trials need to be more long term.

excellent systematic overview. understanding what NOT to invest time/money on is just as important (if not more) as figuring out what does work

I found NMN useful in removing age related fatigue. I also found adding B3 to a carb loaded Creatine had the same effect which shouldn’t be a surprise as NMN is a combination of B3, sugar and Phosphate. It is definitely doing something for me and has been life changing in that I now have the energy to train and the gym after working all day.

I really wanted to see NMN prove itself, especially after all the hype. Thanks for being an honest critic of the research! It is well needed in our day and age..

For most of these trials you did not tell us the dosage. Why leave out this essential piece of information?

The noticeable benefits I've experienced are in stamina and recovery. Those studies are not looking at recovery and little about stamina. I'm not a social media influencer. Nor do I follow any, so I'm not familiar with the hyperbole they're pushing. I've had good results in those two areas. I'm 56, I have been taking 1 gram of NMN sublingually for about five months, and I have experienced significant improvement in stamina during cardio activities, mostly running, and also in muscle recovery. The before and after difference is conspicuous. I am very in tune with my body. I exercise a lot for the majority of my adult life. In my twenties, I was a professional ballet dancer. I was hardcore 24/7. Now, I weight train and run regularly. Before taking NMN, I was constantly battling thigh and hamstring injuries (due to previous ballet injuries) which would lead to frequent periods in physical therapy. A hot spot on my thigh would always lead to PT, reduced or no activity, and a slow, monitored, methodical recovery, which happened regularly. That's how it was the five previous years. I was constantly in and out of PT. That's not the case any longer. Those hot spots that indicated or would lead to injury no longer do so. They last briefly and do not impede my running. Those acute hot spots no longer turn into injury and no longer linger. My increase in stamina enables me to run more miles, which would normally put me at greater risk of injury, but I haven't experienced an injury since starting NMN. The recovery from weight training workouts is not as easy to discern as many factors are involved, but I do push harder as I don't take as long of a recovery between workouts as I used to do because I assume that the recovery benefit I've experienced with running would be similar with weight training. The shorter periods in between workouts have not caused me any issues. I know my body well. My PTs know me well, and the difference is remarkable. These studies are not thorough. More research is needed.

I've been taking NR for several years. First week of taking it, I had heart palpitations. After the first week, everything settled and didn't notice much difference except slightly better endurance when exercising. After about a year however, looking back and comparing pre and post blood works. Wow, what a difference it has made. Lower cholesterol and much lower triglyceride. Started my mother on it, and again, after about a year, her blood sugar went from Type 2 diabetic levels to be within the normal range. Neither of us changed our lifestyle or diet when taking it. One set back though, NR did seem to agitate my liver quite a bit.

I’ve been taking NR for four years. I’m 80, and I feel great, but there’s no way to know if it’s because of the NR, since the science is still in it’s infancy. I figured if it eventually pans out, I’ll be glad, and if it doesn’t I’ll have wasted some money, so I chose to risk the money. So far I have seen precious little in the research about negative side effects. We know it extends healthspan in mice, but there aren’t any mice on either side of my family.

I have no clue why NMN is being studied against any metric other than DNA methylation. The primary purpose of supplementing NMN is to improve ageing, which has to me measured over months and years, and anyone looking to measure it against any time window < 24 weeks, with low dosages, is just not studying it properly. OF COURSE it is going to have a negligible effect on strength, stamina, LDL, HDL, and all of these markers. The primary use of NMN is to make sure NMN is used as part of DNA repair. Second point, DNA repair is upregulated during fasting. In my mind, only studies that supplement NMN during fasted periods (or calorie restricted periods) will be expected to succeed. Specifically, humans are over fed, and the mechanisms NMN is designed to help with up regulate during a calorie or energy deficit. Again, these studies seem to leave this CRITICAL design factor out. To create a metaphor, NMN is like a salve, that helps injured tissue heal during protected rest. I have no clue why this "DNA ointment" is being tested for its ability to make you run faster, or lift more. Its also tested in a context where the body is not in repair mode. So, these findings all are strange, because none of them measure what we are looking to measure. However, I do understand -- Imagine running an NMN trial for 6 months, with people who dose when fasting, and then taking regular DNA methylation tests. This would be an insanely expensive trail, and would have very low compliance. So I get that the researchers decided to go with easy to measure proxy metrics. However, nobody should expect these proxy metrics to relate much to the underlying variable we care about in the short term: DNA damage.

