I was diagnosed with NASH in 2002. They keep telling me they didn't know exactly how it worked at that time. My liver biopsy came back as "moderate stage fibrosis, piecemeal necrosis with portal vein hypertension." They still did not tell me I needed radical weight ( which I did) or just how to go about it. They suggested I lose some weight, but strictly told me I absolutely did NOT need to lose it quickly, nor should I fast, as what few studies had shown that sped up the mechanism in some cases. They essentially prescribed me a Vitamin E and C prescription and sent me on my way. Their vagueness brought vagueness in me. I stumbled on drinking far far too much corn syrup containing drinks for another 4 years. In 2006, a diabetes diagnosis came along and that was my bottom. I cut out everything sweet and started fasting frequently, and in a year, 2007, my ALT liver levels were back to normal levels with only some elevated bilirubin levels remaining. My highest a1c was 7.2% and it was back 4.8%. I had abandoned metformin as it made me sick everyday I took it. I had taken some other supplements as well. Thanks for this explanation, Dr.
Amazing how ignorant doctors can be. As individuals, we MUST take control of our own health! If you haven't already, also check out Dr. Ken Berry. He and Dr. Cywes are the smartest doctors I have ever researched.
In 2019 I was diagnosed with NAFLD with NASH and F3-F4 fibrosis. I changed my diet to remove carbs and now my liver is normal, as confirmed with a follow-up Fibroscan. Low Carb works!
Two years ago my liver was so much engorged that I could not bend over far enough to tie my shoes. After two years of keto and fasting my liver is normal.
Bravo! Delivered with great style and fearless confidence. Listen up, people, the doctor is in. He just may save your life. I know he's saving mine, and I could not appreciate him more.
Glad to see you back Dr Cywes. I briefly thought you were mentally tired of banging your head against the wall trying to promote/show the way to metabolic health. Back with a Lekker presentation. 👏🏽👏🏽
As a physician myself his is one of the best lectures on not only liver disease in relation to fatty accumulation therein but the discussion regarding the two types of people (diabesogenic vs obesogenic) is one I haven't heard talked about as much. Fully explains the pathologic manifestations in patients. I was always perplexed why some patients would balloon up and others would stay thinner despite both being metabolically unhealthy. Like Dr. Cywes said it has to do with differences in nsulin secretory capacity of individuals. Those with high capacity get obese while those with limited get the high sugars and vascular complications. Fascinating. Must watch
@@robertcywes2966Hey doc. My father was a professor of biochemistry who taught medical school and grad school for about 40 years. When I was diagnosed with NASH about 20 years ago despite having been on a low carb diet for 7 years prior, we looked at the literature and discovered that the reason for fatty liver is well known in animal husbandry. It is a deficiency in choline. In fact that is how they fatten livers for geese and ducks to make fois gras or liver pate. Horses are also known to get fatty livers and the cure has always been to give them choline. There was even a study where they gave 18 baboons alcohol to the point they developed cirrhosis. They gave nine choline and it arrested the disease in 8 out of 9. All without choline died of cirrhosis. So in my case, I took lethicin for three weeks prior to liver biopsy. The pathologist concluded that my liver cells were not normal but not fatty. Dad and I concluded he had never seen a fatty liver being cured. I have never had abnormal liver enzymes since. Eggs are high in choline and I eat them almost every day. Other meat is as well.
Good comment. My wife and I are both "diabesogenic", and have slightly elevated blood sugar, but zero fasting insulin, and our blood sugars do not spike excessively after meals. I have postulated this is because of limited insulin production capacity, and our bodys' decision not to over strive to get every last bit of sugar out of the blood.
@@andrewtaylor9799 What I think happens with me after being low carb since 1996, is that my liver is extremely efficient at gluconeogenesis. My triglycerides and HDL are both in the 70 range but my blood sugar is about 105 - 112 with very few carbs and most days near zero.
@@davidgmillsatty1900 Understand. I also think this might be due to all the running I did in my 20s, 30s, 40s, and 50s. My body likes to keep a little extra blood sugar around in case I decide to run 5 miles. The control system is not broken - we are not insulin resistant - but is set slightly high. My triglycerides are below 60 and my HDL is 85 - 95. My LDL is very high.
