Can the OAT marker mentioned here REALLY indicate glutathione need? Here's a great, short literature review a colleague did to answer this question: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-VmkkW3ywG3I.html
Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion, Sushil K Jain 1, David Micinski
Contact Dr Gordon Crozier with the Crozier Clinic in Lake Mary Florida and ask him to explain HydraStat Molecular Encapsulated Glutathione. Tell him Keith Chaisson sent ya!
You’ve given the most informative session on Not just the benefits of Glutathione but so much more, and I’m thankful for all the other information that I was not aware of ., so I’m highly appreciative!
I have to give you many Thanks. My crohns is in serious remission or gone forever. Have stopped my meds and super happy with where I am. Tried many different things with results for a couple of weeks and right back to the way things were. All it took was 1 pill. I am amazed and spreading the word to whoever will listen.
I enjoy watching Dr DiNezza's videos. She is so passionate and enthusiastic about helping people. I wish I lived close to her place of business. Thank you. Dr. DiNezza.
Dr. Berg recommended 10 g glutathione 3x a day. I just started it yesterday... it's a full-on colon cleanse and the bathroom stinks like rotten eggs! LOLOL Smell confirmed the HS SIBO diagnosis. :) Currently fasting and I stopped the ACV, betaine HCl, and bile salts for now. Going full on carnivore after this. I got the reduced L-glutathione from Amazon (pharmaceutical grade). I'm excited to finally heal.
OP, can you please provide a reference (re: NAC dropping DAO 30%)? I'd love to read more about that and validate that claim. Keep in mind that GSH boosts TH1 activity, which in turn suppresses TH2 activity, and thus, mast cell activity. So, depending on the context of the individual, it can still have a net anti-histamine effect.
What are your favorite or top NAC brands? (Also as someone who’s suffered for 4 years of so many digestive issues I want to say I’ve learned more this last week watching your vids then I did the prior 3 years with others).
@@lisagardner4814 glutathione supplements don't work as well because they're not as stable. Better to get into amino acids by food or supplements. I got glycine powder. Gonna look more into glutamic acid and cysteine
I clicked on this video wondering if this might be the solution to my stomach spasms. I eat plenty of eggs, and meat in general. Might have to give bone broth a go as well…
I loved learning about the nutritional affects of all these supplements. I liked your no nonsense approach as well so great to see how the results fit the workings.. Thanks
Your channel is excellent and I like the way you present the information. I came across CELLGEVITY from MAX at the end of 2011. This supplement has Cysteine wrapped in RIBOCEINE which is patented. Taking this supplement in this form allows it to pass safely thru the stomach acids and be absorbed into the Liver, where along with Glycine and Glutomaic Acid allows the making of Glutathione. I have been taking Cellgevity every day for more than 10 years and in testing my levels of Glutathione, the medics tell me its like i'm in my 20s (I'm now 70). I dont get colds, or flu, or any kind of fever. My health is excellent. Riboceine has been shown to be more than 300% more effective than NAC
After reacting to magnesium citrate I realized that I had leaky gut(I should have realized that it was the source of my auto1mmune skin issues) and taking this supplement improved my HRV the same day and now I can tolerate the magnesium. I still have a long way to fixing my microbiome but it is a good start.
If we are tracking our food (Cronometer) but we have (or we suspect) digestive issues doesn't it mean the nutritional stats don't represent true situation because of low stomach acid, celiac, SIBO, SIFO etc? Gets even more confusing knowing that GI issues may affect the absorption of only some nutrients, or some nutrients getting robbed from you by SIBO. And even more confusing knowing that serum levels of nutrients and vitamins (like magnesium or b12) are far from accurate unless tested intracellularly. Just thinking out loud
Such a cool video !!! Kudos to you !! But I have a question : The 3 amino acids of Glutathione are non essentiel amino acid, so why don't we synthesize cysteine from all the methionine we got from the muscles we eat ? (assuming we synthesize a sulfur containing amino acid using an other sulfur containing amino acid) ... Sorry if my question is silly or incorrect !
