SIRT6, FUCOIDAN & LONGEVITY: Will Activating SIRT6 Extend Your Life? [2021] 

OK, I looked into this further. Fucoidan is not the name of a specific chemical substance, but rather the name for a class of substances. There are several different types of fucoidan, each with different molecular structure and different properties. Fucoidan refers to a type of polysaccharide that contains substantial percentages of L-fucose and sulfate ester group, but can also contain other monsaccharides, including mannose, galactose, glucose, xylose, etc. plus other compounds like uronic acids, acetyl groups and proteins. What type of fuciodan a compound is can depend on the type of seaweed that is was extracted from and the method of extraction, to name a few. Check out this page for a small selection of the different types of fucoidan: www.zenmony.com/types-of-fucoidan-f-u-l-g-ga-a27/ So, there are many different types of fucoidan, each with it's own distinct properties. In light of this, it's not too difficult to see why it can be so hard to find fucoidan that can activate SIRT6. Hope this helps.

Great video, thank you. I just ordered the Sirt6 Activator. I currently take Pure Apigenin, Fisetin and CA-AKG. I also take Metformin, even though I do not have Diabetes. I'm 2 months from my 68th birthday. I'm in great health and I have lots of energy. I go to the gym 5 days a week and do weights and aerobics exercising for about 2 hours each day. I love life. Live long enough to live forever!

CONGRATULATIONS Lance! I think your decision to create a longevity course and charge for it in order to support your work on RU-vid is brilliant. Your current videos bring all the detail of the complex chemistry and biology of longevity down to a level of understanding better than anyone else on RU-vid. I know it takes a lot of time and work to do that, and I’m glad to support you in your ongoing efforts. This will, no doubt, be a win-win for everyone. You get support and your audience gets a pre-digested source of understanding and information for the ongoing longevity research and the resulting practical capabilities being produced in this complex field. Here are two aspects of the course that I personally would like to see. First, I would really like to have the course content available in some “printed” form in addition to or instead of video. The amount of information involved and its complexity are very large, and just having a video to watch in order for me to mentally capture everything is not adequate. If only video content were presented, I’d have to spend a large amount of time taking notes and creating complex diagrams that I could use for study and review to ensure that I can confidently reason about what I should be doing to extend my own longevity. Ideally, the course would be presented both in video and in a printed format, such as PDF. If that were done, we students could view the video first to get the big ideas involved, and then study the text and diagrams to cement the details in our heads. Second, a hybrid of one-time purchase and a subscription model of pricing might work well. A person could buy the course to get the first version. The course would have to be updated occasionally, maybe on a quarterly basis, in order to keep up with the rapidly evolving field. So a person could either re-buy the course at full price whenever they think it’s worth doing, or they could subscribe to updates after they have purchased the full course so they could have lower cost access to the updates on a continuous basis. And if you really want to confuse everyone, you could also create two tiers of the course - one lower cost tier of video-only, and a higher cost tier of video and printed material. I’m not trying to tell you how to run your course, Lance; I’m just casting my vote for course features I’d like to see. However you do it, I’m sure it will be a major contribution to the many people who don’t have PhDs in this field but still want to understand it in order to extend their lifespan and healthspan. Thanks so much for doing this!

You're doing a great job.

Great. As a newbie, there's a lot more I don't know than what I do know. Paying you for your knowledge saves me time and eliminates the wasted efforts. I look forward to it.

Great job getting her information! Much appreciated…

Great job sir. Truly inspirational. Probably the coolest thing to do at that age. I just turned 20. Any advice would be wondrous, although this RU-vid channel is more than enough...hope it grows virally.

The work you are doing is wonderful. Your course will be a great value. Sign me up.

Great lecture excellent information I will follow your podcasts Thank you

Great video Lance.

I have been taking this supplement from ,DO NOT AGE, I have noticed a big increase apatite over the past 3 weeks and lots of energy

Thanks for your video. I would be interested to learn more about your course.

Thanks again.

SIR2in, 1-6 Mine must be working well. Began going to the gym for the first time in 40 years. Seems easier than before. Fucoitin?

Any human studies yet defined, and/or done for how well SIRT6 works on humans?

I ' m come form vn. Thanks Lance..!!

please send more informations about your course. I will do . you are a very honest man.

