MHC Molecules Part 2 HD 

Topics:
* Pathway of Antigen Processing & Presentation
* Class I Pathway of Antigen Processing & Presentation
- Digestion of the cytosolic peptides by the proteasomes
- Concept of proteasomes
- Transport of peptides from the cytosol to the endoplasmic reticulum
- Concept of TAP, Tapasin, ERAP and Invariant Chain
- Assembly of "Peptide-Class I MHC Complexes" in the endoplasmic reticulum
- Surface Expression of Peptide-Class I MHC Complexes
* Class II Pathway of Antigen Processing & Presentation
- Proteolytic degradation of internalized proteins in late endosomes and lysosomes
- Binding of peptides to class II MHC molecules in this vesicular compartment
- Concept of CLIP & HLA-DM
- Expression of Peptide-Class II MHC Complexes on Cell Surface
* Importance of MHC Molecules
* Autoimmune diseases associated with MHC Molecules