Should You Take Glucosamine For Arthritis 

I took Glucosamine with Condroitin for 5 years then stopped it. As 4 months past by, I could feel arthritic pain, so I started back on it and all is fine once again ❤

Supposedly, if the joint still has cartilage the glucosamine will help rebuild it. But if all the cartilage has warn off, then it has nothing to stick to and, therefore will not help rebuild the cartilage. I am 78 years old and have been taking it for 25+ years and have absolutely no joint pains anywhere. I used to weigh 270 pounds and slowly lost 120 over the last 20 years. I don’t care what anyone thinks, I’m a believer in the power of glucosamine.🤸🏼

I had bursitis in my hip many years ago (approx 20). I went to the doctor as I could hardly walk from the pain. He took an X-ray and gave the diagnosis also adding I had the beginnings of arthritis in the hip joint. He recommended glucosamine and chondroiton. I started taking the supplement and it helped tremendously. I haven’t had any problems since. How can you dismiss it when you say no proper study has been done? Perhaps big pharma are reluctant to fund a study as there is no financial gain for them? They make more from pain killers that clearly are not good for long term use. I would not hesitate to recommend it. Also using vitamin D3 with vitamin K2 recently which has got proven benefits.

We have been giving it to our older (and rescue) horses for over 25 years. I don't think the horses understand the placebo effect but it definitely helps. I have taken it myself for knee joint pain for 10+ years and yes, it does help.

An orthopedic surgeon had told me that I have a torn meniscus based on a MRI. He wanted to do surgery on my knee. I told him no because a torn meniscus doesn't necessarily mean that's where the pain is coming from. These doctors are not checking to see if there might be an underlining cause that's causing the pain, like osteoarthritis. I avoided surgery and started taking glucosamine and I don't have any more pain. Moral of the story. Don't believe what some of these doctors tell you. Some of them probably just want to discourage you so you can allow them to do surgery on you, this way they can bill the insurance company and make money to give to their wives. So what if glucosamine doesn't work. It doesn't cost that much money for one bottle. If it doesn't work you know not to purchase it anymore.

I'm 73 and have used it over 20 years and find it works really well for my knees.

I have been taking glucosamine after a meniscectomy 25 years ago and wasn't sure that it actually worked. Then I accidentally bought capsules that were half the dose. After a few weeks, I noticed that I was having knee pain, so I checked the bottle of glucosamine and found that I was not getting as much. I doubled my dosage but made no other changes, and the pain went away. I understand that science has not been able to prove that it works, but it seems to work for me.

I’ve been taking glucosamine since getting my knee scoped over 10 years ago. Several years ago I switched to glucosamine sulfate with chondroitin. I dont take it every day, but rather a few days at a time after feeling some knee pain return. The beneficial effect of taking it is always felt within a couple of hours. There is zero doubt in my mind that it works for me. If it were solely a placebo effect, as I am an avid fast walker, Id expect my mild arthritis in my knee to have progressed over the years. But it has not.

Our Rottweiler was suffering from arthritis in the lower spine, typical for a dog of his age. The Vet had us try glucosamine and in thirty days, it was like he was a brand new seemingly younger dog. The Vet said it was hit or miss with no bad side effects for her patients. Or it might have been a placebo effect. Willi was a very smart dog who listened well. I’ve been using it for years. The slight irritation of my finger joints has gone away. I’d say there’s a possible placebo effect but there are no discernible side effects. The cosamine brand sold by Costco was, at the time, the only veterinary brand produced to usda standards, same as for human consumption.

Works for me. I'm 74. I have lived in houses with stairs for most of my life and 20 years ago I noticed that every time I went to the second floor there was a clicking sensation in my knees. I went to my doctor and she said, "It's osteoarthritis." She recommended glucosamine. She said that it doesn't work for everyone but seemed to help the majority of people that take it. Her guess was - 70%. After about ten weeks of daily use the clicking went away. Ten years later I grew complacent and took it on a completely hit or miss basis (mostly miss) and the same clicking returned. I returned to daily dosage and the clicking went away and has never returned. That's a total of 20 years of personal experience. I had severe pain (no clicking) about three years ago and was given two steroid shots that helped. I feared at the time that I might have to get a cane. However, I adopted a five times a week regimen of riding my bike eight miles and swimming a mile. The severe pain downgraded after a couple of months to mild, occasional pain. I don't take any pain medication because of the downsides to NSAIDs. I occasionally make a cup of turmeric tea and have found that helps as an anti-inflammatory. I also went keto and lost about 20 pounds about a year ago. That helped even more. Glucosamine chondroitin has helped me and... given the sequence of events, I would doubt that that's a placebo effect. I think that these docs should be more careful concerning their advice. It's a bit cavalier. Some people short circuit the process by getting shots or using NSAIDs but you can only do that for so long before you pay the price in joint health. The best approach? Diet, exercise, avoiding injuries, and some supplements such as glucosamine chondroitin.

