How We're Reverse Engineering the Human Brain in the Lab | Sergiu P. Pasca | TED 

In the not so distant future, the phrase "I've changed my mind" could have a literal meaning

It is so exciting to know that we're almost getting to science fiction levels of technology right now! This is all so amazing.

This has been one of the most true to form ted talks in years. Brilliant 👏.

It's fascinating how much we can do now with bio-engineering that we are finally getting to the frontiers of understanding brain mechanisms especially since despite the developments in science we never knew how we do the things we do. The fact that it's even happening in our age and time is just mind blowing. I think bio-engineering and genetics is about to go supernova in the near future but people seem to still be sleeping on these discoveries....

Absolutely amazing how far we have come in so little time.

Very informative video..the level of work they are doing is source of awe.

Wow. this moved me to tears. please fund this!

This is fascinating! Scientists are doing amazing experiments. Glad to be in the world of internet with easy access to such brilliant Ted talks. Full of gratitude! 🙏

This is absolutely jaw-dropping!

Felicitari domnule Pasca !!

Truly amazing work

That is so facsinating! It really blew me off and I'm happy to live in such a great time.

I was wondering about this the other day. So happy it’s happening.

Speechless...and in awe...love the future

Brilliant presentation, Sergiu, thank you 🙏🏽😃🧠

this is crazy. absolutely crazy. the first time i got hooked in neurotransmitter was in high School after i saw a movie about ALD disease (lorenzo's oil). and lately im studying abt personality disorder (dsm 5), and these disorder can be genetics bc of lack of neuron in the brain. he is so right. this is huugeee, amazing. lots lots of people with disorders will get benefit form this. i cannot wait to know more in the future!

Thank you for the presentation

it's absolutely fascinating... what a nice time to be alive 👍🏻👍🏻👍🏻

This Ted Talk blew my mind.

I am in awe!!!

The innovative research by Dr. Pasca’s lab is truly awe-inspiring and pioneering. Utilizing this organoid and assembloid technology may afford a not-so-distant future where our understanding of neurodegenerative diseases and other devastating neurologic conditions can be enriched and the prospect of identifying feasible treatments or meaningful improvements could become a reality. I appreciate how Dr. Pasca acknowledged the important ethical considerations inherent to his research. At this juncture, the ongoing research does not seem to overtly violate ethical principles. This is considering that the skin samples are obtained under consent and with understanding that these cells are engineered neural tissue capable of organizing, responding physiologically, and resemble part of the brain, but are not sophisticated enough to have perception or feeling. While Dr. Pasca mentioned the scientific community’s obligation to operate carefully, and communicate ethical questions, societal implications, and potential regulations, the future application of this technology should be subject to diligent ethical evaluation, particularly use in transplantation of these organoids or assembloids into humans or animals. Furthermore, as the science continues to develop, these stem cells will likely be utilized in ways that may not be envisioned right now. With this in mind, the scientific community as a whole needs to hold researchers accountable in order to comply with the ethical principle of non-maleficence or do no harm to all involved. According to bioethicist, Sarah Chan of the Usher Institute of Population Health Sciences at the University of Edinburgh, the benefits of brain organoid research are many and the risks are few at this stage. But, per her account, “if we ever start using brain organoids directly in therapy, as a form of tissue transplantation, then we’ll have to think again about what the risks are.” Ultimately, I believe that with the evolving science involved in this research, we must ensure that ethical considerations and implications are maintained during the research process and match future scientific advancements.

Thank you ....👏👏👏👏

This is insane, I wish this can help us understand more about consciousness as well.

It's almost heartbreaking to me that we won't see the full long term fruits of this labor in our lifetimes. I mean there will be developments and insights but the complete combating of certain diseases will be mostly for future generations to benefit from.

Fascinating

Thanks 🙏

Umbrella Corp got a TED talk!? 😂 No really, this is pretty amazing to watch.

Brilliant!

amazing... amazing... Amazing!!!

Amazing

Fascinating. Reminds me of the other Organoid work that was used to find a cure for the common variety of Cystic Fibrosis. Interesting you refer "The work I do" rather than the work you and your team do. :p

Ted is back!

Very cool.