What's even more surprising than these results is that this video has had 100,000 views, yet only has 26 likes!

I have taken many supplements throughout my life and I feel like NMN is one of the few that I can feel a difference when I take it. I feel like I can get another 15% of productivity out of my day. I know this is anecdotal, but I hear similar results from my friends. It works well for me so I’m going to continue to take it even though it is expensive.

I haven’t changed my diet or taken a high dose. But what is making my hair color change? I would say 80% of the gray/white is now brown. Started to notice after almost 3 months of 500 mg per day powder

I take NMN daily and I tell people that it’s not a magic bullet. It makes me feel like I have energy and want to exercise. I worked out most of my life and started to lose that motivation and high I get from exercise. NMN allowed me to have that high feeling from exercising. I enjoy exercising now. Before NMN I’ve tried dieting and other supplements while still forcing myself to work out. I think now I have no issues So I do agree with Brad that NMN doesn’t have direct benefits but I think it give you a boost in motivation. All my friends also say the same thing. They feel younger and want to work out more. We are all in our 40s and have always exercised before.

Always good to have contrasting opinions to keep us aware. I have noticed though, that Dr. Stanfield specializes in telling us about things that don't work, even when a significant number of folks have had success with it. I have seen reports that show that NMN has worked or has potential. As always, we should each get the best info we can, including pro & con and especially safety considerations and make individual decisions for ourselves, along with the docs. Personally, if I hear testimonials from a large number of people who have had success, that carries weight for me.

Thanks Brad, good video. I have to agree with your findings, I've been taking NMN (.5g-1g daily) consistently for the past 6 months and I've found no notable improvements in my health. I have always adhered to a very good diet and exercise regimen and am not very susceptible to any placebo effect. Thanks again.

This squares with my experience. I took 1g NMN for a year, and measured blood NAD levels before and after. I had a significant boost in blood NAD, which suggests my microbiome didn't munch all of it. I did feel great the first few weeks after starting, but that wore off, consistent with the placebo effect. I'm now repeating the experiment with NR.

Sorry, I couldn't watch the entire video, but here is my experience, I am 37 have been taking NMN for last 2 years and I workout as much as a 20 years old guy in my gym I lost this stamina about 2 years ago and thought I couldn't compete with them ever again, I accepted that I was growing old not any more. But my twin brother who isn't on NMN is experiencing a lot of issues, forget about working out, he can't walk much he has to take a lot of rest in the bed and that is a very bad sign. But we can contribute it to our eating habits and lifestyle choices since we were 20. Coming to my Mom, she is 60+, she has always been a very active person, but since 2021 she was not able to do household works she would start cleaning and then would sit take rest and complete the work later on, she wouldn't be able to stay standing up to cook the food and was getting very frustrated, I was more frustrated that she was not taking rest and was yelling at people due to the fact that she can't work as much. Then came corona people started to die left, right, center in India, so many died in my own locality, I was not going to give NMN to my mother but was afraid that I would lose her. No clinical trials were done on humans that I was aware of, I gave her 500 mg A day and she was working as she used to, she never felt tired again. She started to sleep like a baby. She has been active like she was 20 years ago. She is outworking everyone except me in my family, so I don't know about these studies but this stuff works and if you are on it (now it is cheaper then before), continue taking it guys.

I am 48 and was having meniscus injury at my knee joint. I had been suffering pain for years , not even any medication can cure my problem. After taking NMN for 3 months, my pain gradually go away , and now i can start back my jogging from 1k intially to alomost 10k training per session. Hence, i really doubts of your findings here honestly.

I am an electrical engineer with a solid scientific back ground and is quite well versed reading and understanding scientific literature. I am very cynical about medical science literature , particularly those funded by special interests. Just remember the same type of papers support statins, propagate misinformation about LDL’s, the food pyramid etc and the list goes on. I’d say go with your personal experience when experimenting with a controversial supplement, especially if it does no harm.

