Methylene Blue (MB) Dosage and Administration Approaches 

I take .5 to 1mg per kg daily. I also take NOW brand Cilantro/Chlorella tincture, which crosses the bbb to pull out heavy metals. Even though I take the fish grade at 1.15mg/drop, a recent blood test flagged me for being LOW in Arsenic! I am not worried, as I am also a willing tester who takes the risks. When you have a neuro-muscular disease related to polio (ME) you will be willing to sacrifice quite a lot of safety simply to have a life. MB works lke no other supplement I have tested, and I have tested over 100 items over the past decade. I also found that a pastured ruminant-based diet is by far optimal for me, nothing beats especially liver for nutrient density and availability, it is astounding help. I also now get big midday sun year round for the IFR. I have and use several lights, but nothing compares to the actual sun, especially midday sun sufficient to retain a tan works for me so well. I actually built a solarium to lay in through winter.

I hope this becomes mainstream soon. My neighbor and best friend killed himself 19 mo ago, paranoid schizophrenic. I feel he would have happily tried this just to see if his PTSD and other nightmare effects from the VietNam war would have been lessened. We have so much at hand to help us, but doktors can't tell us what might help.

Thank you Dr. My mother has alzheimers and it's on MB low dose, she has had and continues with improvements... along with supplements, brain peptides and healthier eating ... can't deny it works a lot not just some

I am a dentist. I use Low Intensity Laser with methylene, aka PDT for treatments im my practice. This video shows a serious and professional aproach about the theme(linking the researches). Thank you very much for the information!

Dr. Been, What I find so interesting about this 'blue dye' is how helpful it is to overall cellular function and especially the neuroprotective effect you clearly explain in your video. Shortly after watching these wonderful video's of yours I ran into a coincidence that is hard to ignore. I'll just say I don't believe in coincidences either. Nature just publish this interesting article about a green dye developed by Kodak in the 1950's: The CRISPR-Cas9 gene-editing tool might have cracked the mystery of how death cap mushrooms (Amanita phalloides) kill - and it led researchers to a potential antidote. Using the gene-editing technology, researchers created a pool of human cells - each with different genetic mutations - and exposed them to the mushrooms’ toxin. The toxin could not enter cells that lacked a functional version of an enzyme called STT3B, and cell survival increased. The researchers then sifted through thousands of chemical compounds to find one that would block the action of STT3B. They uncovered indocyanine green, a dye developed by the photography company Kodak in the 1950s and used in medical imaging. Indocyanine green has not yet been tested as an antidote in humans, but it reduced deaths when given to mice. Is all this positive information on 'color' the reason my mother always told us to eat the colors of the rainbow??

PLEASE do a presentation using measurements pictorials. A spoon, cup, measuring cups side by side in order. I can't follow.

FYI even regular pharmacuitical products also have impurities.

Great lecture. In my observations there needs to be more studies done on low dose MB. Anecdotally I’ve seen so many people benefit from starting low (ie 1 drop/0.5mg per day) and slowly increasing. I find the traditionally recommended amounts too much for many people.

I started taking it for my cancer

The best Video on RU-vid about this subject. Thank you very much.

I would suggest that if you’re going to do MB, take supplements known to facilitate heavy metal detox. There’s “Modiflan”, made from a kind of brown seaweed. They used to advertise it as detoxing from heavy metals; they withdrew that claim but the product is still available. (You know how picky the FDA can be about any kind of claims.) That’s just a beginning suggestion for persona research. Discussion: One of the things most helpful about Dr. Been’s presentations is that he provides a more comprehensive inventory of necessary information than perhaps any other online lecturer. It was helpful to learn of the potential contaminants, arsenic, lead, mercury, cadmium, aluminum impurities. We should not automatically overlook the fact that there is really no safe dose of lead, to begin with, nor, in the opinion of many, mercury (note the thimersol controversy). And aluminum, arsenic and cadmium are not exactly friendly. Many people work very hard to detox from all of these heavy metals, so the question of safety issues over ingesting even “negligible” amounts deserves discussion. What amounts are we really talking about? Are they significant below background levels we ingest anyway from the environment? In that case, for instance, an argument for safety might be made that taking MB chronically will not raise a person’s heavy metal load meaningfully above what they’re already carrying. Or the the amounts in MB might be above background, etc., etc. An example of another side of the issue whether simultaneously facilitating the *excretion* of heavy metals might be sufficient to overcome expose from MB impurities. I had a colleague whose family criticized her for eating too much tuna (sushi). Her dietary regimen was otherwise very healthful; e.g., lots of seaweed, tons of vegetables, pure organic food, etc. The whole family got tested for mercury levels. Hers was very low, despite the tuna, while the other family members had a more typically high level. So, a healthy body can deal with a certain amount of exposure to heavy metals. The question then would be, what kind of supplemental heavy metal detox regimen might go hand on hand with taking MB? More discussion is needed, not glossing over it as the cited study seems to do with “of no great concern”. “Of no great concern” is not exactly what one would characterize as *due diligence*. This is not a trivial issue.