" Only risk is....Financial"..Love you guys

I had osteoarthritis in both hands to the point that I could no longer type. Started taking glucosamine sulphate and found mild improvement after one week , significant after two weeks and only mild stiffness by the end of the month. Works for me in conjunction with omega 3 supplements.

I've been talking glucosamine chondroitin for years for knee pain. When I stop taking it, the knee discomfort comes back. It works for me.

"The science is weak"....that's because it's a natural product that isn't fueled by the multi billion dollar pharmaceutical industry. Of course the scientific community won't study something that they can't patent and make loads and loads of money on. If you haven't figured it out yet, medicine isn't always about helping people, it's about pushing pharmaceuticals that people can't afford, expensive surgeries, and making money. If the medical community truly wanted to help people, money wouldn't be the motivator. Sick people = $$$$$$.

I am 75 and taking for last 12 years and it works for me very well 👍

Getting off carbs and sugar will work wonders for getting rid of arthritis. Worked for me.

I have had three dogs and all of the them improved after taking it so I am a total believer!

Before I decide to trust you doctors, did you push vax and masks?

For me, glucosamine was a miracle. I am normally skeptical of the benefits of many supplements. I started a job delivering meat in my 50's. I would jump off the back of the truck, trying to give the impression I was young again. After a few months, my hand and knee joints were extremely stiff and painful in the morning when I woke up. I started taking glucosamine and it brought immediate relief. Because I had worked these joints for only a few months, maybe it would be different for say a carpet layer or bricklayer, who may have done it all their lives. I kept taking them, even after leaving the job after 10 months. After three years I changed brands and it seemed to produce blood thinning and low blood pressure, so I ceased taking the glucosamine. Amazingly, I felt as good as I did prior to doing the job.

I’m 28 years old, and had a partial plica removal and some stage 3 osteoarthritis (about a 10mm pothole in the lower cartilage) repaired in my left knee in December, and my right knee is not much better off. I’ve done a large amount of mountain biking and very aggressive skiing to lead to this so young. As a professional drummer, I also get some joint discomfort in my hands. Thinking about trying this out to help mainly with knee discomfort. Figure it can’t hurt anything and may as well try it

My dog had arthritis and she use to grone every time she got up and i gave her glucosamine and after about one week the groning stopped and she felt better glucosamine works.

If its good enough for race horses its good enough for me 🐎🏃

I took it for a long time and it didnt help so I stopped taking it. I had my left knee replaced in August this year and its wonderful not to have that pain all the time and I'm going to have my right knee done in December and am looking forward to having it done. The pain was the worst but it's worth it to have the great results I have now and i love your videos and how you are so good at explaining things in a cute fun way so please never change and stay safe. Hugs 🤗🤗❤❤

Glucosamine has been proven to relieve pain and improve quality of life for dogs with hip degenerative arthritis...so there

Well, a friend got me a bottle of Chondroitin/Glucosamine @ 10 yrs ago as I was having hip and lower back pain enough to slow me down. I am 73 y. probably;ly from ranching injuries back in the day. I dont do it every day but when the pain gets a little annoying I take 2400mg ea day. I must say the pain is gone for awhile and I keep doing it for a couple more days. I quit Ibuprophine causes liver damage You Drs are great.. P/O

I started out taking glucosamine with chondroitin and it noticed a big difference in a low pain level in my knees..then I switched over to glucosamine with chondroitin sulfate and taking 1,000 mg of vitamin C before I took my pills..the vitamin C is to absorb more of my chondroitin sulfate into my body..in a very short time after doing this about a week I noticed that I had even less pain throughout my body..all of my joints felt vantastic I was able to move without alot of pain that made a big difference..I suffer with chronic pain and have so far over 22 years... I take my vitamins at night this way while I sleep there in my system longer .hopefully absorb more of them into my joints this has turned out to be a positive result for me..by lowering the amount of pain I feel gives me a more quality of life..

