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Treating High Lp(a): A Risk Factor for Atherosclerosis 

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What is this lipoprotein(a) and what can we do about it to prevent atherosclerosis?
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I’ve been wanting to do videos about Lp(a), but there just wasn’t much we could do about it…until now! Okay, so how do we lower Lp(a) with diet? Stay tuned for the thrilling conclusion in my next video (nutritionfacts.org/video/how-t....
What can we do in general to minimize heart disease risk? My video How Not to Die from Heart Disease (nutritionfacts.org/video/how-...) is a good starting point.
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Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution!
-Michael Greger, MD FACLM
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12 май 2020

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Комментарии : 108   
@NutritionFactsOrg
@NutritionFactsOrg 4 года назад
What can we do in general to minimize heart disease risk? How Not to Die from Heart Disease is a good starting point: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-LXigmGZk5FU.html
@ESumner
@ESumner 4 года назад
I have my LPa at 65 right now. I’m 36. My father had an early heart attack at 45! Anxiously awaiting the next video!
@Dualhammers
@Dualhammers 4 года назад
You don't need to await the next video: just eat a low fat (sub 10%) whole food plant based diet from a variety of sources (see the daily dozen checklist). And walk 90 minutes a day or jog 40 minutes a day. It's that easy. Do that every single day without a break for the rest of your life and you will live to be 99
@repentorperish6414
@repentorperish6414 4 года назад
My Lpa is 242 with a healthy lifestyle & athletic. My vitamin B3 was very low & supplementation decreased it but not very much
@drzavahercegbosnaponosna5974
@drzavahercegbosnaponosna5974 3 года назад
ES, please, pay attention to this trial, might help you, I hope. Best. Currently, the most important management strategy for people with high levels of LP(a) is to optimise/treat all other risk factors, in particular LDL cholesterol. The best treatment for LP(a) is to reduce the cholesterol burden of the particle with a statin which will shrink the particle size. A new injectable treatment known as an anti-sense therapy which stops LP(a) being made is currently due to start phase 3 clinical research trials. Work so far has shown this treatment can reduce LP(a) levels by up to 90%. Other treatments shown to help lower Lp(a) levels include PCSK9 inhibitors (reduce levels by 25%) and lipoprotein apheresis, a weekly-fortnightly invasive treatment similar to renal dialysis, which can reduce levels by up to 75%. This treatment should only be considered in those with recurrent CVD despite optimal control of other risk factors. www.heartuk.org.uk/genetic-conditions/high-lipoproteina
@GF-ck4cp
@GF-ck4cp Год назад
Have you had any heart tests done?
@GF-ck4cp
@GF-ck4cp Год назад
How are you doing?
@LeoandLongevity
@LeoandLongevity 4 года назад
Is anyone else surprised their doctor never mentions lipoprotein little a to them?
@swissladydriver8980
@swissladydriver8980 4 года назад
No. Most people aren't affected by it.
@Salemms84
@Salemms84 4 года назад
@@swissladydriver8980 25% of the population has this. I do and have to make sure I ask for it in my blood test.
@swissladydriver8980
@swissladydriver8980 4 года назад
@@Salemms84 Exactly. Most people aren't affected by it.
@megavegan5791
@megavegan5791 4 года назад
He addressed this. You can’t write a prescription for it.
@mariaburgess3058
@mariaburgess3058 2 года назад
I know I’m being cynical but there’s no money to be made by pharma if you have high Lp (a)
@eelkeaptroot1393
@eelkeaptroot1393 4 года назад
But, but, but some of us might be dying to know this...
@tamuctamuc1256
@tamuctamuc1256 4 года назад
I was a seemingly healthy, active guy who had the "Widow Maker" attack at the age of 47. I'd been getting annual check-ups and was told everything was fine. After the attack, I was treated by two cardiologists who never mentioned Lipoprotein (a). I began having my blood tested on my own and the tests I bought included Lp(a). Mine was off the chart! My current cardiologist told me it (high Lp(a)) is my biggest problem. We've attacked it using REPATHA twice per month for about one year. The number has dropped by around 50%. I have been living a Whole Food Plant-Based life for almost four years, lost a lot of weight and I use my treadmill daily.
