If you place land clame - you will not lose the base in POI - and converting a house to a base - when you cut oof the access to second floor is a great idea.
I was really thinking about moving my base over to a pre-built house and building it up but wasn't quite sure how that would work out in the long run... currently I've been building a base onto a mountainside fairly close to the trader and its working out alright... only 20 something days into the game though.. and I think I set the custom seed to have longer game days than the standard
The best tip is to keep watching Content like this to continue learning what you can and cant do. Alot people have suffered from loseing every item they had because "They Built a Base at an already existing POI". If a quest sends you to the POI your base is located at, & if you start the quest at the Yellow marker.... That POI will RESET completely. Deleting everything you changed, added or built at that POI. Build and set a Land Claim. TURN ON THE HIGHLIGHTED MARKERS THAT SHOW YOUR PROPERTY. This will help you realize where exactly your base is while your brainlessly running through missions in the area. Before 1.0 i never lost a base I built due to never setting a land claim block. In 1.0, i did once. Even my Motorcycle vanished. Always set one know 😭