SPERMIDINE & LONGEVITY: Induce Autophagy Without Fasting [2021]

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SPERMIDINE: If you want to trigger autophagy but hate to fast, you'll enjoy this video. In it, we link spermidine, fasting & autophagy to longevity by talking about several studies that seem to show that taking spermidine can extend lifespans.
We'll begin out discussion by talking about what spermidine is and how it works before moving on to how it impacts aging and what you should know if you're planning on supplementing with spermidine. I'll even provide a great place to obtain supplemental spermidine.
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LInks to studies in this video:
www.karger.com/Article/Fullte...
www.sciencedirect.com/science...
link.springer.com/article/10....
www.ncbi.nlm.nih.gov/pmc/arti...
www.sciencedirect.com/science...
www.nature.com/articles/cdd20...
www.ncbi.nlm.nih.gov/pmc/arti...
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3 июл 2024

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Комментарии : 173

@saxxnviolins 3 года назад

There is one animal product that is high in spermidine. Wikipedia says wheat germ has 243 mg per kg. Coming in second is aged cheese (at least one year) has 199 mg per kg. Soy beans come in at 128 mg, while mushrooms have 89 mg. Costco sells a cheap three year aged Vermont Cheddar. That is more palatable than wheat germ, or soy beans. Of course, mushrooms are palatable too, with fewer calories and fat. But you need twice the volume of aged cheddar to get the same spermidine.

@cizcalodiablopanzon Год назад

I don't know how much spermidime i am getting but I add one tablespoon of wheat germ and half a spoon of wheat germ cold press oil to my morning shake

@johnsirko4 Год назад

Weight lifting trigger autophagy too without fasting

@jackbuaer3828 3 года назад

Thanks for providing this info!

@peterz53 2 года назад

Glad you pointed out food sources which far outway the amount provided by expensive supplements.

@johnhancock5542 3 года назад

Great video and excellent use of language. Too many of the healthspan videos bury you by going round in circles with brain numbing advanced microbiology terminology. You have a great skill with language and simplfying the language. Thank you & keep it up. John Hancock

@LanceHitchings 2 года назад

Thanks

@sncnutrition7118 8 месяцев назад

@@LanceHitchingsGreat video. Would love to know your thoughts on this article. Serum Spermidine in Relation to Risk of Stroke: A Multilevel Study. It's on Pub Med Central. I personally had great results on 10mg of Spermidine 3cHcl by doublewood. I did just order the one u recommended in this video.

@ratherrapid 2 года назад

i have concluded tht u can given anything to mice and they will live longer.

@Sonia-zq9ek 2 года назад

LOL 😂

@TheChristopherBlake1 2 года назад

LOL 😂 LOL 😆 LOL 😝 EXCEPT, D-Con of course.

@asdnetwork4268 Год назад

Give them water. Boom, live longer. Give them food. Boom, live longer, give them Gameboy advance, boom live longer.

@chriswright2483 Год назад

Lol 😂!

@wmp3346 Год назад

Very scientific 🧪

@olyav5819 3 года назад

Great info, thank you!

@shy-guy5544 3 года назад

Excellent, informative video, presented well, as usual. Thanks

@LanceHitchings 2 года назад

Thanks again!

@Rocky-dm7bi 3 года назад

Thanx alot 🙏😌There are more to consider than just diet & fasting mental health.. Avoiding Toxic ppl..

@Viv8ldi Год назад

Would u donate me some natural spermidine?

@seattleareatom 2 года назад

Great video. Thanks.

@asdnetwork4268 Год назад

I've been trying to convince my wife of this for a long time.

@gregoryhamilton6161 2 года назад

My goodness found you, excellent

@MikeG-js1jt 2 года назад

I just want to note that on the spermidine life product that you're pitching, the ingredient label doesn't even use the word Spermadine, it's most active ingredient is declared as 800 mg of wheat germ extract, sure enough, wheat germ extract does indeed have spermidine in it, but there is no indication of how much spermAdine is actually in each dose. Inshort 800mg of wheat germ extract does not equal 800 mg of spermidine. Also, It would be nice to know how much spermidine is effective in starting autophagy.

@johnjallen Год назад

You can buy wheat germ from the store and eat it by the spoonful. Very cheap and easy.

@karlfillmore57 Год назад

@@johnjallen Yep. Sprinkle a couple of tablespoons full on your salad and use plenty of olive oil for bio-absorption.

@robertsmyk4102 3 года назад

You said that autophagy creates additional "energy" in our cells but autophagy recycles cellular components (proteins). Energy is supplied by the blood from the liver and consumes the body fat to do so. Mitochondria are rejuvenated by autophagy and become more efficient and thus may become more energetic.

