@Chemiolis I have a video idea and if you do it then please give my channel credit for this peptide synthesis method that doesn’t require coupling reagents or protecting groups. L-Tyr-L-Gly Synthesis: Chloroacetic Acid and L-Tyrosine reaction using DMF as the solvent L-Phe-L-Asp Synthesis: Chlorosuccinic Acid and L-Phenylalanine reaction with using DMF as the solvent
An Erlenmeyer won't cut it. Far too cheap. It has to be something that hurts. Like a Vigreux column with vacuum mantle. Bonus points if it's your favorite one with the perfect length that you can't find anywhere for purchase.
Oh neat, after noticing a lot more truffle flavored products I suspected there must be an artificial flavoring that mimics it otherwise they'd be much more expensive but forgot to look into it. Thanks for filling in that gap for me. With how simple this is to synthesize its no wonder it's become so widespread.
It’s really common to use a form of black truffle that’s easy to find, but pretty much flavorless, and then add this chemical on. There’s a whole video about this by Ethan Chlebowski: m.ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-KKddfnuQtd4.html
Thanks for the demonstration. The explanations of the reaction mechanisms are always quite valuable (it's the ketonic decarboxylation using barium demonstrated in the video of cubane synthesis that gave me confidence that I could use readily available calcium carbonate to get the same reaction, because both cations will attract and link the two carboxylic acid groups. In theory, this could provide a way to use the final metabolites of microbes, such as acetate, propionate, butyrate to make useful ketones). On top of that, the audience actually gets to see the reaction as it happens, which provides much more detail than text.
@@alexpotts6520 either or is fine, if you enjoy recycling or turning things unthinkable to something thinkable, is worth more. This is why he has more subscribers. This helps many fields, while this helps one. Synthetic foods is quite a thing, and recycling into FDA used foods is harder. So. Enjoy being a basic trash troll. Just letting you know, you can make MANY things out of paint thinners, take grade 11 chemistry bro.
Putting the practical aspect aside, these chemicals wouldn’t be that hard to synthesise. Not to be bragful, but since there are no contiguous stereocenters to be set (and quat carbons thankfully) taking the assumption these chemicals will exist as racemates in nature, although there are olefin isomers. Aside from that, good luck with the practicals (I have never dealt with many reagents in a lab before)
It's well-known in the myco community that you can just leave a white truffle in a container with an oil or butter, and the aroma itself will infuse into the oil. I wonder at what stage of this reaction it becomes safe to do just that, rather than trying to get an isolated form. It'd have to be the only thing in the solution with a high enough volatility to evaporate at whatever temperature the process was done at, but maybe somewhere in the chain of reactions you can stop and let the volatility do all of the work?
There’s a truffle native to the southern United States that goes into symbiosis with pecan trees. Sometimes it’s found in pecan groves. Getting various species of truffle to partner with suitable trees being planted… the success rate is supposedly getting better and there are groves of such trees. We’ll see how well it works.
I did some research and asked if one can make cubane from hexane or Cyclohexane, and it looks a bit simpler than the cubane synthesis you did. They do mention that the yields are quite low, but would be interesting. The hexane to cubane synthesis apparently uses metallocenes as catalysts😅, sounds like quite the intersting topic if you want to revisit the cubane synthesis
That list of aroma-active compounds is fascinating! Most of them I can understand, but what's up with 3-Methylbutanol? Roasted, Winey, Onion-like? Those things aren't particularly close to each other. Has anyone here smelled it before?
I probably never tasted or smelled real truffles as the cheap truffles I bought are probably fake. This chemical likely smells more authentic than the one I bought! Btw, the literature value of 98% yield is incredibly high!
It's a simple reaction with very little possibility for side products. The yield from turning HCl and NaOH into salt and water is 100% because there is no other route (unless impurities are present).
@@andersjjensen I understand that the reaction between HCl and NaOH is straightforward and high-yielding, however, I don't think this analogy suits this organic reaction very well given that their nature is quite different.
