FISETIN: A Senolytic In The Fight To Defeat Aging [2021] 

Like to win a free jar of fisetin? Just leave a comment below and I'll pick my fav in about a week. I'll leave an email address as a reply and whoever wins needs to send their contact info to that email address. I'll forward that contact info to DoNotAge.com, the providers of the free jar of fisetin, and they'll ship the free jar to the winner! OK, so I screwed up. I got an email from DoNotAge informing me that the discount code LANCE is for a 5% discount, not a 10% discount like I said. So sorry!

Lovin your content mate. Always thorough and balanced, keep up the good work. 👍

Hey Lance, I'm a chemistry student. I would like to point out that the solvents you listed are indeed all organic, except for water which is polar and inorganic. Of course, you could dissolve your fisetin in alcohol, acetone, or DMSO, but I hope I do not have to point out why that's a horrible idea... Solvents, as the name implies dissolve a fraction of what they're put into contact with, and I would not be surprised if they would dissolve a fraction of internal membranes in the body. A quick fix for the problem you're describing would be to consume the fisetin with or dissolve it in some olive oil, as this is. This could have the added benefit of activating SIRT1, since oleic acid is proven to be a very strong activator.

I am so inspired by you Lance, I hope that if I reached 60 to be as youthful as you are in the 70s! you are one of the leaders in this new movement! Be blessed.

Thank you, ALL day looking for information about Fisetin, and this was the best, in less then 9mts, talk and more advice and best explanation that I understand it well, 👍

Another great video. Imagine that, medicinal benefits inside food. The new sets and presentation are of the highest quality. You're doing a great job and public service for the global community. You're making a difference in the human race, because healthier people make better decisions. You are presenting information that is desperately needed.

I take Fisiten and others that Dr Sinclair said to take I like what you have said about helping older people.

hi Lance I really love your videos and Fisetin looks to be wonderful. I will try. Donotage. thanks.

I really appreciate your breakdown of Fisetin. Hopefully one day I can try this. I belive in NMN and resveratrol when I could afford it well it changed my life. May this find you well and safe Cheers Doug 😎

Been taking one a day for two months. Feel amazing, look younger, and my gray hair stopped increasing.

Discovered your channel just today, Lance. Thank you for your work. I'm excited about Fisetin, even though it's in early stages of research. I don't think the proteolytic enzymes, serrapeptase and nattokinase, are considered senolytics, but I'm sure a fan of these. Do they also clear sensecent cells? I know they work on scar tissue and plaques.

Hi Lance, like we'd chatted before I'm all into learning how to balance mTOR and AMPK cycling to prevent sarcopenia and allow autophagy for maximal anti-/reverse-aging. I am learning more lately about senescent cells and their inflammatory effect on neighboring cells. It is exciting with all of the new research and thanks for providing so much good data. I will look into fisetin myself and also pass it by some good biohackers I have contacts with. Thanks again for your research.

Great video mate.

Hi from France, I discovered fi/seton 10 days ago. In the first 3, I felt more tired, probably the detox effect. Now, I feel rejuvenated. And on the top of it, I am treated my essential tremor I am dealing for years !! For sure, I want to give it a chance on the long term. Marit

Hi Lance, I just stumbled upon your channel and liked your presentation. I too am confused as to the dosage and time-frame in which to take Fisetin. After doing a lot of reading and listening to several viewpoints I decided to do a 5 day Fisetin protocol in which I took 20mg/kg of body weight. I intend to repeat this every 2 months.

Thanks for the video it was very useful information

Hello Lance, I love the way you explain all of this very down to earth even for a neurologist like myself. Since this is all very new to me and very intriguing, what are your thoughts about use of Sena lytics and chronic inflammatory disorders such as rheumatoid arthritis, lupus, etc. When you say it reduces inflammation with these drugs in your other videos, I have to interpret this as it would be a good treatment for autoimmune disorders. What are your thoughts? Thank you very much. My respects to you

Sounds like an excellent product. How do its results comparing to the effects of fasting, I wonder?

Hello, I have been doing research on earthing and now longevity.I am 71 and have been feeling lately like I need to revamp my supplements and make some changes. Thank you for the info in your video.\

Loved the vid,my question is do you take it and if so how much and often?

Nice job . appreciate you

Good overview

A lot of helpful information, showing both Fisetin's benefits and drawbacks. I was not aware of its anti-cancer properties. However, its poor bioavailability, the lack of enough information about the optimal dose, and the paucity of human trials have led me to postpone taking it at this time. Thanks.

This is new info to men thank you

I’d like to know what would be a recommended dose for Fisetin? Thanks 🙏🏻 😊

Bob's your uncle!!! Took me back!!! 😂 Great video. Sounds like a pretty remarkable nutrient. I wonder if it's soluble in stomach acid or fat soluble? I guess time will tell and we'll all find out!

Thanks. Just subscribed.

Amazing 🔥

Hey Lance. Great video (as always!)! For the senolytic effect; would you take Fisetin together with a (3 day) fast or maybe directly before? I have read different opinions. Problem could be the bioavailability if I can just take it with water instead of oil during the fast. Any opinion on this? Thx!

