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I have a lot of protocatechualdehyde along with rare compounds I can send you for example BBr3, Benzyl chloroformate, Boc Anhydride, halo ketones, amines and many more. I would love to see what you can do with it. Let me know if you are interested
Wait until he actually starts creating practical chemistry content.... He probably doesn't realize how hard it is to do a reaction outside of a real lab, (in a shed on Australia, lol.) Having all the reagents you need at your university's disposal is much different than going to a hardware store to source everything, and do it in an garage or shed. (I'm assuming he isn't an amateur chemist).
@@Ryan-lc4blI mean, no one asked anybody to do chemistry on their own garage. If you can’t make proper analysis then don’t claim you synthesized your product at all, it is that simple. Yes amateur chemistry can be fun and with proper safety equipment and education I encourage people to train and challenge themselves. But chemistry is an actual science, you can’t juste randomly claim what you want to. Otherwise that’s just not chemistry. Also, if making a TLC and melting point check is actually THAT hard for you, it’s probably a bad idea to make some amateur « chemistry » content for your own safety. Ofc no one has a personal NMR at their disposal, but come on, very basic analysis could still be done and discuss about the lack of analysis is literally : free.
@@Tom-to7dy I know that one must prove whatever product you got is actually there in order to claim you have made it. But that doesn't mean that just because you can't prove it, it's not in there are all (I know that sounds against the scientific method, but if your reaction products are easily separated, or there're few byproducts, most amateur chemists don't bother with testing their product for purity, because usually others have already performed the reaction many times and the results are quite predictable (alright, everyone's reaction products will be slightly different in composition). I know that melting point analysis is quite easy for an amateur chemist, but most amateur chemists don't do long multi-step organic synthesis anyways (with few exceptions). Anyways, I'm not at all against doing analysis of your products, but we must be realistic, amateur chemists that are just performing simple organic synthesis generally don't test the product not because they're against the scientific method, or just lazy, just not necessary for ALL reactions (even distilling your product can give some information on the purity - i.e. azeotropes).
The editing, the camera quality, the lighting,...everything has been upgraded. even there are less lame jokes now. just straight up chef kiss content. its giving professional. you really steped up your game. congrats on the sponsors. you really invest money in your videos. you deserve big success.
Wow that was a really cool reaction! We appreciate you so much. Also absolutely love the merch. Going to scoop me up a hoodie and that bucket hat right now!!
Potential imputities are pyridine hydrochloride, vanillin, 3,4 dihydroxybenzoic acid and aldol condensation products. I would not expent much of the pyridine since it should have stayed in the water layer. You probably could have gotten less impurities by a salt wash and then sodium carbonate wash of the ether before evaporating. The aldol condensation products are probably the major impurity and not avoidable. A tlc plate could give you some idea of the distribution of the impurities.
@@chemdelicSeemingly small things like @1:45 when you mention not drying the DCM compound to have huge impacts later on. I'm not saying that is the smoking gun in this experiment, just using that step illustratively. I really appreciate your completeness especially regarding yields and hypotheticals outlining your analytical process. Great work. It has inspired me to review the Erowid lit workup. I'm sure someone else will beat me to it but I'll follow up if I find anything glaring.
yes sir, your ability to record your processes and still perform your task at a high level is an admirable accomplishment. make it look easy, when in reality, nothing is easy. @@iuristasiv9360
Hi. I haven't done chemistry but I am very familiar with reaction you are doing. Some notes. Demethylation reactions are sensitive to water so using non dry DCM reduced your yields. Second and more important note is that demethylating vanillin is very very very hard and your yields are about right where I expected them to be. If you would to find a method to demethylate vanillin with over 90% yields you would be rich.
@@chemdelic I am not that familiar with ether cleavage so I cant comment on that. What you can also do is to search for demethylation in google schoolar. There are new methods published since writeups in erowid. Maybe you will find something you like more.
Good stuff Chemdelic. You know you can achieve the same using pyridine*HCl and a microwave? Just gas some pyridine with dry HCl gas, mix with vanillin, nuke in microwave, and you get protocatechualdehyde. In the next step, don't forget to include phase transfer catalyst like fabric softener.
@@chemdelic you can do TLC even without pure standard, you can guess the product from the biggest spot and also from a different Rf in comparison to the starting material. TLC is very common for monitoring undergoing reactions where you have just the starting material to compare it to.
Wait until people who think he doesn’t know that latch on. Then they’ll be on a different watchlist. The stupid one. I say the stupid one because everyone knows there is the smart one and the stupid one.
I really like your videos dude. Very interesting reactions. I've always been very interested in pharmaceuticals and extracts like nutmeg and vanillin and saffrol
Your videos are getting better and more entertaining and after reading a bit of claydens organic chemistry i finally start to even understand what youre doing XD
Very nice! I wonder how effective hot sulfuric acid would be at performing an ether cleavage on vanillin. From my experience, it works really well with ethylvanillin, which gave me close to 70% yield...and let's be honest, literally anything is better than having to deal with the stench of pyridine, haha!
Now every chem channel is afraid of getting into a @That_Chemist video and making at least melting point test, while saving for a 300MHz NMR 😃 An interesting video and everyone loves yellow chemistry!
Am very interested in seeing Part 2! I have attempted the methylenation to 3,4-MDBA twice. First time I believe my condenser wasn't efficient enough and the DCM boiled off thus I had no methyl source. The second time, I used CH2I2 and I had success. The extraction part is the bear as there is NaI and potential polymerization biproducts that dont separate out easily and contaminate both aqueous and organic layers. Steam distillation will be tried for try #3 while repeating the CH2I2 reaction; simply adding water and trying to distill was not successful. I was able to achieve success, but I know yield can be pushed higher, so cannot wait to see how you end up doing with it.
