@@ashleylala4293 I try to get information everywhere. I used to be on low and no carb about 5 years ago as well which is how I found t Delauer, Berg etc. . .
Good to finally see someone covering methylene blue. I feel I've not seen enough knowledgeable people discussing it. Also, good to see you not use a clickbait description. I've stopped clicking on all the "see what this guy does to be amazing"
@@jonathonpotts5666 I dose into breeding bins not directly into my tanks because I'm pretty sure it kills beneficial bacteria as well. It will dye the silicone seals too by the way (I learned the hard way) haha. Definitely some powerful stuff!
Even if you don’t breed it is super useful for aquarium fish. Great for new acquisitions, especially if they’ve been shipped. I add it to quarantine tank water (as long as I’m not needing to run medications that it interacts with) or even the bag water in a bucket if I’m drip acclimating. Reduces the effects of ammonia toxicity, hypoxia from being in the bag for a while, counteracts cyanide (which can still be an issue in some wild caught reef species), acts as a topical antiseptic for any minor injuries from handling, and darkens the water to help the fish feel more hidden/secure thereby reducing stress. So it’s a great general supportive for new acquisitions. I’ve also used it in hospital tanks for many of the same reasons for fish that are not doing so hot. Fish that got beat up by a tank mate, stuck in a filter, or decided to go carpet surfing for example. Methylene blue and either aquarium salt (in freshwater fish) or hyposalinity (in saltwater fish) will go a long way toward preventing opportunistic infections, and improving their hydration and oxygenation so they can heal.
I am on it for Bartonella. It’s made a huge difference. The soles of my feet are far less painful. It’s just like a gender reveal party every time I use the bathroom though.
That’s great news you found a cure especially since I have never even heard of Bartonella so in my layman’s opinion it sounds like a painful and exotic disease that most doctors can not treat!
I've been using liquid oral methelyne blue for general metabolic improvement (aging and weight training), about 20 mg per day, and so far I've experienced zero negative side effects (other than green/blue pee). However, I'm still on the fence about how well it works, since I haven't really noticed any significant positive benefits either. I'll likely keep taking it though, simply because I'm well aware of how it improves the electron transport chain within the mitochondria. Even if I'm not "feeling" much different, it's still likely providing positive results under the radar.
Without a test to prove that. It's highly unlikely. You could get off it wait a few months. Then get a test done and start again for a few months and see what happens.
I've been taking it off and on for about 1.5 yrs. At first it seemed very helpful. I'd notice at the end of a 12hr shift, I would not be so burned out, but other than that not alot of huge "noticeable" benefits.
@@Drscottsherr i have had serotonin syndrome before...what should i stay away from while on oral MB? can i drink caffeine? can i use other minerals and herbs? please help. I have read multiple studies and i am kinda worried.
Just so you're aware methylene blue isn't one of those things that gets better as you increase the dose. At low doses methylene blue helps with oxidative stress but once you take a high enough dose it causes the body to generate reactive oxygen species like superoxide anion. Which unfortunately dramatically increases oxidative stress in your body. Methylene blue is one of the compounds where the phrase "the dose makes the poison" fits like a glove.
There isn't, yet, but clinically it is absolutely a game-changer. Much of this is mitochondrial dysfunction and MB is fantastic at supporting and optimizing mitochondria!
The product that you are promoting is extremely expensive compared to the market. Their blocks are 3mg doses, 16 per box, which is 27 bucks. Or 48 servings at 81 bucks, that equates to $1.69 per 3mgs. Or the competitors are selling the same thing, at about 30 bucks a bottle for 333 servings of 3mgs; which comes out to less than $0.10 per 3mg serving..... That's 18 times more per dose. How can you justify a 1800% mark up from a product being sold at a markup? Greed is evil.
Exactly why I have a hard time taking this guy seriously. Trying to make that big of a markup off of sick, desperate people is a scumbag move that tells me everything I need to know about this man. Better to get your own script and go through a compounding pharmacy.