Love this video. I’m a recovering alcoholic (10y/8m sober) but do consume too much sugary drinks. Latest blood work is AST of 37 and ALT 40, just below the top of the normal range. I’m cutting way out the sugary drinks and taking 600 mg NAC daily. I just started listening to this video and look forward to completing it, and all the sage advice!
I'm a medical student from Italy,hopefully in few months i'll be a registered doctor in my country. This lecture is pure gold,it summarizes all the knowledge that i researched in this field over the past years. Is there a way to have these slides that you used here? Also looking to buy the ketogenic book
Congratulations on the text book, it's on my list. I have family with medical backgrounds, including a PHD, that are sceptics. Again...Thank You! I love the bio chemistry, another installment that requires 10+ views.
Hello from Goa, India, Dr. Cywes! I am currently getting certified by the Nutrition Network as Professional Nutrition Advisor. Your talk on Obesity and Diabetes: Towards Resolution was one of the highlights of the course! Now this teaching video has further grounded me in the intricacies of Liver function. I'm an electronics engineer by profession but I became passionate about the power of real food when my wife complained about her 350+ blood glucose in February 2022 and I started doing the research online. I have listened to a lot of your videos. Your common-sense approach with down-to-earth lay-person-level explanations and your obvious passion to educate people is really commendable. The more I learn, the more I realize how much I don't know but I do suspect that I now know more than many doctors. Thank you very much once again. May God give bless you and reward you abundantly.
@valentineannacoelho: can you please share details of your network nutrition certification? I work as an electrical engineer and am really fascinated in wellness and nutrition.
Excellent presentation. Lots way over my head but plan to watch again. I understand enough to feel very confident now in following my ketogenic lifestyle. I had a body comp MRI done in May 2023. I will be having a repeat done May 2024. The report stated that I had a liver fat percentage of 11.66%. I stopped eating more than 20 total gm carbs/day, moderate protein, higher fat. I am looking forward to seeing my new stats. I am going to ask to get the c-peptide insulin labs done that are scheduled in 3 months. Thank you for sharing and teaching us.
Carnivore lipivore here for 6 years. Dont eat ANY plants at all. Never felt healthier , better and leaner. I wish saturated fats will be consumed and respected soon. Its demonization is killing us.
I'm so glad I found out your channel! I've been thinking the same way as you do but was lacking the biology education which you provided. Thank you so much, I'm going to binge watch all your videos now to learn more!!! I hope to find things talking about autoimmune diseases!
Dr. Cywes. In July, I began transitioning to a Ketogenic diet. I’ve done well with eliminating sugar, Gluten (Hashimoto’s) and have rarely had any refined carbs-except a few times. Earlier this month, I had my labs done: Fasting Glucose 81 Albumin 5.0 (don’t know what that is but it’s high) Total Cholesterol 446 Triglycerides 100 HDL 73 VLDL 16 LDL 357 Calcium Heart Scan 430 Dr. Is now insisting I need to get back on a Statin (I stopped taking them 6 months ago. Was on them for years and make me feel like crap). I explained to Dr. Assistant who gave me CAC score that I would like to tighten up my diet and try to reduce those scores nutritionally, and retest in 4 months. She quickly dismissed me and stated that I will not be able to do anything about my calcium score and that I really need to get on meds. Is that true about the calcium score? There is no way to reduce it?
FYI Doc: Most likely you can configure your cursor so it is more visible during your slide talks. Also, consider using semicolons when you have lists of lists. Great video! I will send it to my doctor. Thanks!