But you've done really excellent job of researching all this stuff hey I'd like to try this stuff out man but you know there's so many scam products out there it's just unbelievable and if I win man I'll give it a try and I'll get back to you and let you know how it turns out thanks man have a good one and keep up the good work

Just ordered two packs of Fisetin and two of Apigenin from Do Not Age. And yes got a 10 percent discount too. Thank you. It will reach me in India Delhi by a young man coming back on n 16 th December 21. 👍. Intend to include Fisetin intermittently ,on basis of minimum effective dose. May be try in DMSO as solvent a transporter. About Apigenin I have to check ,hiw I need to optimise its use . Whether it can be used in MED minimum effective dose principle or intermittent use. Using a good cellular transporter, maybe DMSO. Any inputs on that would be more than welcome. I am 54 years young. Cheers 👍

Lance do you take it and do you notice a difference

Thanks for Russian subtitles

I am wondering about cyanide at low dosage ie eating almonds. Three pounds of strawberries if you partially freeze dried them I think you could get that down at a smoothie.

After illness…… That would be great to try

Hiya Lance. Do you know whether or not senolytics are effective while not fasting? I do extended fasts once a quarter, during which I load up on senolytics for maximum effect (hopefully,) but I'm trying to determine whether or not it's worth adding another round or two of senolytics during non fasting periods as well. Cheers.

Have you seen the alive by science product? I just ordered a few of their things. Interesting made with liposomes.

What about curcumin from the common spice turmeric? It was second only to fisetin and is cheap and very readily available? Solution to low H2O solubility & bioavailability - take them with olive oil or fish oil capsules?

You look 50.Amazing!

So is there any data suggesting that addressing senescent cells with Fisetin, Quercetin and Apigenin would lower the risk of accelerated tumor growth you sometimes hear associated with NMN?

How is the removal or reduction of senescent cells measured ?

Do these cells that gets removed, are then replaced with collagen that is fibrotic or with a new cell?

Fisetin has been around and no doubt been taken in varying dosages from very high to low.I would suppose any nasty problems would have received much attention over the years.A case of measuring risk vs reward?? William Newell

I'm gonna try the 500 mg for 5 days. takin it with black pepper and extra virgin olive oil.

So I started doing some math based on the mice test and the dosages used. Like you said eating 3 pounds of strawberries at once seems kind of cracy. But can we achieve the same number of the 60 mg/kg as they did in mice studies JUST by using food? For myself I weight 66 kg so I need about 3960 miligram of fisetin to mimic the dosages of the study. But like you said they used a hit and run strategy but found a instantaneous effect and a constant effect throughout the period. Now I do not know how fisetin is processed in the body, wether it is stored and used over time ect. But what if we instead of dosing the 3960 miligram of fisetin we try to obain it in that 8 weeks of time? It gives us 56 days of eating to get to that level. Now personally I am plant based so everything I eat will have flavones, flavenoids and isothiocyanates in them. One medium strawbverry is 12 grams on average giving me 1.92 miligram of Fisetin. So one strawberry a day will get me 107,52 miligram of fisetin in that 56 day time window. But I rather dump around 150 grams of strawberries in my smoothy. But that still only gives me 1.344 miligram of fisetin in 56 days. So unless people want to go crazy on the strawberries everyday to get the therapeutic dose you will probably not get to it for the impact of these studies. But for people that want to maintain their youth.. eating a plant based diet that contains lots of onions, tomatoes, cucumbers, apples, strawberries, cherry tomatoes, kale, blueberries, broccoli will however get you alot of the flavanoids mentioned in the study. Like the Curcuming, reservatrol, quercitin, sulphoraphane. These food also align nicely with the concept of Triage theory in nutrition making sure you get all the minerals and vitamins you need in abudance for all your youth perserving functions. So my conclusion is (I am only 31 atm) is that using a Whole Food Plant Based diet will get me everything I need to maintain at a low level of senescent cells without having to reach for the high therapeutic dosages. And If I wanted to do a "cleanup" to catch up on my bad behaviour in the past I would do that by using a fasting mimicing diet (FMD) onece every 6 months to keep a clear slate. But when already older and having more senescent cells diet alone doesn't seem to be cutting it. So then I would do the fisitin hit and run strategy to see if it could benefit me in any shape or form. The good thing about flavonoids is that they hardly come with any negative side effects unlike compounds as NAD+ that impact the system in a more intense way.

Does anyone know how to gain the benefits of fisetin without its impedance on mTOR? Seems that fisetin might have the same health pros/cons as metformin, the draawback in both cases being that you lose on the benefits of exercise due to its effect on mTOR.

Hello. Thanks for the great video. I took 1000mg of fisetin(from Dr's best) for 2 days and I had some side effects such as feeling of tiredness, heart beating harder than usual. It lasted for about 10 days. Is this commen side effects? Do you have any idea why I felt that way? I took it with omega3, evening primrose oil and no other supplements to see the effects of fisetin I am 49-50kg, 163cm so I thought its reasonable dose.