I'm not a social influencer. I'm a life long physician athlete. I have been consuming a number of supplements for years. Nothing besides electrolytes and protein powders have had as profound an effect as NMN. So, somehow all the negative findings of the studies are exactly what I have experienced as positive findings(except for muscle levels I have not tested). I consume 250-400mg per day. How is it that the 50 year old plus athletes I associate with are experiencing the positive results that I am. We are not new to the supplement scene and have taken many a claim with little expectation. NMN has been different.

Brad, I take all my NMN powder sublingually. I started out mixing it with water and administering it sublingually with a dropper, because it was so expensive. Even though the price has gone down I now take scoops of powder and put it under my tongue. I'd really like to see some studies done with sublingual delivery because, wow, if it's a placebo what a placebo.

This video is the perfect antidote to "Reverse Aging: Dr David Sinclair on NMN & Anti Ageing supplements (including their side effects)" which appeared 8 days ago.

Nice analysis. Would be cool to see you interview Bryan Johnson - Blueprint, or at least go over his protocol including his diet, exercise, sleep and supplements, or maybe a video on each category. Need more rational doctors giving a breakdown of it.

Two questions: 1) I seem to recall a video from you awhile back which said that we simply cannot absorb NMN, and so it was utterly useless for us. Was that wrong? 2) What about the mouse studies? NAD plays a fundamental role in vertebrate metabolism (I'm quite sure). Among all things, one would think NAD metabolism would be conserved through mice and humans. Why such a difference? Could the original mouse studies have been wrong?

I think that the nmn in the brain give a bit more bit mental energy but it doesn't necessarily enhance mental performance. That's my experience as far as noticeable effects. Since all I wanted out of nmn was a mental boost I don't regret buying the supplement.

This guy used to be a fan of NMN. Later on, for some reason he is pissing off Dr. David Sinclair and his NMN. It appears now he is getting personal with Dr Sinclair. The bottom line is that this guy publishes his videos for money. So don’t take it seriously on what he is saying. I myself have taken 1g NMN powders everyday. I feel very good with it! I will continue taking NMN and watch this guy with a smile.😂

I think more studies should be done, like effects on energy levels, skin/hair and nail health.

I have been taking it for 3 or 4 months I can tell you I feel amazing when taking 1000 mg a day I can easily run up a mountain Performance is excellent. And I am 72 ….

Any studies on NMN AND TMG? This alone can make a huge difference in results.

Useful... improved walking, muscle strength, endurance, hair, skin, maintained weight after losing some (already slim), better eyesight, no need for reading glasses, unending energy, easy recovery, less hangovers... Lol... and personally I don't think it's a placebo effect, cause I didn't know much when I started it, so I had no hopes or thoughts on the matter, things just started improving and 9 months on it they are still here... A lot of other things improved... btw... I think this is comparable with other thousands of people... On the other hand remember this: This doctor has a beef with Dr. Sinclair, so he will always say negative things about anything he promotes or discovers... And, you can always find tons of other studies showing other results, and then you only cited those... same way like any industry does... selective reporting...👋👋

This is huge in my view. I’ve been questioning the value of NMN for months as I’ve been on it ( from DoNotAge) for 20 months. I’m a 68 yr old male in good health and have experienced zero impacts from NMN in workout, energy, cognition, etc. Many of the RU-vid influencers rely on their personal workout experiences to validate the value of NMN and I’ve been increasingly suspect of these anecdotal, placebo prone reviews. While I like what Berberine has done for my blood glucose and A1c levels , along with my lipid levels…I’m not planning to buy any more NMN from DNA or other reputable suppliers. I’m also a big fan of Creatine but NMN seems like a waste of $ and I’m ending my use of it.

A great summary of the recent peer reviewed research on NMN in humans. Thank you for continuing to provide valuable and objective analyses on a range of health related issues. Greatly appreciated.

Its important to buy enteric coated or liposomal NMN or NR. Because as you said most gets broken down before it can reach the small intenstine. Massive difference in effects between pure powder and enteric coated tablets for me.

My experience from taking NMN is that, and I can say with 100% certainty, it is not a placebo effect. I don't buy into the hype of someone telling me about medications or supplements. What I know is I could barely function anymore and had no due to COPD, asthma, arthritis spine, hip, and neck problems. Now with combined NMN with my other medications, things are far better than they were. There are some other good things that I've been experiencing. Nothing has changed with my diet. NMN has also given me the ability to do a little home therapy. So, with those trials, I have no idea, and it almost seems unreal hearing about them.