This is normal, it takes a lot of effort to put this information on screen. I have no skills on computer, but I hear clearly what the Dr is saying, why bother about commas very trivial. It's a wonder he has all this time to give us so much information. It's not ,Ike you can't hear him
When you look at it like this it becomes more clear. For the past 150 years or so, food production has become the mainstay of large agribusiness (Big Food), but more pronounced since WW2, and most especially since the 1970’s. The way food is grown with all manner of chemicals and poor farming techniques, deliberately engineering (not even considering GMO’s but only the manipulation of the crops by natural means to produce bigger, and sweeter and more pleasing end products), modern day foods, especially the carbs, grains, and starches, and the chemicals made from them, have become, in essence, synthetic, pharmaceutical, man-made drugs that have little to no nutritional biological benefits for the human body, but have HUGE addictive qualities that actually make you more hungry, and is toxic to your mitochondria, enzymes, and hormones, and give you extreme cravings to eat more which makes you more hungry which makes you eat more which makes you more hungry which makes you eat more which makes you more hungry which makes you……….. I used to eat until I was totally stuffed, but wanted to eat more because my head said I was still hungry, even though my stomach was full to the brim. That is actually really the truth. And in some way, maybe in a large way, it seems to correlate quite well with Revelation 9:21 - Berean Standard Bible Furthermore, they did not repent of their murder, sorcery, sexual immorality, and theft. (Strong's Concordance: sorcery, φαρμάκων (pharmakōn) Noun - Genitive Neuter Plural Strong's 5333: A magician, sorcerer. The same as pharmakeus. 5333. pharmakos pharmakos: a poisoner, sorcerer, magician Original Word: φάρμακος, οῦ, ὁ Part of Speech: Noun, Masculine Transliteration: pharmakos Phonetic Spelling: (far-mak-os') Definition: a poisoner, sorcerer, magician Usage: a magician, sorcerer. Cognate: 5333 phármakos - properly, a sorcerer; used of people using drugs and "religious incantations" to drug people into living by their illusions. To put it simply and succinctly: modern carbs are addictive drugs. And to get off of them is directly and exactly like a drug addict on crack or heroin or meth trying to be free from the addiction. I know from experience as well as the research that verifies this. I used to be addicted to crack. Coming off carbs is definitely harder. One reason is because they are perceived (falsely) to be foods. But it can be done if you substitute them with the proper fats and proteins which will eliminate the cravings. I don’t get hungry anymore. Unless I screw up and eat some sugary “treat” the day before. It has to be done right, though, in order for it to be successful and not have the cravings. Also, the modern Health Care System where Doctors are held as practical “saviors” for the body has become a very real RELIGION. Everybody goes around saying you need to consult with “your” doctor (the religious assumption that everyone has or should have one) even if you want to change your diet to heal, cure and prevent the very metabolic problems that the toxic pharmaceuticals that they give you are either causing directly or massively but indirectly causing. There is NO biological necessary essential NEED for carbohydrates to be ingested by humans. Any small amount of glucose needed by the body can be manufactured by the body from essential fatty acids (fats) and essential amino acids (protein). Again, there is NO NEED to eat or ingest carbohydrates by humans as part of their diet. But they are pushed because they are, in fact, drugs, pushed by the Big Food Cartel Drug Pushers and Big Pharma Cartel Drug Pushers that push drugs that make the problem you’re trying to fix, WORSE in the long run because they disrupt natural enzymes, hormones and systems that your body was trying to use to fix the problem.
Re minte56.. I thought first r each sugar molecule that Four water molecules attached, not one. But it makes your point even more important. Don’t overload on sugar/ carbohydrate.
@@robertcywes2966 TUDCA isn't really a drug. It's a type of bile acid. The body produces it, just in smaller amounts. The problem is that a dysfunctional liver produces very little of it.
A one point NASH I had a total Cholesterol level of 212, but I had an HDL of 0 ( zero) only traces found in the sample. Do talk about an outrageous Triglycerides/ HDL ratio level! My Triglycerides never got over 300 that whole time though, nor did my total cholesterol get over 230. Total Cholestrol would stay between 200-210 most of the time. Confounded them I believe. Took them years to decide to give me a liver biopsy. NASH is sneaky as your ALT liver seldom gets over triple normal high and the other enzymes are in normal range until you have irreversible cirrhosis.
A friend of mine had gastric sleeve lost 132 lbs and looks 9 months pregnant, they are telling her she has fatty liver. It seems really strange to me! Yikes!
Weight loss doesn't necessarily heal fatty liver. No carb, low carb will heal fatty liver and many more metabolic problems. Even people that have had these types of surgery's can do a CARNIVORE way of eating, but most probably need to eat several smaller meals throughout the day to be sure to get enough nutrients for a healthy body. Additional weight loss will follow and contribute to healthy benefits.