@@chemdelic That's how I did it. Dissolved in DMSO and a 50% NaOH solution. Added via addition funnel over about 60 min to a heated solution of DMSO/CH2I2. Could smell the MDBA big time. Steam distillation with an exterior steam source allowed me to recover it. It began to crystallize in the collection beaker. Trying to extract from the reaction mixture was useless, could not recover anything that way.
Found your channel just yesterday and I want to say that you are absolutely mad lad, which highly inspires me. You know, I'm a huge psychonaut forums enjoer and there have long been rumors about the extraction of psilocybin crystals. Since you have dea as your best friends and got that Shulgin spirit whispering into your ears what you think about the extraction of these extraterrestrial guys?? I tried to do it myself and even got the crystals, but they didn't work at all:(
not a single recryst? Seriously dude thats the basic procedure for simple purification specially if you have the blessing of having a crystalline/solid product. You had a diffferent m.p than literature, so recryst and test again until it matches or gets the closest possible. That is basic
It's really not needed in this case since the m.p. is very close to the literature range and the compound will soon be used in the next reaction. It's good he even measured m.p. since a lot of chem youtubers don't even bother with that.
Chemdelic, do you have any reccs for learning chem/organic chem outside of schooling? It's always interested me, though the schooling model of just testing rote memorization always put me off from introductory courses back in school/college. Can't afford another 'education' anyways nor would I want one. Unsure how comprehensive Brilliant is & if it also teaches the application of chemistry rather than just theory.
You can buy textbooks on organic chemistry pretty cheap online (I like Clayden’s), and many schools have put their organic chemistry classes on RU-vid for free :)
This might a stupid question but isn't extremely risky to record and post yourself making controlled substances even if the end result isn't something bad or illegal or what ever
You might be able to push a bit more dihydroxybenzaldehyde out of your acidic aqueous phase by chucking in a tonne of ammonium chloride and reextracting with ether. Or it might make it worse. Or ethyl acetate is probably a better extraction solvent.
Can probably use AlI3 as the Lewis acid, right? Can generate it in situ from alu foil and iodine. Although you might need a different hydrogen transfer catalyst with this. DMSO in the paper I'm going to use for ether cleavage. Also less annoying to get for hobby chemists than pyridine.
Get one of those old school melting point apparatuses like a thiele tube and some capillaries closed from one end. tiny bit of compound at the bottom of the capillary, strap the capillary on your thermometer and heat in thiele tube
I’m wondering if you can perform a ketalization using your product and formaldehyde with some p-toluenesulfonic acid to form piperonal, or if it would just react with itself in those conditions
I probably would have just gone with sulfuric acid instead of pyridine to complete the deacetylation, but is an interesting bit. just hitting that like button....
I dont get how it went from the aquaous into the organic layer. You didnt change anything like reacting it with NaOH. Why was it in the aquous layer, then in the organic? You put HCl BEFORE the seperating step.
Are you sure you did not use Ethylvanillin instead of Vanillin? Just asking. This might very well be the best way to get to Piperonal. Great upload. Thank you. Greetings, Jeff
Yeah - and I believe he used Pyridinium Chloride to demethylate the codeine and yield morphine. That was back in 1953, I think. Nowadays, Boron Tribromide would be the demethylating agent of choice, IIRC. At 71, my memory isn't quite what it used to be, but I believe that refluxing in concentrated HBr works to cleave some aromatic methoxy groups, like as in oxycodone to oxymorphone.
I would love to make some 2C-I OR 2C-B . When it was legal i got my hands of a gram of pure 2ci and its still my all time favorite drugs. Better then heroin, MDMA. Mushrooms, acid, meth, crack, cocaine,ketamine, dmt or xanax. It makes you feel the same love and warmth that MDMA does but your tripping your ass off and have the psychedelic headspace. I can eat on it, sex is amazing, and it has zero come up or come down. You high as shit and then boom 5 hours later your sober. Man i miss it, its nearly impossible to find since it was made illegal. It never got popular like other RC drugs did. To bad
I was compelled to give the video a thumbs up immediately upon reading the title.😂 But c'mon couldn't you have drawn your own reactions instead of stealing from Rhodium!!!
Yes I could have, but I didn’t have a lot of time for this video due to school and other commitments. I would have hand drawn and gone over mechanism if I had time :)
Hello. The "project" is based on well-documented pathways that Creatybin did not create. IF he made that specific pathway through his research and it was published by him specifically, then I would give credit to him. Also, anyone can make a video on it. So to say that I "stole" a project just by someone mentioning a pathway they were going to do is completely inaccurate and quite immature as a response. I have seen this pathway before and already planned on making another piperonal video. I would have done this with or without him saying he was going to do it. If he is going to say that I stole a pathway, he might as well contact everyone who also went through this pathway. Like cmon bro🤣🤣💀
When trying to repeat your authoritative experiment, I had to deal with complete inconsistencies in the course of the reaction while fully complying with your method in the presence of no less worthy hardware, the result was different..., the color of the reaction mass was black with a purple tint even before hydrolysis, the reagents were of purity for laboratory use, but something went wrong...
@@chemdelicMoreover, all thermal parameters were not taken outside the limits, the reagents were introduced in the order and quantity suggested by you..., while the whole process turned out to be not typical of your experience... perhaps there was the formation of a complex in the purine ligand or even charring, judging by the color of the reaction mass, which is absolutely not typical for exchange demethylation..., the reaction mass, when mixed with heating, changed color four times, the final one became like oil🤪I would like to analyze the typology of the reaction, especially when a cyclic amine is chosen as the ligand of the methyl group..., I would like to see the etiology on theoretical; mechanisms🙏, in any case, thank you, dear author✌️💪