I started to take an L-Glutamine powder supplement and I had a painful flare up of my IBS/Sibo symptoms. L-glutamine is supposed to heal leaky gut. Did you ever hear of such a weird side effect to L-Glutamine?
I cannot take L-Glutamine at all as it gives me terrible stomach aches. Look into something else to heal your gut like Zinc carnosine (just be mindful that it can inhibit iron absorption).
Wow thank you,i have pmr,and have been treating it with diet,and prednisone but am coming off prednisone,this is invaluable.Doctors totally disregard diet and want to prescribe drigs with high adverse effects.
I get gas from eggs. I’m allergic to dairy wheat gluten sugar corn and rice. I’m getting a round of glutathione iv 2000 6 times in 6 weeks. It’s really helped i felt like constantly inflamed and like i had the flu. I’m also taking nac.
Dr. Dinezza! thank you for such awesome and detailed video as always, love to learn from you! - I was really fascinated to see your chronometer stats and it made me think, I have been using it for 8 years and when I compared mine to yours, we both have the same macros and targets to the exact numbers, but I was blown away by the fact that I eat 52g of fiber, 75g of starch, and 60g of healthy sugars on daily basis, and you seem to follow half of those amounts on daily basis, am I going overboard with the fiber and starch? could these numbers be unhealthy in general?
Hmm hard to say without more context. For example, if you do more cardio than me (it wouldn't take much to beat me there these days 😂😂) you'll need more starch than I do. If you're gut is doing well on 52g of fiber, I wouldn't sweat it. However, sometimes excess fiber consumption can plug ya up and cause constipation, so if that is a chief complaint for you, it may be worth playing with. Hope that helps!
@@gutmicrobiomequeen You've given me the perfect answer, couldn't ask for a better one, you helped me big time by providing reasons why I would want to keep it up and also reasons to watch for why I would want to reduce! :) - being thin and very underweight is what guides me to push the starches, especially since I don't experience much of the negatives by drinking over 2L of water daily :)
Cysteine gonna be low with h2s sibo. My low protein diet makes it impossible to get. Yet when I take sulfur stuff or eat protein it hurts. Only thing I could do is get rid of the bugs so I can eat sulfur stuff again or maybe take cysteine sublingually. Currently trying antrantil and molybdenum as well as glutamine, glycine, and proline to heal the gut.
@@gnosisdespirit I've been taking 2 mg of molybdenum for past week or so. I think though because I present with constipation that I'm dealing with methane and h2s. Just got atrantil in the mail.
Another major thing you need to check into is your vit d levels (make sure to take vit k2 and magnesium if you bump your vit d3 up). Also look into thiamine deficiency - EONutrition has some GREAT info on this - also his latest interviews are priceless.
I've been taking S Acetyl glutathione 100mg a day for about a year. I eat 4 to 5 eggs a day too. Just wondering your thoughts on the absorption factor of this oral glutathione. I hear glutathione in pill form is not absorbed fully. This particular one made by PURE THERAPROR Gold is supposedly acid resistant.
Yeah, they say oral GSH isn't absorbed well. Or, rather, that it breaks down into its 3 amino acids prior to absorption. So, you might as well just supplement with the amino acids you need and call it a day. One paper I read said that oral GSH supplements are just really, really expensive cysteine supplements 😂😂😂
I’ve been taking GlyNAC for about a month. I started noticing almost immediately that I no longer feel soreness after workouts. I’m 64, and previously I would become unbelievably sore between days 3-6 after these workouts. Is this a coincidence, or have I stumbled onto something amazing?
Great idea but you missed of huge point. Alot of people can't tolerate the sulfur in glutathione because of Genetics and I won't get into all the snps...
I'm not convinced of this, actually. I have the +/+ CBS SNP (confirmed with two different companies) and I tolerate Sulfur (including high dose GSH and high dose NAC) like a champion.