I`ve recently noticed a proliferation of anti-NMN findings coming from various corners. Like it`s being orchestrated.

When I started taking NMN, I changed nothing else. I was already exercising daily and eating well. I saw a big improvement in energy and mental focus after starting NMN. I don’t think this is due to a placebo effect since I have been taking it for more than three months. There is something to NMN and I will continue to take it (1000 mg once a day in the morning). I am a woman without existing health problems (and not over weight). Don’t know if that makes any difference. Regarding the studies cited in this video, I am wondering if how one takes NMN and with what other complementary supplements affects its effectiveness. I take it in the morning on an empty stomach and follow it up with TMG.

Hi Brad. Good work. Be aware that the company you promote in Do Not Age currently advertises its NMN as ‘Improving Strength and Stamina” as it main selling point. False advertising or misguided?

Excellent review! The evidence is overwhelming that the number one anti-aging pill is exercise. And the three types of exercise to focus on are cardio respiratory fitness, strength training, and mobility / stability training. Much thanks for taking the considerable time and attention required to produce this and all of your videos, Brad!

A idea for your next video should be Niacin. Google scholar has studies showing Niacin has potential for treating NAFLD but other studies show it has hepatoxicity.

How sad is it when i feel the need to applaud this man for unbiased content! Great stuff. Any plans to do an anti- aging theory of everything?

Considering that NMN turns mostly into Niacin in the gut, all these studies should ideally have an arm with slow release or non flushing niacin.

I must admit I'm quite relieved to learn NMN isn't all it's cracked up to be. The cost of supplementation collectively is not cheap and NMN in particular is quite an expensive option and for that reason alone I have not indulged, but rather focused more on supplements with well-established benefits. However, admittedly I did suffer a certain level of FOMO with regard to NMN and so it's good to now know I've not really been missing out on anything after all. Phew! 👌

Interesting, but I thought NMM mostly should affect aging. Which again is less of an issue on younger people, therefore won't help younger people. NMN levels are more likely lower in older people. I would like to see a study with different age groups and less on sports.

Good analysis Dr. Stanfield. I am 79 years old and have been taking 500m NMN and 500m TMG for three years. I also exercised daily. At times I was very skeptical of your unenthusiastic cautous reviews of Dr. Sinclair's work. Now, I must apologize and commend you for your insight, tenacity and professionalism.

Awesome summary, thanks Brad. Creatine, taurine and omega-3s are my trinity

Maybe it depends, I feel like 10 yrs younger by only take it for two days

Why is muscle NAD level important vs. blood NAD levels? What is the mechanism to raise muscle NAD? And why doesn't something that increases blood NAD also increase muscle NAD?

I notice you left out the dosage for most of the studies. The first study was for 250mg which is nothing. Most people take 1g to 1.5g and also take TMG. You're turning out to be a real disappointment...

As a NMN consumer my self. He is cherry picking studies. I’m impressed by how hard he is trying to make NMN look useless.

Then why is the FDA and big pharma wanting it to only be available by prescription? There are thousands of supplements out there and some can cause issues if taken wrong, yet the FDA doesn't seem to care about them.

Muscles are not the only organ. From what I recall NMN does raise levels of NAD in several organs but not in all organs. Also high 1g or more doses are needed. NMNH is said to be a superior version that raises NAD in more organs and to greater extent.

Thank you! I have tried this for some time with absolutely no notable changes. Lots of money down the loo. Not sure why so many people insist that it has made a difference to their lives. Unless they have financial interests or an amazing placebo effect.

I've been taking it 3 years now. Never had the euphoria experienced by others but then again I have eaten a well balanced whole plant diet for 22 years and weight lifted the entire time several times weekly. I guess I will just bin my latest batch from donotage and wait for the rapamycin studies lol.

There is a recent RU-vid video by Michael Chua MD titled: "Vitamin B3 is the New Holy Grail of Glaucoma treatment, Here's why." The suggested findings so far are that B3 is neuroprotective halting damage to retinal ganglion cells. Large clinical trials are ongoing. As an ophthalmologist, Dr. Chua is clearly excited by this. What struck me was the large doses used, 1000mg, 2,000mg and 3000mg. Way more than any diet could provide. I wondered what your thoughts are on long-term use of high-dose Vitamin B3.

