How Hyaluronic Acid Reverses Skin Wrinkles 

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I have been taking them for 10 years..when it was said "they do nothing"..BS I am 71..my skin is at least 20 years younger. That is one ingredient in my must haves!

The doctor is definitely getting better in the thumbnail game :)

I use a diluted hyaluronic acid serum everyday immediately after showering - I love it, my face shows a lot less wrinkles than before I started. However the real dramatic effect has been on by shins, calves and heels. Every winter they turn dry, cracked and ugly. I've been applying hyaluronic acid serum 2-3 time a week and it's made a huge difference. No cracking and the skin is soft and supple.

I have been supplementing with hyaluronic acid from past one year. Worked great for my skin and joints 👍

Of course all of the studies were industry funded. The only one which was not industry funded was an evaluation of the industry funded research. This does not prove that the studies are wrong just that caution should be taken

Hyaluronic acid combined with retinol/retinoid while using sun cream with minimum spf 50 every day will do wonders for your skin.

It's also good for the gut, so does not necessarily need to go into the bloodstream to be helpful. The gut and skin cells seems to be able to absorb it themselves.

Dr please do videos on Wormwood and Methylene Blue.

Topical hyaluronic acid does have a great temporary effect if applied to moist skin. Rub water on your face, then HA and watch those wrinkles plump out. It will also give your skin a glowing, shiny appearance.

Thanks for the molecular wt commentary hypothesizing gastric breakdown of larger to smaller. That was the sticking point on all previous HA videos.

Yeah, but for the first study where they put something on the skin, even if you simply apply common duct tape to a wrinkle overnight, once you take off the tape in the morning, you will have the appearance of removed wrinkles for about an hour. So, if they measured right after they took off the thing, the results are virtually without merit. They were even measuring with it on, so not sure how they can ensure it did not reduce the wrinkles itself.

Thanks for adressing the high/low molecular weight question more clearly. From previous videos I was under the impression, that you are biased in favor of the "do not age" product.

Pure knowledge without any fluff. Thanks doc!

In 2014 I was taking 4 to 6 hyaluronic acid supplement pills a day and I do believe it helped to plump my skin nicely, however I also have Spondylolisthesis in my spine with one vertebrae and after taking the HA for about 3 months I developed a synovial cyst in the joint of the vertebrae that is slipped forward. I am suspect that all the HA supplements I took for my skin had a big hand in the synovial cyst developing. The cyst pushed on my spinal nerves causing severe sciatic pain. I had 5 spinal steroid injections for pain management and they tried to drain the cyst as much as possible to cut down on the pressure on my spinal nerves. I do think HA supplements work but be careful not to over do them like I did (in case it did cause the development of the synovial cyst which I believe is highly likely)

How convenient the same company you use for supplements made a huge donation to your study

Hey Dr Brad! Could you please do one on reversing grey hair? Thank you

Anyone here use the do not age hyaluronic acid supplement daily? Have you seen a difference in your skin since taking it? Also- since it holds water molecules- has it caused you water weight gain/ water weight retention???

I am over 50 and have used La Roche-Posay hyaluronic acid serum on my face for a few months. (I have no connection to the company.) I have been pleased with the results in reducing fine wrinkles under my eyes but noticed no reduction in the deep forehead and "smile" wrinkles.

Hi, Dr. Brad could you do a review on 'MSM', Thank you.

from a quick search: The organs of most livestock, including beef, lamb, pork, and poultry, contain high levels of hyaluronic acid. While a diet high in organ meats may provide plenty of hyaluronic acids

Thanks for taking on the Hyalaruonic acid on skin(topical) myth, a lot of companies especially exotic brands use these and charge a premium for low molecular weight HA most derms like shireene idriss have talked bout it too

I honestly don't know what Brad is talking about. There are several studies that have shown that HA serum can be absorbed into the deeper layers of the dermis, can increase cellular turnover, and can reduce wrinkles. It also moisturises and it smooths by removing the outer layer of the epidermis. The results are noticeable.

Great video, love that the info is brought as short content Don't want to watch hours of explanation

An honest question: Does HA improve the bodies health, or just how the body looks? Most above 80 years would look younger by fixing/whitening their teeth, but that doesn't mean their healthspan is increased.

glad to be back to the science

How about taking more Hyaluronic acid rich foods? Soy foods such as tofu, soy chunks, soy milk and citrus fruits such as oranges, lemons, limes, and grapefruits contain the most hyaluronic acid. Also, tuber vegetables such as potatoes and sweet potatoes, and green leafy vegetables are excellent sources of hyaluronic acid.

