Making Adrenaline 

best vpn add tbh lol

Can you synthesize melanin🎉

Got an adrenaline rush from watching with great synth. :)

I was wondering how to select between 1alpha and 2alpha methyl 4,5a- dihydrotestosterone? And would it be possible to add a 17B- undec-10 enoate ? I just don't know how selectivity on positional placement

I think the right word is "consumed". They've been consumed by the chaos. Lol

Thanks to NileRed creating mainstream media we have this kind of channels

nurd rage started it off

It was actually much better a few years ago, many active chemistry channels either got banned or left when RU-vid started cracking down on certain chemistry subjects

At 4:25 M*thylamine ha-ha Wowza :D

@@semesabrown8203Going after drug adjacent chemistry videos is like banning the use of 2x4 brick in lego sets.

Too

It's ok. Have you ever seen a video of gazelles giving birth? That baby has to hit the ground running or it gets eaten by the first predator that sees it. That's similar to how Australians are raised. A hostile environment is what they thrive in.

@@xWonderxBreadx 🤣

I‘m not sure it is bullying unless there‘s more beef going on in subrabbits etc.

😂😂😂

What does that feel like?

Do you age fast because of it?

Bill Gates entered the chat

@@jamesbrown99991 adrenaline isn't adrenochrome

@@taiiiz3969 if you get an EpiPen and inject yourself you can find out lmfao they're just adrenaline, or sudaphed is almost the same chemical and reacts very similarly in your body so that would probably be easier to get an idea from, it probably won't be exactly the same but it's like Adderall and meth, people who have done both usually say they're basically identical feeling

The power of enzymes

​@@giuseppedelcuratolo1589Exactly. Once our department head (a pure chemist) said: "come on if that enzyme can do that reduction in 99% ee, we can do it in the lab too". I was just standing there like: "No, just no" Enzymes can achieve precision that is unmatched. It's crazy how evolution turned amino acids into peptides and then proteins and enzymes which perform their task in crazy precision. Take Candida mediated terminal oxidation of alkane chains to carboxylic acids. Even when labile functional groups are present. We need multistep reactions and harsh conditions to do the same thing and need to protect all labile groups.

Evolution.

Love the reaction theory instead of just mindless mixing chemicals.

Keep us updated on what impossible hunts the chemistry people send their apprentices as pranks.

@@Kenionatusshes gonna make YELLOW chemistry

Is this the same as a laboratory technician?

Which is easier for a conspiracy to do without getting caught: traumatize hundreds of children and purify adrenochrome from their body fluids, or suborn one single chemist to buy it for them off Sigma? I mean, I'd think natural products extraction is enough of a pain in the ass without hundreds of traumatized children screaming and attracting police attention.

Of all the things to take from a hunter s Thompson book..

What's also funny is even if it were a super complicated compound only available biologically, the first thing we would do is splice the genes for it into yeast and brew it by the hubdreds of gallons in giant vats like beer.

Many of these conspiracy theorists are mentally ill genuinely. I say this because my father is borderline psychotic and he expresses it with his world view. When he went on a tangent about adrenochrome, I let him say his piece. I didn’t interrupt, I listened, I tried to understand. Then I asked him calmly if I can provide another piece of data. That data was a link to a complete synth of adrenochrome and a link to a site to BUY adrenochrome from a chemical company for the measly price of like $40/g. This changed nothing in his mind. No shift in perspective. No reconsideration of the “facts” as he sees them. (Bear in mind my dad has a successful career and supports his family with an honest career. He is “normal” to society) That was when I realized his world view is unreasonable. Not unreasonable in the sense that he’s difficult to reason with. Unreasonable in the sense that he is “not comfortable to reason” which is the dictionary definition for unreasonable. Rather than reevaluate his personal view and consider concrete data, he just…doubled down. It’s one thing to believe child’s blood has special powers. It’s another to have your theory disproven and instead of find a new explanation or new theory, you just double down on the same one despite evidence?? That’s a deficit in critical thinking and reasoning capacity. Years later, I understand my father is mentally Ill and growing old. I wouldn’t be surprised if he is unable to care for himself 10 years from now. It’s sad, but also scary that so many “normal” people especially of old age are clearly mentally compromised and their higher thinking is at a deficit or compromised. 10 years from now I doubt my father will be “normal” like he is today. Thanks for your comment. Hope this made sense

@@rileymerson8781 That made a lot of sense-- well, as much sense as a discussion of conspiracy theory ever can. I'm sorry you're going through that with your father. It must be distressing to watch someone you are close to lose grasp on logical thought processes. I've started to think about different types of falsifiable theory recently. Normally, we criticize a scientific theory as "unfalsifiable" if it doesn't make any testable predictions. But I've noticed that many conspiracy theories are unfalsifiable in another manner: they make testable predictions, but their adherents refuse to consider falsification as a possibility. I don't understand the psychology of it. Perhaps it's the rush of knowing a secret truth, the pleasure of being part of a tight-knit community (of conspiracy theorists); combined with a disinterest in self-criticism and the dysphoric feeling of being proven wrong. There are some really really obviously wrong conspiracy theories out there, and some people who believe them no matter the evidence. But again--I don't really understand it.