Thank you 💙 perfect timing, I'm just starting this flccc protocol today

Shouldn't the word be 'hormetic' not 'Hermetic'. Hermetic alludes to the Greek god Hermes. Hormesis is the ability for toxins to up regulate anti-toxin processes. Am I right?

Thank you thank you for doing these sets of videos on Methylene Blue

Thought I would try it with all these positive videos and reviews..one drop and bad abdominal pain and bathroom visits

MB also very effective against stationary form Bartonella & biofilm. Most Drs who use this treatment recommended the liposomal capsules from compounding pharmacy but I can’t find a CP that makes it unfortunately. Now Bartonella rearing it’s ugly head so I saw my dr today and I’m back on MB as well as 3 antibiotics starting tomorrow. Rifampin/methylene blue is a recommended combo for persistent Bartonella. I’ll also be taking azith & clarith. I use the USP grade 1% liquid from compass labs. Currently at 10 drops and increasing. Dr Burrescano says it’s important to take antioxidants while taking larger doses MB as it causes severe oxidative stress. The talk was on Project Lyme channel “examining Bartonella”. I read research last year showing MB great for neurological conditions/diseases, Bartonella, babesia, and more… Tick diseases really suck.

Thank you - Your take is Most Superior!

Good luck finding an excellent Certifcate of Analysis for MB. I have looked at Infuse-Serve and what used to be Hopkinton. A couple yeas ago the CoA were NOT impressive. Getting heavy metals out of one's brain is a big challenge.

1:55 Dose for neuroprotection is 0.5 mg - 4 mg per kg body weight. Best to lean towards lower dose. 2:50 Contraindications: G6PD deficiency should NOT take this. NEVER give to pregnant mothers.

I have ME and am very excited about trying it.

How do you know you don't have the condition that puts you to the risk of hemolysis?

My daughter has cancer and was given ifosfamide and had a bad reaction to it. She has a psychosis episode. She did not know what was real and lost function of her body. They gave her methelyne blue to counter act it and it worked for one day and then she reverted back 😢and is still in the reverted state it had been 1 week already they gave her MB along with olanzapine then took her off olanzapine and MB because she got worse and just put her on seroquen and still no help. We took her off everything now except thiamine and still waiting for her to get better. She is unable to talk and her memory is in s loop we have to tell her that she is real and it’s not a dream every few hours.

So far no one has been able to explain to me why I crash after taking MB. It's good for a few days and then boom, lay in bed completely wiped out. No one talks about possible detox. Does MB cause detox? Or is it a serotonin problem? I know the crash was worse with taking tryptophan which is a serotonin precursor. I feel MB does me a lot of good but I can't seem to find any answers. So I stopped taking it. Surely I can't be the only one. I chiro tested me on MB and advised 3 drops 0.5 once a week but still the crash.

Would taking zeolite be advised while taking mb? Or would it detox mb out? Is there a difference or kinds of methylene blue or is it all the same? Appreciate the help. Have had Morgellons for over a decade and hear both zeolite and mb will help a lot.

Excellent explanation. Thank you!

I am researching this now and any comments appreciated. I am 59 female and only known problems is my recent bloodwork shows my RBC steadily climbing and now flagged high and my hemotocrit and hemoglobin has been flagged high for 8 years. Dr is wanting me to go for a sleep study next week something about oxygen🤷‍♀️. Also I have to get a thyroid ultrasound annually , it is enlarged and nodules that needs monitored and I have 2 doctors fighting over whether to take it out •. I prefer to keep my organs and no prescription meds.

Why will no doctor go into detail about dosage for UTI's? It's as though these doctors are unaware of the major crisis in antibiotic resistance for women or just don't care.

Best and most important presentation of all l could find on . methylene blue! Thank you!

Thank you!

Is there a conflict/ contraindication for taking Methylene Blue a n d CoQ 10/ Ubiquinol? Thank you.

Dr. Beem, what is the relationship between methylene blue and hydrogen inhalation therapy? Are they antagonist or synergistic to each other?

Excellent presentation. I have read (not in peer-reviewed source) that there is a negative interaction between methylene blue an nitric oxide. Comments?

Thank you for this great MB info!

I have found combining MB (30mg/day) with NMN (500mg/day liposomal) to have far better energy and mental concentration effect than either by themselves. Can you comment on this? Wise? Stupid? Imagined?

