Sulfonamides are the analogues of PABA thereby they compete with it and inhibit the folic acid synthesis. Sulfanilamide is a simple sulfonamide and can be named as 4-aminobenzenesulofnamide. But this compound is not useful as drug as it forms crystal in urine due to its pka value around 10.6. This can be minimized by structural modifications of sulfanilamide where the nitrogen of sulfonamide is substituted with heterocyclic rings to bring the pKa nearer to the pH of urine.
0:00 Introduction
0:08 Basic structure of sulfonamides
2:06 Sulfanilamide can cause crystalluria
3:39 Sulfadiazine
5:23 Sulfamethoxazole
6:31 Sulfisoxazole
7:40 Sulfacetamide
9:40 Sulfalene
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6 авг 2024
