Making and Tasting the COLDEST Substance Known - Icilin 

tasting your own chemicals just like the good ol days

Pretty chill molecule.

Mix it with Capsaicin, Bromelain & Malic acid and apply to tongue.

OUR BOY BEAT THE LIT YIELD % EVERYONE!!! CLEANEST CHEMIST ON RU-vid #1!!!!!

11:40 I like the fact that you use gloves to handle the product, but at the same time you spread it on your skin 🤣

You have the coolest taste for chemistry subjects for these videos. I enjoy your work. Keep it up!

Can't wait to try this on my mucous membranes!

Random but I really hope someday a talented chemist will be able to discover a pain killer that DOESN'T cause negative physical reactions once someone stops using it. If someone can discover that it could genuinely change the world and improve so many peoples lifes. People that have never experienced physical withdrawals don't fully understand. Someone can fully be mentally ready but no matter what you do, physical withdrawals are completely unavoidable and it makes you feel like an utter failure and our society has a very misunderstood negative perspective on physical withdrawals and physical dependency. I truly believe if some scientist could discover something that doesn't cause physical dependency but helps with pain relief, then I really think it could positively impact the world.

I'm surprised you experienced such a mild taste from the DMSO. I got a tiny drop of it (lab grade) on my skin and a minute later there was a disgusting onion/garlic taste in my mouth. I also visited a veterinary barn where one of the equine patients with septicemia/toxic shock had been given 20cc IV DMSO and the whole place stank to high heaven for the rest of the day.

I've got an exercise in awful for you to try. Isolate whatever is in a green persimmon, the small variety, that instantly dries the mouth and even the teeth, and taste that. I've never experienced something else that could make my teeth dry.

I wonder if the high cost of certain chemicals (like Icilin) is due to lack of economy of scale. That is, you're essentially paying some other chemist to make your specific order just for you, rather than paying some amount from a much larger batch (possibly made by the same chemist).

Your explanations of chemical transformations sound like some strategy war game steps.

I was eyeballing this chemical for a while now, cool to see a video about it

0:50 example of Sigma Aldritch being Ligma-Baldritch

Fantastic. Always enjoyable and well explained

Surely ill buy chemicals from a stranger online to taste! ;) Your tasting is well documented, great stuff

You are the best practical organic chemist on you tube. I need about 2 or 3 lifespans to get really good at chemistry.

Very cool heterocyclic chemistry! More of that please! For the dihydropyrimidinone reaction, maybe you could have avoided the initial precipitation and vigorous HOCN gas evolution (apparently poisonous) by adding KOCN into the AcOH solution of your starting material which would allow for a controlled formation of HOCN. Then add HCl to drive the elimination of water. But again, love the target molecules you're making. Keep it up!

Man I really love this Kind of videos

I kinda want to try using it in cooking.. Putting a tiny bit into some refreshing fruit deserts during the summer sounds banger...

Nice concise video, thanks!

damn i didn't know u were chill like that 😳🥶

You make awesome videos!!! ❄❄

That stock footage of the lab guys is hilarious

Please synthesise conolidine! No lab will make it, it's too complicated they say. It's not illegal, it's a calcium channel modulator and ack3 blocker, it's a fascinating molecule. Con-ol-idine. It comes from Tabernaemontana Divaricata plants. There is a published write up for its synthesis. It uses unusual metal salts in the synthesis.

It's 6am, I should be sleeping.

Oh, finally i got it... I ll open it, taste and measure nmr tomorrow

Best vid ever

Ive always wanted to try icilin

Erythritol is similar, I think. That slight “coolness” is gives to chocolate makes me think it activates the same receptors.

i'm surprised this isn't used more, given how easy and cheap it is to make

Sounds like a good ingredient to use in my limonada.

I'm glad I found this channel because nilered was getting boring with barely any uploads except shorts. Bye nilered, hello Chemiolis 😊

Screw spice tolerance, don’t talk to me until you got your cold tolerance up

Good old DMSO - always enjoyed how quickly the taste of oysters appears when it touches skin. Usually advised to use 85% aqueous since it's hard on your skin if it's pure....(some people use it as a topical analgesic, but the readily available MSM (methylsulfonylmethane) apparently does the same thing....did you know that MSM was briefly a controlled substance in California?

It's interesting that making double bond at @10:00 does not go towards the creation of the long conjugated system of double bonds.

Cool chemistry you got here 😂 🥶

I have actually vaped ws24, but am very interested to try icillin!

my org chem lecturer would scream that you deportonated at the enolisable positions but did not show the mechanism as proceeding through formation of enolate followed by carbonyl reformation to kick off diethylamine, instead going directly to the ejection xD

Could it be that the reaction of acetophenol is driven by anchimeric assistance (aka neighbouring group participation) of the carbonyl oxygen? This would form an oxocarbenium intermediate, which is very sensitive towards nucleophilic substitution and would definitely allow this specific substitution to occur at mild conditions.

how like how for the first time he has made more than the literature says

That would be awesome to add to drinks just so they taste cold even if they arent

A little suggestion: using your Eppendorf pipette for highly corrosive and volatile liquids like conc. HCl will dramatically decrease its lifetime because it can corrode the mechanical parts inside. At least that's what's been told during my undergrad.

