Dr. Maria Victoria Mateos, Hospital Clinico Universitario de Salamanca, presents curative strategy (GEM-CESAR) for high-risk smoldering myeloma (SMM), a post-hoc analysis of sustained undetectable measurable residual disease (MRD).
Background:
High-Risk Smoldering Myeloma (SMM) is an asymptomatic plasma cell disorder with heterogeneous clinical behavior and once R-based regimens have shown to be effective in high-risk SMM patients, our next step was to perform this phase 2 trial, but aiming at abrogating the risk of progression through an intensive treatment regimen with the end point of achieving sustained MRD negativity (MRD-ve) at 3 and 5 years after ASCT.
Conclusions:
Twenty-three percent of high-risk SMM treated with this curative strategy maintained MRD-ve 4 years after ASCT and 2 years after finalizing the treatment protocol. Progression to MM as well as biochemical progression were driven by the persistence of MRD at the end of maintenance and by lack of sustained MRD-ve 4 years after ASCT (2 years after the end of maintenance).
Authors:
Maria-Victoria Mateos, MD, Joaquín Martínez-López, MD, PhD, Paula Rodríguez-Otero, MD, PhD, Jesús San-Miguel, MD, PhD, Veronica Gonzalez-Calle, MD, PhD, Marta Sonia Gonzalez, MD, Albert Oriol, MD, Norma C. Gutierrez, Rafael Rios, MD, PhD, Laura Rosinol Dachs, Miguel Angel Alvarez, MD, Joan Bargay, MD, PhD, Ana Pilar Gonzalez, PhD, Fernando Escalante, MD, Adrian Alegre, MD, PhD, Belén Iñigo, MD, Javier de la Rubia, MD, Ana Isabel Teruel, MD, Felipe De Arriba, PhD, Luis Palomera, MD, PhD, Miguel-Teodoro Hernández, MD, PhD, Javier Lopez Jimenez, MD, PhD, Marta Reinoso Segura, Aránzazu García Mateo, PhD, Enrique M. Ocio1, Joan Bladé, MD, PhD, Juan-José Lahuerta, MD, PhD, María Teresa Cedena, MD, PhD, Noemi Puig, MD, PhD and Bruno Paiva
ASH Abstract #118: ash.confex.com...
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14 окт 2024
