Design, synthesis and evaluation of small molecules as TLR9 antagonist by Kasireddy Nagireddy 

Design, synthesis and evaluation of small molecules as TLR9 antagonist
National Institute of Pharmaceutical Education and Research Page 1
1. Introduction:
The term TLR is derived as this receptor was first identified in Drosophila Toll, which show
anti-microbial defences. TLRs are the trans membrane proteins that recognize distinct
pathogen-associated molecular patterns [1]
.Thirteen mammalian TLR are identified, among
them expression of 10 is known in humans. These are expressed on cells of innate immune
system including monocytes, macrophages, myeloid cells such as neutrophils, dendritic cells
(DCs), and NK cells. Some TLRs are found on endothelial cells, B lymphocytes, T -cell
subsets, including regulatory T cells and some are intracellular.