@drzavahercegbosnaponosna5974
@drzavahercegbosnaponosna5974 3 года назад
Please, pay attention to this trial, might help you, I hope. Best. Currently, the most important management strategy for people with high levels of LP(a) is to optimise/treat all other risk factors, in particular LDL cholesterol. The best treatment for LP(a) is to reduce the cholesterol burden of the particle with a statin which will shrink the particle size. A new injectable treatment known as an anti-sense therapy which stops LP(a) being made is currently due to start phase 3 clinical research trials. Work so far has shown this treatment can reduce LP(a) levels by up to 90%. Other treatments shown to help lower Lp(a) levels include PCSK9 inhibitors (reduce levels by 25%) and lipoprotein apheresis, a weekly-fortnightly invasive treatment similar to renal dialysis, which can reduce levels by up to 75%. This treatment should only be considered in those with recurrent CVD despite optimal control of other risk factors. www.heartuk.org.uk/genetic-conditions/high-lipoproteina
@tamuctamuc1256
@tamuctamuc1256 2 года назад
@Bladerunner2043 YES
@plants_and_wellness1574
@plants_and_wellness1574 Год назад
What was your level? Mine is 380 nmol/L and I have yet to have any heart problems at 39 but I am getting a CT angiogram in a few weeks to look at everything. How are you doing today?
@tamuctamuc1256
@tamuctamuc1256 Год назад
@@plants_and_wellness1574 I'm doing quite well. Thanks for asking. A book I highly recommend is "Lipoprotein (a), The Heart's Quiet Killer" by Joel K. Kahn, MD. It includes a list of suggested supplements I have used in addition to REPATHA and PRALUENT with very good results. I think my highest was 150+, lowest was 68. I get tested quarterly and include a test for Direct LDL. My results fluctuate from 68 - 99. If yours is 300+, don't ignore it. Best wishes!
@JWB671
@JWB671 Год назад
@@plants_and_wellness1574 hey I know you!
@sircorkysriley4904
@sircorkysriley4904 4 года назад
in 1992 Dr linus Pauling with a young dr mathais Rath did a whole lecture on this with findings that vitamin C along with L Lysine significantly reduces the production of lipoprotein small (a). When I asked to have mine checked my doctor looked at me like I was nuts. The lecture is still on youtube Pauling at stanford.
@truefuschniken
@truefuschniken 4 года назад
Love this!!! My brother-in-law died from this, thank you for the info!!!
@natsunflower3805
@natsunflower3805 4 года назад
Wow this is really interesting. I hope I have low levels but I've never gotten tested... I'm excited to know the role of diet in this phenomenon
@Kim-mg6bo
@Kim-mg6bo 2 года назад
Never heard of this until I got tested this week. Should be standard test.
@Parralyzed
@Parralyzed 4 года назад
Damn you Dr. Greger and your cliff-hangers
@user-gi2mn5yf5j
@user-gi2mn5yf5j 4 года назад
Interesting content! Had a dream last night of me explaining to DrG my favorite no milk chocolate oatmeal hack so maybe I should share here?! First I mash a banana with a fork, stir in some peanut butter until thick (budget tight so using natural brand with palm oil but recommend peanut-salt only pb), add flax/cocao/salt, stir, add a little more water, stir, add 1/2C. rolled oats, stir, add 1/4C. rolled oats, stir, add pecans & diced strawberry, add a little water, stir .. chase that down with a warm cup of green tea .. amazing :D
@williammarine973
@williammarine973 2 года назад
Just had my LPa levels and Lipid levels checked. I was in the healthy green range for all my cholesterol but very high on my LPa (139). Just scheduled an appointment with a MD that specializes in Interventional Cardiology.
@plants_and_wellness1574
@plants_and_wellness1574 Год назад
Any updates? How are you doing today?
@ukispargitus970
@ukispargitus970 10 месяцев назад
@williammarine973 : "MD that specializes in Interventional Cardiology": so... what he told you with your Lp(a) (139)?
@brendajoyce7764
@brendajoyce7764 Год назад
Do you have any information about aRteriosclerosis?
@lukasm5254
@lukasm5254 4 года назад
I wonder why I think that a whole food plant based diet and regular physical exercise will be beneficial...
@Guard385
@Guard385 4 года назад
Diet to the rescue!!
@HenchHerbivore
@HenchHerbivore 4 года назад
I just posted a response video to former world's strongest man Eddie Hall's recent blood test vid where his small LDL particles are through the roof and he's totally in denial about the risks. Dr Greger please reach out to him. Would be AMAZING to get him on board if he's willing to listen!
@jjwilwil4800
@jjwilwil4800 4 года назад
My lp(a) above 240 ml/dl. My lipid specialist says the test doesn't show higher so my levels are likely higher. I had a 398 cholesterol levels age 17 and my first stent age 31. I am 46 yrs old with 3 stents now. Scary stuff.