Appreciate the thorough detail, as always. Would love to see a similar study review of niacin supplementation to see how its results differ or are similar to NMN and NR.

Dr. Stanfield, I have not watched your entire video, but did notice a study on muscle strength? I have been consistently working out with weights in the gym for 40 years, I am now 59. I have been taking NMN for approximately 8 months. I have definitely noticed an increase in strength while lifting weights in the gym, nothing crazy, but no question, increased energy and strength while lifting weights. I personally think I know my body best and its limits when it comes to lifting weights. I feel some of these studies are not representative enough when performed. I think if you took 100 men that have been working out with weights consistently over 5 years, and are all over 50 years of age, you would get 100 men that know their bodies and limits when it involves weight lifting and strength. These are the people that can give you a more objective response to NMN increasing strength. I have no "Dog" in the fight for NMN, just my two cents.

Thank you for your study. I have been taking it about 3 years. For me it did two things within the first few months: My night vision came back (I’m 78) and my 10 year bout with gum disease stopped. My blood pressure also improved gradually over 2 years but that could be due to exercise. No help for skin wrinkles etc. why did I have some result while others did not? I don’t know but for me it worked at least somewhat. Perhaps the studies were so short. If it lengthens telomeres it may take a long time as cells reproduce. Prior to NMN I took NR for about 2 years with no result.

This video echoes my own n=1 experience: no significant changes when taking NR. I’ve not taken NMN directly, and since I’ve given NR several months of use, I don’t see a reason to try it. When my NR runs out, that will be it. Im also taking Mitopure (urolithin A) and can report nothing significant in terms of changes. It’s expensive as well so I expect big results. I’ll most likely be dumping it after my current supply runs out. So far, no magic pill.

I’m a 40yo very active male…after taking nmn, my sleep quality noticeably improved and my nails/hair grew faster. 6 mos later, I feel that it does not provide me the same effect it used to.

I'm sorry but I'm reading more of these publications now, and Dr Stanfield just cherry picks everything that's negative about them. The amateur runners on NMN did actually achieve a higher ventilation limit and improved single leg stance. This corroborates all the anecdotal evidence found here and on reddit. NMN doesn't help with strength, but it does help extend aerobic performance.. Some people claim they can run or swim twice what they could do before.

On my specific case (I am suffering from Still disease - a kind of systemic polyarthrite), what I have been able to notice after having tried both NR and NMN is that with NMN I would tend to feel slightly more fatigue and have slight red flares on my hands, which is a sign of inflammation in my condition and in the contrary when I take NR, I feel a bit better, no flares, my skin seems slightly better and above all, I almost systematically remember my dreams when I wake up in the morning. I wanted to share my experience as I think in my case and with my conditions, effects of drugs and supplements are exacerbated and easier to see and feel and that I clearly noticed a benefit with NR and the opposite with NMN.

Higher nad in the blood seems like a good thing to me. You really did a disservice to the topic by emitting the amount of nmn and the delivery method being used in the studies and by youtube influencers. I took nmn and feel like it had profound effects but not consistent. that tells me we have more to learn about how it is best taken in and used by our bodys.

However, Bryan Johnson said on his YT channel that he has experienced the benefits from NMN through his testing equipment. I don't know who to believe 🤷‍♂️ I remain neutral on this, but I don't think I'd supplement with it. We'll have to see.