Good to read in your description that you indicated it for the treatment of osteoarthritis. So many presenters just say “arthritis” when there are many different types of arthritis. How much money have I wasted “trying” various OTC, homeopathic remedies only to find out they are for a different type of arthritis, usually osteoarthritis. I have RA. Please continue this.

I were told after an investigative scan to find the cause of severe pain in my knees that I had severe damage to the joints and both needed replacing. I were told that at age 50 I were too young to have the ops. A relative suggested Glucosamine, I have been taking it for the last 28 years. The pain stopped after a few weeks and I have had no pain since and regularly run up stairs. Some placebo eh?

Glucosamine alone is not enough, it MUST be combined with several other supplements such as MSM, Boron, Chondroitin etc etc. I have 20yrs of MRI scans on my knee that have shown my knee has improved to a point that I am able to squat, walk, run etc with no pain.

I always believe the literature on humans; however my 10 year-old Airedale suffered with hip dysplasia and could not get off a chair without crying in pain. My Veterinarian (a great doctor)suggested Glucosamine Ch. it worked for her with no visible pain. I took her off briefly and pain came back- put her right back on. She lived 5 more years comfortably with no other meds. I highly recommend the Kirkland brand. Many thanks doctors, a terrific channel. I hope others get the same results I did.

I am 26 and was hit by a drunk driver causing my knee to go into the dash (6’3 btw) resulting in a partially torn meniscus and a piece of cartilage that broke off and stayed in there. I am young and did not want surgery and was advised against it but couldn’t afford stem cell treatment. The injury obviously caused a lot of pain, For over a year afterwards and my knee popped and crunched really bad and made nasty sounds. Prolo therapy helped a little but not much, I was told to go on Cosamin for a couple months and I was shocked by the results the crunching went way down and the pain went away even when I went off of it. I will need surgery eventually or to get stem cells but for now if it starts hurting again (usually a little on really cold days) I go on Cosamin for a couple weeks and it won’t bother me for a long time. I love the stuff and know it works, Actually my MRI confirmed it and showed it helped heal a lot in my knee to the shock of my doctor who asked “what did you take this is insane healing for no surgery and there still being broken cartridge in there?” When I said cosamin she laughed and said “I’ve been skeptical but maybe there is something to it”

Lets just say IF it is helping for some, then please do not do any clinical trials because they result in big pharma will name it and claim it and start charging huge amounts.

I am 40 years old. I got lower back pains that started Dec. 2023. I take glucosamine from a freebies to supplements I am taking. It is just free, so I took it. I am happy because my lower back pains are fading after two weeks of taking glucosamine. I WILL DEFINITELY BUY NEW after this bottle😊

My brother took it for at least a decade and a half, no improvement, he has to walk with a frame now...that's my 2 cents, everyone is different I know too...great informational videos, I learn more from these guys than my regular doctor....!

I had knee pain for a year and nothing worked until I started taking....yep Glucosamine.

I wonder what % of reported glucosamine sales are for the pet industry. My dog's vet recommended it = my dog Brodie gave it two paws up.

Of course, surgeons want to perform surgeries; what on earth would you expect from a surgeon.

It's the response I predicted prior to watching, having taken it for a year I've found it's worked incredibly well, unlike the pain medication I was given which ruined my digestive health. Each to their own, but for me, it worked.

It's all about money & foolishness. Now Eye of Newt is terrific.

My 9 year old Akita (dog) had really bad arthritis and this is the only thing that helped. She lived another 4 years and was able to take nice enjoyable walks each and every day. As for myself, glucosamine did not help one bit.

Glucosamine with Chondroitin seems to be very popular even on this page. There are several well-respected Doctors who encourage people to try it. I am an RN and I know surgeons are going to recommend surgery because that's what they do, but surgery doesn't always work either about 30% of people are not satisfied after surgery.

I took it years ago for my knees and honestly did not notice a difference. Just had a partial knee replacement this year and that….worked. 👍

Glucosamine didn't work for my wife or I. Waiting to drop enough weight for knee replacement. Can't wait until they come out with artificial knee cartilage. Surprised no one has gotten the 3D printer going on one of those.