@l-schm
@l-schm 4 года назад
have you already tried changing your diet to a whole-foods, plant-based one?
@repentorperish6414
@repentorperish6414 4 года назад
Wow, that is scary. Mines 242, my vitamin B3 (niacin) was very low. I do a B complex with extra B3 , it lowered but not significantly
@jjwilwil4800
@jjwilwil4800 4 года назад
@@l-schm yes I have been vegan 4 yrs but eating wfpb now.
@l-schm
@l-schm 4 года назад
@@jjwilwil4800 cool, I hope you'll see positive change. The cholesterol you have in your blood can come from dietary cholesterol (not the case when you're vegan, obviously), but also be made by your body, a process that is stimulated when you eat saturated fats, maybe you were eating many of those before? anyway, if you don't know and do it already, I'd limit coconut oil, palm oil and cocoa (the only sat fat sources in a vegan diet), and also cut down on other refined oils. Hope that helps a bit :)
@jjwilwil4800
@jjwilwil4800 4 года назад
@@l-schm thank you..I've been trying to follow Dr Esselstyns diet so I have cut out oils. I wasn't aware of cocoa though. Thanks so much
@madisonone8929
@madisonone8929 2 года назад
Nicotinic Acid (Niacin) is very effective at lowering it. A more recent study in 2020 said Statins increase Lp(a). PCSK9 inhibition works but again fairly expensive
@ukispargitus970
@ukispargitus970 10 месяцев назад
@madisonone8929 "Nicotinic Acid (Niacin) is very effective at lowering it." Do you have the study reference please or it is your personal experience?
@madisonone8929
@madisonone8929 10 месяцев назад
@@ukispargitus970 Google it. Can’t post links here.
@6681096
@6681096 4 года назад
As I suspected, in the first case study the cholesterol may have been normal but it certainly was not optimal: "His low-density lipoprotein (LDL) was elevated at 176 mg/ dL and his high-density lipoprotein was low at 38 mg/dL 4 months before his acute presentation..." As the best studies show, those who have cholesterol under 150, without drugs, have an extremely low cardiovascular risk. Similar to type 2 diabetes the best way to have a healthy cholesterol level (and glucose level etc): lose weight. If that doesn't work? lose more weight. Once your BMI is 19 or lower then come back to me. And yes, I know you have very big bones, you're very muscular, and/or you have slow metabolism etc. I'm not saying it's easy and I'm not saying to beat yourself up, but first thing to do is stop lying to yourself. Also the patient was Asian and they are more susceptible to bad LDL cholesterol and excess weight.
@drzavahercegbosnaponosna5974
@drzavahercegbosnaponosna5974 3 года назад
Please, pay attention to this trial, might help you, I hope. Best. Currently, the most important management strategy for people with high levels of LP(a) is to optimise/treat all other risk factors, in particular LDL cholesterol. The best treatment for LP(a) is to reduce the cholesterol burden of the particle with a statin which will shrink the particle size. A new injectable treatment known as an anti-sense therapy which stops LP(a) being made is currently due to start phase 3 clinical research trials. Work so far has shown this treatment can reduce LP(a) levels by up to 90%. Other treatments shown to help lower Lp(a) levels include PCSK9 inhibitors (reduce levels by 25%) and lipoprotein apheresis, a weekly-fortnightly invasive treatment similar to renal dialysis, which can reduce levels by up to 75%. This treatment should only be considered in those with recurrent CVD despite optimal control of other risk factors. www.heartuk.org.uk/genetic-conditions/high-lipoproteina
@a-love-supremist
@a-love-supremist 4 года назад
I want to order this test. Is it also called Lp-PLA2? That's what I'm seeing a cardiologist recommend.
@ukispargitus970
@ukispargitus970 10 месяцев назад
@a-love-supremist How did that Lp-PLA2 test help in your diagnose?
@hennew164
@hennew164 4 года назад
Dr Greger could you please look into histamine intolerance and what to do about it? Couldn't find anything about it here.
@ESumner
@ESumner 4 года назад
Hen New look at candidiasis! High Candida overgrowth can cause this issue.