THANK YOU !!!

question is how long is the duration of the course? do you take it every 6 days then stop for a day then start again for the next 6 days?

So at 160 lbs. = 72.5748 kgs. for protection against neurodegeneration and brain fog how many mg of methylene blue would be a low dose> ?

Where to buy the best grade quality???

Which MB do you suggest?

Im trying bucal troches from troscriptions at low dosage first and discussed with my internal med Dr .

2.5mg of sublingual dose twice daily is enough to show results

Thank you so much! I am assuming they are talking about powdered Methylene blue. Where I live they only sell 1% solution for external use, but still medical grade MB. I guess I need to do some calculations. My friend used 5 drops of 1% solution in a glass of water twice a day to treat you know what last year. It made the water very blue. Almost spooky to drink. I wonder how many drops would make a dose of 1mg/kg. I am guessing more than 5.

What dosage is advised in the case of TIA or suspected stroke or myocardial infarction? AND, most importantly, if TPA is administered following this, and perhaps they don't know if you took MB, would TPA be dangerous in this combination?? Please respond.

Can you give to pregnant men?

I am concerned of the contaminants present even in USP grade MB. if they are present even in very low dosages, but you take the solution everyday for the rest of your life, wouldn’t this be counterproductive? To put things into context: I filter my tap water to remove fluoride and other elements even though they are in the ppm levels. We do drink a lot of water everyday, which is different comparing to taking MB solution, though. I’m confused as to whether the benefits really outweigh potential issues long term due to the presence of contaminants in MB

Can GERD patients use MB is it safe? The dose for GERD patients please.

Sir your views on probable role of oral methylene blue in multiple sclerosis.waiting for your opinion thanks

I wonder if any studies have been done to look at the effect that orally administered MB has on the gut biome.

I wish I could take this. It gave me a lot of energy and mental clarity. However after a few days I developed horrible peripheral neuropathy, which went away as soon as I stopped.

I would like to know if taking methylene blue and zeolite is safe? Or will the zeolite make the MB useless?

Thanks Mobeen. At 15 minutes the generic name and not genetic name is methylene blue.

Thank you, helpful info

Does adding vitamin C to the water to counteract the staining decrease or modify the efficacy of the methylene blue?

I found it in a dissolvable strip you put on your tongue. It's 20mg every other day.. Is that safe?

in long term animal studies methylene blue has demonstrated some potential carcinogenic activity

I get benefit from a single drop of the stuff (o.5mg) in a quart of water, divided throughout the day. Just sayin.

There are some wild comments here. Not all liquids are the same concentration. A bottle of 1000 PPM is not the same as 5000 PPM. You cannot just arbitrarily tell someone how many drops to take. If you start from a powder, also that powder has a concentration. Be careful how you calculate.

I experienced peripheral neuropathy based on suggested dosage.

Thank you for all the info. I read that it is good against the corona virus. Do you know if it is helps with long covid ?

Can I take MB while undergoing chemotherapy?

The problem is ...that this chemical doesn't have milligram dosage indication. It's not a pharmaceutical proper. SO how can I calculate the drops?

Very good video @Long Story Short but I am still having a bit of difficulty doing all the necessary conversions to find the correct dosage of 0.05mg/kg, as I have a 100ml bottle of 1% methylene blue solution, and as far as I can gather each drop is 0.05ml. I weight about 100kg so should be taking around 50mg which appears to be 5ml, so would about 10 drops be about right?

What does it mean if my urine doesn’t change color when I take it?

What happens if we take one drop iodine for thyroid with then for other purposes, llow dose MB? Can these be taken same time or apart?

Dr Been, I am on serotonin uptake inhibiter 60mg daily, so I assume I need to stop taking this in order to start taking my Methylene Blue. If I stop I will be very dizzy headed for several days and my mood swings will start. How long before I can then start the methylene blue dose of 0.5 mg per body weight?

I'm taking the mito lab methylene blue which is 0.5mg per drop. Is it normal or possible to have a herx/negative reaction from it? I find it does the opposite of what it's intended for and I usually stop using it pretty quickly because of this. I just wonder if I carry on, will the positive effects eventually come?

Is there a alternative Way to get MB in Europe...without the Troscriptions Blocks which I use now. Thanks and greets from Andreas in Alsace /France. Update March 2023.... I found a Source in Australia which works good for me and cheaper in the longrun as Troscriptions MB.

How many mgs of MB are in one drop of a 1% solution of MB?

MB is good for focus and energy but my hidradenitis suppurativa aggravated. So I have to stop.

For a 250lbs male taking MB taking .5 mg per kg of body weight is 56 drops per day? Can someone who knows confirm if this is correct?

