I have a polyclonal Vdj TCR with seronegative celiac disease. I have now high hemoglobulin (18),high hematocrit (52) with high mcv and mch (most likely due to my chronic gastritis). I have read that kidney can also be damaged ( Berger disease) by Iga. How do I know if my kidney is damaged if I do have the seronegative type ( IgA/Ema and fecis). Is Cd4 produced in the bone marrow?
hii mam this is manikanta kolasani did my Integrated MSc in systems biology from University of Hyderabad India mam I was watching ur video b cell devolopment this is phenomenal
I think that the delta loci is directly downstream and adjacent to the mu loci for the b-cell heavy chain. That's why the two can be produced from splicing variants. In your drawing, it had delta at the opposite end from mu, which I thought was a little confusing. Also, when class switching occurs, it is entirely possible that any other constant region isotype loci downstream of what the cell is switching to stays intact meaning that it is possible for the cell to type switch again. That being said, it is impossible for the cell to switch back to a previous isotype as that dna was excised from the genome.
oof sorry man, but that is not one I excelled at. If you want them toward a micro slant I recommend armando hasudungan. I have found his pretty helpful to me in the past!
