If every gastroenterologist, nephrologist, endocrinologist and pathologist watches this small lecture it would save hundreds of thousands of lives with in few years.
I eliminated my psoriasis and psoriatic arthritis after 40 years of suffering. You might want to consider fasting and following Dr. Gundry. The elimination of lectins and the fostering of mitochondrial uncoupling were the keys.
" Insulin resistance has its hand in essentially every non-infectious chronic disease." That needs a mike drop. There should be a special circle in hell for Ancel Keys and George McGovern.
Some of it isn't Keys' own fault. He even admitted in his study conclusions that he had found no strong link between saturated fat and CVD/CHD/CAD. A lot of charlatans and lazy scientists took his premises and half-finished data analysis (the latter of which IS Keys' fault, especially since the raw data were never published) and turned them into conclusions fraudulently to the detriment of the western world (which is now spreading to the eastern world). And up to a point, we actually wouldn't be in a very bad position IF, instead of grains & legumes, Keys' work had kicked off the industrial growth of leafy greens, squashes, nightshades, etc.. McGovern, however, certainly deserves to burn for his reckless action in all of this.
@@zombiechow9974 Keys cherry picked surveys to demonise saturated fat despite knowing cigarettes and sugar were linked to heart disease. McGovern introduced the US dietary guidelines for grains and carbs as the foundation of the food pyramid because of his interest groups. World population health has declined in the decades since...
A graph of my fasting insulin/glucose looks just like the one presented, except the ending. My fasting insulin/glucose has gone from 69/149 to 18/89 in 1 year of LCHF.
Such great and easy to understand video. I wish our school system would have some version of this. Everyone should know how to understand one of the biggest problems with human health in the world.
Fantastic presentation as always, calm and clear. I also appreciate his full disclosures, including pointing out his personal lifestyle and bias. Excited to read thw book, coming very soon now.
The normal range of fasting insulin at labs should be revised asap! Now, it is 2.5 - 24 and metabolic health can only be reached when fasting insulin is less than 6. 🌡🧪🧬
Great point! As a concession our lab has made the range up to 10. I always calculate a HOMA-IR for any insulin level over five. If the level is over 10 there is insulin resistance but I still like to calculate HOMA-IR.
I agree. However I think elevated insulin is only a marker. The underlying pathology is more complicated. Fat and liver release compounds that may yet to be discovered
Had my fasting insulin checked last month. It was exactly 6.0 uIU/mL. My fasting BG tends to be around 105 mg/dL. I've been mostly carnivore for 16 months. I've lost 30 lbs. I'm down to 167 lbs.
Two questions, please: 1. What drives the accumulation of ceramides? 2. Prior discussions of obesity (which is certainly strongly associated with T2DM) have postulated that adipose accumulates because it maintains insulin sensitivity longer than muscle, and so excess energy is able to be stored rather than continuing to circulate, searching for a home (as it were). Why do you suggest that adipose loses IS first? Is that in the PMIDs listed? Thanks for another very informative session.
Is ceramide accumulation associated with damage coming from oxidative stress due to phytosterols from vegetable oils? This may explain the correlation seen between increasing use of vegetable oils in diets with the same upward trends in cardiovascular disease, diabetes, etc.
You are right it is insulin resistance but occasional insulin resistance is normal for all humans we produce Human Placenta Lactogen some fraction of the time. Type 2 diabetes is HPL leaking into the blood.
Dr Bikeman I always respect and appreciate the information and research you provide with a very determined target of sharing good information - Thank you I would humbly ask you to listen to the views of Dr Fung who proposes a theory that puts the cause of many of these conditions at the door of HYPERINSULINEMIA as you have - but suggesting that the body is deliberately not listening to insulin’s signals anymore because the cell is SO overburdened that this resistance is the protective response to any further insulin stimulation. The work I do with - insulin resistant patients seems to me to show- based on focusing on reducing their insulin levels- to be the trigger the body needs to trigger glucagon to reactivate and cause the utilization of stored energy. I would dearly love to see the name Type 2 diabetes changed to Hyperinsulinemia As this would change the approach to the treatment of the syndrome dramatically. Which at the moment medicates the patients as if they were TYPE 1 Diabetics raising insulin even higher to the point they become INSULIN TOXIC I would love to hear your response to this - to clarify for me my response as a nurse involved in trying to improve metabolic response. Thanks again
Is ceramide accumulation associated with damage coming from oxidative stress due to phytosterols from vegetable oils? This may explain the correlation seen between increasing use of vegetable oils in diets with the same upward trends in cardiovascular disease, diabetes, etc.
