Epigenetics and Aging: The effects of DNA breakage and repair 

I'm in my mid 50s and I hope in my lifetime we can reverse ageing.

Still lots of work to be done. Epigenetic age reversal in mice was done a couple of weeks ago and the mice lived 9% longer than the control. Rapamycin gets mice to live 30%+ longer. This epigenetic reversal was only done once though. The trick is there are 200 different cell types in the body - some types of cells 'age' faster than the other. The liver for example regenerates quickly so if you give the same factor to a liver cell as a brain cell, the liver cell would be rejuvenated too much and become a cancerous tumor. In addition, just because you're say 50 years old doesn't meet all of your cells are 50. The age of your individual cells follow some distribution such that if you give them all the same factor the old cells get rejuvenated and the young cells get cancerous. So in theory age reversal is possible but I think we're one breakthrough away. How can you identify at what stage of the cell cycle each cell is and only target certain cells at certain stages - that my RU-vid friends will be the end of aging.

Thank you Dr. Sinclair to you and your group for dedicating your life to studying this arduous work.

It’s coming. I can’t wait for us to finally stay looking good our whole lives. I hate how old age disfigures your body and makes it impossible to date when you’re older

Many of us might one day owe our lives (or part of them) to this guy. Doesn't sound like it was easy to get where he is now either. Definitely recommend his book "Lifespan".

Thank you for explaining this complicated topic in a way that people with only basic biology education can understand.

Thanks for sharing this info so freely Harvard - optimism through science!! Disregard at your own folly PLEASE keep posting and keep the love of learning alive 🙏

wow, amazing work. Asides from aging, just in terms of chromatin remodeling and PIC-recycling, paradigm shifting.

That video was surprisingly well made

Wonderful news! Thank you so much for your amazing work 👏🏼👏🏼👏🏼

I would never be able to learn all the things I want to within the normal life span of the average person and as we get older the harder it for us to learn, hopefully this can help us all.

thanks for the amazing work and groundbreaking study about the meaning of life.

This is amazing!!! Thank you!!

Thank you for explaining such a difficult research in an accessible language. Love you, HMS 🤍

David Sinclair looks good for his age.

I wish you good luck and success in your future research.

Good stuff David! Keep going with it all, hopefully you can put things like PKD (kidney diaease) , and othera into the hiatory books.

The sound effect of DNA “loosing” was VERY disturbing

Deserves more views…

Good stuff David! Keep going with it all, hopefully you can put things like PKD (kidney diaease) , and others, into the history books.

Interesting how anti-aging is essentially negative entropy, and nucleic acids being informational units of the cell, you need to maintain high informational capacity.

Can stem cells assist in the de-aging process somehow? Im assuming if these proteins/cells are "Getting Tired", can we recruit new stem cells, program them to the specific organ we want to target and send them in to produce "New Born" proteins/cells that will continue producing DNA accurate cells? I know that there are amazing studies and discoveries involving stemcells... is there anything we can do to reverse aging using a combination of epigenetic reprogramming and stem cell therapy?

Pls do it quickly before I turned 40. Life is good here.

Very nice, perhaps my kids will love longer and healthier lives.

You've found immortality and only a few million people know about it. This discovery is beyond incredible. I'm proud to live in the same era as you. I kiss your hands. I'm in tears. Thanks a million❤

How a privilege to live in the 21st century !

omg this is amazing AMAZIIIIIIIING

I love how everyone in the comments is an expert on this stuff. Thanks for all the hard work doc now hurry up and keep me young forever so I can create my familial army

Has anyone tried this on normal aged mice and was the imbalance from transcriptional stress from DNA lesions favoring short proteins present.

I, for one, am glad they animated the tldr for me

What's that part about reversing BLINDNESS??

Eu realmente curti seu canal. Obrigado pelo trabalho que você dedica em seu canal!! Eu também tenho temas relacionados à saúde. Efetivamente, eu sou especialista em telemedicina, prestando assistência em todas as regiões do Brasil. Continue postando!

Give it to us NOW... We had no problem taking part in the mRNA Experiment.

Both mice are adorable

So they aged the mouse that is grey, they didn't reverse age of the other mouse. What this did tell me is that they are able to make it so you could be born with the ability to age you, or reverse age you.....I wonder what they could do with that? What would you do in order to be reverse aged?....or keep them from aging you?