Need to put this in my pre workout…

i wonder if 'chewing gum' companies like extra/wrigleys/orbit etc would love this stuff to be encapulated in some kind of nanoparticle to make a chewing gum that would last forever or at least much longer than anything out there right now.the cold peppermind and wintergreen sensation is what everyone loves and associates with the flavor lasting a long time. so interesting!

I want to taste this molecule!

I mean, it reminded me of the toffees I used to make at home, with Chili and Menthol Flavor... I called them the Hot and Cold. Very strange feeling eating them.

now make toothpaste :)

How is „potent“ vs „strong“ defined? How can something be stronger but less potent?

danm i wish i had a lab so i could make it and sell it at half or quarter price. how much would it cost to setup making it on average since its easier than most other things?

Would you be willing to cover RB-64 at some point (salvinorin derivative compound)?

Hi Chemiolis, great vid. I was wondering, where do you get your reaction mechanisms from? Do you draw them yourself? Thanks!

This is straight up alchemy

Taking "got ice in my veins" to a whole other level

Have you tried making candies with it? Like heating it up with a little bit of water and a lot of Saccharose (and maybe some glucose) till all the sugar melts Then letting cool down in small pieces (basically making menthol candy on steroids) The this could distribute it rather well in the sugar and make it easier for the rezeptors to detect

Okay but how do you predict the way molecules will rearrange themselves within the right conditions with the right reagents? How do you ensure the chemical bonds as intended? Is it simply chance, followed by a gleaning of the intended chemical?

ICEEE 🥶

Heat? Very interesting. I have some menthyl methyl lactate, I wonder how this compares. I'm guessing the heat is because both propylene glycol and DMSO are causing a heating sensation when they pull moisture from your mouth, or are actually heating up from exotherm.

Good job and interesting molecule!

@NileRed should do this too

they sell propylene glycol at pharmacies as a pure powder to treat constipation

Quick question, how do I learn analytical techniques and literature like this?

Is it really chemistry if u don’t taste the products?? 🤷‍♂️😉🍻

Can you involve the papers that you used?

I want an Icilin vape!

bro skill issued literature OMEGALUL

Where can I buy Icilin? Thank you

Mom can we get NileRed? No we have NileRed at home NileRed at home:

Is it not lipophilic? I was a bit surprised when you said “this leaves me with one option” and it wasn’t an oil.

Well that was a good peek into the world of chemistry, My probably (at least to the best of my own perception, grades aside) least understood school subject, that I've never further build upon after end of High School. Considering how most of what is going on inside humans is affected by exactly stuffs like that... Imagine what the people that understand, understand this science do... and can do... Like that was a week long process by a single person to make an bubble gum compound on steroids, now multiply that by 100ths of staff members of well funded government orgs operated for years upon years, having all the previous research and know how available. Well ~or private.

Great video thanks for sharing

if menthol is used on drinks to make them fresh, would it be viable to make an icilin soft drink?

I think a really cool project for you to consider is making ferrari pigment red

I was stoked to see this and immediately wondered "what about the WS- compounds?" Interesting historical note, the WS in WS-5, WS-12, and WS-23 alludes to "Wilkinson Sword", a shaving products brand that evolved from a gun manufacturer in Great Britain started around 1775. Apparently they wanted better cooling sensation compounds for things like shaving creams and discovered some that are now in chewing gum and pretty much everything else. Which brings me to the question: Why doesn't Japan approve amides as food additives?

DMSO with WS 12 may have potential as a pain killer. However the enhanced solubility of DMSO may lead to toxicity. I don't know if it been greatly researched? I plan to show how to make DMSO, copper nanoparticles and spearmint essential oil extract.

This is like the fentanyl of spearmint

I don't understand what you mean by 2.5 times stronger when it at the same time needs 200 times less of icilin than menthol? Please explain?

Solomon's Preparation

Propylene glycol. Interesting. Could it be used in vapes?

Get John Cena to promote it when your store goes online. I-Cilin is the new Bing Chilling. 🍦❄☃️

is it safe to randomly taste a chemical without doing some tests before? i dont know anyzhing about chemistry but to me it seems unsafe/dangerous. wasnt one of the chemical something with cyanide?

Do you take suggestions? I think it would be cool to have a video detailing the differences between food grade/lab grade/industrial/military etc chemical preparation.

What happens when you mix capsaicin with icilin?

🥶🥶🥶

Canada is watching....

this guy spills less without a funnel than chemdelic with one

DMSO is tastable???

Icillin probably is so inaccessible because menthol is dirt cheap and easily available.

Did you characterize it? Maybe the yield is so high because of some unsoluble impurities

you should try drinking cold water after tasting it to get the full experience

I assume at some point soon, one of the chewing gum companies will use this in their mint gum.

Yellow chemistry

WS-23 is one I hate, its frequently in E-Liquids and the cold sensation is waayyyy to strong in the throat it actually hurts breathing in after if you vape a good amount

What if we put it in a cig

now make a chewing gum with it

Bro shulgin'd it😭

How many weeks until somebody tries to vape this stuff

Да, хорошие синтезы автор проводит.!

So you basically made 240.000$ worth of icilin 😎

Chemistry is very interesting, but in indian high schools we have to just remember organic name reaction and whole s,p,d,f block elements reaction. We learn 99.5% Chemistry theoretically. Teacher asks Chemistry practical question svia theory 😔. No one gives importance to practical and experiment...