@erwinrogers9470 2 года назад

Love your content

@LanceHitchings 2 года назад

Thanks.

@erwinrogers9470 2 года назад

@@LanceHitchings Absolutely

@Linshark 2 года назад

Aged cheese also has a lot of Spermidine, like Cheddar or Blue cheese.

@hamid237 2 года назад

I have taken Spermidine for short while and i have better mental clarity. Thanks for the info!

@ahsanriazkhan3068 2 года назад

Desit help to verse gry hair

@hamid237 2 года назад

@@ahsanriazkhan3068 Actually it has helped with hair regrowing a little bit. It has to be taken for a long time to see all the benefits.

@yogastu3952 Год назад

Love the video! Thoughtful and informative. Thanks :)

@gemagel20 3 года назад

Just a correction. Autophagy is not latin. It is Greek :-)

@LanceHitchings 2 года назад

Good to know. Thanks.

@ThaUnseenTruth 2 года назад

@@LanceHitchings “Elevated levels of polyamines have been associated with breast, colon, lung, prostate, and skin cancers,” www.ncbi.nlm.nih.gov/pmc/articles/PMC4027058/ “The polyamines spermine, spermidine, and putrescine are involved in various biological processes, notably in cell proliferation and differentiation, and also have antioxidant properties. Dietary polyamines have important implications in human health. [...] “The antioxidant and anti-inflammatory effects described for polyamines can play an important role in the prevention of chronic conditions such as cardiovascular diseases and diabetes. On the other hand, cancer is associated with high levels of polyamines, brought about by an alteration in their homeostasis.” www.frontiersin.org/articles/10.3389/fnut.2019.00108/full

@yuvalkapellner2551 3 года назад

Fasting + Spermidine works. 16/8 approach + Spermidine before bed (1mg to 3mg)

@Viv8ldi Год назад

Does 16/8 mean 8 hours of fast? Like during sleep? Do u have to take spermidine while u are fasting?

@denisaugustoliossi9117 2 года назад

Thats important information

@XeNos3131 2 года назад

Excellent video.. Don't want to be petty.. But please note that autophagy is a Greek word:The term 'autophagy' comes from the Greek words 'phagy' meaning eat, and 'auto' meaning self

@LanceHitchings 2 года назад

No problem. I love it when people point out something that I've gotten wrong. How else will I learn?

@mitchellzastey 2 года назад

im going to be taking spermidine at night when I just begin my intermittent fast, I think it will work more naturally that way and I was thinking the same thing about rapamycin! Maybe if you're taking spermidine your rapamycin intake would not need to be so frequent and taking rapamycin on one of the days you take spermidine would make sense. Maybe once a month or every other month rapamycin.

@JoeMama-ud5eh 5 месяцев назад

How did get rapamycin?

@Viv8ldi Год назад

What do u think about grape seed extract?

@loupagnucco3719 3 года назад

Trehalose also increases autophagy. I welcome your comment.

@user-br6rn7sx2k 3 года назад

Спасибо

@ScottSummerill 3 года назад

We don't need one more course. We need current research to stay up to date.

@LanceHitchings 2 года назад

I was unaware that there are currently ANY courses available on longevity. Links, please.

@romancatullo7496 2 года назад

Any thoughts on prepared HuShuWu ?

@bojames7841 3 года назад

the evidence - particularly the pre-clinical one - is fascinating. But it seems to me that a normal diet will provide all the spermidine I need (and for $95 I can buy a lot of good food).

@michaelharrison9340 3 года назад

"normal" doesn't mean the Standard American Diet of course

@giannibravo347 2 года назад

@@michaelharrison9340 thats a lot of special miracle mushrooms :)

@moiLawUk Год назад

When is the best time to take spermidine? Without or with food? :) Thanks

@Viv8ldi Год назад

So could it be said that aciding of the body causes aging in general?

@holyddogg7 5 месяцев назад

What about daily dosage

@edisonclaro5363 2 года назад

Hi Lance Nice video. I can take spermidine with NMN? thanks

@madpower2000 3 года назад

What about lkm512 probiotic which induce endogenous spermidine production ?

@lyleburns8532 3 года назад

I started eating aged Gouda cheese because it was supposed to have spermidine in it. Have no idea if it is causing autophagy. But it greatly improved things in the bedroom if you know what I mean. Who knows if there was some other compound in aged Gouda but I would say give it a try if you are over 40.