Excellent explanation of sirtuins, in particular, SIRT6. Thanks

Great video and I appreciate your pinned comment. Anyhow, there is one little piece of info missing: which type of fucoidan is the type that works? Any ideas, or is this unknown by everybody except those in Prof Gorbunova's lab?

Awesome information, thanks for the hard work and research you put into all your videos, Lance! We have a video in which we talked about fucoidan's activation of sirtuins and some other health aspects of fucoidan, as well. Would love to hear your feedback. Thanks!

Hi Lance, is there a requirement to take a NAD+ supplement along with this Sirt6Activator ? Thanks

Where can u order this product

Hi Lance. Thanks for the work. Please provide a Patreon or other contribution link. Thanks!

Once again, if a function is good for you, you can probably activate it fasting. Thanks for this video!

I wish I could afford it too Lance! Anyway the sirt info was nicely detailed thank you. I can see what Brad has given up on reservatrol as it seems to only activate sirt1.

Hi Lance: Thank-you for your work on this video - would you mind sharing the discount code for the DONOTAGE product -

Great video lance. I've watched some of the other peoples videos and I was confused as well. And it seems like there is still some confusion remaining. I'm suspecting the researchers are now influenced by $$$ and might be making some less conservative claims. Thanks for sorting through all of this and boiling it down to 20mins. It must have taken you a long time! I'm going to wait a few more months for more coherent results. One question. If NMN activates all Sirtuins, why bother with Fucoidan? Or is it that NMN only activates the de-acetilysation part of SIRT6?

problem is i live in the Philippines and if i order from do not age the cost ends up tripling

My life time is INVESTED in my PIANO. I LIKE YOUR INFO TO ESTEND MY LIFESPAN.

1st what is your code and 2nd what other products are available to use for SIRT6

There are many molecules considered giving longevity. Like taurine, metformine, glysine, nac, creatine, resveratrol,nmn, ca akg etc. All these can be swallowed together or should maintain a distance minimum time between each molecule

Resveratrol activates SIRT6 does it not? The french paradox & subsequent investigation into said "paradox", lead researchers to the polyphenol RSV.

Hmmm... LANCE Discount code didn't change the price.... when I tried to order. {shrugs shoulders}

Wow 🔥

to live longer do you have to take this stuff for the rest of your life

Great video for learning. I am like you, searching in sites for studens of pharmacy, biology and so on. I am reading books for students, and ... Ill have a look on your offer. By the way, Im in contact with do not age too, because I havnt an answer on my questions jet. They offered me a phone call which is really nice! Maybe I will try their product.

are we to take Ms. Gorbunova at her word or is there some evidence out there that Fucoidan supports Sit 6?

i guess the seaweed that japanese and korean people eat is not better than the special fucoidan

I am taking Okinawa Fucoidan made by Japanese company Kanehide Bio.

One problem I can point out, alpha ketoglutarate was suppose to increase lifespan by mildly suppressing ATP generation!

Have anyone tried this product

"I'm not sponsored by Do Not Age because I want to keep this channel unbiased..." "...but I am an affiliate."

most fucoidan blocks sirtuin 6 what the,,,,,

The discount code?

Hello Lance, I seem to be the only person using cyanidin as a SIRT6 activator-via ribosylation, as well. Have been taking 200mg daily for two months. Fucoidan can occasionally work at 'cross-purposes' methinks, yet cyanidin is potent and rarely an inhibitor. Thoughts please.

Elderberry

Evidentemente la extensión del 27 % en varones es sobre la vida media esperada que, en este sexo, es menor a la de mujeres. En cuanto a éstas, el 15 % de extensión o ganancia se daba sobre una esperanza de vida media superior a la de los varones. Cuando después habla de una extensión del 11 % para varones y un 15 % para mujeres ya no habla de vida media esperada sino de longevidad máxima o vida máxima conseguida sobre cada sexo.

Anthocyandin(iirc) is the best SIRT6 activator by like 13x. Found in dark berries, elderberries have highest concentration. Even at 13x the next best, it is tiny on the grand scale. Some might say a fools errand.

Hi Lance, I like your presentations. Please add to your information presented which (natural food) sources provide TMG. For example there is no reason for people like me who eat a steady amount of Wheat Germ, Beets, Spinach, Quinoa, to fork over $100 for TMG supplements, which I would venture to hypothesize are not nearly as bio available and surely not as broadly nutritious as the natural sources as follows: Here’s the amount of TMG found in a 3.5-ounce (100-gram) serving of several foods (24Trusted Source, 25Trusted Source, 26Trusted Source): Wheat bran: 1,339 mg Wheat germ: 1,241 mg Spinach: 600-645 mg Quinoa: 390 mg Beets: 114-297 mg Shrimp: 219 mg Wheat bread: 201 mg Keep in mind that several factors impact the amount of TMG found in foods. For example, certain cooking methods, particularly boiling, significantly decrease the TMG content .