I've taken glucosamine on and off for many years. What I've noticed is when I stop taking it my hand pain comes back. As soon as I start taking it again, the pain slowly subsides. It doesn't help back pain though. I've read that many find this true as well.

OK. So for Everyone who is Takeing glucosamine & Condroitin. WHAT brand is the best? there is SOO much on the market I have no clue what one is best. Thanks in advance for everyones advice?

It is disappointing to see glucosamine not working for so many people because it sure worked for me. You do have to take the more expensive version which combines glucosamine with chondroitin. The stuff isn't a cure but after taking one a day my level of pain in the knees is about 1/4 of what it used to be.

I have just read on the net that women over 60 should not take it because it not only thins your hair but it also can cause glaucoma! This was alarming to read for me as my mum had glaucoma. I think there should be a warning on each bottle sold to this effect.

Absolutely works for me!

Just as an aside to your subject - isn't the PLACEBO EFFECT actually a REAL RESULT, in terms of what happens?

it does nothing. my husband took it for his knee and it was a waste.

Gentlemen, please be genuine doctors and scientists, serve your viewers as your oath demands, and say "THERE IS NO EVIDENCE THAT THIS WORKS" !

All I know is that it works with our cat's arthritis!

Years ago had issues with my hands for about four or five years, it got so bad I thought I would have to stop working. About five years ago my daughter recommended I try it, after asking my doctor he agreed. I started taking the recommended dose and in a few months I started to notice a bit of improvement, at five months I would say an 80% improvement. I use to have to run warm water over my hands in the morning before I started my day. I haven’t had to do that in years. The times and contrast in stiffness and pain before and after made me a believer.

Interesting comments Docs. Really love the rapport between you two, makes for great videos

I'm 27 now. 10 years ago I ruptured my patella tendon and tore my ACL at the same time. Didn't repair my ACL after the patella tendon repair due to the fact my quad was strong enough to support my knee. Atleast that's what I believed. Dr. Schmitt from San Antonio said my ACL somehow repaired itself from the rest of the first surgery. That the ends of my ACL were so close together while split that they and hanging so close together that it healed. which is really hard to trust in that. Would take glucosamine a lot back then but stopped and now when I lock my knee it cracks. Do you recommend getting back on it? I know it's a rare Injury for both happening at the same time still puts me down at times.

I take M&Ms T.I.D. by mouth!😝 I go by the Science, and the industry has not impressed me. Naproxen takes the edge off. Happy Thanksgiving to all. Good health and blessings to all!

My biggest experience with this comes from an elderly dog that I owned. She could not walk up the stairs anymore. We built her a ramp to get in and out. After starting her joint supplements, she ran up the stairs instead of choosing the ramp. I don't think dogs get the placebo effect.

I have taken glaucosamine for over ten years. I have been diagnosed with arthritis in my neck, lower back and in my knees. The first sites were diagnosed years ago. The right knee in early 2020 when I ruptured my quadriceps tendon. I had no idea if it was effective until I stopped taking it for 3 weeks some 6 or 7 years ago, at which point I developed a noisy and uncomfortable neck. I went back on and in 2 weeks everything was fine again. Fast forward to about 3 years ago and my neck was sore again and may turning was limited. I went home after a bad day and checked the glaucosamine bottle for strength, it was 500mg, I had picked up the wrong bottle a few weeks before. My usual is 1300mg glaucosamine/condroitin and MSM. I returned to my usual dose and my neck was good again in 10 days. How did I take the wrong dose for days without noticing it? I use a pill box. Since surgery on my knee for the tendon in February 2020 I have been taking 2 x 1300mg daily along with 2 x 1000 iu D3.

