This page is amazing. It helps me so much to learn about this different processes and mentions all the important aspects. Great! Thank you! And congratulation for the page!!
Such a wonderful video...lipid metabolism is like a nightmare for Entrance exams...thanks for such simplified video...now it would be easy to understand the text...
I have a biochemistry exam this Thursday and this video really helped but I was wondering if you had any explanation for the actual reactions occurs in Fatty Acid Synthase. I know that there are 6 enzymatic capabilities of the enzyme but don't know the actual steps. Do you happen to have any information?
I really liked this video and the whole presentation. I was just a little disappointed, that a video of that length didn't even include the actual reation of the fatty acid synthetis. don't get me wrong, the overview ist great but since you already broke the entire mechanism up into two videos I was sort of expecting to get all the details. maybe a disclaimer in the titel or the description box would be helpful.
I skipped my 2 lessons of my biochem class due to medical leaves and I couldn't understand anything from the textbooks or the notes. Thank you so much this made me understood in less than one hour 🙏🙏
Just a note. Although this is all correct, on a standard western diet you rarely ever produce fatty acids from glucose. You would have to be on a very low fat diet and ingest an excess amount of calories in carbohydrate alone in order for this reaction to have a notable effect. Ofc our beloved vegans could do this but most vegans are malnourished and dont take in enough calories making this quite a rare event in biochemestry.
Very helpful video, but I want to point out that for each molecule of acetyl coa that is carboxilated and activated by the synthase (7 of the 8 because one acetyl coa is used as a primer), 1 water molecule is produced, and so, there would be 7 water molecules in total and not 6. It'd also be pretty cool if you made a video in which you went more in depth on the domains of the synthase complex. Again, very helpful!
+Camila Penuela the reason it's 6 water molecules and not 7 is because once the entire 16-c chain is made, to remove it as free fatty acid from the fatty acid synthase, you need hydrolysis of the bond between the S of the fatty acid synthase and the carbonyl group of the fatty acid... you end up with a fatty acid synthase that can do the whole thing again and a fatty acid with hydroxyl group on the carbonyl group. hope that helps?
your depiction of the fa synthethase is wrong to my knowledge. you didnt distinguish between the peripheral and central sh groups ( acyl carrier protein). still you managed to convey the basic concepts of things really well, so that counts for something and makes the video worth watching.!
I don't want to be hung up on details too much, great vid btw, but at 5:20-ish you say we make 6 water molecules, shouldn't it be 7? like 1 water molecule for every 2 reduced NADPH??? Thank you
(On Saturday of February 18, 2023). On The Matter of Fatty Acid Synthesis And the Metabolism Therein (Chemical Reactions of Substrate-Enzyme-Product): 1) Stoichiometry of Fatty Acid Synthesis (Acetyl-CoA, Acetyl-CoA Decarboxylase [Fatty Acid Synthase], And Polymerization Therein Yielding the Product of Palmitic Acid); 2) Allosteric (Citrate Positive Regulation; Fatty Acid Negative Regulation) And/Or Hormonal Regulation (Insulin Positive; Glucagon Negative) Along with Product of Fatty Acid Synthesis; 3) Carbon-Carbon Bonding and ATP Hydrolysis Therein; PhD Jasmine Rana, es gut ist zu verheilen und kennen Die Krankheit auch aber man vernichtet sich mit Seiner Dummheit. Heil!