If this has been so successful on animal testing as I have been reading, why aren't we offering such treatments to our pets now whilst we work on making it work on humans?

Love it.

So how much longer do I have to live for the anti-aging drug to be approved and will my insurance cover it?

Please also see the Flaws and Human Harms of Animal Experimentation

Sir may you help me that what should I study to take part in the reverse aging research can I get your contact sir please help me sir I want to research on reverse aging it's my goal sir please guide me to what I should study

I saw another one with this guy talking about the same mice he said that they reversed the aging in the younger looking 1. But in this when he said they sped up aging in the older 1. So which is it?

I hope gene therapy can allow scar tissue removal so healthy tissue can replace it retina, heart, brain, liver, etc.

How can I help my 72 year old father with this technique.

Wow Amazing.!

Good science does not only come from accredited "schools." It can come from any individual practicing the scientific method.

This is a new divide to the science of anti aging

Amazing work but the aging of cellos is always different . Brain cells and liver cells take paths are different , so a 50 year old could have. Very health liver cells. How would that be regulated .

Where the pills sold

I wonder if this can do anything for cancer.

(On Monday of January 30, 2023). On the Matter of PhD David Sinclair's Ideation of Epigenetic Ageometry (Epigenetic Dysregulation, or, My Personal Touch, Entropy at both the Genetic and Epigenetic Levels). A Phenotype of Frailty Syndrome (FS) is hardly disintergratable form the Genetic and Epigenetic Mechanisms as much as Function is a Direct Correlation to Structure. Malnutrition seems to be herein Common to all Phenotypes in the Matter of Geriatrics, for which I indicate naturally an Increase in Protein(s), Amino Acids, along with Standard Vitamination And Minerals (Essential Nutrients if not Biological Molecules of Trace Proportions); and only indicate Caloric Restriction (Anorexia is a common Cause of Malnutrition along with other Factors) when Diet is Questionable (As in Pesticide ridden foodstuff). And, this genuinely seems to be the parameters influencing the Mice Studies also; The Aged Homologue (altered mouse) might have been Epigenetically Altered but notwithstanding the Diet Cofactor is a Plausible source of more rapid Aging while the non-Aged one is rather less phenotypically manifested. However, determining length of Lifespan on wholly on Epigenetic Chronometry and Aetiologic Agent of Ageing is an Overstretching of Molecular Mechanism(s) therein. I have delved in the Matter of Epigenetics slightly but could not negate the Genetic Disarray (Both Genomic and Gene Expression [Transcription/Translation Axis]) in a Homeostatic Dysregulated and Sarcopenic Subject as much as I would attribute Healthy attributes to mice on the same terms as to Man (even if such an Experimental Human Could Exist). While Genomic And Genetics are a Thriving and Flourishing Enterprise (Certainly More than as A Science), the Standard of Care (SOC) should still include Basic and Fundamental Essentials (Geriatric Comorbidities of Dehydration and Malnourishment should not be Relevant in a "Well-Developed, Industrial Society") and Therapeutics therein should still be under such traditional Methods because the best part of our Failures as a society are in Common Sense--Preventable--Factors based (Cardiovascular Disease, Metabolic Syndrome(s), Stroke etcetera) and less having to do with inherited Disease of a Genetic Basis (Even though such are not yet proven but associated with Genetic Regions only). Perhaps, one day there will be such Sophistication of Technology and Understanding; but, to forsake the Standard of Care (Conventional Science Basis) for a Speculative (Most theoretical) therapeutics, is sheer Malpractice. Heil!

I thought the story of the mice had to do with NMN... was that not the claim in earlier iterations of how one mouse was older and one younger? Or am I encountering another Mandela effect?

Dr Pius Ozigbe is Always on time. compassionate. Empathetic. easy to take to and relates exceptionally well. Hands down the most effective and efficient doctor I recommend him. thank you doctor!!!!!

Err, so how is the reversal even done? It seems like it's much easier to enhance aging (cutting DNA) than slowing it down.

when you think of the protein machinery as actual machinery, its reasonable to apply the wear and tear principle When you accelerate the anabolism of proteins and the machinery is cranked, you are accelerating aging because the machinery is slowly getting wore down like with high calorie diets and spiking mTOR all the time, or some growth factors

Let's live better lives

this is a year old and I am just hearing about it now :(

Are Chromatins addressable?

