I swear, every single time that I forget about this channel for a few courses and feel hopeless because I have no way of putting the information from lectures into context; I rediscover it and understand everything. Great job on this channel, you're a hero!!!
Great video, they're perfect for reviewing and clarifying the mess of information thrown at us in lecture at school ahha. One thing though-- around 2:15 you mentioned that pyruvate -> acetyl coa is done by pyruvate decarboxylase, and correct me if I'm wrong, but I think that the pyruvate dehydrogenase complex does this conversion. I think pyruvate decarboxylase is involved in anaerobic breakdown of pyruvate
Thank you for saving my ass for my exam! your explications is very clear and your scheme is so helpful to visualize. I just discover your chanel, wich is sad because the semester end soon, but at least I can understand before my final exam :)
But why aren't the amino acids that eventually form pyruvate also ketogenic? Pyruvate can also be converted to Acetyl-CoA, which leads to ketone bodies...?
Thanks for this clear introduction to the glucogenic and ketogenic amino acids! I'm a newbie to biochemistry so sorry if my question sounds silly. You mentioned that tryptophan is both glucogenic and ketogenic as it can form pyruvate and then goes to acetyl-CoA to form ketone bodies. How come other amino acids listed in the same box that form pyruvate not both glucogenic and ketogenic? If alanine, cysteine, glycine and serine also form pyruvate, can't they go the other direction and form acetyl-CoA to generate ketone bodies?
Sir, Help me please.. I'm conffuced.. are all essential amino acids transaminated and deaminated? in some books, it was explained that the carbon skeleton of transaminated amino acids would be used as an intermediate in the citric acid cycle, glucose synthesis, and the manufacture of fatty acids. then whether essential amino acids that enter the body cannot be directly used for protein synthesis? must be remodeled again ... if it becomes glucose ... what's the point of consuming essential amino acids from protein in food while glucose can be obtained from carbohydrates for amino acid synthesis?
If you need Oxaloacetate in addition to Acetyl CoA in order to form Citrate, then you had Oxaloacetate from the get go. That is, you have the molecule you need for gluconeogenesis. So what's the point of the citric acid cycle? Am I missing something?
If a molecule of histidine gone through deamination and the carbon skeleton of that histidine enters the Citric acid cycle during the fed state, would there be a net production of ATP?
The histidine's carbons are converted into alpha-ketoglutarate, so there should be a net production of ATP. Catabolism of amino acids shouldn't require any energy input, since the point of amino acid catabolism is to gain energy. Because it's filtering into the Kreb's cycle at the alpha-ketoglutarate step, which is before the ATP-producing succinyl-CoA --> succinate reaction, it should net some ATP.
Why do we use these Amino acids to produce Glucose through the citric acid cycle for Energy production? I mean, Citric acid cycle is used to produce intermediates for Energy production, isnt this quicker and more effective? Or am I missing something
It's because this all happens in tissues that aren't in the CNS. The CNS requires that we keep blood glucose levels up to feed neuronal tissues. When we're starving, we break down amino acids and convert them to glucose through gluconeogenesis or to ketone bodies that feed into the Kreb's cycle. This is more of a last resort for the body, as it's using proteins and muscle tissue to feed the CNS. Typically, we use glycogen or fatty acid oxidation to feed the brain instead of amino acids.
Thank you soo much!! I was so confused about why acetyl co A couldn't be fed into the cycle and produce glucose, and I had searched everywhere (and given up), so thank you soooo much
Maybe it was saying that Met, Val, and His are all only glucogenic, not that they are the only purely glucogenic amino acids? If not, then yes, it is wrong. Most amino acids are purely glucogenic.
ak can you please get a nice collared shirt with a small logo on it. haha I'll wear it to pharmacy school. your videos are amazing, the grad level videos are spot on jkeep up the good work!