@LanceHitchings 2 года назад

Great tip, thanks

@lotzen8524 2 года назад

Take Minimum 12 months aged Cheddar not Gouda

@ManageDeMaia 2 года назад

Gouda has a lot of mk-4. That should have some effects on testosterone.

@mikelance7175 2 года назад

@Admiral Nelson I thought eating too much dairy cause cancer is it called the China study or something

@melinakoufalis281 Год назад

I just had gouda tonight lol

@guravi4295 9 месяцев назад

Sadly , currently, commercial spermidine comes from wheat germ oil, which usually contains Gluten. Not for Coeliacs (Gluten allergy) like me.. Does anyone know of a product where spermidine is isolated from other sources?

@bshul10 2 года назад

Hello...with regard to autophagy. It is proposed that senolytics be applied intermittently for maximum/safe effect. Spermidine, as part of diet would be taken continuously....how do you reconcile this?

@LanceHitchings 2 года назад

As I understand it, spermidine is not a senolytic. It does impact senescence because autophagy makes cells more healthy and less likely to become senescent in the first place. I guess I don't see the conflict.

@bshul10 2 года назад

@@LanceHitchings Thank you....got my definitions straight...senolytics destroy senescent (non functioning) cells....autophagy agents cleans out waste products from functioning cells.

@bshul10 2 года назад

hello, I think we should be careful with spermidine supplementation for at least two reasons. Spermidine effects cardiac potassium ion channels in the direction of promoting atrial fibrillation. Additionally spermidine is competitive for the activity of DAO which increases histamine exposure. i have the references.

@kimcantswim174 2 года назад

@@bshul10 So it isn't safe?

@gsuitter Год назад

"And what about fasting while taking spermidine"? Anything new on this? Spermidine and fasting seems like a good combination. I take wheat germ extract as a source for spermidine to induce autophagy. Does anyone know if the extract would break a fast if taken during a fast?

@Viv8ldi Год назад

Ofcourse all the good and interesting questions and those that might change something will not be answered sadly

@cococgb5389 Год назад

I would think anything that needs digestion would break a fast

@tomwoodall1463 3 года назад

I went to their website and chatted wit the rep. She stated that this is not a fast acting supplement and requires a build up to work. wow! imagine activating autophagy 24/7 instead of just sometimes. If this is true, this is a really bad idea.

@LanceHitchings 2 года назад

Not as bad as never activating autophagy. Most people have so many nutrients from constant over-eating that they never activate autophagy. And I don't think that you can activate autophagy 24/7. But that's my opinion, not scientific fact.

@tomwoodall1463 2 года назад

@@LanceHitchings yes, but there are other ways to only sometimes activate autophagy. Doing it all the time is not a good idea. According to the rep I spoke with, this activates it all the time..

@victorfinngall3911 2 года назад

Watched this

@mannyb7511 3 года назад

I take Ultra Spermidine 700 mg . Can you take spermidine with NMN?

@dwintablet Год назад

If spermidine activates autophagy, can you eat regularly?

@Viv8ldi Год назад

Memo: there is a connection between autophagy and learning memory

@matthiasmaiwald8236 2 года назад

Tiny correction, autophagy is Greek, not Latin.

@rdance3 3 года назад

Every Spermidine supplement, that I have found, seems to be derived from wheat germ. I have steered clear so far, because I have celiac disease and I doubt that they are GF. Agmatine Sulfate is a precursor to Spermidine. I take this supplement in my preworkout. Do you know how effective this would be in increasing Spermidine and do you know if Spermidine is GF?

@timh-c7186 3 года назад

"spermidineLIFE® includes approximately 1.3mg of gluten per daily dose. Please consult with your physician to determine if spermidineLIFE® fits within a gluten-sensitive diet."

@scottmiller2591 3 года назад

Ditto if you are on keto.

@Scottlp2 2 года назад

Supersmart spermadine (amazon has it) sells spermamdine from rice extract

@rdance3 2 года назад

@@Scottlp2 Thanks!

@marlenecampbell5439 Год назад

I seen one on Amazon made from rice in a black jar. Also double wood makes one that is chemical not made from wheat.

@demiberikaki505 Год назад

autophagy is a totally greek word, not latin. Αυτοφαγία (autophagia) means as you said self-eating.

@LanceHitchings Год назад

Yep, misspoke.

@birage9885 2 года назад

Some say that spermadine trihydrochloride is toxic, but some companies use it, and I haven't seen good studies proving that it is harmful. If anybody has any, please post.

@LanceHitchings 2 года назад

That's interesting, I hadn't heard that. If you learn more, let me know.

