I made some of this once from almond extract and RC fuel, lol...no crystals though, it was more of a test than anything. Great video, Shulgin would be proud of that +95% yield!
Yeah kinda surprised at how well it worked. There has to be a little water or solvent in there tho. I tried to get it out under vacuum, but we will see after it’s in my drying chamber. Can’t wait for your next one brother!
I remember him writing about the potential of writing at "HiHKaL", or "Histamines I Have Know and Loved"..... i know Hamilton Morris has done A LOT of great work & interviews/videos & research into all kinds of 'chemicals', and he HAS brought up the Shulgin's many times; but i wonder who out there might have any logs, journals, notes, research notes, etc., of Alexander & Ann Shulgin....🤔 I would LOVE to see/hear somebody go into some depth of the "Histamine-IHKAL" idea, AND if theres any sort of existing journals or notes of theirs that hasnt been published in their well known books. Or just any of material, period. They were both brilliant in intelligence, emotion, & Spirit. RIP Sasha & Ann Shulgin. .....the Shulgins I Have Known & Loved ❤🔥⚗🧪🔬💊 You are greatly missed & highly respected 🙏🕉☯
Theres a nonprofit, also the shulgin index and pages of notes as well. Also he did write a book before he died archiving various Isoquinolinkids @kaebee1129
I hadn't realized Ann had passed 😭 I was fortunate enough to have attended Sasha's memorial service (appropriately held at Berkeley School High!) They were both brilliant minds and lovely people.
well done sir enjoyed that, we all miss alex his methods of figuring out new pathways of subtituted phenythlamines hopefully that research continues its interesting to know whats still possible discoverable new compounds with research
Yeah, β-Nitrostyrenes just oiling out is annoying. Beautiful crystals you got there. But the 2,5-dimethoxy substituted ones are even prettier. Those shiny/sparkling bright orange crystals are a feast for the eyes. Great video. Keep it up.
I really appreciate you taking the time to make videos about certain questionable compounds, they’re more interesting than most other people’s chemistry videos. And way to pay respect to Shulgin 😊
Shulgin was a great man who had a rare talent of being able to predict certain things in the future. Still wish I had all his letters from the early 90s.
2ce was one of my all time favourites. And the candidate list is very long. Oh how I miss the days of discrete and responsible sharing of 'research chemicals' across the planet.
@@kirkc9643scene is still going obviously most of these are gone, tryptamines are mostly ignored by feds. Scene did get fucked up by all hedonistic compounds
As someone who is a huge fan of shulgns work I would personally love to make a large batch of 2C-B or my favorite 2C-I. It's such a amazing drug it sucks very few humans have tried it. It puts mushrooms and lsd to shame nearly impossible to have a bad trip on 2C-I set and setting doesn't seem to matter with that class of drugs. The body feeling of mdma with the crazy visual of high dose LSD.
I once took 250mg of 2C-I and I tripped hard for 17 hours the come down lasting about a day. These were the early days of the silk road and erowid wasn't a thing yet. I never missdosed myself ever again that's for sure.
@@Scotty-vs4lf Oh I did them again I was just careful. But I'm 36 now and I probably only have a mushroom trip once every 5 years. DMT on the other hand is short acting so I'll do that occasionally.
@@Widderic i more meant that either u learn your lesson or accidently overdose lol, but thats obviously not as much of an issue with psychedelics just out of curiosity do u ever do dissociatives?
@@Scotty-vs4lf I experimented with dextromethorphan in highschool and had some of the most intense fractal visuals I've ever had. Other than that, I experimented with ketamine for a little bit but was never into disassociatives all that much, they made me feel awkward and anxious.
Wording in procedure is so damn important. I wanted to prepare N-(2,4-dinitrobenzenesulfonyl)-2-formylpyrrole by reaction of 2-formylpyrrole and dinitrobenzenesulfonyl chloride. But couldn't get it done with KOH as base (according to procedure). Had to do it with NaH and still got only ~20% yield (report with KOH gave ~55% yield).
Still my favorite online chemistry teacher! I remember reading thru Sasha's findings and being absolutely obsessed! Even managed to make it out to his property once! I'm so lucky to find so many interesting people in this life
Best video and channel on yt !!! I was a Chem major at Santa Clara University In 1973. I was 2nd in my class. Ended Up as a Dana Point, California Real Estate Broker for 45 years. Now retired. Still think Chemistry is the Language of the Gods!!! Absolutely Fascinating !!! Mark
John was a gift to thousands of garage chemists around the world. A great dude who took the time to sit down with anyone that needed help understanding or solving a problem. He had the makings to be a great chemist. But unfortunately a life time of drug use and the resulting mental illness is the story we have to tell.
Impressive work! I would love to see yiu try your hand on (2S) N-methyl-1-phenylpropan-2-amine, very interesting substance, and would make a hell of a title!
