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Spermidine is a natural polyamine found in many foods you likely eat; mushrooms, broccoli, apples, nuts, soy, aged cheese & much more. Like the other polyamines, putrescine and spermine, their attraction to negatively charged compounds like DNA, RNA and some proteins have resulted in them being connected to a variety of different cellular processes ranging from cell growth to cell death.
In terms of spermidine, one cellular process it activates where there is much scientific evidence for, is autophagy. Autophagy is a regulated cell mechanism that removes unnecessary or dysfunctional components - it is often thought of as a recycling process. Life extension seen in model organisms supplemented with spermidine seems to be autophagy dependent. This has caused much interest in further exploring how spermidine is acting and what anti-aging benefits it could have.
For example, in this video we will take a look at a recent study that shows dietary spermidine improves cognitive function in flies and mice and there is a correlation with spermidine intake and cognitive performance in humans. But are there risks to spermidine supplementation and would food intake be sufficient to get these benefits? Find out in this video.
TIMESTAMPS
Intro - 00:00
What is spermidine - 00:30
Spermidine & anti-aging (autophagy) - 02:30
Cognitive function - 05:20
Clinical trials and thoughts - 10:30
REFERENCES;
Dietary spermidine improves cognitive function - doi.org/10.1016/j.celrep.2021...
Spermidine in health and disease Science 26 Jan 2018:
Vol. 359, Issue 6374, eaan2788
DOI: 10.1126/science.aan2788
Eisenberg, T., Abdellatif, M., Schroeder, S. et al. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med 22, 1428-1438 (2016). doi.org/10.1038/nm.4222
Eisenberg, T., Knauer, H., Schauer, A. et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11, 1305-1314 (2009). doi.org/10.1038/ncb1975
Nutritional Aspects of Spermidine - doi.org/10.1146/annurev-nutr-...
Minois N, Carmona-Gutierrez D, Madeo F. Polyamines in aging and disease. Aging (Albany NY). 2011; 3:716-732. doi.org/10.18632/aging.100361
Clinical Trial - clinicaltrials.gov/ct2/show/N...
Partridge, L., Fuentealba, M. & Kennedy, B.K. The quest to slow ageing through drug discovery. Nat Rev Drug Discov 19, 513-532 (2020). doi.org/10.1038/s41573-020-00...
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence - doi.org/10.1016/j.molcel.2019...
DISCLAIMER: This video is for educational purposes. I am not a doctor and don't offer health advice.
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4 авг 2024