@birage9885 2 года назад

@@LanceHitchings Will do, and if you find out more, please make a video. If it is safe, it is far cheaper. DoubleWoods has that in their spermadine supplement, and they say it is safe.

@scottpreston5074 2 года назад

I am sceptical that enough spermidine could be dosed in the few milligrams that are contained in spermidine supplements. And, the amount of food you would need to eat to get a therapeutic dose would obviate the benefits of fasting. I believe that larger amounts (therefore cheaper) would work better on an intermittent fasting schedule. But, really, it's way too expensive.

@tomlwallace 3 года назад

Many of us use broccoli seed sprouts for the Sulphoraphane (spelling?) Content. Are you aware of broccoli seed sprouts being a good source of spermidine as well?

@Libertas_P77 3 года назад

They are not especially high in spermidine. The highest natural food source by a long way is wheat germ. A few teaspoons a day is what I have added to my diet.

@mortkebab2849 2 года назад

But I like fasting.

@Viv8ldi Год назад

Is all spermidine created equal?

@Viv8ldi Год назад

Memo: it can be created by tissue or bacteria

@kharesiddharth2526 Год назад

Skip to 1:30

@H1TMANactual 2 года назад

Bro why r u asking us for info? We're here to get info from u 😭

@LanceHitchings 2 года назад

Because this is a community. I don't know it all, not nearly, and I'm always learning something new by reading the comments on this channel.

@danluther1741 8 месяцев назад

According to Dr. Greger the best, cheapest source is Wheat Germ. I will never argue with him!

@LanceHitchings 7 месяцев назад

Yeah, but you'd have to eat so much wheat germ to do any good that your caloric load would be through the roof.

@radic888 6 месяцев назад

Actually, on Dr Greger's list of spermadine sources, wheatgerm is not on the top of that list.

@danluther1741 5 месяцев назад

@@LanceHitchings Interesting. According to the National Institutes of Health (NIH) Wheatgerm is an excellent source.

@iblisthemage 3 года назад

Rapamycin/Rapamyacin? Unsure on what it is called/how it is pronounced…? Getting my spermidine from aged cheese :-)

@lotzen8524 3 года назад

Aged Cheddar (Minimum 12 months) or better Wheat germ

@iblisthemage 3 года назад

@@lotzen8524 aye :-). I have a cheese box in the fridge, I get about 70-100g a day of Cheddar, Pamadano, Harvarti, etc, all aged at least 12 months. I eat low (no) carb due to prediabetes, so no wheat germs for me. Also, I really like my cheese 😎

@Viv8ldi Год назад

Memo: autophagy=selfeating

@mreudeco 2 года назад

Blue Stilton cheese has spermidine? Another video says that.

@Zarcon2008 3 года назад

Does anyone know who this guy is?

@jonduringer5848 3 года назад

A friend of mine (IRL) for a few years.

@LanceHitchings 2 года назад

Thanks, Jon!

@scottpreston5074 2 года назад

Someone worth listening to.

@Viv8ldi Год назад

Memo: spermedine is a polyamine

@thomasjohnson6808 Год назад

No wonder my gf looks so young!

@Viv8ldi Год назад

Well if u hate to fast and the pain that comes with it maybe u dont deserve to live longer? No pain no gain baby

@tumbleweeduk7479 2 года назад

I like the way you explain things in such a straightforward manner, repeating the important bits but I gave up all drugs to avoid the vivisection and torture of innocent animals and yet I find there is just as much torture of creatures that would normally be our pets justified in research of supplements! It is horrific and a unacceptable. If we just ate the way our grandparents did and stopped relying on the pharmaceutical industrial complex we would be healthy and not torturing adorable little sentient beings to make up for our lazy addicted food habits. So sad! The number of animals being tortured in the name of a renamed virus and vitamin D3 deficiency is heartbreaking and nobody should accept injections based on such appalling cruelty. I buy supplements that Are not tested on animals but what is the point if they rely on research based on unscientific unnecessary animal cruelty. ? When human beings manage to destroy themselves completely with their greed and gluttony, the planet will be a much better place, peace on Earth will be reinstated without humans. We do not have to be like this, there is still time to change But change does not come with mandated injections! Thank you Namaste 🙏

@forgodsolovedtheworld3389 Год назад

Jesus Christ will bring peace to the earth when He comes to rule what's left of it and humanity after the Great Tribulation. His rule will be just and fair and He will restore the planet to its previous glory after the end of His glorious 1000year Millennium reign. Seek the Lord whilst He can still be found...