@@ashleylala4293 It's a quality and precision dosing thing. So much MB On the market is contaminated because it is very difficult to make and source. We've had to through out $$$$ in the past because it didn't meet our standards. Always ask the manufacturer for a CoA before you buy it. Plus drops are notiriously underdosed per mg as well. That said, compounding pharmacies can be good here but also check their CoA a well!
@@KJB0001 honestly I've been going by taste/color and worked out the dose based on how I felt.. it's very small.. like you'd need microgram scales. I'm guessing around 5-15 mg a day but I could be off. I use something like 50-100 mg to make a concentrated MB water, and then I use some of that in my drinking water usually when I train.. I guess I make a couple of gallons out of it. I don't drink this all day so I probably drink it over 10 days. MB keeps the water from developing any bacteria if you keep it for a bit, it's used for fish tanks etc.
@@KJB0001I personally use 5-10 drops in a cup of coffee, juice, or other liquid. I dont know what that translates to in cc's or milligrams, but if I take MB in conjunction with my stack and I use more than 5-6 drops I get too wired.
Methylene Blue has been the first thing that has worked to improve (almost eliminate) my long covid symptoms (PEM, ME/CFS, chronic hypoxia, inflammation, MCAS)
Methylene blue is the antidote used for cancer patients that experience ifosphamide encephalitis a side effect of that particular chemotherapy. No idea why it worked but it was always kept in stock on the ward for that specific use.
@@Drscottsherryou dumb trash shills know it literally induces ROS… must be nice to have a bunch of idiots as your patients to believe whatever nonsense you spew.. these are literally Nazi bioweapons yall push as medicines.. clown world
The instant tests show negative by the appearance of a blue line, so yeah blue urine would F that up for sure. Unfortunately this would probably result in your sample being sent to the lab.
Some people are just more sensitive than others! But drops can also be very variable and difficult to dose + often contaminated. Make sure you ask for the CoA from the. manufacturer or check out Troscriptions as another options!
Being a bit pedantic here, but hearing it repeatedly was driving me crazy. O2 percent is constant when changing altitude. The barometric pressure changes, so there is more O2 pressure (21% of 760 mmHg (=160 mmHg O2 partial pressure)) at sea level vs at high altitude (21% of 596 mmHg at 2000m (=125 mmHg O2 partial pressure)). I think he was converting this back to seal level equivalent (21% O2 * 596/760 = 16.5%). End message was accurate, but wording used to get there was not. Like I said, I am being a bit pedantic here.
Appreciate the clarification! People tend to get more confused when you tell them that 02 % is constant when changing the altitude...believe me, I've tried lol. But I very much appreciate your math here!
Science! its the lack of pressure so less less of all gasses can dissolve into the blood at altitude. this is especially important to know for those who have anemia and so their blood can hold less oxygen with less hemoglobin. Usually the body just breathes more to keep 02 saturation at a good level. Breathing is a physiological response to elevated CO2 levels in the blood before oxygen levels. When O2 gets too low chemoreceptors in the carotid arteries and Aorta tell the brain stem to increase respiratory rate. Expelling CO2 and using up the oxygen drives more of it to dissolve into the blood. One thing not talked about is the dryness of the air and hydration. If you are dehydrated the lungs cannot function as well. In an Airplane the air is very dry as the air is being taken from outside at 10-15k feet or whatever the cruising altitude is. Drink plenty of water or your favorite electrolyte drink when flying. especially on long flights. Thanks for reminding us of partial pressures.
@@Drscottsherr Thanks for great video, BTW, very eye opening. I really appreciate when experts like yourself take the time to share their knowledge and experience.
Interesting. I had no idea it was used s a therapeutic drug in the past. I only knew about it as a cell stain in school Science! its the lack of pressure so less less of all gasses can dissolve into the blood at altitude. this is especially important to know for those who have anemia and so their blood can hold less oxygen with less hemoglobin. Usually the body just breathes more to keep 02 saturation at a good level. Breathing is a physiological response to elevated CO2 levels in the blood before oxygen levels. When O2 gets too low chemoreceptors in the carotid arteries and Aorta tell the brain stem to increase respiratory rate. Expelling CO2 and using up the oxygen drives more of it to dissolve into the blood. One thing not talked about is the dryness of the air and hydration. If you are dehydrated the lungs cannot function as well. In an Airplane the air is very dry as the air is being taken from outside at 10-15k feet or whatever the cruising altitude is. Drink plenty of water or your favorite electrolyte drink when flying. especially on long flights. Thanks for reminding us of partial pressures.