12 years ago I started to get knee pain after running 20 miles a week in my mid 20's. At that point I had been running for around 3 to 4 years with 2 rest days a week. I had to rest longer and tone down the mileage to 10 miles a week. I still got the knee pain and had dealt with it for about 3 months. around that time I started to look for answers because I didn't want to take pain medication or potentially get surgery. Tried to go natural by making a ton of bone broth and drinking it but that didn't help; it was a long process. 3 months after looking for answers I decided to go over the counter with supplements since glucosamine kept popping up on Google searches. My running started feeling better after 2 months of constantly taking it and I was able to get back to 20 miles a week after 6 months. The only times I got knee pain is when I did the tough mudder race or if I don't take it for a while with a 6-month break from working out and jumping back into running. But taking a break over 6 months and taking glucosamine 2-3 months prior to long runs stops the knee pain. Going over 30 - 40 miles per week of running I did get some stiffness or my knees feel weird even with glucosamine. About 5 years ago I started to incorporate balance exercises like single-leg balances which also helped. I'm in my late 30s now. Last year I was able to do 30+ miles per week and have no issues with my knees. I'm coming back after an 8-month break, and took glucosamine for the past 3 months and doing single-leg balance exercises. Now I'm doing 10 miles per week 2 rest days and jump roping for 30 minutes(every other day including on run days) for the past 3 weeks with no pain. Will start doing 20 miles per week next week and hopefully 30 miles per week by September. Also doing full body exercises since I'm considering joining the airforce before the cut-off age.

Halo, gospoda lječnici, molimo prijevod na hrvatski. Nismo svi poligloti a želimo nešto naučiti. Hvala unaprijed Anđela Zagreb Croatia

I have used glucosamine for the last 17 years. It takes a few weeks to work on joint. I have stopped taking it a few times and that's when I have pain. For me it works for joint pain. I am waiting for a knee replacement at this time so it does not regenerate anything as my knee is bone on bone.

They are doctors of course they have to say this.They will loose business.. I like researching and I have found 29 casada that this works.

It works for me I have been on it for over 20 years. Six months after starting taking it my knees stopped making a popping & cracking noise. And are still smooth today at age 73.

On my deed, glucose works well in touch with gymnastics, workout. Use it before exercise s That's work at least on results, that's make you do it easier an more enjoyable

_Love the Anchorman reference to the 'Sex Panther Cologne' scene. LOL You guys are my two favorite 'long-distance' doctors. 👍_ *And thanks, as always, to both of you for continuing to share your insightful knowledge with the world.*

My own experience of treating a severely rheumatic little finger/wrist with a combined glucosamine sulphate (400mg), chondroitin (200mg, MSM (50mg), and vitamin C (80mg) pill twice a day for the last five years has been a steady climb of progress in reduced swelling and redness of the 'hot' joints, and very slowly returning mobility. Pain started to subside after only two weeks. I believe these nutraceuticals work for my condition, the results are objective, not placebo. Sad to say, I do not believe the studies, I think that they were performed by biased non-believers and designed to find 'no effect', or just throw away the good data if found. Why? Well, BigPharma rules, that is why. (I am willing to believe that you are quoting the dodgy studies uncritically but in good faith. But not unreservedly.) However, the trivial amounts spent on glucosamine, etc are very small compared to the patented palliatives and symptom-relievers of BigPharma, and this you clearly do know, fie on you for not pointing this out.

What I find with glucosamine is, when I stop taking it, for example after I see something like this video, my pain in my knees gradually increases over time. When I start taking it again my knee pain decreases over time. Currently I am taking it, and have been for a number of years, and I have no pain. I am 65, I swim laps for exercise, run on the elliptical, play tennis and golf a couple times a week. I also stretch everyday, and ice my knees after I play tennis. Placebo effect, I doubt it, but who knows.

The ONLY reason the US will ever NOT recommend something is because there is something more expensive out there they will rip you off for. I hate life as it is today.

I have arthritis in my hips. I take Glucosamine & Chondrotin as well as Tumeric. I actually think the Turmeric helps some with inflammation. Not sure about the G & C.

Eat CHICKEN PAWS. You can also give chicken paws (I cook in water on stove top for 12 minutes) to your arthritic (and also as a treat) dog and cat. You will feel a NOTICEABLE difference after approximately one month. Don’t forget strength training, cold showers, and cold-water swimming. As well, eat a plant-based diet AND fast (intermittent fasting: it is miracle grow for your body AND brain).

Thank you so much for your great videos. Another supplement I have heard about for stiffness and pain in the knee joint due to osteoarthritis is natural eggshell membrane. Would your recommendation be similar to the effectiveness of glucosamine?

"Should You Take Glucosamine For Arthritis". no, but you can take it against arthritis

I’ve been using glucosamine/chondroitin with MSN for about 15 years. I take it because it works for me. I started taking 3 a day for about 2 weeks then 2 a day for 2 weeks then dropped to one a day. I can miss a few days but then I have to start taking one a day again. I know of 4 people that it works the same way as I did.

