Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis 

S'up player?

Thank you 👍 God 🙏❤️ bless Andrew Huberman.You are a positive force to the human race 🎉 With love 💕 and respect from Lagos Nigeria

Why ads for premium subs? It’s the only podcast I pay for and still am forced to listen to ads. It’s annoying man. Love the content but annoying

Thank you for making science so accessible! I just wish if you could read the Quran and make an episode where you discuss the scientific evidence in the book. The very first verse that was revealed is: “ read!”. It’s all about science! Thank you!

Dr Huberman, your podcasts have taught me so much and also helps affirm the intuitions I have had about healing myself. Thank you! Please keep doing this AMAZING work! I appreciate you so much. Namaste 🙏🏻

Great response 🎉❤

good work ethic and good job supporting families, too many singles in california who are sad once they realize hookup culture is wasting your life. its good to know families exist and broken homes are the reason so many kids are messed up and cant pair bond and are gender confused

Maybe have the family help out so you have more time to yourself. Women make up 80% of all autoimmune diseases. Don’t get burned out. You can’t take care of others without taking care of yourself first.

I even listen to it when doin the deed…endorphins exploding all over her back🫡

Diego’s humility in acknowledging his research team is from the gut.

🎯 Key Takeaways for quick navigation: 00:00 *🧠 Gut sensing overview* - Gut sensing is not just about the microbiome. - Gut sensing involves receptors in the gut that respond to food components. - The gut communicates with the brain to influence emotions and behavior. 08:10 *🏥 Gut-brain axis explanation* - The gut-brain axis was traditionally thought to involve hormone signaling. - Recent research shows direct neuronal communication from the gut to the brain. - Enteroendocrine cells release hormones and make direct contacts with the nervous system. 17:01 *🧬 Discovery of neuropod cells* - Advances in neural circuitry tools led to the discovery of neuropod cells. - Neuropods are cells that make direct, precise connections to the nervous system. - Neuropods provide a faster, more specific form of communication compared to hormones. 23:39 *🧠 Neuropod Cells in the Body* - Neuropod cells are specialized neuroepithelial cells found throughout the body. 27:13 *🧲 Connectivity of Neuropod Cells to the Brain* - Tools providing resolution allowed the visualization of receptors inside cells. - Isolation of cells showed the formation of an interactive circuit in real-time. 30:38 *🧬 Neuropod Cells Sensing Nutrients* - Enteroendocrine cells in the gut express various receptors for different nutrients. - Sensing of macronutrients along different sections of the gut. 37:34 *🔬 Neuropod Cell Reactions to Nutrients* - Cells sense multiple layers of information from nutrients, including taste, absorption, and metabolism. - Detecting nutrients activates a chain response leading to the release of hormones/neuropeptides. 47:14 *🍽 Connection between gut surgery and weight loss* - Overview of gastric bypass and vertical sleeve gastrectomy surgeries - Reduction of gut surface area impacts hormonal changes and food preferences - Changes in physiology, hormones, and food choices post-surgery. 51:28 *🧠 Optogenetics in gut-brain research* - Explanation of optogenetics and its application to study gut-brain communication - Challenges of using optogenetics in the gut due to movement - Collaborative efforts to adapt technology for studying gut cell function. 57:46 *🍬 Sensory cells in the gut influencing food cravings* - Gut sensory cells play a role in food preference and craving - Neuropod cells affect perception of taste and influence behavior - Gut sensory cells calculate intensity and valence of food stimuli. 01:11:42 *🍔 Relationship Between Food and Gut Sense* - Ingesting highly processed foods can lead to excess calorie intake. - Evolutionary food choices shaped by convenience, taste, and variety. - Gut deconstructs food to shape future food choices. 01:16:02 *🥩 Influence of Protein and Fiber on Food Choices* - Removal of protein from a diet leads to food avoidance. - Animals consume more low-protein diets to compensate for protein deficiency. - Gut microbiome synthesizes essential amino acids in the presence of fiber. 01:19:40 *🥗 Plant-based Diets and Nutrient Combinations* - Agriculture focuses on planting complementary food pairs like fibers, sugars, and amino acids. - Traditional diets aim to balance nutrient deficiencies in plant-based diets naturally. - Nutritional arrangements on a plate reflect a mix of essential macronutrients. 01:34:59 *🧠 Fascination with the nervous system in physiology class* - Enchantment with the nervous system's control over life experiences. - Realization of the body's functioning similar to a machine. - Delving into synaptic terminal processes. 01:36:20 *🌿 Plants in the Amazon and their wisdom* - Plants possess extensive knowledge due to millions of years of experience. - Native people's profound sensory perception of the jungle and its elements. - Importance of plants not only for food but also for medicine and various functions. 01:41:51 *💊 Evolution of food choices and flavor preferences* - Trial and error in consuming different plants and nuts. - Neuropod cells playing a crucial role in discerning nutritious and safe food. - The sensory perception tied to food selection and survival. 01:48:42 *🌱 Plants as a source of medicine and psychedelics* - Many medicines are still derived directly from plants. - Plant-based psychedelics gaining interest in scientific and clinical research. - Incorporating plant wisdom into modern medicine for comprehensive effects. 01:58:35 *🍫 The Science of Chocolate and Guayusa Drink* - Ecuador is producing some of the best chocolate in the world, challenging Swiss and Belgian claims. - Chocolate quality can be enhanced by pairing it with unique drinks like guayusa. - Mixing extreme dark chocolate with guayusa tea creates a unique experience. 02:00:19 *🧠 Pathway from Gut to Brain and Sensory Integration* - Information from the gut is sent to the brain stem, particularly the nucleus tractus solitarius. - Neurons active in the brain affect cravings and food choices. - The gut's connection to brain areas involved in dopamine release contributes to pleasure and reward. 02:06:12 *📊 Electrical Patterns of the Gut and Circadian Rhythms* - The gut generates electrical patterns that change during fasting, feeding, and circadian rhythms. - Neurons like ENT neurons and interstitial cells of Cajal coordinate these electrical patterns. - Synchronization of electrical waves in the gut and brain may impact hunger and alertness. 02:11:14 *🤔 Gut Intuition and Food Synchronization* - Gut intuition involves storing past experiences in the body to influence feelings. - Shared meals can enhance bonding and synchronization of feelings between individuals. - Business decisions and even social connections may be influenced by shared food experiences. 02:22:02 *🧠 Vagus nerve activation and its effects* - Vagus nerve stimulation can induce arousal effects, not just calming effects. - Vagal nerve stimulators are sometimes used to treat depression, leading to alertness. - The vagus nerve acts as a superhighway with various inputs and outputs, influencing different physiological states. 02:24:23 *🎶 Gut-brain axis and sensory systems in the gut* - Specific frequencies and sounds can influence vagal activity and induce calming effects. - Humming has been linked to vasodilation, associated with a calming effect. - Sound plays a significant role in regulating arousal and calming responses. 02:27:08 *📚 Gut memory and the communication between gut and brain* - Memories associated with taste and smell are tightly linked to the gut. - Gut and brain communication influence emotions and overall well-being. - The sensory system in the digestive tract plays a role in memory recall and emotional responses. 02:30:05 *🤸‍♂ Listening to the body and gut sensing* - Paying attention to signals from the body, including the gut, is essential for making better decisions. - Learning to listen to the body's signals can lead to improved health and decision-making. - Self-care involves listening to the body and understanding its needs for overall well-being. Made with HARPA AI