I hope and prey individuals considering the gastric surgery are will informed as she was given a super high doses of narcotic and lost another 32 lbs, but still looks 9 months pregnant ;(
She absolutely adores her group so she is not very open minded! They seem to be working with her mostly to attain skin removal surgery all the meanwhile her sugar drops and she passes out it work! She gold me she eats avacafo toast and soup and daily! Clearly not enough protein by far!
Yes it is but it is very expensive, even the ebook version is dear. Just do a google search for Ketogenic textbook. The full title is Ketogenic: The Science of Therapeutic Carbohydrate Restriction in Human Health. There is YT channel Nutrition Network where there are some videos about the chapters in the book: www.youtube.com/@nutritionnetwork/videos
It's not always simple, though. My husband began carnivore in April 2018 and by September 2019, his fatty liver was completely reversed (as was his prediabetes, and he lost 80 lbs). But because carnivore still wasn't helping with his nausea and vomiting episodes, he went on amitriptyline, being told it was "abdominal migraines" or "atypical migraines" or "Cyclic Vomiting Syndrome." He took amitriptyline from September 2019 to Spring 2020 (he hasn't touched it since then), but that seemed to set him on a course for severe metabolic syndrome that even carnivore cannot reverse. It's like his body goes crazy making glucose. His insulin is sky high, he's progressing back towards diabetes (rising A1C), and fatty liver is so extreme that his liver is now enlarged. He gained back most of the weight he lost, as well. Something is very wrong and nobody seems to know how to help him. I booked an appointment with Dr. Cywes, but it's not until Feb. 14. In the meantime, he is so sick now that he has to be on sick leave and can't work.
My father was a biochemist who taught medical school and graduate school for about 40 years. I was diagnosed with nash about 20 years ago although I had been low carb for 7 or 8 years at the time. I started doing some research for my dad to review and we discovered in the literature that a deficiency of choline is the primary reason for fatty liver. This is well known in the world of animal husbandry where birds of different kinds are given a diet deficient in choline to induce fatty liver for liver pate or fois gras. So I bought some lethicin capsules ( half choline) and took them for three weeks before my liver biopsy. The pathologist’s report was that the cells were not quite normal but not fatty. My dad I concluded that the pathologist had never seen a fatty liver on the way to being cured. My liver enzymes have stayed normal ever since. Meat is high in choline, especially eggs. But you can buy choline capsules or lethicin capsules at your pharmacy over the counter.
@@davidgmillsatty1900 he has been carnivore for over 5 years and eats 6 eggs every morning. How can he be deficient in choline? How can he have reversed his fatty liver, taken amitriptyline for 6 months (while continuing carnivore), and developed fatty liver again with it being more severe and not reversing? Too many unanswered questions and choline seems too easy.
@@SarahPoulin Meat alone my not be high enough. All I can suggest is to try choline capsules. My philosophy these days is meat for nutrition and plants for medicine when meat is not enough. Being very low carb for 20 plus years did not keep me from getting the shingles from hell. One more thing. When I was reading the literature on this 20 years ago, one paper stood out. The researchers used 18 baboons and allowed them to drink all the alcohol they wanted till they all had cirrhosis. Then they put nine of them on choline and let them all continue to drink. Choline arrested the cirrhosis in 8 of the 9 and the one whose cirrhosis was not arrested did not die. All that did not get choline died. How do you forget that paper?
High glucose production might be due to elevated glucagon levels. Glucagon is made in the alpha-cells of the pancreas, while insulin is made in the beta-cells. Insulin causes decrease in blood sugar, glicagone acts the opposite way. A glucagon level test is rarely ordered by docs, but might be helpful in your case. Also, green juices, lots of salads/steamed veggies and a bit of fasting have never hurt anyone obese with high-blood sugar levels, to my knowledge. Could be tried.
In Ketosis I thought the majority of energy for the body came from fatty acids used directly by the mitochondria not ketones as you seemed to say. The brain uses a mixture of glucose and ketones but the heart and skeletal muscles uses fatty acids released into the bloodstream by lipolysis in the fat cells. You seem to say that the liver provides most of the energy for the whole body through ketones during ketosis, which is unlikely. Are you calling the free fatty acids ketones?