@@DangerousLab It isn't, many organic reactions also have acid base reactions steps. The reaction in the video also as acid- base reactions, both lewis acids and bronsted acids.
Im completely new to chemistry and would like to know where to start to know how to produce these things. Any videos, playlists or books would be very helpful! 🤔
It's really diving into the deep end but you could always pick up a used organic chemistry textbook, it will explain all of the basic concepts of electronegativity and mechanisms for beginners, then go super deep into everything. If you like the more casual side of it, this channel and Apoptosis are great for intro videos that show you random little things that can also be extrapolated to other chem.
OHHHH YESS theres this chips brand with a truffles flavor and its sooo good. ive known that theres no way that its real truffles, but well how did they make it truffly. this is great
Ideal properties of reaction solvents: 1. High solubility of reagents 2. Chemically inert 3. Easily removed from product 4. Inexpensive DMSO: #2 is optional, right? (Also, is #3 a joke?!)
@@christineg8151 I've used a lot more DMF than DMSO, but DMF is like DMSO Lite™️ when it comes to removal. What kind of products are you trying to isolate from it?
@@CDCI3 Water-soluble Azo dyes. Thus far, my best luck has been precipitating them out with dichlorimethane. Recovery isn't 100% (closer to 70%, tbh) but it's good enough, since I'm usually recovering them from NMR samples, rather than reactions. Reactions get run in DMF, and those crash out pretty nicely with ether.
@@christineg8151 Azo dyes, assume there's at least one aromatic group in there, so it might not help, but maybe a little toluene would crash it out? Or maybe ether with just a little DCM to help the DMSO and ether mix? Honestly, if you're not too worried about recovering the rest, ignore me. I haven't gotten to do chemistry over like a year now, and I miss it.
update: i just did it, though I had to do a short path distillation in the end since mine was contaminated by some yellow residue that my old acetic anhydride had. i did not expect the smell to be so sharp and quite honestly horribly bad 😭i guess im never buying truffles lmfao
Surprisingly simple synth - except for the acetic anhydride LOL I wonder - would flushing the reaction apparatus with argon have produced a better yield? Where's that rotovap by the way? ;D May the gods bless Chemiolis will +2 to yield for the foreseeable future!
Would it also be possible to just do a double nucleophilic Substitution on DCM with Thiomethanol or sodium methylthiolate? And can you do a video about how you clean your glassware?
He probably just cleans his glassware with ethanol, rinsing into proper containers for halogenated/non halogenated waste, then washes with soapy water possibly followed by more ethanol
In theory you can, but dichloromethane is not that reactive towards nucleophilic substitution, because it has two chlorine atoms attached to carbons and chloride is one of the best leaving groups.
Your obsession with yields is perhaps misplaced when we're talking small scale demo-reactions. Sure, if you're making expensive reagents for use in other experiments yields matter a lot, but you already hated the truffle smell. Imagine if had made twice as much....
I find this reaction weird - it's clear that the sulphur is being reduced, but it's not clear to me what is being oxidised. I mean obviously something has to be somewhere...
I think you should try a synthesis of DXE from phenyl boronic acid bpin ester and bromo cyclohexanone to make phenyl cyclohexanone then an alpha bromination using CuBr2 and an amination hmm
Gruwelijk ouwe Dacht het al te horen maar je Engels is top 👌 Lekker bezig En knap dat je al die chemicaliën weet te vinden hier 😮, zou niet weten waar ik moet beginnen voor dingen exotischer dan basis zouten en oplosmiddelen
@@MandrakeFernflower I think the closest mustard agent would actually be Bis(2-chloroethylsulfanyl) methane. Or basically at least what I can tell from PubChem and Wikipedia. I wonder why not just throw some chlorines at the ends and call it a day but I guess it works better with longer chains and isn't as volatile? We'd have to modify our kitchen chemistry procedure a little unless it's really just as easy as bubbling chlorine through like 30 lbs of Costco truffle oil.