I received my HMWHA today from do not age! I am so excited to start using it! Thank you for this video!

Great video Brad! On the product page that you linked to people will find the TED Talk that our lead researcher, Professor Vera Gorbunova, did on hyaluronic acid and the importance of high molecular weight. Thank you!

What about liposomal HLA? Is there any benefit in taking it in that form? Great video!

My supplement list is as long as my arm already watching RU-vid 😀

I take HA powder mixed in a smoothie daily & HA knee injections, The Knee injections are 100% effective, been getting for several years (OA in the knees & elsewhere). The powder in the smoothie turns to a gel before I drink it. Is it still going to be "digested & absorbed"? Also taking collagen. 76 YO skin looks younger.

Touching base on the cancer subject, recently scientists from the Institute of Cancer Research in London realized/discovered, because hyaluronic acid is a sugar based molecule, fuels cancer especially pancreatic cancer. Specifically talking about what naturally occurs in the body and supplement form. Aside from fueling tumors, It has been found to play a major role of the density of pancreatic cancer tumors and other types of cancer tumors making it harder to deliver cancer drugs to the tumor. Also, when glucose and other forms of sugar isn't available to provide energy, cancer feeds off Uridine-derived sugar from RNA rich foods, especially pancreatic cancer. It has been known for years that cancer feeds off sugar, all forms of sugar. When one form of sugar isn't available, cancer uses the next form for fuel. What took scientists so long to "realize" that? “If it'd been a snake it would have bit them!” Uridine, is found at different levels in meat including organ meat, seafood, fish, legumes, broccoli, spinach, mushrooms, tomatoes, asparagus, soybeans and soy-based products, whole grains, nuts and seeds, dairy products, beer, bakers, nutritional and brewers yeast. As far as hyaluronic acid goes, so far the molecular weight matters. High molecular weight is great for hydration, joint health, anti-inflammatory, anti-cancer, . It's the low and medium molecular weight hyaluronic acid that has great concern. This is a recent breakthrough for all types of cancer especially pancreatic cancer and breast cancer!

Hi. Interesting. Does this work better than collagen? Thank you.

FYI some people use microneedling devices with HA serums with excellent results

I love your content you’ve gained a subscriber

How about Pycnogenol or Pine Bark Extract to promote the body's own production or Hyaluronic Acid, rather then just taking the latter?

My skin at 42 looks fantastic with Vichy mineral 89 HA serum, Topicals do work, and I notice instant plumping and smoothing, skin looks and feels great.

This is a welcome message because of many unsubstantiated H.Acid messages seen on the internet, other than at this site. Re: reaching deeper layers of skin. Castor oil is reputed to be a general cathartic. When applied to the skin, castor oil is said to penetrate through the skin completely and then drive various detritus toward the nearest lymph duct, effectively cleaning the skin and the subcutaneous layers. If true, could castor oil behave as a carrier and drive H. Acid into subcutaneous layer ? Cleopatra was said to have used castor oil, and they say she was a beautiful Egyptian Queen with many suitors. Edgar claims to have cured many conditions with castor oil between 1900 and 1943, including scleroderma, a lethal skin condition.

Another option may be to inhibit the enzyme which breaks down hyaluronic acid, hyaluronidase. If I recall correctly, a chemical in rosemary dose this. But have no clue about amounts needed and whether topical is helpful.

Thank you, Brad, for this episode. It is both a gentle reminder and rebuke that I should remember to take my HA supplements. It is quite encouraging.

Thank you! Do you know how long the skin benefits continue after taking the supplements? Do the wrinkles come right back if you stop taking them?

Very interesting! I find it hard to find high M weight HA, does it go under any names? Also have you done a video on glycine supplementation?

Dr. Stanfield, what about liposomal hyaluronic acid ? Recently there have been new products on the market which have liposomal delivery. Does it make sense or is it a waste of money ?

Excellent infromation Dr. Brad - clearly another one to explore further.

how was the Hyaluronic Acid taken? i theorize that dissolving it it water is the best i also theorize that dissolving with Collagen and Gelatin will make it better

Chondroitin and Glucosamine and Hyaluronan are winning combo

Great work, Dr! It would be great if you could mention the efficacy of sodium hyaluronate! You know, for the plant eaters ;-)

thank you for listing the source links!

Thanks for the great info! I was wondering about baldness, do any treatments to prevent hair loss work?

Thanks for this. Interesting info and great video. 🧬

This is interesting. I've never looked at the studies. But I always see the difference when using them vs. when I don't.

Keep going Dr S. Much appreciated

It only works in a humid climate. If you live in a sonoran desert (as I do), it will do nothing for your skin because there's no moisture in the air to draw on.

