When Deadpool lost his wife he was depressed and wanted to die. When Deadpool found a girl on a ledge he "talked" her down. Yes, Deadpool understands who, what, and why of every world he's in but to him all of those worlds and every person around him are still very real.
Bruh...Deadpool's schtick is that he knows he's in a comic/movie. So him saying Paul Rudd's name is LITERALLY ON BRAND. It's not going to hurt the MCU. Just stop.