So what they're selling for that price is Fucus Vesiculosus. Can't you just take bladderwrack which is extremely high in it? On top of that, if you combine the bladderwrack with sea moss and burdock root and you get all of the minerals the body needs? Dr. Sebi used to talk about Fucus decades ago for extending longevity.

Its the old trick, say that only your offering is good while others will not work. Whatever fucoidan I am "led" to buy, will work for me. No shake down artists please.

I think the Do Not Age Sirt6 activator may be a total scam. Somebody needs to do a third party test to see if it activates Sirt6. When the people making it and selling it are the same ones testing it there's a potential for fraud. There needs to be third party testing for this product and so far as I know there isn't any.

Just change the shape of the distribution, Lance. Move the middle more than the right tail for instance.

im pretty interested in a course that will give me the understanding about longevity and apply them to be commercially be produced cheaply. best regards from the philipines

In capitalism the cure to high prices is......................high prices. I remember when quercetin cost a fortune - like spermedin does now.

I bought the starter package including SIRT6 from the this company 8 or 9 months ago and I didn’t notice any positive difference. I get headaches and itching every time I take it and it has a fish smell. Did I receive a bad patch? Did anyone experience something similar?

No disrespect intended Lance, but 'sigh,' more pills and potions? Isn't there a way where you can accomplish the same thing at home through exercise and diet or some kind of lifestyle intervention instead of expensive nostrums which as some of the comments indicate, have the potential for severe gastrointestinal distress and who knows what else?

Don't be stupid, everybody! The seaweed extracts in question cost almost nothing and are not patentable: in just a few months, the competing companies will have had the time to formulate exactly the same fucoidan extract for much less: which is why they want you are subscribing now for a year, at shockingly expensive prices, because they are the only ones on the market, but they know it can't last long... Nonetheless I really consider their brand is a very good one, especially for thieur apigenin at a very competitive price... Anyway, Thanks and thumb up, Lance, for the excellent review !

I don't know why none of these organizations have genetically engineered foods to produce significant amounts of the ideal form of anti-aging compounds, like fucoidan.

11:25 Wrong!.. "Now that just doesn't make any sense to me...". This is possible because life span is variable and are people which life very shortly. So SIRT6 helps peoples live longer. But helps only for mouses which liver shorter than medium.

Once they find the kind of seaweed that has the right activation why don’t they take that seaweed and grow it?

median lifespan is how long most of the mice live. Max lifespan is how long the oldest mouse lives. If most mice live 48 months, then 30% increase is (48 x .3). If Max is 58 months then max is 58 x it's percentage increase. Thus max lifespan could still be higher than median lifespan notwithstanding the fact that median increased by a greater percentage value.

I've read that the most powerful sirt6 activator of all is a substance called cyanidin found in such things as the brightly-colored skins of berries like elderberry, blackberry, cranberry, blueberry. Being pretty ignorant about this area, I don't know if those sources of cyanidin would affect the deacetylation or the ribosylation function. May I please ask you for your opinion on the possible sirt6 benefits of taking extracts of these natural flavonoids above and whether they might have the same benefits as fucoidan if taken in large enough quantities?

Some fuciodan activates SIRT6, and other fuciodan supresses it, even though it's the same exact chemical. OK.

I took two capsules of Do Not Age Sirt 6 Activator and afterwards was taken to rhe hospital emergency. Got terrible stomach cramps that needed to treated with an infusion. They asked me what I had taken, I told them about the product. They never heard of it - of course. I am sure the cramps came.from the capsules. I never had pain like that before in my whole life. I won't take any of these capsules ever again. Even though, they were damn expensive.

Personly I do not believe they are the only ones that sell the specific fucoidan that works,sounds like a money tree, considering it is a very cheap substance .

Too rich for me as well

Lance your face age is not showing results

You're misleading. You do take money from donotage.

Instead of spending $1,100 / year you can buy 120 capsules off of Amazon for $25. Nice scam you've got going there.

Thanks again.