@hennew164
@hennew164 4 года назад
@@ESumner Dr Gregor has debunked the whole Candida phenomenone. ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE--74POLmi4iA.html
@krzysztofh6308
@krzysztofh6308 4 года назад
Lp(a) is body's response to endothelial damage, not a cause of it. It will form a plaque, but only in response to injury. It was proven long time ago (unfortunately only on rodents, but mechanism is the same). The problem is that, as it was proven in rats, when they had gene, which was responsible for producing Lp(a) knocked out, they didn't develop plaque, but lived shorter than rats, which developed plaque in response to endothelial injury. Another words, if you get rid of lp(a) you will not develop plaque, but can end up with shorter life. You have to stop injuring your arteries to avoid plaque formation, but please remember, that lp(a) is there to heal, not to cause damage. The higher level of lp(a), the higher body's ability to form the plaque/scub/crust.
@williamhartman9
@williamhartman9 4 года назад
You seem to understand this well,do you recommend wfpb and the typical protocol to prevent arterial injury Along with other healthy lifestyle choices,please let me know your recommendations if possible
@krzysztofh6308
@krzysztofh6308 4 года назад
@@williamhartman9 wfpb diet seems to be helpful, but please don't be obsessed about cholesterol, it is critical for human health. Avoid things proven to domage endithelium like smoking, PM 2.5 pelarticles, so if you are jogging or hiking, please don't do that in cities, high blood sugar spikes (wfpb diet even high in carbs don't spike your blood sugar, it can improve insulin sensitivity, which is crucial for health in general) avoid sugar (50% glucose/50% fructose) and high fructose corn syrup, fructose is proven to cause non alcoholic fatty liver disease and worsens liver sensitivity to insulin, but only in context of excess energy and it is hard to do on wfpb. Vit D and k2 plays also a role, but it also will do nothing if you are insulin resistant. The factor, which led to plaque buildup in rats was inability to synthesize vit C, but you should get enough following the protocol. It also requires collagen, but you should get enough amino acids to make it from beans and legumes. Remember, that both Pritikin and Ornish included fish, dairy and meat in their protocols. Meat is also our food and was for at least hundreds of thousands of years. Just avoid processed meat with additives like nitrates etc. I would suggest eating a lot of soups, as plants in general are hard to digest, which means your absorption of vitamins and minerals is limited, but when you boil them, the minerals stay in water. There is a lot of high vit c veggies (red pepper), so try to eat them also raw. Adding sprouts to raw food is also a good idea. Don't chase fiber to much, especially insoluble, it can be problematic for some people. It is soluble fiber, that feeds bacteria. And you must know, that some people can't synthesize vit A from carotenoids so it is better to add some animal fat to the diet, same with DHA, we can't make enough just from short chain FA like from flux seeds. The single worst thing you can do is to have a diet high in both fats, heated seed oils and simple sugars. Try to do Kraft test for insulin resistance. It is the best test I know of and just follow the diet which brings you closer to healthy score in this test. Insulin sensitivity is just a marker, if you are sensitive to it, it simply means you are sensitive to other hormones etc and your body works as designed. High insulin levels also inhibits many other processes in our bodies. This is not any medical advice, this is what I would do😉.
@Mimicry161
@Mimicry161 Год назад
Wish this was voted higher up in the comment section.
@starbright1256
@starbright1256 6 месяцев назад
Wow thank you for the information
@krzysztofh6308
@krzysztofh6308 2 месяца назад
@@pdblouin just use any search engine and you will find out that guinea pigs have lp(a). That will show you how reliable are his videos. You will also find the study i am talking about.
@VeganTierra
@VeganTierra 4 года назад
Wow!!! interesting..i always tough this was do to age!!! This is why we have to stay whole foods plantbase.go Vegan..
@trees915
@trees915 4 года назад
*thought *due
@susan_wojcicki_is_a_ho3909
@susan_wojcicki_is_a_ho3909 2 года назад
nope
@d2imagine
@d2imagine 4 года назад
Mine is over 200 and I’m mostly WFPB vegan with occasional vegan junk food. Niacin flushing is too much for me. Is there another solution?
@6681096
@6681096 4 года назад
What's your weight and height? What is your activity level?
@lisasiegmann7102
@lisasiegmann7102 4 года назад
I found quercetin blunts the flushing and most times completely eliminated it. I learned of it from some research studies and tried it myself.
