You're a saint for helping us get through these tough classes. You should set something up so that when students become doctors, you get free medical care for life :)
Thank you so much man! You're a lifesaver! I really appreciate your detailed drawings- it takes me a while to write them in my notebook, so I assume it takes you a long time drawing them. I really appreciate your efforts and am so thankful!
Hello, I am very glad, you exist and make those videos. I would like to see all of them, your videos are really helpful. You are really amazing teacher and very good speaker, I am czech and I understand you every word. Very good job. I wish you all of the best.
Aye man good luck to whomever has a biochemistry final exam coming up. Mine is in exactly 2 weeks and I'm just starting to study for it. This shit looks so tough man :(
sir... i almost write you comment on every video i watch for you because i'm always fascinated by your great explanation and the way you get into deep details ... just exactly what i need for my medical biochem class..... i'm forever thankful and this channel is underrated it is actually perfect
Ak you have been the best so far.. I actually used your video as a substitute for my text book when I had enzymology text.. and here I am using your video for a substitute for lipid metabolism text.. I appreciate your efforts in putting up those writing and skillful representations to avoid imagination.. thanks again
Thank you so much for making these videos! I was having trouble understanding this process since lehninger biochemistry is rather advanced. Somehow you manage in 16 minutes so make everything crystal clear wheras the book and my lecturers failed to do so after many hours. A first year med school student thanks you dearly. Cheers from Sweden
thank you so much for the effort im so glad that i found your channel ,, its really a BIG help ! i literally would fail without your videos please keep up the hard work
I love all my professors, but as a person who has little to no background on biochemistry and then taking the class in med school, they sometimes go too fast for me to understand. Thank you for all these lectures!!
I don’t know how to thank you 🙏! You’re the best ever man who have youtube channel .. you should get a huge award for this ! Even if they gave me Nobel award .. it would be not enough to give it u!
I Always watch your lectures because you just make my learning 1000% more efficient and save me tons of time. I wish you were my lecturer. Thank you very much.
I love love love all d videos of yours . those help me a lot to understand the things deeply and also in a easy way . thank you very much for making such amazing videos .
Thanks, sir it is very nice and easy to digest. Thanks for the efforts taken to simplify such a difficult portion in detail pls continue it for us, sir.
Would be awesome if you got subtitles for your videos :) the auto one is okay, but sometimes not correct and I find it better to learn when I can read and hear. Thanks for the great vids!
Thank you very much indeed. However, what is the difference between acetyl CoA used in the first step in synthesis and the one used to produce malonyl CoA?
Thanks for all those helpful lectures .. but I have a little question .. does the acetyl bind first with ACP !! I've read it in Harper I guess that the Acetyl bind with CYS-SH while the Malonel bind with ACP.. Can u please tell me which references do u use ??
Is this a little incorrect? You need another "charged manonyl group" to get on there and act as a nucleophile upon CO2 leaving. Then it can attack an acetyl, CoA.......but you don't have the last step set up for that.....isn't the chain supposed to be on the Cys-S- side(flopping back and forth so to speak) as it grows in order to provide access for a nucleophilic attack?
I'd like to see a video comparing and contrasting the human biochemistry with regards to eating a pure fat diet versus a pure carbohydrate diet over a day, week, month and until death. With considerations to a hypo-caloric, iso-caloric and over-caloric calories of these single macronutrient diets. Biochemistry of liver, muscle and fat cells. Hormonal communication btn the various organs including the brain, heart, kidney and the aforementioned.
hey , just wanna put out some love out there , would have probably honestly failed without you. you put the video up just in time for my exam. i would suggest having other topics in biology explained by you or your colleagues . as currently the explanation videos of science and especially current biology is of very low quality. much love . peace
Thanks for ur efforts! u made it much easier. but frankly, this is the most difficult lecture i ever watched on ur channal😔😔 why our body is this complicated ?!! 😅😅
From what I understand it's also O.K. to write it like you did below, the only thing being it's 14 H+ as you are using also 14 NADPH's. By using that stoichiometry you are taking into consideration also the ATP molecules you used in the 7 reactions of the Acetyl-CoA Carboxylase reaction.
Mr. AK, its me again, first step is catalyzed by acyl transferase or acetyl transferase? or it doesnt matter which one? bcoz acyl n acetyl are different molecule. thanks for posting anyway
+CitraTheKrumZ It's Acetyl-Transferase, it transfers an Acetyl residue from Acetyl-CoA to the -SH group of Cys in the Conjugating ensyme which then conjugates this Acetyl residue with the Malonyl residue placed on the Phosphopanteteinil group and CO2 is then removed.
Yeah. Biotin is a coenzyme, meaning that it is needed for ACC to function properly. The carbon from HCO3- binds to biotin before getting transferred to acetyl-CoA and if there is no biotin, this step can't proceed meaning we won't be able to commit acetyl-CoA to fatty acid formation
Biotin is a carrier molecule of CO2. It's what holds onto the CO2 for the carboxylase to add it to the acetyl CoA. Biotin is attached to the acetyl CoA carboxylase enzyme