Adrenoreceptor activators come in many tasty shapes!

Actually, it does not know and absorbs things in a non-specific way. But as long as your sample is relatively pure, you'll get a higher purity sample at a cost of small yield loss

But why ? I do understand why crystallization does improve purity thanks to the equilibrium of every species : X(solution) - X(s) and that considering the composition of the solution doesn’t change the solubility of the species that much. With carbon, you could write a similar equilibrium but I would have say that having a concentrated solution of A would favor A(adsorbed) over B(adsorbed) (with B an impurity, in smaller concentration), because the carbon would saturate itself with A ? So as a result you would loss as much of A than B and conserve the ratio ? Idk… I can’t think it right I guess but if you have an explanation it would be welcome !

​@@Tom-to7dy I have found some claims that activated charcoal preferably absorbs conjugated molecules with high MW (which are usually colored), which makes sense considering that activated charcoal mostly used for decolorization. So not 100% "non-specific" I guess...

@@Tom-to7dy It is just a gamble, sometimes the only thing charcoal does is steal some of your yield. It can absolutely happen that it binds much more strongly to your desired product, there is no easy way to predict it. You just have to try it, and note down the results so that the next person doing the same reaction is better informed.

In the video's Friedel-Crafts reaction, the byproducts are likely oligomeric conjugated molecules resulting from the oxidation of catechol, so activated carbon appears to have worked in the favor

@@peepeepoopoo5932 I was working on my own dopamine synth long before Pyrotechnical scooped me, and I ain't stopping progress until I HAVE PURE FREEBASE DOPAMINE

Go for it my guy.

@@breakinglegsandbreakinghea3167 thanks man! Math never made sense to me but this time I can see the rhyme reason & beauty. I’ll update this comment when I take the placement test in a couple months and let y’all know how it went

@@toomanycactus3138huge W, commenting so youtube (hopefully) notifies me

Adrenochrome is just oxidised adrenaline

/tinfoil hat just get traffic children for the elites you will get some

It's kinda scary/funny how easily convinced an entire group of conspiracy theorists were that it *only* comes from sacrificing children and that politicians use it to stay young. I know perfectly intelligent people that would normally be smart enough to look into it and see how easily it could be synthesized by a decent lab that would totally avoid using their brain just to believe their echo chamber. Sad state of politics right now :X

@@friedrichvonsnatch3501 Yes. Exactly. It is in the body in low amounts but usually people have many pathways so that it does not stay stable in the bloodstream. It's a hypothesis of Abram Hoffer showing that it has psychotomimetic properties like LSD or mescaline. It's a theory but he has many studies showing that psychotic symptoms can be reversed by high dose niacin (B3) and vitamin C as an over-methylation and oxidation happens in these people from chronic stress and malnourishment. He did ingest some and gave him paranoid depression for a week. The science community ignores it. Call me crazy but this guy has cured dozens upon dozens of psychiatric patients and got "debunked" by the usual fact-checkers.

​@friedrichvonsnatch3501 is it true that it gets you high if you take it?

I once worked on photoswitchable diazo PROTACS and I kid you not, I went through a complete rainbow during the multistep synthesis. From white to blue, to violet, yellow fluorescent then green and in the end after diazo coupling a pure red. This was really nice.

you're trying to say you do meth??

adderall

SNRI?

venlafaxine ftw

yup, atomoxetine

Not exactly anti-profanity I'd guess but yeah.

It’s to prevent any chance of the video being flagged 💀

Crazy right, fucklyamine is a common and useful chemical. So sad.

Lol I think we synthesise it from amino acids instead

@@vicesimum_phi8123 Levodopa

Tom and Joey, according to the video

​@@NebulonRangerNilered is called Nigel

Why did u censor the word methyl?

​@@kingmewto7148 To poke fun at the censorship. Methyl has the letters meth in it - the narcotic drug methamphetamine is also shortened to meth.

You can't make meth with methanol

Activated carbon is good at binding with colored impurities. Can't tell you the exact mechanism as I don't know that level of chemistry, but yeah, it is quite promiscuous with its adsorption. Binds to a lot of stuff, especially stuff wit visible light color and ions, and if it doesn't bind to your product, it will pull a bunch of extra random stuff off. Really, solvent washing is not much different from that. Chemical reactions are a random process, you just try to select for the one compound you need. Were you to make the chemical that activated carbon would adsorb, you would simply not use activated carbon to purify it. Among those that you've seen on youtube using activated carbon, none were of that type because people generally know what they're doing. P.S. Maybe you should do at least a cursory internet read before assuming that a widely industrially and chemically used purification method is snake oil.

@@uncleal thank you, it seems i didn't even try...