If only more college professors displayed the talent for elucidating their subject matter in the clear and engaging way that Dr. Bikman does , more and more students would take a genuine interest in the sciences. I subscribe to multiple RU-vid channels related to low carb, and multiple podcasts on Spotify that pertain to low carb, and whenever Dr. Bikman is the featured speaker I never miss a chance to listen to him. Rarely do I give a thumbs up to a presentation BEFORE listening to it. However, given Dr. Bikman's consistent track record of always teaching me something new, and doing it in such a memorable way, I went ahead and I am giving it a thumbs before I even hit play. I am sure I won't be disappointed.
i am in the 12 percent but ironically so as i deal with secondary adrenal insufficiency syndrome- meaning i am dependent on my daily prednisone. this is the result of 30 years of having this drug in my prescribed arsenal against rheumatoid arthritis... my hands are crippled, almost every joint has been replaced or fused or needs(elbows) replacing, and i have had melanoma... so maybe the 12 percent is much smaller... ps recently switched from 30 year vegetarian/ vegan/raw food diet to low carb, high fat, high protein, intermittent fasting, keto. i have been underweight for 28 years but under nourished for many more... so relieved i did my own deep dive and have folks like ben bikman, chris mason, thomas seygfried, amanda ohearn, gary taubes, jason fung and more to thank for my future health.
Thanks Ben, love your work! As a family practice doctor occasionally working in our urgent care clinic I always look at the weight graph on patients. If I notice a rapid weight gain I figure out someway to check their insulin level. Rapid weight gain could be a sign of “peak insulin“. Insulin levels consistently come back elevated. I hypothesize that the next step clinically is a plateauing of the weight and rising of the blood sugar.
I think insulin testing should be a part of normal blood work along with A1c and BG. Are you familiar with Dr Kraft who started doing insulin assays in the 60s? He pretty much predicted the T2 epidemic we are seeing today.
I would love to get rid of my sugar, and all my meds for that, every time I go to the Dr. Every 3 months my a1c is 8,she wants to put me on more meds for it,shots metformin,
@@ednacollins5157 You need to do something. That glucose circulating is doing harm for sure. Did you go low carb and fast? Get a trainer to do heavy resistance work to get your muscles to take up more glucose? Metformin may be a short-term solution. Hope you took action. We're on your side?
Insulin Resistance Syndrome was a much more apt name! If that were the name when I looked it up I would have been able to figure out what was going on much sooner!
Fabulous. That glucose /insulin/ time graph I show my patients, they GET it, poor little pancreas clapping out, overworked. They may agree to help their pancreas by not flogging it with glucose( carbs, sugar, starchy foods)
Do statins often lead to mitochondrial dysfunction? I suspect that they did in my medical history of increasing pain levels with increasing statin dosages, and subsequent rapid pain reduction upon stopping statin medication. I did see some research indicating total number of mitochondria reduction with stain use in some percentage of people. And, how can mitochondria be recovered at all? Especially in a 75 yr old body.
I think, insuline-resistance is the natural way of our body to deal with chronic hyperinsulimia and too much energy; in a low-insulin-state, every mechanism promotes energy-utilization. Really nice talk - Dr. Bikmans are always one of the bests.
It's amazing that I was obese and insulin resistant for over 40 years, and never "flipped the switch." Thankfully I got on a ketogenic diet before that happened. But it was going to happen if I hadn't changed.
Agree. I wish I knew about this 40 years ago. So glad this research and is no longer suppressed and more and more medicos truly interested in helping are getting the message to us.
My all time favourite Professor❤️and Ive had a lot academically and watched a lot,you couldnt get more measured,authentic,smart or humble imo.A shining example of what transparant legitimate research should be.
It would seem that the usual characteristic of obesity for a type 2 diabetic, suggests the adipose tissue are insulin *SENSITIVE*, and are quite effective in storing energy. But if muscle sinks up to 80% of the blood glucose, how much is the liver and pancreas each responsible for? Since the liver makes fat and glucose.. but is the fat the liver makes the Ceramide type.. or is that only generated locally in the fat/muscle/pancreas tissues? For example, how do you address the 2 non-hyperinsulinemia pathways of becoming insulin resistant : Cortisol and Inflammation? What are healthy numbers for glucagon, fasting / postprandial insulin levels? And can these numbers report normal, and still be at risk towards increasing insulin-resistance->t2d?
Imagine that all general medical practitioners were trained by Dr Bikman, I wonder if there would be so many people in the world undiagnosed with insulin resistance or t2d? I think not, I ticked most of the boxes for metabolic syndrome and none of my doctors ever mentioned insulin resistance or t2d but because of videos such as this I took it upon myself to make a change and wow my life has changed. Thanks Dr Bikman Hope that’s not a COVID cough you have
I was in the same position as you and in 2.5 months I brought my insulin down to a normal level. I strictly did intermittent fasting daily and changed to low carb.