Would it work better if people's epigenetics was more towards the healthier side? I wonder if the negative studies take into account people diets, alcohol consumption, exercise routine etc.

Thank you Doc B and Doc Z. Yes, I have taken it. And it was actually recommended by a rheumatologist I had seen in the past. No, I did not see any improvement whatsoever. I did however take the entire bottle so I could report my improvement or not based on not just taking a weeks worth. So, in saying that I did try it on my aging dogs as they sure needed some relief too. No improvement with them either. I put them on CBD oil and see a result that is favourable. I still suffer and due to kidney disease and allergies to nsaids, I have taken lots of different medications. What I’m waiting for is my tkr in 2022. We are in charge of our own health and I’m glad to hear it being said at the end of your videos.

Idiot medicine. I'm glad they are talking about this because my Mom takes that crap and she is always complaining of pain.

I have not taken glucosamine ever but I have given it to my elderly dogs and both have seen significant benefits from it ( the supplement for dogs not people).

I tried GC and did not see any improvement in my shoulder pain; in fact it got progressively worse. What ultimately worked to eliminate the pain and restore full range of motion was 6 weeks of physical therapy. On the rare occasion that my shoulder starts to get stiff or achy, I just do the exercises the PT taught me 😊 BTW, y'all are great. I truly appreciate your evidence-based approach to medicine.

My doctor prescribed glucosamine, so what you are saying is that is like a placebo. Should I keep taking it seeing as though it (aint realy gunna) work

Hi Docs I tried Glucosamine years ago and didn’t notice any difference. Thanks for the videos. Wasn’t it used on horses?

I started taking glucosamine in my late 30s. Taking it consistently since then, but there was a period about four years ago where I went off all supplements, including glucosamine. And within a year I was planning on my first knee replacement. My knees were diagnosed with arthritis when I was 24 and told then that I had knees of a 64 year old. A couple days ago my doctor said my knees look like those of an 80 year old and I’m 62. The point of the story is when I went back on glucosamine after a year the pain I had developed during the year went away, and I stopped planning for a knee replacement. So I think glucosamine does work I’m an active person, so may be a lot of people who take it aren’t active. Recently I started again the process to get a knee replacement but then I went on WeightWatchers and after losing 15 pounds I’m no longer planning on a replacement this year because the pain reduced.

Hi I took glucosamine and didn’t see any significant change in joint discomfort particularly in my back. HOWEVER, when I took the combination of glucosamine and hyaluronic acid I did experience improvement in joint discomfort. It was quite by accident that I ended up getting a bottle of Gluc. + HA so was I shocked when I felt better. I actually had to look at the ingredient label to see what was different and that’s how I found out about HA.

Glucosamine(1500mg) chondroitin (1200mg) with 3mg boron works for me. I ran out for it for a couple of days and I felt my right cartilage was throbbing. I'm never going to stop taking it. It's cheap in comparison to knee troubles.

I take the recommended dose twice a day, and I have for years. While I'm not concerned about the cost (about $50 to $60 a year), I did wonder if it was working for me. So, I stopped using it for a month. My joint pain increased very noticeably. I returned use with the same daily dose, and within a couple of weeks the pain relief returned. Couldn't tell you if it was a placebo effect, but I really doubt it. While my "experiment" was not "scientific", and would be considered anecdotal, I'm satisfied that this supplement is working for me. Glad I found you guys. I'm now a subscriber. 😊

I am from India. I took Glucosamine HCl in 2005 for 2 months. The pain was gone and I had no pain for a long time. The next time my joint pain returned was in 2013. Again took Glucosamine HCl for 2 months and stopped. The pain never returned to date. My present weight is 266 Pound (121 Kg).

I don't remember what the diagnosis was for chronic pain in my shoulders, but I was getting periodic cortisone shots. I started taking glucosamine and condroitin about 2 decades ago on my own and no longer had any pain. It has not prevented the need for a total hip replacement coming soon. I enjoy your discussions. Thanks.

