I _really_ liked your house, room, and furniture analogy with proteins, domains, and motifs respectively. I applied your analogy to the Polynucleotide Kinase Phosphatase (PNKP) protein you discussed and, if anyone sees this, I hope it helps! *FHA (Forkhead-associated domain) recognizes the 3’ and 5’ ends while the motifs are the specific proteins that bind to the 3’ and 5’ ends.* *Phosphatase **_dephosphorylates_** the 3’ end and turns it into a hydroxyl group.* *Kinase phosphorylates the 5’ end and turns it into a phosphate group.* *The FHA motif is like the front door, while the FHA **_domain_** is the front entrance room connected to the front door: It’s the starting place to get to all the other rooms (i.e., the starting place to get to all the other domains).* *Phosphatase is like the wine cellar: It takes away your energy (phosphorus) and replaces it with alcohol.* *Kinase is like your gym: It forces you to put down the alcohol and improve your fitness which, in turn, **_increases the amount of energy you have._*