@drzavahercegbosnaponosna5974
@drzavahercegbosnaponosna5974 3 года назад
Please, pay attention to this trial, might help you, I hope. Best. Currently, the most important management strategy for people with high levels of LP(a) is to optimise/treat all other risk factors, in particular LDL cholesterol. The best treatment for LP(a) is to reduce the cholesterol burden of the particle with a statin which will shrink the particle size. A new injectable treatment known as an anti-sense therapy which stops LP(a) being made is currently due to start phase 3 clinical research trials. Work so far has shown this treatment can reduce LP(a) levels by up to 90%. Other treatments shown to help lower Lp(a) levels include PCSK9 inhibitors (reduce levels by 25%) and lipoprotein apheresis, a weekly-fortnightly invasive treatment similar to renal dialysis, which can reduce levels by up to 75%. This treatment should only be considered in those with recurrent CVD despite optimal control of other risk factors. www.heartuk.org.uk/genetic-conditions/high-lipoproteina
@r1r597
@r1r597 4 года назад
Make a video on benefits of vegan vs vegetarian 🙂🙂🙂🙂🙂 How does a vegetarian do well, compared to meat-arians, and compared to vegans 🙂🙂🙂🙂
@anthonyromano8565
@anthonyromano8565 4 года назад
@@LaurenBurger Whole food Plant based oil free wins. Vegan means nothing.
@swites
@swites 4 года назад
@@anthonyromano8565 What about whole foods oil free vegan? Does that mean nothing as well?
@anthonyromano8565
@anthonyromano8565 4 года назад
@@swites The word vegan is not necessary, it has political insinuations.
@swites
@swites 4 года назад
@@anthonyromano8565 Everything's political. Being a-political is still political for example. A vegan for example who calls themselves "plant based" is doing so for political reasons. Maybe they're embarrassed, or don't want to be type-cast, associated, or written off by others as a stereotypical vegan? Having an issue with the word vegan or vegan people in general is again a political stance imo. So it goes both ways. Vegan is also very descriptive in terms of diet when adding caveats such as oil free. "Plant based" you can be eating dairy meat, eggs shellfish etc to some arbitrary amounts. 5%? 10%? 49% plant based? So like the term vegan, plant based can be completely meaningless.
@anthonyromano8565
@anthonyromano8565 4 года назад
Dr Mc Dougall has done just that with citations as well as interviews with the scientists and doctors who were involved in the studies. Guess who did best?
@MsMousepusher
@MsMousepusher 4 года назад
I wanted to share these videos with my mother, but Dr Greger speaks so quickly, slurring his words, she just couldn't understand him. He ought to get someone else like an actor who can speak clearly to get the message across more effectively to a wider audience.
@kwikitti
@kwikitti 4 года назад
On nutritionfacts.org web site, below the video, there is a grey tool bar with the left option being "View transcript". You can copy the transcript and paste it into an email. Or in the video, click on the CC icon at the bottom of the video. Then stop and start the video as needed to read the closed captions. Another control feature is in the gear icon, where you can slow down the playback speed. HTH.
@wolfich4684
@wolfich4684 4 года назад
Wow .. i ve thought that i dont know english
@ludicrousone8706
@ludicrousone8706 4 года назад
On the RU-vid video itself in the upper right corner are three dots. Touch those and a menue presents that lets you slow the speed of the video. I used it at the beginning until I got used to Dr Greger's speechpattern.
@MsMousepusher
@MsMousepusher 4 года назад
@@ludicrousone8706 For some reason, I don't have the little dots, but I was able to slow it down using the gear symbol. It helps a little, but he still doesn't ennunciate his words clearly . In slow motion the slurring is even more evident. He's obviously trying to get the message across to bright early adaptors, but if he wishes to extend his message more generally to people like my eighty three year old mother, he needs elecution lessons! Don't get me wrong I love Dr Greger, but I feel that some of his massive effort to save humanity could be better focussed.
@ludicrousone8706
@ludicrousone8706 4 года назад
@@MsMousepusher I hear you. Have you tried some of Dr Barnard's video? His style is very different.
@TheCrusaderRabbits
@TheCrusaderRabbits 4 года назад
Is there a way to get rid of plaque
@carl13579
@carl13579 4 года назад
Read "How to Prevent and Reverse Heart Disease" by Caldwell Esselstyn.
@drzavahercegbosnaponosna5974
@drzavahercegbosnaponosna5974 3 года назад
STRICT plant based diet + add d3 vitamin, b12, eat grounded flax seed (omega3!), also ad one daily dose pill of minerals and vitamins. good luck. ru-vid.com?search_query=Caldwell+Esselstyn
@lindapb6529
@lindapb6529 4 года назад
Thanks for not being a doctor (human being) who writes these things off as 'nothing can be done anyway, so why bother' ❤️
@Youtubedisco
@Youtubedisco 3 месяца назад
My Lipoprotein-a is 31 nmol. I eat 80 percent animal products
@BasketmanRyohta
@BasketmanRyohta 4 года назад
please japanese
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