Started carnivore 2 weeks ago..fatty liver, gallstones. Was doing fine and then had ‘gallbladder attack’. What do I do now? What to eat? Pursue cholesystectomy? Wait and see if it improves? I don’t want to go back to old way….
This frustrates me to the lecel of anger. I had a liver transplant at emory university hospital. Not one doctor, nurse, dietician or nutritionist ever said a word about sugar/carbohydrates. My diet consisted heavy on breads, rice, pasta, sugar. Even as an inpatient. Went into rejection 6 years later and been trying to recover my numbers. Even still none of my emory drs ever suggested changing my diet. I was never obese. Struggled with anorexia. Equally as bad for your liver. Have given up carbs. So keto is better for me than carnivore? What about keto carnivore?
I would like to know if there is an image of the pyramid you showed here available to download. I searched your description but couldn't find a link. If there is no pyramid image for downloading, that's fine. Also, does a whacked out thyroid play into weight loss inability even on an omnicarnivore diet plan?
This is incredible content, quite a bit above my knowledge level, you have inched me closer to a consult with you. I have fired the medical industry for childlike suggestions and concerns in all matters, from nutrition, diet , meds and recently contagious diseases.
Doc, I went from 2 years keto to 3 years carnivore. Strict. My health deteriorated. I'm now 4 months starch based...wfpb no added fats. Nuts and seeds. My body is healing and my a1c is lowest ever result. 4.5. I'm 59. I eat white potato. Sweet potato, whole grains fruits and vegetables. How can this be? I don't have a gall bladder. My stomach and esophagus were damaged from high acid high fat diet. Diverticulosis ..I have colonoscopy results 5 years apart to document. I couldn't slerp in ketosis. I wore CGM. I didn't lose weight beyond a few lbs. I did lose 40 on keto but carnivore....not much. I loved eatimg the meat. Was never hungry. But I got sick. How can My blood glucose be so good eatimg nothing but starch and plants? I want to understand. I'm not here to argue. I'm sharing my results with you because I know you are receptive to different outcomes. I also had ct scan and after the 5 years of ketosis ..I sthowed fatty liver. I just want to be healthy.
Thats me stented and terrorized by our sick care model when i had my stroke doctors didnt see it oh shes not diabetic but i am easily carb sick todayi am poor chronically illketo is notgoing well this time round
Am I correct in saying that the typical treatment of type-2 diabetes by prescribing insulin just shifts the sugar problem from diabetes (high blood sugar) to inter-cellular hypoglycemia making the whole system break down further?
OMG. 🤯 i need to go back to collage and take bio chemistry 😂❤ So, I'm confused, in an extended fasted fat adapted state, let's say 4 days, will we burn muscle if we still have excess body fat?
Even if saturated fat weren’t associated with heart disease which they are, the effects on pancreatic function and insulin resistance in the muscles would be enough to warrant avoiding it. Despite popular press and propaganda , saturated fat intake remains the primary modifiable determinant of LDL cholesterol, the #1 risk factor for our #1 killer-heart disease. See The Saturated Fat Studies: Buttering Up the Public and The Saturated Fat Studies: Set Up to Fail. Saturated fat intake? As low as possible, according to the U.S. National Academies of Science Institute of Medicine: Trans Fat, Saturated Fat, and Cholesterol: Tolerable Upper Intake of Zero. Excess saturated fats are very hard in the kidney's liver, and pancreas.
