Lesson on the glucose-alanine cycle (Cahill cycle), how nitrogenous waste is produced in the muscle, how the skeletal muscle “stores” nitrogen in the form of alanine, and how alanine is transported and processed in a liver hepatocyte. Skeletal muscle metabolism of branched chain amino acids, and degradation of purines and pyrimidines leads to the production of ammonium and other nitrogenous wastes. Since the urea cycle does not occur in muscle, the skeletal muscle cannot process the ammonium directly, and thus the skeletal muscle incorporates the ammonium into alanine and glutamine, which are transported to the liver and processed.
********NOTE: 2 Mistakes have been identified in this lesson.
1) Alanine aminotransferase is abbreviated ALT, not AST... AST is actually aspartate aminotransferase
2) The last step in gluconeogenesis in the liver is performed by glucose-6-phosphatase, NOT glucose-6-phosphate dehydrogenase.
I'm very sorry for the mistakes and confusion******
Hey everyone, this lesson is on the glucose-alanine cycle. In this lesson, you will learn about the importance of the glucose-alanine cycle, how nitrogenous waste is produced and “stored” in the skeletal muscle in the form of alanine and glutamine, and how alanine and glutamine are processed in the liver to recycle the carbon skeleton and nitrogenous waste in gluconeogenesis and the urea cycle, respectively.
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JJ
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ
4 дек 2017