USP grade (pharmaceutical grade). Be careful, many companies lie about this. Ask for 3rd party tests to validate purity and absence of heavy metals. If they won't provide to you, go to another company.
My Wife wanted me to trim the hege, and my excuse was, i could not pretend to be an Arborist, she replied why not you pretend to forget the honey do list all the time
i used it 15 years ago to protect goldfish eggs from fungus. It caught my interest a while back but a picture of a brain dyed blue put me right off! shall listen to this with interest 🤔
I wanna know if it be wise to take it 3-4 hours after you take pre workout with tyrosine? Take it with mushroom complex supplements? What supplements do you need to avoid putting in your body if you take MB?
This is fascinating. How have I not heard if this sooner?? And yes as someone who lives at elevation I never took the correlations made between health and elevation seriously. Honestly if you’re not healthy and can’t handle the elevation you’ll just move to a lower elevation. (That’s what I did when I was living at 10k ft and had some health issues making me chronically hypoxic). If you are healthy it’s so beautiful which helps with stress and motivates you to get out and be active. The sun is also stronger at elevation - helping with vitamin D. Whatever extent the elevation reduces appetite or provides a hermetic stress is very minor, or might not be real. Most of the benefits I cited could easily occur in the tropics at sea level.
Far too little discussion of potential negative effects imo. This substance seems especially bizarre and I think deserves more scrutiny and research before just taking it.
it has been around for over 200 years. I use it daily, a moderate amount 20mcg mixed with 500mg ascorbic acid. not expensive either. $60 got me a 2 year supply...
The way I see it, Urolithin A has a positive multifaceted effect on cellular respiration through its enhancement of mitochondrial autophagy, among other things, but this is just one pathway, and Uolithin A doesnt have a long clinical research history as does MB. But my thought is that if both substances enhance cellular function in complex ways, and you want to experiment on yourself with both-- then it would be prudent to start with small dosages of one (Ua for example, and titrate the dosage upwards over a period of two weeks, and then add MB (5 drops in liquid) to your Ua regimen) and titrate MB upwards gradually a couple of drops at a time til you begin to notice a difference.
What I’m confused and I NEED answers on this PLEASE. Is that it inhibits nitric oxide. All the studies show that nitric oxide is good. Even your erections and muscle pumps depend on it. So how is this good if it does that? Would it give you erectile dysfunction?
I've had this same conundrum for YEARS now regarding MB and nitric oxide. Still haven't found a sufficient answer.... I don't think it will give you ED though, from everything I've read & heard
This risk was pointed out in the Skeptical Inquirer: When Medicines Go Rogue, Part 1: Methylene Blue. This was an article critical of taking MB as a general tonic. Even the guest in this video states that MB is experimental and not well tested for general health improvements around 22:50. Though at the end of the day, often when you take a clinically tested substance, it's still an experiment to see if it works in you individually. Many BP drugs and natural substances that have high efficacy rates in studies, seem to do nothing for me.
@@Joe_C. clinical doses of MB against NO production lie higher than doses used for nootropic purposes. clinical doses are around 1-2 mg MB per KG of bodyweight.
Wrong Oxygen in the atmosphere does not go down when you go up altitude, what actually happens is there's not enough air pressure to push the oxygen into the capillaries in your lungs
I'd be careful just because the aquarium grade methylene blue might have dangerous impurities that we don't worry about for short lived pet fish but do worry about for long lived humans. A legal alternative is vitamin C, which does a lot of the same things as methylene blue, but isn't as potent because it isn't this tiny little synthetic molecule. I hear good things about liposomal vitamin C specifically, as the fat soluble nature of it allows more of it to be absorbed and used than standard vitamin C. But make sure you get the ones with phospholipids, as some fat soluble vitamin C that doesn't have liposomes is still marketed as "liposomal" because the esthers are fat soluble. Once your body digests that kind, it's just regular vitamin C, yet they're significantly more expensive.