Is it OK to put one or two molecular hydrogen tablets in 16 oz water along with methylene blue at a rate of 40 drops of 1% for my weight of 140 lbs? I also use DMSO over top of Povidone Iodine (Betadine) several times a week, which heals almost by the next day, any cuts or scratches or bruises from construction work or the cats . I also use liquid chlorophyll daily, as well as a whole ground up lemon minus the seeds. Does methylene blue compete with NO? And if you take beet root powder and other NO protagonists such as arginine, will that nullify or reduce the effects of the methylene blue? I also take colloidal silver on a fairly regular basis. What kind of reaction do these chemicals have on each other. I am now off of all my prescribed (15 to 17) meds, when my Doctor fired me for trying to reduce my pharmaceutical load that they had me on a few years ago. My health has since improved about 1000% since I was fired by my Doctor and they refused to "treat" me by my "Health Professionals". I had diabetes, high blood pressure, GERD, 3 degenerated disks, ADHD, OCD, major depression, anxiety, arthritis, probably NAFLD though not obese (then about 165 - 170 lbs. and then height of 5’ 6” down from 5’11” in early adulthood, but have since have regained a little over 1 inch back again, and now about 140 lbs and lost about 7 inches in my belly, after about 3 years on keto), and more. I am now 71. If you or anyone else can provide me with good information on the interaction of these chemicals, it would be greatly appreciated. Thank you very much for your kind response to this request. Spencer Douglas James djames314 (is at) (g)mail (at dot) com spence3141 (RU-vid) For about 1.5 to 2 years now, I have increasingly been practicing a healthy keto lifestyle with intermittent fasting in about a 5 to 6 hour window of eating. In addition I water only fast for about 42 to 44 hours each week. Occasionally, I go on a 3 to 5 day water fast. The longest fast I have ever done is 21 days when I was about 35 or so. I eat 3 organic pasture raised eggs (local when I can) and an organic avocado and a whole ground up organic lemon (minus the seeds) with added organic ginger or turmeric daily, grow my own sprouts, homemade pickled/fermented garlic, organic grass fed and finished beef, some pork, no chicken, electrolytes, bone broth, pro- pre- and post-biotics, organic EVOO and coconut oils and apple cider vinegar (6 tablespoons daily each), and organic salads (no spinach). I make my own homemade mayonnaise and other sauces. When I need a sweetener I use Monkfruit, Stevia, erythritol or allulose. I don’t eat anymore packaged processed and ultra processed foods, junk foods, fast foods, restaurant foods or omega 6 oils (vegetable oils, which most restaurants, bakeries, etc. exclusively use with rare exceptions). I weigh around 140 lbs, about the same as when I was a competition swimmer as a teenager and later as a young adult until about 35 or 40 when I started eating a high carb and starchy diet and started gaining weight up to a max of about 175 to 180. I used to make homemade keifer, but stopped when I wanted to stop drinking milk. I also take a whole bunch of good quality supplements. I try to stay away from foods high in glutens, oxalates, lectins, carbs, omega 6’s, chemicals, and and I try to concentrate on real whole organic living foods (local as much as possible) that help increase and strengthen mitochondria and gut microbiome, nitric oxide, and reduce inflammation. The goal is to become fat adapted to begin to burn ketones instead of sugar in order to become insulin sensitive instead of being insulin resistant.. All carbs and starches, and grains are sugars - they are polysaccharides - many sugars. So that piece of bread is really a big piece of sugar that actually has a higher glycemic index greater than equal weight of pure table sugar. Table sugar (sucrose) is a disaccharide of 2 sugars - glucose and fructose. Glucose by itself is a simple monosaccharide of one sugar. Cellulose that all plants are made from is the 3D structure of carbohydrates. Fructose is especially damaging to the body as it is massively added to practically every processed food, because the equipment to process the food is specifically designed to utilize fructose because it helps maintain the proper flow control for the food to be processed in the first place. So they can make it more cheaply with less loss and increase their profit margin. Therefore it is used everywhere, even and maybe especially, in its hidden forms and under different names so you cannot recognize it. It can only be metabolized by the liver, which is very difficult on the liver as well as most other critical areas of the body, and causes many problems, especially if consumed on an ongoing basis and in virtually every processed food in the grocery store.
Diagnosed liver tumour that was in July 2023. Immediately tightened up my protein intake and removed fruits from my diet increased fat uptake slightly keep calories under 800 a day 80g meat on meat days, 1 to 2 eggs a day, WCSALMON, sardines IN GOOD OLD OMAD fashion. September 2023 during biopsy session I was told my tumour is shrinking therefore best thing was to leave it alone and keep it closed monitored. PS Yesterday I had fruit it felt like I was high on some kind of a drug. My heart feels slightly funny. It’s like same effect caffeine has on me. I just wanted to go to the loo after a month of no bowl movement. One single mango did do the trick. LESSON TAKEN I will certainly incorporate at least one mongo or papaya to my weekly schedule. I SHALL consume the fruit after my meal, not before nor on its own. I did not appreciate the effect of that fructose rash into my brain. Pss My body is been ketogenic for 40 plus days. Very happy indeed.
