I'm interested in knowing what you guys think. Do you think that supplementing with apigenin & quercetin will inhibit CD38 enough to maintain NAD+ levels, or do you think that you need to supplement with NAD boosters like NMN or NR? Or, do you think that you should do both? Or, third option, do you think that clearing out senescent cells with a senolytic is an effective approach? Let me know what you think.
As with so many poorly understood topics in health, I wonder if we're identifying the firemen as the problem instead of the fire. Rising CD38 levels could be the body's response to prevent cell damage due to underlying metabolic dysfunction. Do we want to raise NAD+ levels in sick senescent cells? I'm not sure. I'm pretty ignorant of this topic, but If I had to choose an intervention, I would go after the senescent cells. I loved this deep dive into biochemistry!
Just off the top of my head, I think a two-phased approach is best. Tear down the senescent cells in one phase and then build in another phase with both CD38 inhibitors and NAD boosters. As far as timing, take care of senescent cells in the winter and build the rest of the year. That would imitate the yearly cycles of our ancestors. Of course, CD38 is useful to keep around. Apigenin just brings it down to more youthful levels. Boosted NAD levels in animal studies have proven health and longevity benefits overall.
Tough question, as in many areas of biology it it not the substance that is the problem but the amount. The positive anti-inflammatory affect of CD38 on SASPs certainly gives pause to outright elimination UNLESS the senescent cells have been greatly reduced. MORE MORE on senescent cell elimination please.
I take NR and eat parsley daily (such as in tabouli), and a couple of cups of chamomile tea. I am doing remarkably well for age 71, and have both measurable benefits and benefits that I feel.
I’m a big fan of quercetin. I started talking quercetin with zinc as a deterrent to COVID 19. As a result, I experienced a noticeable increase of sustained energy. I also observed an increased cardio performance. As a result, my blood pressure decreased slightly.
@@exxzxxe I used a formula with bromelain which is suppose to help with absorption and I take a multi-vitamin with vitamin C. When I took the stack, I noticed the increased energy and strength during the following day’s workout. It was pretty substantial and noticeable.
@@Antelocapra7 I took it daily for about 3 months. Then, Cycled off of it. I just recently started it back up (different brand), and it had the same positive effects.
this is surprising as studies have since shown that there are no changes in blood or and levels. In fact both fisetin and quercitin have little to no effect on biology
@@cd2888 Hi, I am interested in taking quercetin to help with my allergies. May I ask which brand(s) you have used thus far? And I understand that you took it daily then stopped briefly. How long did you stop before taking it again? Would really appreciate your feedback. Thank you.
nice presentation. appreciate it a lot. CD38 is one of the most misunderstood molecules. In order to understand the nature of cd38 it is important take a systemic and evolutionary perspective. Once you see it, it is striking. CD38 not only breaks down NAD+, it actively blocks the uptake of and later the conversion from NMN and NR to NAD+, thus lowering the level of NAD+. 80% of its activity is extra cellular, not intra-cellular. CD38 goes up with Inflammation, is secreted by tumor cells and the related senescent cells. In inflammation, the immune system "wants" the body to calm down, reduce fuel burning. Tumor cells want to reduce fuel burning of the rest of the body to get more for themselves. Hence it can be concluded that CD38 is the hinge between the immune system and energy production control. Note that demanding activity from the body, demanding the production of energy is anti-inflammatory!!! In the immune system itself it has multiple roles, both activating and slowing down. Such, key is not to block CD38, but prevent inflammation and reduce senescent cells. You talked a lot about that. from a systemic perspective, blocking of CD38 seems to me kind of messing up almost everything. It should not be blocked without measuring it before. I think we have years to go until we know enough about it. Now towards the end of 2023 I still do not find studies that would target exercise, NAD AND CD38 in elderly, or diabetics (but see this one: Duggalet al, Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?' Nature Reviews Immunology, vol. 19, no.9, pp. 563-572.) small note about apigenin in dried parsley: 140 mg/g would mean that in dried parsley 1 part out of 7 is pure apigenin. I think, that's hard to believe. what about the cellulose, the lignin, the protein of the wet leaf, which makes the biggest part of the dry mass? True its a protective agent, that is additionally built during drying. but drying takes just a few hours, if at all, the machinery quickly stops, not many days like growing a leaf. The rate of synthesis to reach the prclaimed final concentration would be extra terrestrial. I know, everybody is citing those 140mg/g. but maybe the original paper is wrong about it. ...btw how are : You?
