Gabriel Malonic Ester Synthesis of alpha Amino Acids

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leah4sci.com/aminoacids presents: Gabriel Malonic Ester Synthesis for Alpha Amino Acids - MCAT Tutorial Video
📺Watch Next: Memorize and Draw the 20 Amino Acids • Memorize and Draw the ...
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This is video 9 in the MCAT amino acids tutorial video series. Learn the reaction and mechanism for synthesizing alpha amino acids using the Gabriel Malonic Ester reaction - A combination of Gabriel Amine Synthesis + Malonic Ester Synthesis.
Catch this entire video series along with my amino acid cheat sheet, tutorials and practice quiz on my website:
leah4sci.com/aminoacids
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Опубликовано:

6 авг 2024

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Комментарии : 31

@kalkidanberhanu7708 3 года назад

this actually makes so much sense! thanks leah!

@Leah4sciMCAT 3 года назад

You're very welcome!

@ravenarellano8415 5 лет назад

this was so helpful oh my word thank you God bless

@Leah4sciMCAT 5 лет назад

You're very much welcome! :)

@mohsinraza-dr2bj 8 лет назад

wow.... all the lectures on amino acids r amazing........ thanx ....keep up the good work mam

@Leah4sciMCAT 8 лет назад

thank you

@taylorcalibo4883 4 года назад

Your voice is much easier to listen to than AK LECTURES. But I also love that guy. Keep it up! Subscribed and liked

@Leah4sciMCAT 4 года назад

Welcome aboard!

@rachid12117 5 лет назад

you are the best , thank you

@Leah4sciMCAT 5 лет назад

Thanks and you're welcome! :)

@radhapatel1170 4 года назад

Thank you

@Leah4sciMCAT 4 года назад

You're very welcome!

@cristinaalexandra3432 3 года назад

hello, Leah! thank you for your work, organic chem seems more approachable now; what app is the one you are writing on?

@Leah4sciMCAT 3 года назад

You're very welcome!

@annieregan4940 6 лет назад

How can the R group attack from either top or bottom? Because the step before it is an SN2 reaction (i.e. backside attack) of a bulky group, and so surely the back of the molecule (away from the screen) is sterically shielded, forcing the R group to attach from the front?

@Leah4sciMCAT 6 лет назад

At which specific point in the video?

@ricarmmtz 3 года назад

Thank you, Leah! I wanted to ask, does this rxn only synthesize methionine or can it be used for all amino acids?

@Leah4sciMCAT 3 года назад

Great question! This synthesis can be used to produce any of the alpha amino acids, even though this video works through the one example of synthesizing methionine.

@m-linko 2 года назад

Hi there, could you point me to the malonic ester video you mentioned? I couldn't find the link anywhere. Thanks for the video btw!

@Leah4sciMCAT 2 года назад

Hi! This is the Malonic Ester synthesis video. I'm unsure of which other video you're asking for, but the entire series can be found on my site at Leah4sci.com/AminoAcids

@ThorirLenvik Год назад

I'd use it to make thalidomide analogues!

@Leah4sciMCAT Год назад

Cool!

@petergobina362 Год назад

Solid and solution phase synthesis of peptides

@Leah4sciMCAT Год назад

I don't understand whether you have a question. If you do, feel free to contact me through my website at Leah4sci.com/contact

@fauxpassant 8 лет назад

Hmmm... you didn't really explain why EtO- was used other than the fact that there was COOEt for the malonic ester. It's to prevent transesterification?

@Leah4sciMCAT 8 лет назад

My enolate Orgo series leah4sci.com/enolate covers this. See the claisen condensation video

@Leah4sciMCAT 8 лет назад

But yes, it's to prevent a side reaction which... guess doesn't really matter here because you're turning the ester into a carboxylic acid

@fauxpassant 8 лет назад

Ok thanks!