I do not understand why the your statements are directly contradicting the conclusions of the very studies you are referencing, or directly contradicting other studies and human clinical trials, and I also don't understand why you are cherry picking and leaving out studies like the following: Karol Mateusz Pencina and others, Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study, The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 8, August 2023, Pages 1968-1980. I am so confused by the conclusions drawn here.. The second paper you reference states quote "Insulin-stimulated glucose disposal, assessed by using the hyperinsulinemic-euglycemic clamp, and skeletal muscle insulin signaling (phosphorylation of AKT and mTOR) increased after NMN supplementation, but did not change after placebo treatment. NMN supplementation up-regulated the expression of platelet-derived growth factor receptor β and other genes related to muscle remodeling. These results demonstrate NMN increases muscle insulin sensitivity, insulin signaling and remodeling in women with prediabetes who are overweight or obese." And the section you point to claiming that NAD+ levels were not increased in muscles is taken out of context.. why would you choose to do that, what is your motivation here? the full quote: "Although muscle NAD+ and nicotinamide content did not change after 10 weeks of treatment in either group (Fig. 1, ​,EE and ​andF),F), muscle N-methyl-nicotinamide, methyl-2-pyridone-5-carboxamide, and N-methyl-4-pyridone-5-carboxamide increased after NMN but not placebo treatment (Fig. 1, ​,G,G, ​,H,H, and ​andI),I), suggesting NMN treatment increased muscle NAD+ turnover." The key sentence here: "suggesting NMN treatment increased muscle NAD+ turnover." In other words, yes, NAD+ levels went up but there was such a deficit and such a need for additional NAD+, that they only observed the metabolites. But those metabolites would not have increased if NAD+ production had not increased. The same is true for most of the papers you've referenced, your conclusions, and the conclusions of the authors stand in stark contrast. I'm just confused, I want to believe that you are a trustworthy source of information. But for whatever reason, you are distorting the conclusions of the papers you are referencing. I find it incomprehensible why you would so that... I really do want to know why?

Brilliant, unbiased, fact based content 👌🏻

Hello Dr Stansfield, I took NMN for 3weeks and experienced absolutely unbelievable results, unfortunately I had to stop taking it due to a bad reaction. I am more than happy to talk to you about this if you are interested, thanks.

NMN has definitely worked for me and i know its not placebo

We need human studies on significant IV NR or NMN doses (1 g or more) to really see if there's a benefit. Taking piss poor doses which get completely broken down to NA isn't going to show any effect, let's be honest. IV NR and NMN increased tissue NAD levels in mice in the Liu NAD flux study.

I'd definitely love to see larger studies and for much longer, like over a year or at least 6 months, but also with an equal amount of time viewing the levels of the people involved prior to see how it may effect anything that is going downhill in the people studied. I had heard somewhere about it not reaching far past just being in your blood prior, though.

This video should be shared on SO many influencer feeds

Does this also pertain to niacin supplements?

My personal experience NMN has been life changing. For the positive of course

Don't forget that he also needs to promote his Own vitamins for Longevity... just saying...🙄

one of the best videos about NMN, indeed it delivered the missing big picture over the studies

I've taken nmn for 6monhs and felt that overall it may be a placebo effect, the rise in blood serum may be helpful in the brain energy department, but it doesn't do much for muscle or lungs, I find things like beta ecdysterone, rhodiola and epicatechin induce greater gain

Wow i have never ever read so many positive experiences about a supplement like NMN

What were the time frames of the studies? Was it for the duration of the study or as suggested by the suppliers over a minimum of 3mths?

Try it for yourself and then you’ll know. I’ve been taking supplements my entire life and nothing has given me more energy better feeling of well-being and complete elimination of my muscle soreness and inflammation.

Why is the FDA trying ban it and plan to make it prescription only?

This is the major problem with studies that only measure improved blood levels. If the substance, in this case NAD+, doesn't get into the cells and tissues, it makes no difference, as simply having more of any substance in the blood means nothing. In fact, in some cases, such as increased calcium in the blood, is harmful. The best supplement to allow the body to make and increase its own NAD+ into the cells, among a bunch of other anti-aging benefits, is Urolithin A.

I have tinnitus from antibiotic treatment and regular headaches from being an IT and staying on the pc all day which NMN helps with. Also don't sleep good because of a young child. I take about 600mg of nmn a day and it gives me a lot of energy. If I stop it for few days everything starts going back to normal(it is surviveable but not pleasant). Not seeing any anti-aging benefits - my beard continues going white :D but I feel better overall.

8:05 the disappointment was so big Brad turned SSJ

"Slow walking speed, so I'm just going to exclude this" = cherry picking

interesting that so many comments report positive benefits after taking NMN, contrary to what is found by science. Perhaps the video should have also included who sponsored those studies or the criteria used to select the studies

How many of these studies were across a matrix of dosages? My observation is that most of the youtubers out there with positive stories take far more than 300mg. That may or may not explain things but it seems like it should be part of any study.

Very informative video, thank you so much.