@@Hassan.Mithun I am still kind of undecided about that. If at all, then only low dose as a supportive agent, sth like 50..100mg per day.. I would even argue the other way round, as there are 2 main activity centers\sources for CD38: (1) senescent cells (2) immune cells . Meaning, high CD38 point to chronic microbial burden or large amounts of senescent cells. Both can and should be addressed as a root cause, rather than blocking the symptom.
I love this video. This video is the fountain of youth. It's your best video yet. A healthy body will not produce something it doesn't need. There's a need for CD38 and it is connected to senescent cells. Just like you said, that right there, is the source. Instead of dealing with CD38 and NAD+ issues, the source of aging of the body is physical wear and tear on cells, just like any other machine. The best way I believe to deal with senescent cells is through prolonged fasting and autophagy. Apigenin, fisetin, and quercetin are also hugely beneficial. Good food, smart supplements along with a solid fast. That's the body's natural mechanism to fix itself. Once you reduce the number of senescent cells, then the quantity of CD38 should naturally decline because of less of a need for it. Then NAD levels should elevate as well due to CD38s decline. Then elevated NAD then can fuel Sirtuins, PARP and the electron chain for optimal health. The secret to the fountain of youth is good food, good eating habits, HIIT, and periodically doing prolonged fasting to trigger cellular clean up and autophagy. You're pretty much doing that right now, optimal living.
I do fasting up to six days at a time. The only problem is how much to do (and managing to do it) and that when you get older you could easily drop dead from fasts of several weeks. I would also worry about grey hair on very long fasts from lack of methithione for long periods. So unfortunately I doubt you can knock out even close to all your senescent cells, though more research is needed.
A healthy body won't produce something it doesn't need for propagation of the species/genome, but a certain individual replacement rate within a species may be optimal for adaptation of the species, and therefore the interest of genetic propagation isn't necessarily perfectly aligned with the interests of the individual, which, as individuals, is what we're concerned with. Also, healthy bodies become unhealthy spontaneously and over time, so we can't just take it for granted that whatever a healthy body does is itself optimal... lots of gaps in this logic in general
Thank you for this very informative and precise video. One question: I have heard in another channel that one should not take quercetin for too long, but only for a while and then stop. What do you think/reccommend? I was taking it since one year and so I stopped when I heard that.
I strongly agree. I do intermittent fasting and extended fasting, including multiple 3+ day fasts ever year. That is combined with exercise: walking, jogging, HIIT, and resistance training. I feel good on this regimen, but I can't prove that I've eliminated senescent cells.
I started of using suppliments of NAD+ including Apigen & Quercetin, all of which I now use intermittently about 3 times a week as I have found incorperated a range of fermented foods and high anti-oxidative foods into my diet where these precusers either exsit naturally or conribute to the body making use of them. But great video and it reminded me why I started using these suppliments
Are there any human in vivo studies that show that taking apegenin or quercetin will lower CD38 and raise NAD+? Has anyone tested their NAD+ levels after taking these substances?
they need to do more human trials on this topic ridiculous how only few human trials and mostly mice research this is groundbreaking and needs attention.
If we were to increase the expression of SIRT6 to regulate telomere length resulting in prolonged healthy cells; would that result in NAD+ maintaining levels as CD38 levels wouldn't raise due to the lack of senescence cells secreting SASP? the addition of NMN and NR, would significantly increase longevity? Geniuanlly want to know as I am just a highschool student.
An intelligent and very interesting question! Shame nobody has answered. Are you taking any supplements that effect SIRT6? I guess you are too young to need to. Cheers ^_^
Hello, I read somewhere that Tart Cherry 🍒 extract may also provide adequate amounts of apigenin. Just wondered if this claim has any grounding? Thank you.
Great video! Very informative and easily understood. One question though - do you take both, or just one? I've added a gram of Quercetin (with 100mg of Bromelain. I also take it with Vitamin C.) And I'm trying to determine if I need to start taking Àpigenin as well. Thanks in advance for any insight.
I'm wondering exactly the same thing! I'm already taking quercetin, and wondering if I really must add apigenin? What did you discover, or decide, in the end? Cheers ^_^
Wowzer... I need a roadmap or a decision tree for navigating the various supplements. Age? Below 35 go left, above go right. Above 70? Take NMNh and/or NMR. Sigh...