Choose vegan hyaluronic acid produced by the bacteria. Can solution be used on skin when microneedling?

Incredible how it changed your hair color as well.

How can I figure out the molecular weight of a supplement?

Profhilo has been a game changer

Blending Castrol oil and hyaluronic acid together will take the hyaluronic acid deeper into the skin cell.

Ive been using a topical serum and my acne has reduced to almost nothing ( i broke out a lot before using the serum) and my skin looks more even. Reduction in wrinkles? maybe a little. I use the Simple range. In the UK it cost me about 7 pounds. Good stuff

What is the Regimen for this Product? TY

where is this hyaluronic acid derived from??

The Hylauronic acid that you recommended gave me really bad 😢anxiety. Why would that be?

Hello, I have a question. Do you store a lot of water and cause it to float? I take hyaluronic acid capsules and it seems to me that my legs are fuller and so is my stomach. Very best regards 

Doc, 1st, You claim that the 2017 study used both LMWHA and HMWHA appears false. By the definitions, shown later in your presentation, of LMWHA (of less than or equal to 50kDa) and HMWHA (of greater than or equal to 1000 kDa or simply 1Mda) the higher molecular weight HA used in the 2017 study had a value of 300 kDa so is neither LMWHA (below 50 kDa) nor HMWHA (above 1000 kDA) . I'd say ,based upon the 2 definitions that 300kDA is "Medium MWHA". 2nd, your claim that HA was found to be good for osteoarthritis of the knee is, at best, in doubt. The study you cited, appears to be from: "The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain" An 8-week randomized double-blind placebo-controlled trial - Wang, Shyu-Jye MDa,b,∗; Wang, Ya-Hui MDc; Huang, Liang-Chen MD. For which they used a combination of liquid LMWHA with glucosamine and chondroitin. in their discussion they say and I quote, "Yet, it is of importance to note that the oral liquid supplement in our study is a combination of low molecular weight HA with molecular weight between 5 × 104 and 5 × 105 Da, glucosamine, and chondroitin sulfate. As the supplement contains glucosamine and chondroitin which are usually consumed as chondro-protective agents,[25] the potential effects of ingredients other than HA on knee OA symptom relief cannot be denied." I watched the TED talk associated with the HMWHA like you use from Do Not AGE. I believe the Ted Talk presenter may have something to her proposal that the naked mole rats long lifespan may be related to HMWHA and I believe that shar-pei dogs extremely low incidence of cancer might be related to HMWHA (1MDa or above). You seem to be making a point that LMWHA may help against skin wrinkles, I doubt that anyone has a problem buying that. But why do you mention HMWHA at all. And mention arthritis that may just be responding to glucosamine and chondroitin, a commonly used treatment for joint problems? And even if the arthritis thing is, at all, associated with HA, its LMWHA. This presentation is very confusing and misleading and makes me wonder about your association with that "DO NOT AGE" company influencing the quality and even the veracity of your presentations. I will continue to watch your presentations as I do believe I have learned some things from some of your presentations. However, my faith in you credibility has been severely shaken by this (and a few other presentations that I did not comment on). Early on you gave me the impression that you were a highly ethical, if idealistic, intelligent young man interested in the longevity space... however you appear to be getting influenced by the AMA, sponsers and perhaps other interests. I still like you, but I feel obliged to bring this up.

At 3:16, the Japanese company name that you pronounced was not correctly spoken. You pronounce it Kew ( like a long Q) and pie part of its pronounciation is say long sound of P. Now, you got the Japanese tounge to say "Kewpie" properly. 😘 By the way, the Kewpie Corporation is well known company for the Japanese mayonnaise. I bumped into some German ladies who were going crazy in buying their mayonnaise in Germany 🇩🇪. I asked them what they like about the product among rest of other mayonnaise production makers out of curiosity. They told me that the Japanese mayonnaise from the Kewpie has more eggs and the flavor wasn't oily in compared to other mayonnaise available at local German supermarkets. In short, people who live outside of Japan can find such mayonnaise definitely at Japanese supermarket try out this , and I am pretty sure that you could find it at Asian stores. Anyway, I better listen to your presentation further on the hyalronan relieves wrinkles... 😎🥳👍❤️ You know that is also good for your eyes, in case you haven't looked into other subject areas of specialists' studies. Thank you doctor! I am going to check out on the hyaluronan details in-depth. We got so much to learn about the unknowns... 😋 But, for scientific research studies, perhaps your ways of pronounciation may be also correct in serving the purposes of encryption and decode of such encrypting method of understanding. I find it simply 😎 cool.