At therapeutic doses it has no discernable impact on the gut microbiome. Large doses that you might see when treating CO poisoning do cause die-off, but that's not a dosage you'd even come close to when supplementing daily.
i have been taking it for 3 months for long covid/Epstein Barr... I recently took a GI spotlight test and my functional medicine dr said wellll, you don't have much bad bacteria but your also low on good bacteria. So I am taking Probiotics along with the yogurt and good culture cottage cheese trying to make sure I am repopulating my gut... not sure if it would cause an issue or resistance in the future but curiouse.
I take about 6 drops of MB once a week. I get massive nocturnal erections when I take it. This effect only happens when I sleep. I typically get a good restful sleep, therefore better energy and alertness the next day.
@@SullivanKelly85He lives in the arctic circle where it is dark all winter, if he took it more than once a week that would lead to a permanent nocturnal erection which his mates at the Icelandic sauna find disturbing 😂😂
There are major drug interactions here. You need like 6-8 months before and after to NOT be using methyl blue to NOT die. When taking anti depressants and/or blood thinners and/or mdma. Be very careful!
Good shout mate 👏 just looking into this, I knew there would be some catch to this; looking into it it's an MAO inhibitor!!! That's not something to take willy bloody nilly. But it might be something to take with a certain vine from the Amazon wink wink
The scope of the studies underlying that are at doses for its on label use as a treatment for methemoglobinemia (CO poisoning mostly). That's a much higher dosage than you'd be taking for therapeutic effects. The possibility for interactions exists but you just want to start low and slow if you have contraindications. Unless you're on a really really high dose SSRI, a few drops of a 1% solution generally won't have appreciable side effects.
@@MsCGarnica We're proud to be the 3rd-best snuff film company in our neighborhood. And we're actively involved in several charitable organizations. Especially feeding the homeless --to ferocious wolves.-- )
There's some preliminary data suggesting it can help, and anecdotal cases online. It's been investigated for a variety of psychiatric disorders and seems potentially effective. That being said, it's probably best as an adjunct to CBT, akin to Adderall.
Can methylene blue reduce the amount of good bacteria in your gut biosphere overtime, even with low doses overtime? In healthy individuals can using metformin and methylene blue cause hyperthyroidism? And ultimately advanced muscle degradation?
Great question! high doses, >1mg/kg for long periods can shrink microbial diversity but we haven't seen this at lower doses (4, 8, 12, 16mg). MB does increase metabolic rate but I haven't heard about any cases where it induces hyperthyroid. If a patient already has this, they would have to be careful with any drug/supplement that enhanced metabolic rate!
that is due an interaction with tyramine. Not all types of alcoholic drinks are affected. Yet, old cheeses and cured meat should be avoided. however, that cauion applies only for classic MAOI drugs. Methylene blue is a weak MAOI, so if dosed low, as it should outseide of medical treament, here should be nothing to worry... just monitoring
Search "worst case scenario side effect" of literally any drug or medicinal substance and you will find horror stories. Some people will die if they eat an apple. Big farmer does NOT want people taking MB and you can be assured that the (corrupt) google search results will reflect this. MB is nothing to worry about if you do some basic reading. Can interact with SSRIs but for this to be a significant concern the MB dose would likely have to be very high. You can definitely eat cheese and cured meat whilst taking it - this is not medical advice.
Been taking MB everyday for over a yr . Nothing bad to say about it other than my counter having blue dots on it lol MB has been researched for many yrs btw . This is another thing that “they “ don’t want us to know about because it’s cheap and can help keep you healthy and get over being ill . Love this stuff
Hey I stained my mom's counter and metal sink... Vitamin c ascorbic acid powder, mixed with water into a paste, took it right off after sitting a few kinutes
I wonder if someone is in Ketosis producing ketones which by definition have more energy and less ROS, and then add Meth-blue, would seem to supercharge your energy?
@@Drscottsherr I’m thinking for some of my actor friends. I was a rookie standin on set filming for 13 hrs a day, just mentally and physically exhausting. Any acting clients? Thx