I have gone to sports doctors about arthritic shoulders and they were reading from the same hymn sheet as the doctors in this video. No proof it will help, but it probably wont hurt. After taking glucosamine for 2 months my pain was almost non-existent. This was after going off prescribed anti-inflammatory that did essentially nothing. Interesting there is “evidence” for the prescribed medicine that didn’t work but not glucosamine 🤔 Although there is alot of real world evidence for people improving on glucosamine. Also interesting in Europe it’s prescribed because apparently there is evidence there it works, but for some reason the evidence of it working on a North American human doesn’t exist…🤷🏻‍♂️

Our doctor said, “ don’t bother with it unless you want expensive pee”. Saved my money. 👍🏼🇨🇦

Once claimed and projected to be best products suddenly becomes useless is it research failures or making space place for new products /business.

I tried it but it made by joints feel weird and uncomfortable. However, my dog had hip dysplasia and she couldn't walk without it, it was a miracle drug for her!

Thanks Again Doc's- If You Get a Chance Sometime-I Would Like to get Some Info. on Cervical Problems and Their Relation To Headaches and Severe Neck Pain. I Have Had a Lot of Neck Trauma in the course of my job as a a Police Officer. Thanks Again-Tom Tesh-Germanton N.C. 27019

Thank you for setting the record straight.

After about a year of pain in my left knee (osteoarthritis shown by MRI), I decided to give it a shot with Glucosamine/Chondroitin/MSM (one 500mg pill about every 8 hrs to maintain a steady state of bioavailability) and within a week it's helped significantly. I can now sleep much better without worrying about the position of my knee. If you're not sure, buy a bottle, try it for three months, and if it doesn''t work - don't buy it again. As a retired Ph.D. chemist, I'm happy to say that this experiment worked for me! Thanks Guys!

In 2001 I had chemo, I was having a lot of knee pain, so my GP suggested an X-ray and it showed I had 30% cartilage in 1 knee and less than 10% on the other. (Side effect of chemo, apparently) Doc gave me a prescription (UK) for glucosamine and 3 months later, my knees where up to 80% and 65%. Every time I get joint pain I take out the glucosamine and a couple of weeks the pain has gone. I’m 67 and won’t be without them. Maybe they don’t work for everyone, but I’ve suggested them to friends and the majority found that they helped. Worth a try! No?.

Intramuscular injections of chondroiton-glucosamine in horses has a night/day effect when addressing pain issues in their knees and hocks. Usually a series of one injection per day for 7-14 days will last 2 or 3 years in terms of effectiveness. Pretty sure horses don't know what a placebo effect is. I've seen horses with seriously ugly joint xrays have their jumping careers extended five or more years.

Hi Docs, I have had knee pain for over a year. I'm 60 and overweight. I started taking Glucosamine to see if it would change anything. I did not have any expectations so I don't think I suffer from the placebo affect. After 3 weeks, my knee pain was gone. After a year of pain, 3 weeks of Glucosamine and no pain anymore. I don't know, but it really sounds like it did something to me. I guess I could stop it for a while and see if the pain comes back... I'll let you know how I do.

Fear not using the words "science". You guys are science based no? That's what we want to hear. Hey, maybe it hasn't been long enough but you guys must have patients using marijuana balms on knees and proclaiming the effectiveness of that product. I can imagine it has no effect on the pathology of an affected joint but apparently greatly reduces pain. Any chance you speaking on your experience from patients using such a product? I've used a marijuana once as a sleep aid. Apparently I used the wrong product and woke up high. Not gonna use that product again, that was terrible. Anyway, all the best Docs and thanks for sharing.

I had a dog a few years ago with arthritis in her back hips. She would still love to go for walks, but after a short time would start limping. I found a dog treat with glucosamine and after 2 weeks taking that, she stopped limping. That was proof enough for me to take it for my own arthritis. With people it’s harder to tell the effect as there’s such variance in diet and activity … but with my dog those were a constant.

Often comes in supplement form and also includes chondroitin, calcium and vitamin C. Given that the last two are useful and the pills are usually cheap . . .

I had chondromalacia patella for almost a decade beginning in the 1980s. I could not walk for more than a mile or two without such severe knee pain that I had to stop walking. Doctors suggested knee surgery, which I did not want to do. In the '90s. I started taking Glucosamine regularly, sometimes in a supplement that also included Chondroitin. As time went on I was able to take longer and longer walks without any pain. For the past 20 years I have continued to take Glucosamine, and I regularly go on 5+ mile hikes without any pain at all. While this is just one anecdotal experience, trying out Glucosamine for a sufficiently long amount of time may be worth doing, to see if it helps you.