Can we talk about Thiamine? Elliot Overton has a theory that many people are deficient. This is connected to glutathione, and has been used to treat parkinson's...
Theoretically? In several doses throughout the day taken away from food. Practical take: I personally hate taking pills between meals (I never remember them which means I take fewer doses per day AND pills tend to feel stuck in my throat if I don't chase them with food 😑) sooooooooo I just don't. I'm willing to live with theoretically slightly worse absorption.
@@gutmicrobiomequeen thank you for the great context I a on nac and it’s only 900 a day I think I’ve plateaued and I need to add another capsule. I’m going to do one in the morning and one at night. Does that make sense or should I do the other one mid day or afternoon?
Thank you for commenting! I appreciate the help in my quest to conquer the algorithm 😉 I've been taking 500 mg 2-3 times per day. Occasionally I would take more (when sick), and occasionally I would forget to take it for a few weeks though 🤦♀️ I've played with glycine here and there, but I've never been diligent with it. I have been more diligent about using collagen peptide protein powder, though, and that has glycine in it. Again, I'm very inconsistent, but I'd day I average using that about 3 or 4 times a week.
@@gutmicrobiomequeen Thank you for this great info. I wondered 2 things. When do you stop taking supplements before your testing so that the results are not effected? Also, I understand that cysteine can also effect hormonal levels by effecting DHEA levels? What does that mean for post menopausal women?
@@salleone6387 I think I discontinued all of my supplements for 3-4 days prior to testing. For me personally, I knew that my GSH and some B vitamins were low when I wasn't supplementing and I don't intend to stop my multi or my NAC... So, in a way, I wanted to test how effective those were for me rather than simply testing my levels. I hope that helps! Also, I'm not savvy enough with the DHEA thing to really weigh in on it... but, I'll share this. If you were supplementing way above and beyond your nutritional needs (ex. cysteine), then I could see it potentially mucking with other systems. But, I find that many people are under-consuming Cysteine to begin with, as was the case for me. So, most of us are not supplementing above and beyond our physiological need- we are simply filling in the holes from an inadequate diet. When that is the case, I'm inclined to think that it's quite safe.
i tried 1 drop of it (brand by seeking health), and it immediately caused a headache and not a general good feeling. it’s either because my crab cycle is not balanced (confirmed by OAT test) or i can’t convert glutamic acid. i know my body needs it because of my chemical intolerances but im not sure what needs to be done.
That's why I advocated focusing on nutrition (especially getting enough cysteine) rather than supplementing with GSH directly. It's pretty common to get funky symptoms from glutathione but tolerate cysteine containing foods just fine.
Interesting, but some bacteria might cause a problem with this. I have had a problem with Citrobacter Freundii and found that "Citrobacter degrades methionine enzyme in the PLP sulfur degrading enzyme category" - this might mean a problem for this approach.
My ast/alt are high, in the 50s but all other counts are great. I consume zero alcohol, zero sugar, zero drugs. Drs. told me to go off almost all of my supplements. Do you think that will help? I have done 5 rounds of a parasite cleanse in 2 1/2 mo. do you think that the cleanse alone could cause the ast/alt to be high? I also take 1,800mg B1 which eliminated my IBS of 14 yrs (fast motility). Would B1 cause my ast/alt to rise? I have done one glutathione drip and will do one weekly for 3 more weeks - do you think this will help? My dr. says I have a hyperactive/hypoacrtive thyroid, had severe symptoms including innner shaking and zero appetite but at least that's 90% better. A bioidentical hormone dr. told me that I need a compounded pharmacy type of progesterone cream to eliminate inner shaking. Any thoughts? Thanks!!!!!
Hi would you say whey protein powder would be good to take for increasing glutathione?iv read that whey protein is really good at increasing glutathione?so waS hoping maybe i could just use this to increase my levels , i suffer with mast cell so hoping i dont react to the whey protein 🙏thanks😊
Should someone take other liver supplements like milk thistle etc to support the liver detox phases? I wish I could eat eggs alone. They give me major gi issues. :(
Milk thistle works quite a bit differently. It protects the liver cells from damage as opposed to supporting detoxification. If you can't eat eggs, then I'd focus on other Sulfur-rich foods (red meat, brassica veggies, onion, garlic), B vitamins (many are needed by those detox enzymes), and protein (in general). Hope that helps!
