I just watched a video of some australian scientists that have hypothesized that the insulin receptor site is functional in type 2 diabetics, but underneath its not correctly phosphoralizing IRS1/2 thus not beginning the cascade. I exercise daily and notice that my blood sugar always spikes for like 15 mins before it begins to drop. Probably because AKT doesn't get activated until I put enough stress on my muscles and/or its using up its existing glycogen stores until the stress begins. Then I can effectively drop my sugars continuing to exercise. This video is great as it visualizes the mechanism that I was wondering. Thank you.
This is a SPLENDID MARVELOUS presentation! Very well done :-) Just EPIC and cutting-edge. Very well articulated and broken down. Animation was incredibly precise.
THIS IS SO COOL!! The animation is amazing, always been envious of people who were amazing at science AND art... I can barely draw a smiley face. Well done! Love this video
This is very elaborate. Well illustrated with the animation. So I guess that training in a persons state would allow for better glucose uptake due to the action potential rather than insulin driven. Depending on the severity or level of insulin resistance. And I’m wondering how Leptin comes in to play. You consume carbohydrates the night before training this Stimulates insulin as well as leptin secretion.
Thank you so much for this. Actually an amazing video with thorough information, and a very peaceful experience overall. Preparing for the USMLE and need more of this zen.
look into potassium or snake juice. lower cortisol which lowers gluconeogenesis. understand that every cell NEEDS to be insulin resistant from time to time
This is so cool! It left me with the question of how muscles obtain energy when people are on low carb diets and aren’t consuming sugar? Do they conserve the little glucose they do have, or can fats and proteins also be converted to glucose?
Fat gets converted to ketone bodies in the absence of insulin, OR gets put into storage in the presence of insulin. Amino acids can be converted into glucose via gluconeogenesis
the techniques for working out which protein goes where and does what is just a matter of good molecular biology methods and the accumulation of several teams worth of research over some years. the actual cause for insulin resistance is so much more complicated. diabetes type 2 is one of the more complex diseases to understand. as with many "complex" diseases, it combines a number of vastly complex systems: immune regulation, vascular science, nutrition and the biochemistry of metabolism, genetics (MANY genes implicated) etc we do have some leads but it's not as simple as "this microorganism pumps out this toxin and boom - disease" this is a good start, although the paper is a little old now: www.ncbi.nlm.nih.gov/pubmed/16563942
According to my text book the decrease in insulin sensitivity in Type II Diabetes is caused by down regulation of cell receptors. In order to maintain proper homeostatic balance, cells that are constantly exposed to high levels of insulin caused by high level of glucose in the bloodstream will loose insulin receptors. On the reverse side, this is why low carb diets and moderate to high intensity training works to treat Type II Diabetes. Lower glucose in the blood stream leads to lower insulin in the blood stream and the cells respond by creating new insulin receptors (up regulation).
She did not say how long a vigorous excercise is needed before the glucose is uptaken. A patient said he measured his glucose before a 15 min run and after and only 15 min of very fast sprinting reduced his BG by a significant amount. I am interested in knowing how long for and when does the glucose uptake stop if so. And 8f it runs out of blood glucose does it tap into Glucagon stores?
The only problem is the way the woman speaks is like those hypnotic relaxation types of speeches... "feel your body relaxing... let your mind travel to another dimension... flow weightlessly through space..."
You have my maximum respect Dr Igudia, I am now negative from my type 2 Diabetes after I did the test, I wonder what might have become of me it I didn't get the herbal cure From your RU-vid channel. God bless you sir.