😂🎉

You should of listened to it, it was great 👍

My gut agrees, and informs me it might even turn out to be sublime.

The entire integumentary system in general would be great. I'd love a discussion about healing touch like skin to skin for newborns, massage therapy, etc.

Yessir

I've been given vitamin e cream for a bad cut on my face their almost no scar years later

@@drippy6706 I am glad for them but what about your scars?

No, I don't think that makes sense.

This would be SO helpful… I get so turned on by all the info, but have a hard time explaining to someone else the next day

Yes!

I like it 👌😂 A fun game at the end, with Andrews guests acting like Lex and answering the questions in their own idiosyncratic way, id wager Lex in a black suit or a pirate outfit being a clown 😂 Or how he does his supplementary vids on his clips channel, like he did with McGill exercises, although the quizzes would be way more fun at the end of the vid.

Oohh! I love this idea!!

I think that’s a great idea but with a tweak. Make it optional. You know how he does write up summaries on his website for each episode? Add a link to the end of it to test yourself on the material. Why? Because the ones who take the test are who this material is meant for and will take actionable steps.

👏👏👏

get a hobby and stop focusing on what doctors tell you, get to a farmers market and grow more of your own food, get off the head meds and meet a strong man to support, most ladies these days dont have strong role models nor do they have hobbies to keep them busy, roominating does nothing for your health, ayurveda has all the answers heck even cannabis should be combined w/ calamus root yet people smoke it by itself and wonder why it has side effects, stop relying on farma and rely on natures cures

Some newer micro biome info indicates that yes, depression comes from the gut. Documentary on Netflix explains. I am a 3c colon cancer survivor. Go plant based. Check your D levels. B 12 usually needed and after chemo our thyroids stop working. Follow the Society of Integrative Oncology.

Water fasting is what you need.

Water fast for 3 days and try a carnivore diet of only grass fed red meat. Cancer cells thrive on sugar. I know it sounds crazy but please search for anecdotal stories from other people in your situation and consider trying it.

I am so sorry i am too having depression basically since i was in college. I hope you are getting better.

As a person struggling with mental health and addiction at the moment I needed that last sentence

Amazing story. Loved it , congratulations on all the barriers you overcame ❤

@@rebeccadand7720 thanks for your nice polite comment.

Software to neuroscience...I like the transition. 😜

Carnivore MD i think he has been talking about thism

Was that on hubermans channel. I dont trust anyone who classes their selves as carnivores because they aren't as knowledgeable about basic human diets etc and so would only trust people that Hubez trusts. And huberman goes so indepth too.

get to a farmers market and stop eating stabilizers and gums. its simple really.

Eat pickled veggies twice a day according to a different huberman podcast about the gut.

@@danielnaberhaus5337 we do indeed eat pickles especially when I can convince him to do so! :)

If you didn't know already, he talks a lot more about interoception on another show, I can't remember which one but maybe meditation/mindfulness. Edit....I checked it is this one 'How Meditation Works & Science-Based Effective Meditations', the whole episode is pretty much based around it.

And VanderKolk (Body Keeps the Score).

Read The Gut & Psychology Syndrome

stay away from drugs, even that really popular one you think is "safer than alcohol" LOL.

@@oli7120How could you say something that dumb after watching this channel? lol there’s thousands of drugs in the world and you expect nobody to use any of them for any reason?

Have you tried the GAPS protocol?

Every person I know on spectrum has seriuos gut issues from babyhood. I've remember from research somewhere that the two are connected.

@@shelly7017 not yet. I feel like it would mentally be very difficult for me because of his food aversions I don’t think he will eat

I was interested also in how research might give us more information on this. I was sitting opposite a student who eats only beige food and has done for years. They had great skin, bright clear eyes, thick hair. Could we find out more also about hypermobility and gut brain links. It has been such an interesting pod cast and I failed Chemistry GCSE!

Right? There's one thing I got confused on though. Huberman said if I limit meat intake I'll have increased hunger. But what if I add more fiber at the same time? I think huberman might have gotten confused when he said that

Agree.