Dr Bikman is a fabulous teacher, so lucid and engaging! i will watch his videos or listen to his podcasts above most others in this field. His new book, 'Why we get sick' is a tour de force.
Thank you again, Dr. Ben! Always interesting hearing your talks ... I am continually trying to firm up my understanding of the processes of biology and chemistry within the body ... especially as they relate to glycogen and insulin's effects on our health status. Old ladies of 72 can learn new things.
One day I woke up with giant thirst. After drinking 2 gal per day for 3 weeks, I lost 30# and muscle mass. I liked the weight loss so I kept going. After 5 weeks past thirst event, I developed severe constipation (tmi). Then, I called Dr. Glucose was 380 and H1C was 14. Dr. wanted to send me to ER. Within 3 weeks, I'm at glucose 90 with no meds. Keto with
My hero, Ben! Such a great teacher, educator and I am a big big fan of all your work, indeed your passion and intent to make us understand our health at such a fundamental level. Your book, which I own, should be mandatory reading at every diabetic clinic and medical interview; but what if we could introduce this learning in the classroom...now that would be a real game changer for our society. As an educator myself in the secondary system, I can perceive a better way, but fear it will take decades for this to even be a consideration for the education system. I am so grateful that your lectures are accessible and do my part in letting others know they exist. A small step. Blessings and respect. xx
I thought lipogenesis mixing with the glucose caused NAFLD, where did I make the wrong turn? I understood the glucose caused the deadly fat/fibrosis/cirrhosis. Thank you.
Can you imagine the big health insurance companies finally listening to a guy like Ben!! It will completely change the trajectory of health care. I hope this happens and I hope he gets rich doing it! This will be THE way this gets fixed. Big health insurance waking up and going to war with big pharma and big food. The real cost of the SAD needs to be borne by the food companies not us via our health ins premiums and taxes.
For diabetes deaths, I think you could also point to infections since statins are basically automatic in many practices for diabetics and lowering ldl effects immune response to infection.
My main symptom pf insulin resistance was migraines. The Keto/carnivore diet was the only thing that resolved them. I suffered for 10 years with chronic migraines (20+ a month), now I’m down to maybe 2 a month during my cycle.
Because of my symptoms I think I may have insulin resistance and/or diabetes. I have NAFLD and liver fibrosis. I also am extremely thirsty, pee every hour, am very fatigued and have neuropathy, yet my A1C is only 5.6 which I know is not diabetes but approaching pre diabetes. I have started monitoring my glucose levels and have found that after eating I get big spikes of up to 80 points then it comes down within an hour to either my pre meal glucose level or sometimes hypoglycemia and then I need to eat again. I'm sick of being sick. What does this all mean?
Very interesting. A Prof Bart Kay is on RU-vid saying it is the Randle Cycle that causes insulin resistance (which he calls a construct). Prof Ben Bikman is pointing to ceramides. I'm going to keep looking for good videos and articles - keep digging. If anyone knows a good youtube or article on this matter, pls link it for me! Thanks in advance!
Basically its almost impossible to reverse diabetes when insulin resistance exists. Even with the ketogenic diet??? Diabetes is basically a death sentence in slow motion. I have been diabetic for 17 years and been limiting my carbs severely but my bs still run above normal because of insulin resistance. I eat 2 meals generally protein and vegetable but my liver must be dumping glucose. I take 40 mg glipizide and 1 30 mg piglitizone a day, I don’t know if these meds are keeping me diabetic. I don’t want to give up. I have come a long way i came off insulin in 2019 and lost 43 lbs. Now im having trouble losing any more weight since pioglitizone. Im not a big fan of exercise energy to do so is limited. Don’t know what im doing wrong. Help me. I don’t want my dr to put me back on insulin.
Dr. Bikman is one of the few experts who understand how hyperinsulinemia develops in early life. (from high carbs) If standard blood tests tested for insulin levels instead of A1C we could mitigate the development of metabolic disease early in life and save millions of lives. Unfortunately and sadly, insurance does not pay for insulin blood tests. 😢
I thought that the A1C was a reliable measurement for the blood sugar. What would be a reliable name for an insulin blood test? Does it mean if I have an A1C of barely over 5 I still have to worry?