It is likely that beta-nitrostyrene can crystallize into a few different polymorphs, hence the differences in color/recrystallization patterns. It would be really interesting to isolate a few of the polymorphs and perform a melting point analysis on each of them!
Having an oil might be fixed by using a starter crystal of b-nitrostyrene as a nucleating site. Great vid man! I’ve thoroughly enjoyed seeing you progress from where you started to now!
Just a small advice, if i can say something here, but it would be great to have the molecule of every reagent you add next to their name, so people who are not chemist know what you're adding. Anyway great content, im subbing!
Shulgin is responsible for so, soo many of the most intense, beautiful, and ultimately important and transcendent/transformative experiences I’ve ever had the opportunity and/or pleasure to submit my ego and soul to.
The colour change when you add the recrystalisation solvent is probably a solvent dependant effect caused by the aromaticity of the whole molecule. It would be interesting to see what other colours you would get with a range of polar and non-polar solvents like DCM, DMSO, acetone, THF, etc.
I know a similar synthesis with nitroethane and benzaldehyde. N-butylamine was the base. This was perfomed without any water but toluene as a solvent. By refluxing with a dean stark trap the water was removed. As water is one of the reaction products the reaction was driven forward and after cooling down the toluene and recrystalizing from isopropanol the yield was about 95%. Nice bright yellow huge needle like crystals which cause allergy like Symptoms upon skin contact.
everyone I knew who made the mistake of going into synthetic chemistry for grad school and shortening their lifespan due to 80 hour work weeks, frustration of teaching intro labs to Pre Med undergraduates, and the constant anxiety of seeing their total synthesis PhD projects scooped at the end of their 4th year always took the Pihkal and Tihkal preps and quoted yields to be either an amalgam of multiple, un-connected, repetitions of each (ie the optimization results for each), or straight up lies Shulgin's reputation and position in the lore and mythology of this area of culture will never be supplanted, but its a simple fact: David E Nichols and his grad students contributed more, with more concrete importance, than Shulgin by about 3 orders of magnitude. Shulgin's books even include his synthesis of Nichols' inventions
@@chemdelic I remember from university geting better yields (substitued benzaldehyde, longer nitroalkane) by using anhydrous methanol and THF 1:3 by volume as a solvent; to a saturated solution of given aldehyde in this solvent a 20% excess of nitroalkane was added and diethylaminoacetate was used as a catalyst. Solution was left in cooling water bath overnight. Next day the solution was transfered to a beaker and left to cool in a fridge. The resulting nitroalkene crystallized in about 2 hours from the solution, the crystals were filtered and washed on filter with more of the solvent (cooled in the fridge beforehand) and the product was used in further synthesis. Of course, for academic purposes only.
There is a 3-4 methylenedioxy analog of beta nitrostyrene I’m assuming? Will this same procedure work if you start with 3-4 methylenedioxy benzaldehyde (piperonal)?
is what happens to something chemically during a high velocity impact the same as when a compound is exposed to extreme acceleration of equal force? I'm thinking even if the force is equal between acceleration and impact what happens to a chemical mixture isn't the same. the root of my question comes from a box of exploding air gun pellets I recently bought. using my mass accelerator, at 800fps they work as advertised. what would happen, if anything if I launched them at 2000fps. would it go off in the accelerator or act normally. the chemistry and the physics are a bit beyond my ability to determine theoretically I want to understand what's going on before I experiment with things.
Probably that your product was stuck in the methanol phase. In this case, your product is really insoluble in water, so it could pull methanol out of the water and stay as a solution. You could've tried to put the oil in vacuo and see if any crystals formed. Since you dripped the acid in the methanol/water phase, the concentration of methanol was slowly decreasing, thus forming an oil. By dripping the methanol in the acid, you essentially drop the methanol concentration to basically 0, making the product precipitate.
Thank you for your efforts. Please Can you make a video about the synthesis of sodium ethyl sulfate from sulfuric acid and ethanol with sodium carbonate without using any other materials?
A vendor of grey market chems had this a while back and it was before i had access to 2cb so i almost bought it. Ik its not active but it was just having smt close to it was cool
A part of shulgins legacy with psychodelics is changing your life for the better and living healthier. And while psychodelics help heal the mind, do you know what really heals the body? Thats right, it's BPC 157. Could you make me while again by showing the process of making it one day as well?
I tried that for a tendon injury, I think the TB500 was much better. Then again I was doing a lot of rehabilitate it at the time, was it the combo or just that it'd already being healing for 18 months by then.
If you drip your nitroaldol product into a "sea of HCl" it can't react with itself. If you drip HCl into your concentrated product where it's surrounded by other unhappy nitroaldolly boys it will very much react with either its neighbours or intramolecularly with itself depending on what decorations you have on your styrene