What are your thoughts on Methylene Blue and Pulmonary Hypertension. A few study authors reviewing MB have expressed concern on its inhibitory action on Nitric Oxide, potentially worsening the PH. Considering a good amount of long covid patients have PH, would MB be contraindicated? "Among 50 post-COVID-19 patients, 30% of patients had normal pulmonary artery pressure, 30% had pulmonary hypertension with PaO2 ≥ 60 mmHg, and 40% had PH and RVD with PaO2 < 60 mmHg"

Any comments about methylene blue and ClO2 at the same time? Thanks!

is this same with MB they're using in aquarium fish?

Critically absent from this talk is how to ingest the recommended amount. If I were to buy 1% MB solution, how many mg of MB are in one drop? This information is also absent from the bottles. Thank you.

I am 78 very healthy have controlled high blood with meds since in my 40’s. Just recently noticing my short term memory failing. I’m going to take 1 drop a day in a glass of water & see if I can feel anything happening. I’m very aware of my body. Is it true you need to see it in your urine what if you do not?

I tried the methylene blue for 3 days, 1 drop and then 2 drops once a day. One day I only put it on my face in a cream. Every time, I'm completely flattened the next day. Very low mood. After 48 hours I'm good. I'm wondering if this is detox and need to lower dose or I shouldn't take it. There is that G6PD contraindication thing that is rare. I really want to take it, I feel it's helping but I can't crash like that each time. Anyone else take it? I'm a senior.

Do you know if we would detox the harmful metals in MB naturally or do they get stored in the brain?

I'm just over 100kg, would 1ml of 1% MB, which = 10mg be a good starting point?

Which source do you recommend ?

No mention of the percentage... I got MB powder and have mixed it 1% Is the oral dosage of .5mg (20 drops) in the video based on a 1% solution?

When taking methylene blue, does the blue urine color indicate its uptake or usage in the body? If taking MB and there is no appearance in the urine, what does that indicate?

How many mg of meth blue is ther in 1 ml of a 1% solution?

If the half life is around 5 hours, then why do I continue to pee green 36 hours after a dose? I took 10mg's, I'm 230 llbs and very active?

when you say 0.5 - 4mg/Kg body weight are we talking about the MB powder or already in a 1% solution? And if it is the 1% solution is it affected if added to water and consumed?

I am taking low dose methylene blue. But I developed a bad ulcer on my palate. Could it be because of methylene blue.

3:10 How can you find out if you have G6PD?

But where to buy Methylene Blue which is safe for humans to take with little decontamination? Also it is a bit odd, that the dosage is so huge apart to what to take, 5mg vs 300mg total dose per day is a huge difference.

I can't figure out the math so I guess my 1% solution bottle will sit collecting dust. I'm 70kg in weight. There are 10mg of MB per ML in the bottle. .5mg low dose x 70kg body weight = 35mg/10mg=3.5ML. That's probably wrong, and a lot of the product to be taking in relation to the $mall bottle.

How much is Methylene Blue 10-20 mg daily?

I’m still a little confused on dosage. I get the .5-4mg/kg, but how does that equate to each drop. In other words, if I weigh 140lbs, how many drops from an eye dropper would net me 1mg/per kg?

How much do I need to take if I weight 90 kg? Please can someone help me

I used 1% liquid. I used 5 drops twice per day. I also use medicinal cannabis and ended up with serotonin syndrome in 4 days. It is awful, please be careful with any other substances that activate serotonin. I'll give a rest then take one drop 3 times per day, try that.

Thank you very much! Can someone please help me calculate: how many drops of 1% solution per day (I am having troubles converting mg to ml) should I take? I weigh 230 pounds.

dosing info is really unclear given the fact it comes in a 1% solution or 100% powder. A dozen MB dosage video's into my research and I still have no clue if the dosage every seems to agree on is based on the 1% or 100% purity.

Methylene blue inhibits nitric oxide production, nitric oxide is used for vasodilation. CVD or Renal Disorders need nitric oxide for relaxing and widening the vascular system without it it could cause bad angina or heart attacks under the right circumstances.

77 kilograms takes how many drops?

People in high school & college would slip in phenopthalein or methylene blue into other peoples food or drink as pranks.

1mg = how many drops? 120lb's how many drops recommended?

I have the usp grade MB in a 2FL OS bottle in a liquid form for oral use.. i was advised to get some from a lady that owns a hyperbaric oxygen chamber clinic.. can someone tell me what the dose i need to take?

Dr Been, do you think it’s ok to take 0.5 mg per kg/weight orally if simultaneously taking 40 mg Prozac per day? Going off Prozac is not an option, alas.