Hi DOC awesome information .Just started GSH precusors by Immunocal company ...am yet to see the impact . I hv What EPI and so my gut is a mess . **** Doc do you know of any isotonic supplements that I cld use to buy pass digestion .Am loosing so much weight ! As always thank you for that spirit 💕 .
I notice when I'm on certain types of retention enemas, like coffee or fermented vegetable juice, I feel really relaxed/sensual...is that indicative of glutathione being released, or maybe something else?
It’s a mystery to me why I get somewhat depressed and tired the next day after taking glycine, even though I take Sam e during the day for joint pain as high as 1600 mg some days?
Glycine can act as an inhibitory neurotransmitter. That is totally separate from it's other roles (glutathione production, detoxification, etc). SAMe is a methyl donor that can boost Serotonin and dopamine, but I'm not aware of it affecting glycine in the brain. My guess is that you tolerate the addition of excitatory neurotransmitters better than you do the addition of inhibitory neurotransmitters.
I thought that ALA was also involved in the production of Glutathione. Agreed that Cronometer is awesome. I just can't stand weighing my food. I used it for Keto a couple of times.
Of you take NAC and have high levels of sulfur eating bacteria, will they not ear the NAC? Would it not be better in this case to take liposomal glutathione while working on reducing the sulfur causing bacteria?
It complicated organic chemistry stuff that many of us have chosen to block out of our memory LOL 🤣🤣🤣 But seriously, there is a D and an L form (isomer) of most molecules. In this case, we're using the L isomer.
What do you suggest when someone experiences a lot of gas, bloating, and general malaise from several days of glutathione, and it continues after stopping glutathione?
@@gutmicrobiomequeen Thanks for the reply. Sure but you use a good scale to measure the weight of your food to enter it correctly. I wanted to know what food scale you use. I'm tired of buying crappy ones. 😝
@@littlebear853 OHHHH, gotchat. I honestly don't know. We just have one we got on Amazon 10+ years ago! I didn't get super exact, though. I'd say I weighed or measured my food about 50% of the time, and I just eyeballed it about 50% of the time (particularly later on when I was getting better at eye-balling).
That's what I advocated in the last section of the video 🙂 I mean.... I CAUGHT YOU. YOU DIDN'T WATCH MY FULL 40-MINUTE VIDEO!? HOW DARE YOU! 🤣 Just kidding, of course. I know this was a looooooooooooooooooooooooooong one, even for me!
I suck liposomal glutathione (200mg is enough). It boosts REM sleep which is really helpful for people with ADHD. Sorry to interrupt your conversation but that’s what people with ADHD do 😮😮😮
I'm hoping you can help me. I took one glutathione and now having stomach rumbling and diarrhea. Should I not take it anymore? I am type 2 diabetic with fatty liver and low functioning gallbladder. Thank you in advance 🙂
Try watching Dr Brad Stanfield’s U Tube video on glutathione. He says you should not take glutathione because it bypasses the bodies regulatory system and can deliver dangerous amounts of glutathione where it’s not wanted. Best use NAC and glycine it allows the body to manufacture and regulate its own glutathione and deliver the correct amount to the cells.
I mentioned toward the end of the video that you might as well take NAC. They are different molecules, but NAC gets made into GSH anyway and is much cheaper :)
Hard to say without knowing more about the person who has the condition. Here's a good bit of info to get you started, though: www.lifeextension.com/protocols/infections/hepatitis-b
1. Since the growth of "bad guys" is highly dependant on the presence or absence of "good guys," it depends on the architecture of the microbiome overall. I hardly ever treat one marker in isolation. 2. I cannot give medical advice via RU-vid or social media. I hope you understand!
