Translation - tRNA Charging (Aminoacylation) and Open Reading Frames

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How are amino acids attached to specific tRNA? How does AARS distinguish multiple tRNA and know the correct amino acid to attach to the tRNA? What are open reading frames and why do they matter? And why is it a bad idea to write anticodons in 5' to 3' direction? Get answers to all about these question in this video.
Jump to your favorite section:
00:00 Introduction
01:42 Open Reading Frames (ORFs)
04:55 Why do ORFs matter?
05:49 Anticodon Orientation
07:11 tRNA Charging
Translation introduction (mRNA syntax): • Translation - Introduc...
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3 июл 2024

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Комментарии : 10

@theCrux 2 года назад

A word of clarification: At 9:17 I say that there is only one aminoacyl tRNA synthetase. The clarification is that there is ONE aminoacyl tRNA synthetase for one amino acid - meaning that it can recognize multiple tRNAs for the same amino acid. Since there are 20 amino acids (61 coding tRNAs), it suggests that there are at least 20 aminoacyl tRNA synthetases in total (the actual number is around 40).

@ShreyashiPramanick 2 месяца назад

Best explanation I found on this topic

@di3486 2 года назад

I just started my PhD in Molecular Biology and I cannot thank you enough for these. Have saved me more than a few times, lol. Very clear, accurate and beautifully executed!

@theCrux 2 года назад

Congratulations on starting a PhD! Happy that these videos helped 🙂

@ginolabella7607 Год назад

Hands down Mr., you have a gift to explain things so complicated in such a short amount of time and with crystal clear clarity. Greetings from Argentina

@kingt2229 2 года назад

Very beautifully done

@faheemfarooq475 2 года назад

very smoothly explained. keep it up and please don't give up on this channel, you are doing a really great job. and yeah one more thing, you should make a separate video on amino-acyl tRNA synthetases like how they are able to charge a particular tRNA with its cognate amino acid. once again, your videos are very simple and easy to understand and they give us a really deep insight into the molecular intricacies.

@theCrux 2 года назад

Thank you for the kind words. Happy to hear that these videos are useful 🙂 And thanks for the suggestion as well - it is now on my list!

@okpolihenry983 2 года назад

Apt and well explained, thank u so much for this. So much information in this video. I have found a new Channel for my molecular biology program

@al_ns4930 5 месяцев назад

hehe..what a machine !!! I'm just wondering how evolution could make an enzyme that charging tRNA (aminoacyl synthetase I guess) that apparently "speaks two languages", how the DNA Code was created by chance (I don't know any code nor do I know that anyone has observed the creation of the any code by a random process instead of intelligent effort) or how the evolutionary process created a legging stand that synthesizes in the opposite direction and in fragments, how is it possible that some mutation produced such ingenuities and saving time and space?... is it possible that people learn and put this much information into their brains, get Phd's but cannot understand that it is impossible, that their own knowledge denies them at every step if they believe and promote the evolutionary concept ??