Another quality video. I was wondering about dosing when you said neither supplier had frequency of dosing. Interesting omission. I'll try sending Do Not Age a query on the issue. If I get a response I'll post it. Have you read anything about side effects?

Ive been fisting for years but haven't seen any anti aging results. Should we be doing it more frequently? Please advise

I tried to search if combining other Senolytic agents like Apigenin with Fistetin can be more potent in fighting senescent cells, there are multiple stacks that combine Fistetin especially from Life Extension, where they claim synergetic effects of theses combinations and I can not figure out if this is true or which is the best one.

Hi - is taking Fisetine and Apigenin a good idea?

Logically think this through. Using fisetin in a hit and run dosage schedule is ideal. Clinical trials are using 20mg/kg. When you are inhibiting mtor and other pathways, you want the volume turned to 11. You need to push the protien expression way beond what a senescebt celks likes, because it cannot do it itself. You also want pro inflammatory signals suppressed as much as possible so the t cells can go killing. 1.5 grams for 3 days x 3 weeks is what most triaks are doing.

So how many months or years use this supplement to get full benefits?

Love your work brother!!!! I've been taking 100 mg daily, just wondering if a consistent low dose might be helpful. I will be updating my dosage one day a week to 500 mg and keep the 100 mg dose for the other days. Maybe the best of both worlds. Thanks for all the hard work and sharing!

Where was that 25-50% of senescent cell types that fisetin targeting got from??? Few websites say upto 70%... Confused... Pls reply...

I am confused by the dosage. You take 1.8 grams for 2 days every 3 weeks. The entire jar from DONOTAGE is 600 mg. Am I missing something. Kindly explain.

Dr Green mentions that he feels there is some conflicts between desatanib/quercitin and Rapamycin. So he alternates weeks of both. One week Rapamycin. Next week Desatanib/Quercitin combo. Do you think that there would be a similar conflict with Fisetin.

is there any substance that eliminate autoantibodies ?

Senolytic dose? I am taking and it says only 3 capsules a week? Why? Can I take more . I am 62

Are that Daily dossage? I am 80 kg, then I would have to Take like 40 Grams Daily?

My dog has been suffering from a resistant bacteria for over 2 years. She is my world. Can dogs take this?

You should gift me with some of that extra virgin olive oil. I sure could do with some of that goodness

What shall we use to reverse aging...... Nmn, nr, or senolytic drugs?

The biggest problem is what purity we use vs in studies. Most sell the 10% fisetin and now on later days 50% powder is sold, and 100% extract is only sold in china. So, are we at best using fisetin with 50 % purity? And think we get the 25mg/kg they use in studies to get results, while instead we only get half of the effect... seems soo.

Can someone with hashimotos take fisetin

So is not Resveratrol? Same thing ?

Based on Amazon reviews, Fisetin is also a great psychosomatic supplement.

My Diabetes blood sugar levels improved radically after taking Fisetin. Coincidence? Maybe

Fisetin VS curcumin study

Intriguing, hello my name is Destin Delgado. I saw your video and would like to tell you about a powerful senolytic you may have never heard of. There called SR9009 and SR9011, there extraordinary powerful and life changing compounds. I have some personal research on how effective these compounds are and I assure you that if you could be taking any senolytic. It should be these compounds.

If ethanol and methanol is solvents then maby I could down this with some booze?

I take 3 grams for 3 days every 2 weeks. It is soluble and must be taken with fat "quotes fr Dr. David Sinclair"

Fisetin is water soluble?

_What gets us into trouble is not what we don’t know. It’s what we know for sure that just ain’t so._ -Mark Twain _When you change the way you look at things, the things you look at change._ -Max Planck Exercise moderately; laugh a lot; have awesome orgasms; fast once a week; eat in moderation 95% organic food; take a superior multivitamin/mineral cap or tab; take hydrolyzed collagen peptides, types I and III; and take these *_liposomal_* supplements: alpha-ketoglutarate (CaAKG), apigenin, berberine, fisetin, glutathione, NAD+, NMN, NR, resveratrol, and vitamin C. 💕☮🌎🌌

One cannot defeat aging, slow it down yes.

Too commercial😢

I'm hoping to become the last living Baby Boomer.

Maybe yes maybe no! Someone on video promoting a product that is STILL in PRELIMARY tests and only in mice and then promotes it's anti ageing potentials MAYBE in humans and can't say how much to consume ,for how much time , and no facts that it REALLY works except on a self presented chart , and what are the side effects short term or long term , and promoting an anti ageing product by a person that is aged and doesn't mention what credentials he has to even promote this product as a person of science . Same thing as David Sinclair that promotes nmn and reversatol as a anti ageing regime that shows promise AGAIN in only mice! and many people JUMP on wagon and follow the regime that IS ONLY A TEST ! IT HASN'T been PROVEN that it will slow down ageing in humans ! Those results on David's regime WILL NOT be known for DECADES ! BUT videos showing promises DOES SELL products !

Links to products that you profit from strains your credibility. Do Not Age is so grossly overpriced

The Fisetin you recommend is massively overpriced 24g for £65 ? Lol

This is incomplete information. Total marketing garbage really.