Thanks a ton for this video, I have a question though, if I bought dried parsley packets, would you say it would have same amount of Apigenin? Or the fact that it was not stored at the temperature you mentioned in the video, would affect a great deal the level of apigenin?
The same amount of apigenin as what? As a therapeutic dose? No. You'd need to eat about 8 grams of parsley a day, and that's before you consider the bioavailability issue. I think you're better off taking a supplement. The point I was making about temperature was that apigenin is unstable for long-term storage, unless stored at low temperatures. That's for pure apigenin, not dried parsley.
@@LanceHitchings - The dry weight of dried parsley is about 1.6 grams per tablespoon (according to a study i read online), so 4 or 5 tablespoons a day should be enough. That's not so much dried parsley in my opinion. I can easily eat that much by adding it to scrambled eggs, salad, and other things. Considering that supplements can't always be trusted, dried parsley seems a safe bet. I get a large bulk sealed bag on Amazon for a reasonable price. I'm glad to hear you say I shouldn't have to freeze it
You mentioned that CD-38 may be helping to prevent an increase in the inflammatory response in the body. But as nowadays people are supplementing with NAD+ precursors. Shouldn´t the body be trying to increase CD-38 to compensate for that too? what is going on with CD-38 when there is supplementation of NR or NMN? All the CD-38 is produced by senescent cells?
@@LanceHitchings fresh spinach is said to be alright, it is when it is cooked. same apparently with rhubarb. that oxalates become problematic. maybe, when drying parsley, forced heat, should not be applied. how is apigenin produced, is heat used?
I noticed do not age brand and most other apigenin products are not liposomal, is this adequate? Can just straight apigenin powder be sufficient? What is the bioavailability?
I'm leery of liposomal formulations. I'd rather present the substance to the cell and let it take it if it wants it than to force it in through membrane aggregation.
Apigenin : the most unpredictable supplement with the strangest dosing/effect by different individuals. Anyone trying it should read individual reviews to prep for efx. Not: it has a half life if 92 hrs. One capsule would work u for 4 days.
I'm a 47 year old male with IBD, leaky gut, HLA-b27 gene mutation with Ankylosing spondylitis. I eat clean, fats, meat, veggies and some carbs. I have always had low estrogen levels. Do you think I should avoid apigenin because of its effects on estrogen? thx a bunch for your time and great content!
@@LanceHitchings BTW, interestingly I had my first Pfizer vaccine jab. Most of my friends report varying pain and discomfort. Mine, just a little tender where the needle went in my arm muscle. I'm guessing the Quercetin has an anti inflammation effect shielding me.
Just a warning, Quercetin inhibits estrogen sulfotransferase in the body, for males this isn’t good because it raises serum estrogens. Resveratrol/Pterostilbene do this as well. I would just supplement with NMN/NR. All these polyphenols have off target effects on hormones.
once these substances are produced. the quality capture, or how long before the quality starts to be affected? interestingly, you say that some of these produces need to be freezed. yet sellers of these produces, say that these products, should not be frozen. these then leads to the question, on where does the information about temperature come from?. with bacteria, some info say that bacteria should be in cooler , so to stop it from growing, as if it does keep on growing without food, it will surely die. probiotics if not cooled . after awhile , after being produced. say . kept in a bottle, the bacteria count will start dying. you say that apigenin should be kept cold, yet you say , parsley produces more apigenin when dried, is this when it is freeze dried, as drying with heat could affect the apigenin count?
Wonderful, Lance! Extensive information and I will probably keep up my apples and dried parsley as well as take the supplements of apigenin. I'm not sure I can afford Quercetin too as this may result in me having to leave home! Greetings from Scotland, oh, and I forgot to say that I take NR and Niacin.
Thank you, very interesting video. Ive read that high doses of Quercetin around 1g can cause kidney damage. Wouldn't it be safer to recommend around 500 mg per day
Hello Lance, I enjoy watching your videos. Always to the point and easy to understand. I would like to know about Do Not Age Apigenin. They told me it's bound to 'beta glycosides'. That's somewhat confusing since it says 100% Apigenin. Do you know what the label actually says (that part of the label is not shown on their website). Thanks
small correction about parsley: 100mg/g apogenin would mean that it mostly consists of apigenin... Probably t would not even be green anymore hehehe... and lkewise you would have to eat 7 kg of dry parsley :)) it is not milli but mikro grams
No, I mean just the opposite. Senolytics such as fisetin are the first step I would take to upregulate NAD+...because it blocks the effects of CD38, which consume most of your NAD+.