Astounding, inspiring and primitive, in posterum

This isn't only the future of curing mental disease, but might be the key to fixing the aging process altogether I just wish I'd still be alive and able to access it when we reach this point

How far away are we now before we can start using these organoids/asseenoids?

I hope this research can help people with cerebral palsy and other developmental disabilities.

This.. is amazing. This is the kind of research which will save my entire generation.

Wow!

people are awesome!

This has blown my mind! I think we should focus More on bio-engineering and Upgrade humanitiy befor building AI and lose the top of the food chain.

So when this project a succes one, can they give person another personality or control your personality?

Free Energy Principle proponents like Karl Friston should check out immediately the data associated w/ the auto(ish) connections created inside the (connected) organoids

10:20 did not show the actual video, can he show it next time? Thanks.

it would be interesting to rewire our brains toward thinking, since thinking is very costly for our body we developed to not think. with the amount of easy accesibble food now we could change this.

Very good

Wow

2:36 he pause there a little hoping for an applause, but the audience was stll sceptical about it. 😅

Polio powoduje horoby umysłowe ?

Imagine using these in our computers in the future. Or using it to build robots.

Yep...hopefully I'm dead by the time this really gets going.

Graph theory is gonna be big here

i wish he would help me

pretty crazy stuff lol. hopefully it is used for good only.

I'm studying neuroscience so of course I'm in awe. I would like people to understand that autism can be debilitating, but not always. I think autism is my superpower. I wouldn't care so much about neuroscience if not for my hyperfocus and lack of friends

On the human cortical motor pathway. Your study may time into future transhumant or cyborg study and creation. This is something I’m looking forward to. It’s silly to even think robots could take over the world.

I wish he mentioned that to turn cell into a stem cell you basically use anti-aging technique which can be used in any cell, in any body and will make soon human immortal.

I'm interested in the chemical soup he mentioned

Staggering

The Singularity is approaching pretty soon

If you listen really closely to the neural organoids you'll hear a faint _"What is this? Why am I hear? Life is suffering. Kill me!"_

What ever it takes 2 make us immortal

11:11 they made a homunculEYE

He’s in the historical cloud library

The function of the brain being understood by the brain, not sure if thats a paradox. If the brain is complex enough to understand its own function, is it really that complex? (can we ever really understand it completely?)

This vidio is goat

Can you build a A.I. brain model through full cognitive movements and motor functionality is that a posability

wow...

did he say infecting them with polio virus ?? 11:54

Does this mean we've finally reached the future?

I believe science will create a human being someday though it may not happen in our generation.

This is so radically simplified, it’s unclear what he does or how legitimate the work is.

Great

Nations belongs to its scientists.

Questions: How large and complex can we make the 'human' brain? Would it even still be 'human'? Let me get my brain extension and think about it some more.

What if we and our entire universe are all part of one single consciesness in a brain organoid just like those in that lab?

🙏🏻✨🙏🏻✨🙏🏻

Could we put them back into the brain to extend our brain mass? 😂 Might be a good cure for some people as well 🤪

Stem Cells are amazing. I have nerve damage and something tells me stem cells could cure this damage. The problem is, here in the USA, stem cells are for the rich.

subahanallah

That still doesn’t explain why some people don’t seem to use their brain.

How isn't it a miniature Frankenstein's monster?

Very insightful but scary

Absolutely phenomenal science!!! But, it's so sad to me that any scientific advance ALWAYS becomes WEAPONIZED :(

Omg, soon I can change my brain to rocket scientist

New treatments or new diseases. It depends in which hands it fall's

Funny how i already knew about stem cells from reading mangas

no way

Would it be ethical to grow a conscious brain?

Incredible stuff

There are two ways to study the human brain. One, by engineering it in the lab or use of animal models. Two, by looking within and experimenting with your own brain in a holistic way. I leave it to you to decide which way is the most effective.

This is wonderful, excellent

but does it have consciousness?

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That’s unbelievable, absolutely impressive, thanks for that

That’s scary af

👏👏💯💯👍👍

Holy efffff! This is some insane PR. This is beyond speculative and riddled with misleading ideas.

That is the future but Still far from now.

Finally, Frankenstein's monster is on the way muaahahahahha