Bunch of thanks I am Pakistani my native and national language is urdu I have barrier in understanding English but your calm way of speaking clearly help me to clear doubts stay blessed
hi friends, if you are interested to know about pharmacokinetics, then this video is for you. I hope you will like it ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-sqgVb1KH2dM.html
pharmacology is actually not that difficult imo but because they drag it out in uni (since one class is like 2 hours long) it's easy to get lost in all the small details you forget about the big picture then you suddenly can't understand anything anymore
hi friends, if you are interested to know about pharmacokinetics, then this video is for you. I hope you will like it ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-sqgVb1KH2dM.html
Thank you very much for the video! It is very understandable and useful. May I have a question unrelated to the topic? Speaker (lecturer) where are you from? What is your accent?
Drawings so amazing making these concepts a lot of fun to remember, and accent is cool n distinctive too with much command over the subject :) Thanks!! (Btw just curious to know which tablet or software u use for these videos)
Amazing video. Very informative. I was wondering if you could make a video with a stepwise tutorial of the phase 1 and phase 2 mechanisms of elimination. My professor’s explanation is a little wonky. Thanks 👍🏻👍🏻👍🏻👍🏻👍🏻
Hi if you're a medical student how can I contact you??I'm releasing USMLE question and answer books in amazon tomorrow for every part of medicine and I need some reviews and some help
hi friends, if you are interested to know about pharmacokinetics, then this video is for you. I hope you will like it ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-sqgVb1KH2dM.html
hi friends, if you are interested to know about pharmacokinetics, then this video is for you. I hope you will like it ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-sqgVb1KH2dM.html
wow, I've been reading lecture notes and watching lecture videos with zero understanding, until I thought why not try RU-vid, just maybe, it might be helpful. This was very helpful, I pretty much have more understanding of pharmacokinetics now than before I found this video. Thank you so much!!!!
When suddenly the penny drops and all those worries through Pharma lectures you had melt away ... Thanks for the Video and making so much sense in light of hours of mind bending long winded lectures !
Thank you for making this subject a little bit more simplier and easier than my lecturers' teaching method in uni. Why I just found this amazing youtube account by now..? T_T
Thankyou so much 💖 Very Informative 💯 I have also started my new youtube Pharmacology learning channel💊💯 Would you please give me your guidence & support.
Just wondering how does our body follows mathematics (in reference to first and zero order kinetics)? I mean fixed fraction or fixed amount getting eliminated over a (fixed?) Period of time is something so not random as i first expected... Grabbing these concepts first yourself and then finding a way to explain in tutorial form to us must be so time consuming and hard work by you. Very impressive! (How do one present the topics in as much innovative way as you do?)
an33za keep in mind that this is not an exact science. however mathematical models can provide useful insight into pharmacokinetic behavior of a drug despite their much simplified depiction of human physiology. good question
+an33za It's not really that your body follows mathematics, we come up with mathematical laws to predict and understand the body. In first order kinetics, the more of the drug you have, the more receptors work to degrade it, and usually that fixed percentage of the drug cleared reflects how quickly the receptors can degrade the drug. In zero order kinetics, the receptors have become saturated, so they're doing the maximum amount of work they can do. That means, if you take more drug, you don't have more receptors to breakdown the extra amount of drug, the receptors are already breaking down the maximum amount of drug per unit time, so it's going to be a set amount of drug. These are properties of how the body interacts with the drug, and scientists have observed this and graphed it in order to try to get a better understanding of it. I hope that clarifies a bit
I guess, it's because usually in zero-order kinetics, the drug saturates all your enzymatic systems for excretion/biotransformation, etc... so the rate of elimination is not dependent on the drug concentration and it's fixed over time, so graphically it's a straight descending line. On the other hand, in first-order kinetics your systems are not saturated and the rate of their reactions is dependent on concentration (see Michaelis-Menten equation).
Think about it like this, you have two workers, one of them can remove 5 cups per minute so no matter how many cups you stack in front of him, the maximum cleared amount in a minute (or whatever unit of time you choose) is 5 cups. The fraction changes because its dependent on the denominator (how many cups are left). 5 cups out of 100 gives you a 5% clearance, while 5 cups out of 5 gives you 100% clearance. The longer the 5 cups per minute is allowed to work without adding new cups, the "more he cleans fractionally" but its always the same number of cups. On the other hand, your second table has a machine that can only remove exactly 1/4 of the total amount of cups per minute (or unit time). Now we can see that instead of changing the number of cups by a static amount (5 cups) we are changing it based on how many cups are left! As a result, starting with 100 cups, removing a quarter puts us at 75 cups, but the next time the machine removes a quarter its going to drop the 75 by another 1/4! It doesnt care how many cups it removed, only how many are left. hope this cleared it up
Summed up my 10hrs of reading and lectures in 15min. However, I strongly advise any other fellow med/pharm students to use these videos just as recaps and not as the main sources of information. Why? These leave a lot of tiny, yet still very important details unsaid, especially in the physicochemical department, which you do need to be very familiar with when progressing into much more complex courses.
Give him Nobel Prize man... Believe me , faculties pour shit over your body in the name of teaching pharmacokinetics and and their attitude be like--This is tough subject so tough will be the way to remember it , tough , tough .......Tough my Ass BC..........Seriously man , this guy is a genius----Hats off to you SIr.