Much easier and cheaper to take 7 gm of dried parsley a day than to take any supplement , just mix them with some water and drink as one shot , don't forget that parsley is rich in chlorophyll which improves detoxification and supports weight loss.
I take 375mg (1 capsule poured out and mixed with olive oil + 500mg of resveratrol). My supplement says my quercetin is extracted from sophora japonica buds . Hope the olive oil helps with absorbtion
Exactly. I read The Kauffman Protocol, and have been taking apigenin and quercetin since then. Good presentation. I'm using the Jarrow brand Quercetin, but it does not indicate what type it is. I've also used bulk-supplements quercetin dihydrate, which obviously is not phytosome. I just checked in my copy of Perlmutter's new book "Drop Acid", and there is no mention of the more bio available form. Interesting. This is way always keep digging for information. I'll try your recommendation next order.
Hello Lance. Thanks for the video. When is the best time to take Apigenin and should it be taken with a meal and/or a meal with fat? I was thinking about taking it on an empty stomach before I go to bed with a couple tablespoons of olive oil. Will this be effective?
heyy Lance! just want to ask your opinion: do you think a 27 year old like me should start using tru niagen? or wait until my mid 30s like dr brad is planning to do?
In my opinion, I wouldn't. In fact, I don't think I'd do it in my 30's either. The first thing I'd do is to use a senolytic to clear senescent cells, then I'd take apigenin to block CD-38. And if it was me, I'd test for NAD+, and I'd do it on a regular basis, track it over the years. I wouldn't start taking NMN or NR until I saw it begin to drop in spite of the other interventions I was doing.
@@LanceHitchings ohh ok cool! I actually was planning on buying 4 products from life extension that has ingredients of what you mentioned in another video about clearing senescent cells: GEROPROTECT® Longevity A.I., GEROPROTECT® Autophagy Renew, GEROPROTECT® Stem Cell, and Senolytic Activator®. Please feel free to tell me if it's overkill as I'm fairly young still but I'm starting to get anxious as I approach the age 30!! also I do live a healthy lifestyle; which focuses on diet, exercise, and sleep. Awesome channel btw, you are very knowledgeable in the aging category and hope people like me who seeks information regarding on how we can slow down or even reverse the aging process based on scientific evidence would watch your videos to be more educated in this specific area, as we are just starting to really understand how we age.
LANCE I would be grateful if you could answer a question for me, I was going to add parsley to my diet in order to increase my Apigenin, but I have read some negative stuff with regards to it being phytooestrogenic and may be contributory to breast cancer in women (and I believe I may be genetically predisposed to this, so I am concerned). However I am presuming the dosage Im going to get from dried parsley is going to be a fairly small dose. Any information you could provide would be helpful thank you.
Let me state that I'm not a doctor, and I certainly don't know everything about apigenin, or any other drug or supplement. I haven't heard that apigenin is phytoestrogenic or contributing to breast cancer in women, but just because I haven't heard it doesn't mean it isn't true. I do know that the amount of dried parsley that you would need to eat to get a therapeutic dose of apigenin is quite large. For that reason, I take it as a supplement, not as a food. But the phytoestrogenic aspect would concern me as a male who it attempting to raise his testosterone levels. Let me know what you find out.
What do you mean, "Where is the data?" It's in the medical publications that I list in the description. I listed 4 studies that back up my points in this video.
No, absolutely not. I'm just a layperson who has made longevity my passion, who has read extensively on the subject, who has implemented many of the strategies & interventions I've read about into my own life, who has had great success with those strategies and who has decided to share what I've learned.
Are you able to name the brand of Apigenen and Quercetin that you use? I want to make sure I get it from a reputable company. Most of the major brands like Thorne do not carry it.
@@LanceHitchings - Have you tried the liposomal apigenin? Alive by Science now has it. I'm on the fence about apigenin. But have been taking NMN and NAD+ that I've been making into my own homemade liposomal form. I've decided to by the liposomal NMN and NAD+ from Alive by Science.
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