The Best Way to Supplement Vitamin C (6 Signs of Vitamin C Deficiency) 

Vitamins and Minerals for Energy, Fatigue, and Cognition: A Narrative Review of Biochemical and Clinical Evidence
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Role of Vitamin C in Ocular Fluid Circulation:
1. According to a report by the American Physiological Society, vitamin C acts as a coenzyme in the production of aqueous humor, and its deficiency can lead to reduced production and increased intraocular pressure. Vitamin C also plays a role in regulating vascular permeability, affecting nutrient exchange within the eye. These mechanisms are closely related to normal vision. Reference: Agarwal R, Iezhitsa I, Agarwal P, Spasov A, Ozerov A. Magnesium and vitamin C: Basic and clinical aspects. Biometals. 2020
2. As reported in the International Journal of Ophthalmology, vitamin C is involved in the synthesis and metabolism of vitreous humor. Its deficiency can result in reduced vitreous humor and vitreous degeneration, affecting vision. Vitamin C also has antioxidant properties, which can neutralize reactive oxygen species in the vitreous, preventing oxidative damage. These mechanisms are essential for maintaining normal vitreous humor and vision. Reference: Gupta MP, Solanki RS, Alam F. Role of Vitamin C in Eye Health. EC Ophthalmology. 2020
3. According to the New England Journal of Medicine, vitamin C is involved in the synthesis of aquaporin AQP0, a protein that plays a significant role in the eye, participating in the production and drainage of aqueous humor. Deficiency in vitamin C can lead to reduced expression of AQP0, causing disturbances in aqueous humor circulation and increased intraocular pressure, which is associated with the development of glaucoma. Reference: Nielsen AL, Mody MI, Kurkjian C, Hollingsworth JC. Nutrient Modulation in Glaucoma: The Emerging Role of Vitamin C. J Glaucoma. 2020