It is sinful! I requested a fasting insulin after 6 months of a ketovore diet and the MD had to be creative with a reason code to cover the test. My result was 4.3 (excellent) but understand this- the reference range on my test must have been calculated from a diabetic population! It said: optimal is 19.6 the local hospital didn’t even run this test it had to be shipped to a larger city…I get the impression few doctors order it. A non savvy doctor who never orders this test would look at someone’s 18 and say to the patient-great! And IT IS NOT!!!
Wow, insulin and glucose uptake - love this presentation. Always new info from Dr. Ben feeding my hungry brain cells 🤓 Hope you’re doing well Doc, sounds like you’ve got a little cold 😬 maybe bump up your vit.C to 2000-4000mg per day. And a fresh ginger with lemon juice herb tea 2-3 x a day. That usually does the trick. Love your work, so captivating!!!
@Ben Bickman @Low Carb Down Under After rotating between very low carb keto & carnivore, I transitioned towards 30g carbs and have noticed higher blood sugars. Is this because my body is insufficient at producing enough insulin for the increase (no history of diabetes)? Are zero-carbers making their bodies insulin-resistant or insulin-insufficient? How would that be ideal in those hunter-gatherer times of not having sufficient fatty proteins and needing to forage/depend also on plants and still thrive? Also, some docs say high fat protocols can lead to T2. Where's the balance to become flexible, sporadically have higher carb days or just stay
I am puzzled with the same issue. I have been on low-carb diet for about 2 month and lost weight and felt great. My blood glucose numbers are good and consistent with the food I consumed. Recently I notice my morning fast glucose number went from 80s to 90s. So I tested more after 30 carb meal, the numbers are worse than they were before my low-carb diet journey. I am prediabetes, so there is a possibility that I may not have enough insulin and actually my recent fast insulin level is very low at 2.7 (2-6 is the normal range). Or it may just be that our body takes time to switch to use carbs as in your case? Kindly share more information if possible, please?
Dr. Bikman: alas there may be some problems with your explanation. Please review all your references to ascertain if any of them made a mistake I have been finding in published literature. When folks discuss glucagon & insulin, some are not making a clear distinction between biological & biochemical processes that occur inside of cells versus processes that occur between the pancreas & target organs. Hence the liver may not be "fat" any longer but still people do not completely resolve all the metabolic dysfunction that is sitting behind the diagnosis of type 2 diabetes. The processes happening inside of pancreatic cells? Those doing cell research & growing pancreas cells in medium are finding some findings to indicate insulin abundance is stopping insulin secretion via beta cells. Dr. Jim Johnson & Dr. Barbara Corkey have both published some very interesting information on this phenomenon.
My daughter is type one and we have these debates on insulin and sugar. The thought is insulin lowers glucose by getting rid of the sugar. It’s not a glucose eraser, but an enabler to place or use. I believe the adipose tissue is the first is because that’s our large storage facility. If you can’t create additional fat cells, there is no place for glucose to go. You can keep filling a tank beyond the ability to use it. At some point the tank becomes full, then the reserve tanks. This is how I understand insulin and t2 diabetes.
Very good.....I've always wondered what happens when a person makes the jump to Type 2. So, up until that point, this is where doctors are talking about Pre-Diabetes? What tests have to be performed to determine that? It seems like most people are tested with procedures that just give false hope! Thanks
Prediabetes diagnosis is based on an a level of A1C. It is an advanced state of insulin resistance where the glucose levels stay higher than it should be but not “diabetic” levels yet.
Why is it you never bring up the fact that when the liver and muscles cells are full of animal fat they are not able to accept the insulin, and can be a major factor in causing insulin resistance? This type of insulin resistance can be reversed by diet.
I just listened to a discussion between Dr Ted Naiman and Dr Ben Bikman. I was disappointed to hear Dt Ted being so dismissive and ignorant on the role of excessive insulin in our body health.
Ceramide supplements are pushed in beauty circles for skin health. I wonder if they could contribute to insulin resistance on top of everything else. Or whether something like that is so nominal it doesn’t really effect anything.
Dr. Bilkman, My mom started off obese and diagnosed with fatty liver. This progressed to eventual Primary Biliary Cirrhosis of the Liver. She had a transplant 5 years ago and now the new liver has been diagnosed with fatty liver. She eats tons of sugar and is still overweight. Do you think there is an association with insulin resistance and this disease? I know there is a skyrocketing of this disease that is now seen at gastro clinics.
Very clear ! Now i am very curious to learn more on stress and inflammation inducing the ceramides... i had heard previously that not only carbs were at the origin of the IR /DB II pandemic. The amount of toxins in the environment leading to chronic inflammation - could be an important cause as well - via the ceramides then. Might doctors prescribe cortisone by inflammatory diseases, would be the ceramides production and the IR even worsened