Idk, doc it seems like you actually started to have sponsored vid from companies and it is impossible to see how genuine you're, there is a huge conflict of interest. I think you gotta do ads very ethically or you might lose credibility and don't even notice it yourself. I tell it with all kindness and gratitude for your work, don't get me wrong.

in love with this topic

❤ If it's absorbed in the Cecum when taken orally....then it can take up to 12 hours to be absorbed...yet it says it can take minutes to an hour (at most)...so what's the answer ???

ACE + HA Takes back 10-20 years younger. Buy bulk mix your own.

This is off-topic, but I've been hearing stuff about a supplement called "Shilajit" and I was hoping to get your take on it, perhaps in an upcoming video if you're open to doing some quick research on it, if you haven't already. Thanks!

I like it when products allow reviews on their websites. I see no reviews online about the Donotage product. Since it is not a well known brand, I am nervous about trusting it.

Excellent content

Kewpie (kyoo-pee) Corp does a lot of things, but are most likely known by most people for their mayo. I work in FSQ at an egg productions company to which we supply Kewpie with egg products for their mayo. They are quite stringent about all aspects of the product and packaging. They do R&D as part of their business. I don't necessarily think they would skew any research data. Of course any business that funds research should still be taken with a grain of salt.

Apparently a high molecular weight is what is required for optimal absorption orally.

I'm using neocells hyaluronic acid serum

200mg is good, but when i upped it to 400mg per day my skin looks even better now!!!

I'm using HA pills since I was 26 or 27...now I am 45...I took them with regularity every single day with no pause...200 mg/day...I guess I could be an experiment myself...I never knew about those studies that HA might cause cancer and now I am really actually extremely worried... I don't seem to have any kind of health problems for the moment but I am worried about what you have mentioned with those studies.

Is it effective to get your HA through bone broth protein?

@DrBradStanfield Hey Doc, is it save or recommended to use the liposomal variant of Hyaluronic Acid?

The great skin hack that I use is taking 5 g all in one day to front load Hylaurronic acid . The effects on skin appearance is tr dramatic the next day

Spending my money on stuff that hopefully extends lifespan + health span is a no brainer for me. Most people, including me, spend money to have fun. But you can't have fun if your health is sh*t or your dead lol. My goal: have as much fun as possible for as long as possible. Therefor it makes total sense to buy stuff like this.

If the bacteria breakdown the HMW hyaluronic acid into LMW what does adding more molecular weight do if it will just get broken down to lower weight? Sounds like no matter what you’ll be absorbing the LMWHA which induces inflammation, no?

Hi! Are Hyaluronic Acid supplements Keto-friendly? I'm eyeing the NowFoods and Youtheory 100mg Hyaluronic Acid supplements but I'm not sure if they're keto.

What about HA with microneedling? Will that help it penetrate deep into the skin?

Thanks, but no mention of the thumbnail. Possible it also altered the grey hairs?. Or was that the l'oreal?

How about HA injectable moisturisers and fillers? Are they safe and do they work?

Interesting. I may just dump the topical version after all. I do use topical B3 which does have evidence of working. I've been thinking about adding a very tiny amount ''diluted more than usual'' of methylene blue into my lotion at night along with my retinols 😅 Would love to see you talk about methylene blue btw.

Hello Dr Stanfiel, despect your suggestion most of supplements in the market provide low molecular weight. Do you know why? Thanks a lot.

I'm on the fence about HA I dont really care about wrinkles and am more interested in the joint health and inflammation. I shopped around and found one that is 1 mil daltons which is borderline HMW but less weight then the DoNotAge one. Since I want it for joint health mainly I'm unsure if the 1 mil dalton one will be okay or not.. anyhow.. i'm gonna try it and see if there is any difference.

Hey doc should I take a multi vitamin or continue to take individual pills? Currently Yakima c,d3,magnesium,zinc,lipoid acid, beet root powder. Going to add b vitamin

Brad is actually 50 years old.

I wonder how does Tremella compares to the hyaluronic acid

Great info. Thank you.

I take 150mg of sodium hyaluronate for about 1 year now im 24 should I continue? since you recommend high molecular and sodium hyaluronate is low molecular I believe.

Very nice thanks for this

The serums do work for a day on my face. I take 200mg per day capsules too. Is that enough?

Great video Dr. Brad! I'm taking the HA from DNA and my nails look great! ❤

Can you talk about vitamin patch and research on those? Iron deficiency generated this curiosity in me. I hate taking pills

Can you talk about restoring hair color what supplements to take and what would help