OK, you can now accelerate ageing. But how far on going the other way are you? The next step is preventing it, then reversing it. This will most likely be more difficult than accelerating it. For reversing it, the genes that should be turned off should be turned off and those that should be turned on should be turned on. I suspect that's easier said than done. Bummer. And I wonder what the effect on life expectancy will be.

oh my that sound effect gives me agony. other than that, lovely video

So from the System Administrators' perspective, seems aging is a configuration drift issue.

Dr.Bruce Lipton said this in like the 70s

Nice video and content

So what happens when you reverse the aging beyond age 0

Tissue regenerative if human succsesfuly made, then how will look like the future people male to female

Can you add me to your list to have the first injection to prolong my life 🧬

If they want human guinea pigs, I'm up for it.

Intersting work. I couldnt help wanting to free the lab mice. Always been my issue with biology. Let them retire and taste freedom at some point.

I volunteer to be an experiment 🙋🏻‍♀️

The Fusion of Longevity.

Wow 🤩

Clue. Aging is in the circulatory system mostly the lymph.

At least all people who fight aging and death in their way,be it advocating,research,funding etc...we would have gave a fight for this goal even if we fail in our mission. Only by trying we could succeed. We won't go down the cliff like the ones who are in denial or are naive in some fairy tales who for sure can comfort but in no way stop the suffering of old age and the bleeding in seeing our grandparents and our parents die.

So where is the human version? I need it fast for my parents.

in sya allah aminnn ya allah

This is an amazing research, Honestly I’m so glad to know someone is working on this, incredible i must say. I am also using curcumin capsules from planet ayurveda for it

I winder if i will still het to benefit from this and if private for profit inustry will get its dirty pawns on this. 😢

Got something to help mom?

To me it is unbelievable that whole humanity is not involved in this in some way. This is way to important to do and life would be so much better for all if there is more involvement to gain control over aging. How is it that only small percentage of people are trying to find the solution for worse f thing that can happen to people ? LET'S ALL INVOLVE using internet for connection, AI for help analyze data and cure this shit already !!!!

My social media credit score is screwed.

🙌🙌🙌🙌🙌🙌

If this gonna be successful, can they apply this to humans as soon as possible??

This is the way I see it, if you're lucky, you have about 75 years to live and a eternity to be dead. What's the friggin rush to shuffle off this mortal plane? If modern medicine can make me live 2-500 years, I'm all in! Over 100 years ago, the average lifespan of a man was 50 if he was lucky. A fair majority of us surpass that every day. Let's go for it. I gotta see this.

Should we start celebrating Lamarck Day? See ya August 1.

ILL PARTICIPATE IN YOUR STUDY LOL

I wish we had a solution to the ageing process right now. I've just turned 50 and I'm not liking this at all.

Eventually, they're going to get this figured out, but how will the mind cope with a thousand years of information.

Excellent research, but all I'm thinking about is that poor mouse. :c

Any work being done on how NMN might rejuvinate female fertility as yet? A lot of women are now taking NMN in the hope that it can impact human ovaries in the same way it helped those elderly mice that had healthy live births. I hope us females don't get forgotten about, as is so often the case with medical studies. Being able to rejuvenate fertility for women who have had fertility struggles will be pretty major worldwide. I just hope NMN doesn't become prescription only as it will mean UK women won't be able to access it so readily, if at all.

We can slow again and live until we are 700! The government: New retirement age is 675.

Does the covid mRNA vaccines age you too?

It's like you're bubbling on a tiny tiny scale

DNA gap is the best solution to epigenetic aging.

I think, once it's ready and made affordable for the public, euthanasia should also be made legal. Even if it's past an age bracket. I like the thought of getting old without the pain, wrinkles and grey hair. But I wouldn't want to live forever. I can also imagine the population issues if everyone started living twice as long at least.

A superintelligent computer could figure all this out in a decade. It might sound crazy, but so did ChatGPT six months ago.

Take chances, roll the dice, screw laws, cure aging by any means necessary, act like God, well done work

😟

If they get this process right, we'll all be able to work until we're 150 yrs old. Won't that be fun.

So basically we humans are trying stay at the reproductive phase forever ar atleast as long as possible...

Imagine if you could be 25 forever.

nice, the elite will be immortal soon