What's funny is that this game somewhat predicts the plot of Arkham Asylum considering that both involve the Asylum being taken over, both have Zsasz, Killer Croc, and Poison Ivy as one of the boss fights, both involve the subplot of rescuing Commissioner Gordon, and facing The Joker at the end. The main difference is that you also have to confront Ras Al Ghul after beating the Joker since Arkham Asylum was just a level and not the whole plot along with Joker not needing to take a super steroid.
To be fair, the plot of the villains taking over Arkham Asylum is pretty expected. You get all those villains in one place and it's sort inevitable. Like Arkham City.