Based on the reversibility, enzyme inhibitors can be categorized into irreversible and reversible inhibitors. Irreversible inhibitors would bind to the enzymes by forming much stronger interactions and “permanently” modify the enzyme. Reversible inhibitor binds to the enzymes by forming relatively weaker interactions or reversible covalent bond. When the inhibition is reversed, often times the enzyme could function again.
Based on the inhibition mechanism, enzyme inhibitors can be categorized into competitive, uncompetitive and non-competitive inhibitors. Competitive inhibitor would compete or prevent the binding of the substrate. Uncompetitive inhibitor would bind onto the enzyme-substrate complex that’s formed after the enzyme binds the substrate. While in noncompetitive inhibition, the binding of the inhibitor and the binding of the enzyme substrate are independent of each other. But in reality, the inhibition mode is often mixed, and the boundary is not as clear (mixed inhibition).
-About me-
I am a computational chemist in the pharmaceutical industry. I created the Mole Man Chem channel to explain some basic medicinal and biochemistry concepts because I believe the best way to relearn a concept is through teaching.
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6 авг 2024
