David Sinclair , Harvard Medical School, USA presents at the 10th Aging Research and Drug Discovery conference: Epigenetic stabilization and reprogramming: an update.
They should work with Michael Levin’s lab who has shown there’s an electrical interface inside cells and the human body which controls the programming of cells and biological substrates. Like you can see the formation of biological formations like a face as electrical energy before a face is created for example.
They will never do that, because they're obssesed with control and micromanaging and pushing new expensive wonder molecules and procedures to the market from which they profit. Michael & Josh's work is a hundred levels past that. Sinclair is still in the NMN - vegan - protein war and obssesed about single gene activations like sirtuins and yamanaka factors which he desperately wants to control, instead of letting the body control the process. Very primitive, just like computers in the 50s.
I love dr Levins work. yes that cancer can show electrophysiologically before anything, xenobots etc. please cite your sources as his work is amazing and everyone here would benefit from watching.
I am particularly intrigued by your experiments involving the optic nerves of mice, where you have demonstrated the potential of these factors to repair and possibly rejuvenate damaged nerve cells. However, I have a couple of questions regarding the specifics of these experiments: Distinction Between Nerve Regeneration and Repair: In your studies, how do you ascertain that the observed improvements in the optic nerves of mice are the result of the repair of originally damaged nerves, and not the regeneration of new nerve pathways? Since the reconstruction of neural pathways might lead to memory loss or other issues. Direct Aging vs. Induced Damage: Your experiments involve inducing physical damage to the optic nerves before applying the Yamanaka factors. I am curious to know why this approach was chosen over directly inducing aging or degeneration in the nerve cells themselves. Would the latter not provide a more direct model of age-related neural degeneration? Experiments on Naturally Aged Cells: Have there been any experiments where you applied Oct4, Sox2, and Klf4 to naturally aged cells, particularly in the context of nerve cells, to observe whether similar rejuvenation or repair effects are noted?
The 1st author Dr Ryan Lu basically answers the 1st two Qs in the LEAF journal club on their nature paper on the lifespan youtube channel: "Partial Cellular Reprogramming Restores Vision in Aged Mice"
Sinclair is a very gifted communicator. My only gripe is that one would be for given thinking that he invented partial cellular reprogramming. Needs to give a better nod to those coming before him IMO.
20 years is too long. These labs need funding, now, in the 100s of billions of dollars, and for “regulatory” agencies to get out of the way and stop interfering
@@Inanothertimeandspacethey aren’t fully developed, there has to be clinical trials to determine efficacy and even if you want to dismiss safety no point in approving something that ain’t gonna work unless it’s proven through clinical trials
@@JZGreengoThe point I’m making is that it takes far too long to get to a clinical trial at all. If a patient is dying of aging (as we all are) we should have the right to assume risk to test efficacy. There are gene therapies available in Colombia, for example that are currently increasing telomere length. These therapies are being utilized by the ultra wealthy to demonstrated safety and efficacy, yet are unavailable here for even a simple clinical trial. We have a right to our bodies or we don’t. The last thing we need is another mouse model. For those who are willing to test these drugs they are legally provided for under Helsinki Protocol.
still talking about mice and rushed thru the monkey part which didn’t even sound promising because he said that he didn’t know if monkeys vision improved or not
@@timothygrey-nn4odWe don't need meat to function. The 7th Day adventists have long since proven that. You just want it. That's a different story and far from scientific.
There are so many companies he is financially mixed up in (16+) that the title slide doesn't even keep track of them and lists Tally Health twice. LOL. Skepticism deserved. 10 years crazy hype, the progress now is that it's just "mostly" crazy hype. Sinclair remains part of the hype problem. His yeast work was debunked after only a few years, crazy that he still ignores the literature that followed. It really should be called the Information Hypothesis of Aging. It's far from a scientific theory at this point.
Sure. He has still done a lot to raise the profile of the field. There are other, more promising lines of research than his, but he has brought attention to a lot of things. I've benefitted a great deal from intravenous NAD for a bunch of medical conditions, including a devastating benzo addiction. Ironically, Dr. Sinclair is down on IV NAD, when it is WAY more powerful than NAD in tablet form.
Thanks ICE mouse , we think our girl’s need to focus on these treatment’s to make it cheaper as colaborators’, organisers’, early learner and learning teacher’s. So in David word’s “don’t quit”.
There is no backup information the universe has the good information right know everywhere, like the brain is just a antenna to another dimension field that create the reality itself, so just low stress and good nutrition slow aging, some activities activate mechanism of rejuvenation like fasting, hot yoga meditation in a hot sauna, extreme cold meditation, extreme cold, high oxigante, low oxygenate, and those substances that we create doing those activities can be found in nature and more and ingest them and become some young again, but become like a teenager?? so the elixir of young is on those chemicals?? we need them now here, all people young again, better than bejore young ja. Cool.
I would like to know you said this company is going to make NMN Into a drug, how is that going to affect the rest of the people that you are educating on his benefits, to me that would limit it greatly as to who can get it?
Who wants to put money into confirming results? Professors won't put their PhD students on projects to confirm other people's results because then they won't be able to have groundbreaking papers. The system is broken
nice analogy, they are collecting all the tennis balls and so no one is playing tennis anymore, Ie the enzymes and etc. are so worried about repairing old stuff they can't expend resources on new stuff.
Did I hear him claim to have dead lifted almost 1,000 pounds?? If so can't he hold a stationary Iron Cross on still rings with 100 extra pounds strapped around his waist?
Besides myself, and I'm about 80 from a family both sides live long, someone needs to talk to Elon Musk and convince him to talk to David Sinclair. He seems to be aging too fast and I would like him staying around creating and inventing...ha ha!
Are there anybody here who’s at least made the smallest attempt to figure out what happened to Dr. Sinclair’s previous project? :D the guy sold a not working piece of bullshit for millions of $$$.
